GIULIO DRAETTA to Animals
This is a "connection" page, showing publications GIULIO DRAETTA has written about Animals.
Connection Strength
0.485
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Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature. 2019 04; 568(7752):410-414.
Score: 0.029
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In?Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Rep. 2016 06 28; 16(1):133-147.
Score: 0.024
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Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells. Cell Metab. 2015 Oct 06; 22(4):543-5.
Score: 0.022
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Tumors and mitochondrial respiration: a neglected connection. Cancer Res. 2015 Sep 15; 75(18):3685-6.
Score: 0.022
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Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer Res. 2015 Mar 15; 75(6):1091-101.
Score: 0.022
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Cancer drug discovery faces the FACT. Sci Transl Med. 2011 Aug 10; 3(95):95ps34.
Score: 0.017
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EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes. Oncogene. 2004 May 27; 23(25):4454-65.
Score: 0.010
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Regulating mammalian checkpoints through Cdc25 inactivation. EMBO Rep. 2003 Jul; 4(7):671-7.
Score: 0.010
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SMARCB1 regulates the hypoxic stress response in sickle cell trait. Proc Natl Acad Sci U S A. 2023 05 23; 120(21):e2209639120.
Score: 0.010
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Immune landscape of a genetically engineered murine model of glioma compared with human glioma. JCI Insight. 2022 06 22; 7(12).
Score: 0.009
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PGC1a/? Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer. Cancer Res. 2022 04 01; 82(7):1423-1434.
Score: 0.009
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Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J Med Chem. 2021 10 28; 64(20):15141-15169.
Score: 0.009
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Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis. Science. 2021 Sep 17; 373(6561):eabj0486.
Score: 0.008
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Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer. Cancer Res. 2021 11 01; 81(21):5572-5581.
Score: 0.008
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PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Nat Commun. 2021 07 30; 12(1):4626.
Score: 0.008
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Targeting the av integrin/TGF-? axis improves natural killer cell function against glioblastoma stem cells. J Clin Invest. 2021 07 15; 131(14).
Score: 0.008
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Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer. Gastroenterology. 2021 07; 161(1):196-210.
Score: 0.008
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Loss of ARID1A Promotes Epithelial-Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress. Cancer Res. 2021 01 15; 81(2):332-343.
Score: 0.008
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Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties. J Med Chem. 2020 11 12; 63(21):12957-12977.
Score: 0.008
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Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res. 2020 11 01; 80(21):4840-4853.
Score: 0.008
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Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells. J Exp Med. 2020 08 03; 217(8).
Score: 0.008
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Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma. Cancer Res. 2019 Nov 01; 79(21):5612-5625.
Score: 0.007
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Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma. Sci Transl Med. 2019 05 08; 11(491).
Score: 0.007
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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell. 2019 02 11; 35(2):204-220.e9.
Score: 0.007
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Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors. Cell Rep. 2019 02 05; 26(6):1518-1532.e9.
Score: 0.007
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Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Rep. 2019 01 08; 26(2):469-482.e5.
Score: 0.007
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High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer. Nat Commun. 2018 11 29; 9(1):5079.
Score: 0.007
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UBPY: a growth-regulated human ubiquitin isopeptidase. EMBO J. 1998 Jun 15; 17(12):3241-50.
Score: 0.007
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An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat Med. 2018 07; 24(7):1036-1046.
Score: 0.007
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11th European Cell Cycle Conference: April 23-26, 1997, Gardone Riviera (Italy) and Symposium on Cell Cycle Regulation (17th International Congress of Biochemistry and Molecular Biology): August 24-29, 1997, San Francisco, CA. Biochim Biophys Acta. 1998 Feb 20; 1377(1):R11-20.
Score: 0.007
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EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming. Cancer Res. 2017 12 01; 77(23):6651-6666.
Score: 0.006
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PRKCI promotes immune suppression in ovarian cancer. Genes Dev. 2017 06 01; 31(11):1109-1121.
Score: 0.006
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Cdc25 protein phosphatases in cell proliferation. Biochim Biophys Acta. 1997 Apr 18; 1332(2):M53-63.
Score: 0.006
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Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017 02 16; 542(7641):362-366.
Score: 0.006
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Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017 02 02; 542(7639):119-123.
Score: 0.006
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In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype. Cancer Discov. 2016 06; 6(6):650-63.
Score: 0.006
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Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25; 59(4):1440-54.
Score: 0.006
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Mammalian G1 cyclins. Curr Opin Cell Biol. 1994 Dec; 6(6):842-6.
Score: 0.005
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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014 Oct 30; 514(7524):628-32.
Score: 0.005
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Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell. 2014 Jul 03; 158(1):185-197.
Score: 0.005
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The Schizosaccharomyces pombe casein kinase II alpha and beta subunits: evolutionary conservation and positive role of the beta subunit. Mol Cell Biol. 1994 Jan; 14(1):576-86.
Score: 0.005
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Molecular pathology of the cell cycle in human cancer cells. Stem Cells. 1993 May; 11 Suppl 1:51-8.
Score: 0.005
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Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J. 1993 Jan; 12(1):53-63.
Score: 0.005
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Distinct forms of human CDC2 identified by novel monoclonal antibodies. Eur J Biochem. 1992 Jul 01; 207(1):169-76.
Score: 0.004
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PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models. Cancer Res. 2011 Apr 15; 71(8):3052-65.
