"Ethacrynic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.
| Descriptor ID |
D004976
|
| MeSH Number(s) |
D02.241.081.018.386.682.300 D02.241.511.316.682.200
|
| Concept/Terms |
Ethacrynic Acid- Ethacrynic Acid
- Acid, Ethacrynic
- Etacrynic Acid
- Acid, Etacrynic
- Ethacrinic Acid
- Acid, Ethacrinic
|
Below are MeSH descriptors whose meaning is more general than "Ethacrynic Acid".
Below are MeSH descriptors whose meaning is more specific than "Ethacrynic Acid".
This graph shows the total number of publications written about "Ethacrynic Acid" by people in this website by year, and whether "Ethacrynic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ethacrynic Acid" by people in Profiles.
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Development of an assay for cellular efflux of pharmaceutically active agents and its relevance to understanding drug interactions. Exp Hematol. 2017 08; 52:65-71.
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High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid. Oncotarget. 2016 Apr 19; 7(16):21631-43.
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Implementation of a diuretic stewardship program in a pediatric cardiovascular intensive care unit to reduce medication expenditures. Am J Health Syst Pharm. 2015 Jun 15; 72(12):1047-51.
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Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum. Proteins. 2003 Apr 01; 51(1):137-46.
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Hormonal and pharmacologic regulation of sodium absorption in rabbit cecum in vitro. Dig Dis Sci. 1992 Dec; 37(12):1874-81.
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Changes in the plasma anion gap during chronic metabolic acid-base disturbances. Am J Physiol. 1978 Oct; 235(4):F291-7.
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Effect of diuretics on urinary excretion of phosphate, calcium, and magnesium in thyroparathyroidectomized dogs. J Lab Clin Med. 1970 Aug; 76(2):257-66.
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Localization of diuretic action from the pattern of water and electrolyte excretion. Ann N Y Acad Sci. 1966 Nov 22; 139(2):328-43.