Clinical Trials Data Monitoring Committees
"Clinical Trials Data Monitoring Committees" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the "Common Rule") require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.
| Descriptor ID |
D026661
|
| MeSH Number(s) |
N05.700.685.149
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| Concept/Terms |
Clinical Trials Data Monitoring Committees- Clinical Trials Data Monitoring Committees
- Data Monitoring Committees
- Committee, Data Monitoring
- Committees, Data Monitoring
- Data Monitoring Committee
- Monitoring Committee, Data
- Monitoring Committees, Data
- Safety Monitoring Boards
- Board, Safety Monitoring
- Boards, Safety Monitoring
- Monitoring Board, Safety
- Monitoring Boards, Safety
- Safety Monitoring Board
- Data and Safety Monitoring Boards
|
Below are MeSH descriptors whose meaning is more general than "Clinical Trials Data Monitoring Committees".
Below are MeSH descriptors whose meaning is more specific than "Clinical Trials Data Monitoring Committees".
This graph shows the total number of publications written about "Clinical Trials Data Monitoring Committees" by people in this website by year, and whether "Clinical Trials Data Monitoring Committees" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Clinical Trials Data Monitoring Committees" by people in Profiles.
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The Data Monitoring Committee: A Collective or a Collection? Ther Innov Regul Sci. 2023 07; 57(4):653-655.
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Clinical trials in a COVID-19 pandemic: Shared infrastructure for continuous learning in a rapidly changing landscape. Clin Trials. 2021 06; 18(3):324-334.
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Traumatic injury clinical trial evaluating tranexamic acid in children (TIC-TOC): study protocol for a pilot randomized controlled trial. Trials. 2018 Oct 30; 19(1):593.
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Data monitoring committees: Promoting best practices to address emerging challenges. Clin Trials. 2017 Apr; 14(2):115-123.
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Rejoinder. Clin Trials. 2017 04; 14(2):126-127.
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Global harmonization of quality assurance naming conventions in radiation therapy clinical trials. Int J Radiat Oncol Biol Phys. 2014 Dec 01; 90(5):1242-9.
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Radiation therapy digital data submission process for national clinical trials network. Int J Radiat Oncol Biol Phys. 2014 Oct 01; 90(2):466-7.
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Enhancing trial integrity by protecting the independence of data monitoring committees in clinical trials. J Biopharm Stat. 2014; 24(5):968-75.
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A Bayesian dose-finding trial with adaptive dose expansion to flexibly assess efficacy and safety of an investigational drug. Clin Trials. 2010 Apr; 7(2):121-35.
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The data monitoring experience in the Candesartan in Heart Failure Assessment of Reduction in Mortality and morbidity (CHARM) program. Am Heart J. 2005 May; 149(5):939-43.