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PARMESWARAN DIAGARADJANE

TitleAssistant Professor
InstitutionMD Anderson
DepartmentExperimental Radiation Oncology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Debeb BG, Lacerda L, Anfossi S, Diagaradjane P, Chu K, Bambhroliya A, Huo L, Wei C, Larson RA, Wolfe AR, Xu W, Smith DL, Li L, Ivan C, Allen PK, Wu W, Calin GA, Krishnamurthy S, Zhang XH, Buchholz TA, Ueno NT, Reuben JM, Woodward WA. miR-141-Mediated Regulation of Brain Metastasis From Breast Cancer. J Natl Cancer Inst. 2016 08; 108(8). PMID: 27075851.
      View in: PubMed
    2. Manohar N, Reynoso FJ, Diagaradjane P, Krishnan S, Cho SH. Quantitative imaging of gold nanoparticle distribution in a tumor-bearing mouse using benchtop x-ray fluorescence computed tomography. Sci Rep. 2016 Feb 25; 6:22079. PMID: 26912068.
      View in: PubMed
    3. Deorukhkar A, Ahuja N, Mercado AL, Diagaradjane P, Raju U, Patel N, Mohindra P, Diep N, Guha S, Krishnan S. Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation. Cancer Med. 2015 Feb; 4(2):278-92. PMID: 25450478.
      View in: PubMed
    4. Chatterjee DK, Wolfe T, Lee J, Brown AP, Singh PK, Bhattarai SR, Diagaradjane P, Krishnan S. Convergence of nanotechnology with radiation therapy-insights and implications for clinical translation. Transl Cancer Res. 2013 Aug 23; 2(4):256-268. PMID: 25279336.
      View in: PubMed
    5. Prasad S, Yadav VR, Sung B, Reuter S, Kannappan R, Deorukhkar A, Diagaradjane P, Wei C, Baladandayuthapani V, Krishnan S, Guha S, Aggarwal BB. Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. Clin Cancer Res. 2012 Sep 15; 18(18):4942-53. PMID: 22832932.
      View in: PubMed
    6. Puvanakrishnan P, Diagaradjane P, Kazmi SM, Dunn AK, Krishnan S, Tunnell JW. Narrow band imaging of squamous cell carcinoma tumors using topically delivered anti-EGFR antibody conjugated gold nanorods. Lasers Surg Med. 2012 Apr; 44(4):310-7. PMID: 22415634.
      View in: PubMed
    7. Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB. Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. Int J Cancer. 2012 Aug 01; 131(3):E292-303. PMID: 21935918.
      View in: PubMed
    8. Chatterjee DK, Diagaradjane P, Krishnan S. Nanoparticle-mediated hyperthermia in cancer therapy. Ther Deliv. 2011 Aug; 2(8):1001-14. PMID: 22506095.
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    9. Xie H, Diagaradjane P, Deorukhkar AA, Goins B, Bao A, Phillips WT, Wang Z, Schwartz J, Krishnan S. Integrin avß3-targeted gold nanoshells augment tumor vasculature-specific imaging and therapy. Int J Nanomedicine. 2011; 6:259-69. PMID: 21423588.
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    10. Deorukhkar A, Shentu S, Park HC, Diagaradjane P, Puduvalli V, Aggarwal B, Guha S, Krishnan S. Inhibition of radiation-induced DNA repair and prosurvival pathways contributes to vorinostat-mediated radiosensitization of pancreatic cancer cells. Pancreas. 2010 Nov; 39(8):1277-83. PMID: 20531243.
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    11. Atkinson RL, Zhang M, Diagaradjane P, Peddibhotla S, Contreras A, Hilsenbeck SG, Woodward WA, Krishnan S, Chang JC, Rosen JM. Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy. Sci Transl Med. 2010 Oct 27; 2(55):55ra79. PMID: 20980696.
      View in: PubMed
    12. Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Yadav VR, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB. {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer Res. 2010 Nov 01; 70(21):8695-705. PMID: 20864511.
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    13. Krishnan S, Diagaradjane P, Cho SH. Nanoparticle-mediated thermal therapy: evolving strategies for prostate cancer therapy. Int J Hyperthermia. 2010; 26(8):775-89. PMID: 20858069.
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    14. Park J, Estrada A, Schwartz JA, Diagaradjane P, Krishnan S, Dunn AK, Tunnell JW. Intra-organ Biodistribution of Gold Nanoparticles Using Intrinsic Two-photon Induced Photoluminescence. Lasers Surg Med. 2010 Sep; 42(7):630-639. PMID: 21399728.
