"Negative Staining" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The technique of washing tissue specimens with a concentrated solution of a heavy metal salt and letting it dry. The specimen will be covered with a very thin layer of the metal salt, being excluded in areas where an adsorbed macromolecule is present. The macromolecules allow electrons from the beam of an electron microscope to pass much more readily than the heavy metal; thus, a reversed or negative image of the molecule is created.
| Descriptor ID |
D016624
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| MeSH Number(s) |
E01.370.225.500.620.670.520 E01.370.225.750.600.670.520 E05.200.500.620.670.520 E05.200.750.600.670.520
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| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Negative Staining".
Below are MeSH descriptors whose meaning is more specific than "Negative Staining".
This graph shows the total number of publications written about "Negative Staining" by people in this website by year, and whether "Negative Staining" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Negative Staining" by people in Profiles.
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An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIa within a flexible DNA repair complex. Nucleic Acids Res. 2021 01 11; 49(1):306-321.
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Utility of Butvar support film and methylamine tungstate stain in three-dimensional electron microscopy: agreement between stain and frozen-hydrated reconstructions. J Struct Biol. 1997 Nov; 120(2):158-67.
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Performance of a slow-scan CCD camera for macromolecular imaging in a 400 kV electron cryomicroscope. Micron. 1996 Apr; 27(2):129-39.