"Fenclonine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Descriptor ID |
D010134
|
| MeSH Number(s) |
D12.125.072.050.685.440
|
| Concept/Terms |
Fenclonine- Fenclonine
- para-Chlorophenylalanine
- para Chlorophenylalanine
- p-Chlorophenylalanine
- DL-3-(4-Chlorophenyl)alanine
- Fenclonin
|
Below are MeSH descriptors whose meaning is more general than "Fenclonine".
Below are MeSH descriptors whose meaning is more specific than "Fenclonine".
This graph shows the total number of publications written about "Fenclonine" by people in this website by year, and whether "Fenclonine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fenclonine" by people in Profiles.
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Serotonin synthesis inhibition reveals distinct mechanisms of action for MDMA and its enantiomers in the mouse. Psychopharmacology (Berl). 2005 Sep; 181(3):529-36.
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Effects of serotonin synthesis blockade on interleukin-1 beta action in the brain of rats. Brain Res. 2001 Oct 12; 915(2):244-7.
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d-Fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release. Eur J Pharmacol. 1994 Oct 13; 264(1):111-5.
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Dopaminergic stimulation of pituitary but not hypothalamic estrogen receptors in ovariectomized rats. Endocrinology. 1983 May; 112(5):1839-46.