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    15. Diagaradjane P, Deorukhkar A, Gelovani JG, Maru DM, Krishnan S. Gadolinium chloride augments tumor-specific imaging of targeted quantum dots in vivo. ACS Nano. 2010 Jul 27; 4(7):4131-41. PMID: 20586481.
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    16. Harikumar KB, Kunnumakkara AB, Sethi G, Diagaradjane P, Anand P, Pandey MK, Gelovani J, Krishnan S, Guha S, Aggarwal BB. Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer. Int J Cancer. 2010 Jul 15; 127(2):257-68. PMID: 19908231.
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    17. Harikumar KB, Kunnumakkara AB, Ochi N, Tong Z, Deorukhkar A, Sung B, Kelland L, Jamieson S, Sutherland R, Raynham T, Charles M, Bagherzadeh A, Bagherazadeh A, Foxton C, Boakes A, Farooq M, Maru D, Diagaradjane P, Matsuo Y, Sinnett-Smith J, Gelovani J, Krishnan S, Aggarwal BB, Rozengurt E, Ireson CR, Guha S. A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther. 2010 May; 9(5):1136-46. PMID: 20442301.
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    18. Kunnumakkara AB, Diagaradjane P, Anand P, Harikumar KB, Kuzhuvelil HB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB. Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. Int J Cancer. 2009 Nov 01; 125(9):2187-97. PMID: 19623659.
      View in: PubMed
    19. Puvanakrishnan P, Park J, Diagaradjane P, Schwartz JA, Coleman CL, Gill-Sharp KL, Sang KL, Payne JD, Krishnan S, Tunnell JW. Near-infrared narrow-band imaging of gold/silica nanoshells in tumors. J Biomed Opt. 2009 Mar-Apr; 14(2):024044. PMID: 19405772.
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    20. Tong Z, Kunnumakkara AB, Wang H, Matsuo Y, Diagaradjane P, Harikumar KB, Ramachandran V, Sung B, Chakraborty A, Bresalier RS, Logsdon C, Aggarwal BB, Krishnan S, Guha S. Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res. 2008 Aug 01; 68(15):6100-8. PMID: 18676832.
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    21. Diagaradjane P, Shetty A, Wang JC, Elliott AM, Schwartz J, Shentu S, Park HC, Deorukhkar A, Stafford RJ, Cho SH, Tunnell JW, Hazle JD, Krishnan S. Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy. Nano Lett. 2008 May; 8(5):1492-500. PMID: 18412402.
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    22. Verma A, Guha S, Diagaradjane P, Kunnumakkara AB, Sanguino AM, Lopez-Berestein G, Sood AK, Aggarwal BB, Krishnan S, Gelovani JG, Mehta K. Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer. Clin Cancer Res. 2008 Apr 15; 14(8):2476-83. PMID: 18413840.
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    23. Kunnumakkara AB, Diagaradjane P, Guha S, Deorukhkar A, Shentu S, Aggarwal BB, Krishnan S. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. Clin Cancer Res. 2008 Apr 01; 14(7):2128-36. PMID: 18381954.
      View in: PubMed
    24. Diagaradjane P, Orenstein-Cardona JM, Colón-Casasnovas NE, Deorukhkar A, Shentu S, Kuno N, Schwartz DL, Gelovani JG, Krishnan S. Imaging epidermal growth factor receptor expression in vivo: pharmacokinetic and biodistribution characterization of a bioconjugated quantum dot nanoprobe. Clin Cancer Res. 2008 Feb 01; 14(3):731-41. PMID: 18245533.
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    25. Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res. 2007 Apr 15; 67(8):3853-61. PMID: 17440100.
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    26. Dai T, Yaseen MA, Diagaradjane P, Chang DW, Anvari B. Comparative study of cryogen spray cooling with R-134a and R-404a: implications for laser treatment of dark human skin. J Biomed Opt. 2006 Jul-Aug; 11(4):041116. PMID: 16965144.
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    27. Diagaradjane P, Yaseen MA, Yu J, Wong MS, Anvari B. Synchronous fluorescence spectroscopic characterization of DMBA-TPA-induced squamous cell carcinoma in mice. J Biomed Opt. 2006 Jan-Feb; 11(1):014012. PMID: 16526889.
