"Hemicholinium 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent inhibitor of the high affinity uptake system for CHOLINE. It has less effect on the low affinity uptake system. Since choline is one of the components of ACETYLCHOLINE, treatment with hemicholinium can deplete acetylcholine from cholinergic terminals. Hemicholinium 3 is commonly used as a research tool in animal and in vitro experiments.
Descriptor ID |
D006426
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MeSH Number(s) |
D02.092.877.435 D02.675.276.435
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hemicholinium 3".
Below are MeSH descriptors whose meaning is more specific than "Hemicholinium 3".
This graph shows the total number of publications written about "Hemicholinium 3" by people in this website by year, and whether "Hemicholinium 3" was a major or minor topic of these publications.
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Below are the most recent publications written about "Hemicholinium 3" by people in Profiles.
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Spinal endogenous acetylcholine contributes to the analgesic effect of systemic morphine in rats. Anesthesiology. 2001 Aug; 95(2):525-30.
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Hemicholinium-3 binding: correlation with high-affinity choline uptake during changes in cholinergic activity. Neuropharmacology. 1988 Jun; 27(6):611-5.
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Endplate channel actions of a hemicholinium-3 analog, DMAE. Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar; 332(3):230-5.
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Uropharmacology: part VI. Parasympathetic depressants. Urology. 1977 Nov; 10(5):503-10.