Score: 0.004
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Cyclin A, cell cycle control and oncogenesis. Prog Growth Factor Res. 1991; 3(4):267-77.
Score: 0.004
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Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends Biochem Sci. 1990 Oct; 15(10):378-83.
Score: 0.004
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Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. Cancer Res. 2010 Mar 15; 70(6):2476-84.
Score: 0.004
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Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia. Br J Pharmacol. 2009 Nov; 158(5):1183-95.
Score: 0.004
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Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell. 1989 Mar 10; 56(5):829-38.
Score: 0.004
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The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle. J Cell Sci Suppl. 1989; 12:21-7.
Score: 0.004
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The phosphorylation of calmodulin and calmodulin fragments by kinase fractions from bovine brain. Biochim Biophys Acta. 1988 Oct 28; 972(1):69-78.
Score: 0.003
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Synthesis of p34, the mammalian homolog of the yeast cdc2+/CDC28 protein kinase, is stimulated during adenovirus-induced proliferation of primary baby rat kidney cells. Oncogene. 1988 Jun; 2(6):553-7.
Score: 0.003
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Purification of calmodulin-stimulated phosphodiesterase by affinity chromatography on calmodulin fragment 1-77 linked to sepharose. Methods Enzymol. 1988; 159:573-81.
Score: 0.003
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Regulation of the vertebrate cell cycle by the cdc2 protein kinase. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:195-201.
Score: 0.003
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SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science. 2007 May 11; 316(5826):900-4.
Score: 0.003
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Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner. Mol Cell Biol. 2005 Apr; 25(8):3338-47.
Score: 0.003
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The effects of lidocaine and procainamide on the sarcolemmal membrane high affinity cyclic AMP phosphodiesterase of rat myocardium. Gen Pharmacol. 1985; 16(2):115-9.
Score: 0.003
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Characterization of the BUD31 gene of Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2004 Aug 06; 320(4):1342-50.
Score: 0.003
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Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis. Oncogene. 2004 Mar 15; 23(11):2050-6.
Score: 0.003
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The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1. EMBO Rep. 2002 Nov; 3(11):1062-8.
Score: 0.002
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Histone deacetylase 1 inactivation by an adenovirus early gene product. Curr Biol. 2002 Apr 02; 12(7):594-8.
Score: 0.002
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p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J. 2001 Dec 03; 20(23):6672-82.
Score: 0.002
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[Experimental research on the toxicity of PVC administered orally]. Boll Soc Ital Biol Sper. 1981 Apr 30; 57(8):926-8.
Score: 0.002
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Interaction between Cdc37 and Cdk4 in human cells. Oncogene. 1997 Apr 24; 14(16):1999-2004.
Score: 0.002
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CDC25 phosphatases as potential human oncogenes. Science. 1995 Sep 15; 269(5230):1575-7.
Score: 0.001
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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 1995 Aug 04; 269(5224):682-5.
Score: 0.001
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Differential modulation of cyclin gene expression by MYC. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3685-9.
Score: 0.001
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Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts. Mol Biol Cell. 1993 Apr; 4(4):397-411.
Score: 0.001
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Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: role of cyclin A-associated protein kinase. J Cell Biol. 1992 Mar; 116(6):1431-42.
Score: 0.001
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cdc2 phosphorylation is required for its interaction with cyclin. EMBO J. 1991 Nov; 10(11):3311-9.
Score: 0.001
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E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products. Mol Cell Biol. 1991 Aug; 11(8):4253-65.
Score: 0.001
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A cdc2-like kinase phosphorylates histone H1 in the amitotic macronucleus of Tetrahymena. EMBO J. 1991 Aug; 10(8):2069-75.
Score: 0.001
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Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest. Mol Cell Biol. 1991 Mar; 11(3):1185-94.
Score: 0.001
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Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell. 1989 Jul 14; 58(1):193-203.
Score: 0.001
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The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell. 1989 May 05; 57(3):393-401.
Score: 0.001
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Inhibition of adenylate cyclase by transglutaminase-catalyzed reactions in pigeon erythrocyte ghosts. Biochem Biophys Res Commun. 1986 Jul 31; 138(2):596-603.
Score: 0.001
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Genetically engineered calmodulins differentially activate target enzymes. J Biol Chem. 1986 Jul 25; 261(21):9896-903.
Score: 0.001
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Do porins inhibit the macrophage phagocyting activity by stimulating the adenylate cyclase? J Cyclic Nucleotide Protein Phosphor Res. 1986; 11(2):87-97.
Score: 0.001
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Different modes of interaction of calmodulin with its target enzymes. J Cardiovasc Pharmacol. 1986; 8 Suppl 8:S52-6.
Score: 0.001
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The stereomorphologic disposition of the muscular capillary network. Experimental research into the effect of training, age, arterial insufficiency and chronic treatment with EPL. J Sports Med Phys Fitness. 1984 Mar; 24(1):1-12.
Score: 0.001
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Relationship between the fluidity of the membrane lipids and the activity of the membrane-bound proteins: the effects of lidocaine on the adenylate cyclase activity of rat myocardium. Gen Pharmacol. 1983; 14(6):669-72.
Score: 0.001
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Endotoxin inhibits the fluoride-stimulated adenylate cyclase activity of rat liver membranes enriched with bile canaliculi. Experientia. 1982 Jul 15; 38(7):831-3.
Score: 0.001