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    28. Diagaradjane P, Yaseen MA, Yu J, Wong MS, Anvari B. Autofluorescence characterization for the early diagnosis of neoplastic changes in DMBA/TPA-induced mouse skin carcinogenesis. Lasers Surg Med. 2005 Dec; 37(5):382-95. PMID: 16240416.
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    29. Dai T, Diagaradjane P, Yaseen MA, Pikkula BM, Thomsen S, Anvari B. Laser-induced thermal injury to dermal blood vessels: analysis of wavelength (585 nm vs. 595 nm), cryogen spray cooling, and wound healing effects. Lasers Surg Med. 2005 Sep; 37(3):210-8. PMID: 16175632.
      View in: PubMed
    30. Parmeswaran D, Pushpan SK, Srinivasan A, Ravi Kumar M, Chandrashekar TK, Ganesan S. In vitro and in vivo investigations on the photodynamic activity of core-modified expanded porphyrin--ammonium salt of 5,10,15,20-tetrakis-(meso-p-sulfonato phenyl)-25,27,29-trithia sapphyrin. Photochem Photobiol. 2003 Nov; 78(5):487-95. PMID: 14653581.
      View in: PubMed
    31. Diagaradjane P, Madhuri S, Aruna P, Gupta PK, Ganesan S. In vivo pharmacokinetics of 8-aminolevulinic acid-induced protoporphyrin IX during pre- and post-photodynamic therapy in 7,12-dimethylbenz(a)nthracene-treated skin carcinogenesis in Swiss mice: a comparison by three-compartment model. Photochem Photobiol. 2002 Jul; 76(1):81-90. PMID: 12126311.
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    32. Pushpan SK, Venkatraman S, Anand VG, Sankar J, Parmeswaran D, Ganesan S, Chandrashekar TK. Porphyrins in photodynamic therapy - a search for ideal photosensitizers. Curr Med Chem Anticancer Agents. 2002 Mar; 2(2):187-207. PMID: 12678743.
      View in: PubMed
    33. Native cellular fluorescence characteristics of normal and malignant epithelial cells from human larynx. 759-764.
    34. Photothermal and photochemical effects of laser light absorption by Indocyanine Green (ICG). 27-35.
    35. Photodynamic activity on human erythrocytes by a newly synthesized sensitizer - trithia sapphyrin sulfonate. 94-100.
    36. In-vivo pharmacokinetics of δ-ALA induced PPIX during photodynamic therapy on mice tumor model. 128-133.
    37. Narrow band imaging of tumors using gold nanoshells.
    38. Autofluorescence characterization of DMBA-TPA induced two-stage carcinogenesis in mouse skin for the early detection of tissue transformation. 41-50.
    39. Two-photon-induced photoluminescence imaging of gold nanoshell's tumor biodistribution.
    40. EGF-conjugated Near-infrared quantum dots as nanoprobes for in-vivo imaging of EGFR expression.
    41. Theranostic Applications of Gold Nanoparticles in Cancer. 639-657.
    42. miR-141-mediated regulation of brain metastasis from breast cancer. Journal of the National Cancer Institute. 108.
    43. Quantitative imaging of gold nanoparticle distribution in a tumor-bearing mouse using benchtop x-ray fluorescence computed tomography. Scientific Reports. 6.
    44. Comparison of PDT efficiencies for photooxidation of substrate (NADPH) using a photosensitizer (Photofrin II). 97-103.
    45. Native fluorescence characteristics of blood plasma during rat liver regeneration. 15-19.
    46. Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model (International Journal of Cancer (2009) 125, (2187-2197)). International Journal of Cancer. 126:799.
    47. Convergence of nanotechnology with radiation therapy-insights and implications for clinical translation. Translational Cancer Research. 2:256-268.
    48. Measuring gold nanoparticle concentrations in tissue using diffuse optical spectroscopy.
    49. Gold nanoshell mediated hyperthermia enhances the efficacy of radiation therapy.
    50. In vivo detection of gold nanoshells in tumors using diffuse optical spectroscopy. IEEE Journal on Selected Topics in Quantum Electronics. 13:1715-1720.
    51. Microscopy of gold nanoshells in tumors using two-photon induced photoluminescence. 71-72.
    52. Comparison of bond strength and surface morphology of dental enamel for acid and Nd-YAG laser etching. 86-90.
    53. Measuring gold nanoparticle concentrations in tissue using diffuse optical spectroscopy.
    54. Erratum. IEEE Journal on Selected Topics in Quantum Electronics. 14:251.
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