"Teniposide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
| Descriptor ID |
D013713
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| MeSH Number(s) |
D09.408.348.800
|
| Concept/Terms |
Teniposide- Teniposide
- Demethyl Epipodophyllotoxin Thenylidine Glucoside
|
Below are MeSH descriptors whose meaning is more general than "Teniposide".
Below are MeSH descriptors whose meaning is more specific than "Teniposide".
This graph shows the total number of publications written about "Teniposide" by people in this website by year, and whether "Teniposide" was a major or minor topic of these publications.
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Below are the most recent publications written about "Teniposide" by people in Profiles.
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Efficacy and tolerability of VCD chemotherapy in a UK real-world dataset of elderly transplant-ineligible newly diagnosed myeloma patients. Eur J Haematol. 2021 Apr; 106(4):563-573.
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Taxanes in the treatment of advanced (stage III and IV) non-small cell lung cancer (NSCLC): recent developments. Cancer Invest. 2003; 21(1):87-104.
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Intensive alternating drug pairs for treatment of high-risk childhood acute lymphoblastic leukemia. A Pediatric Oncology Group pilot study. Cancer. 1993 May 01; 71(9):2854-61.
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Total-body irradiation and high-dose teniposide: a pilot study in bone marrow transplantation for patients with relapsed acute lymphoblastic leukemia. Cancer Treat Rep. 1987 Jun; 71(6):645-7.
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Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage. Cancer Res. 1984 Dec; 44(12 Pt 1):5857-60.