NICOLAS YOUNG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Precision Environmental Health
    DivisionCenter for Precision Env Health

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse Research 
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    F32CA139893     (YOUNG, NICOLAS L)Jul 1, 2010 - Jun 30, 2012
    NIH
    Investigation of the Histone Code in DNA Damage Response and Repair Mechanisms
    Role: Principal Investigator

    R01GM139295     (YOUNG, NICOLAS L)Sep 1, 2020 - May 31, 2025
    NIH
    Neutron encoded activity based probes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Park KW, Wood CA, Li J, Taylor BC, Oh S, Young NL, Jankowsky JL. Gene therapy using Aß variants for amyloid reduction. Mol Ther. 2021 07 07; 29(7):2294-2307. PMID: 33647457.
      Citations: 1     Fields:    
    2. Young NL, Dere R. Mechanistic insights into KDM4A driven genomic instability. Biochem Soc Trans. 2021 02 26; 49(1):93-105. PMID: 33492339.
      Citations:    Fields:    
    3. Taylor BC, Young NL. Combinations of histone post-translational modifications. Biochem J. 2021 02 12; 478(3):511-532. PMID: 33567070.
      Citations: 4     Fields:    Translation:HumansCells
    4. Holt MV, Wang T, Young NL. Expeditious Extraction of Histones from Limited Cells or Tissue Samples and Quantitative Top-Down Proteomic Analysis. Curr Protoc. 2021 Feb; 1(2):e26. PMID: 33534192.
      Citations: 1     Translation:AnimalsCells
    5. Andrews AJ, Young NL. Methodological innovations drive conceptual innovations forward in chromatin biology. Methods. 2020 12 01; 184:1-3. PMID: 33069800.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Guo YR, Fan Y, Zhou Y, Jin M, Zhang JL, Jiang H, Holt MV, Wang T, Young NL, Wang D, Zhong W, Tao YJ. Orsay Virus CP-d Adopts a Novel ß-Bracelet Structural Fold and Incorporates into Virions as a Head Fiber. J Virol. 2020 10 14; 94(21). PMID: 32817218.
      Citations:    Fields:    Translation:AnimalsCells
    7. Srzentic K, Fornelli L, Tsybin YO, Loo JA, Seckler H, Agar JN, Anderson LC, Bai DL, Beck A, Brodbelt JS, van der Burgt YEM, Chamot-Rooke J, Chatterjee S, Chen Y, Clarke DJ, Danis PO, Diedrich JK, D'Ippolito RA, Dupré M, Gasilova N, Ge Y, Goo YA, Goodlett DR, Greer S, Haselmann KF, He L, Hendrickson CL, Hinkle JD, Holt MV, Hughes S, Hunt DF, Kelleher NL, Kozhinov AN, Lin Z, Malosse C, Marshall AG, Menin L, Millikin RJ, Nagornov KO, Nicolardi S, Paša-Tolic L, Pengelley S, Quebbemann NR, Resemann A, Sandoval W, Sarin R, Schmitt ND, Shabanowitz J, Shaw JB, Shortreed MR, Smith LM, Sobott F, Suckau D, Toby T, Weisbrod CR, Wildburger NC, Yates JR, Yoon SH, Young NL, Zhou M. Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry. J Am Soc Mass Spectrom. 2020 Sep 02; 31(9):1783-1802. PMID: 32812765.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    8. Dai S, Holt MV, Horton JR, Woodcock CB, Patel A, Zhang X, Young NL, Wilkinson AW, Cheng X. Characterization of SETD3 methyltransferase-mediated protein methionine methylation. J Biol Chem. 2020 08 07; 295(32):10901-10910. PMID: 32503840.
      Citations: 3     Fields:    Translation:HumansCells
    9. Jiang Y, Hu T, Wang T, Shi X, Kitano A, Eagle K, Hoegenauer KA, Konopleva MY, Lin CY, Young NL, Nakada D. AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia. Blood. 2019 12 12; 134(24):2183-2194. PMID: 31697807.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    10. Holt MV, Wang T, Young NL. High-Throughput Quantitative Top-Down Proteomics: Histone H4. J Am Soc Mass Spectrom. 2019 Dec; 30(12):2548-2560. PMID: 31741267.
      Citations: 3     Fields:    Translation:HumansCells
    11. Holt MV, Wang T, Young NL. One-Pot Quantitative Top- and Middle-Down Analysis of GluC-Digested Histone H4. J Am Soc Mass Spectrom. 2019 Dec; 30(12):2514-2525. PMID: 31147891.
      Citations: 3     Fields:    Translation:HumansCells
    12. Wang T, Holt MV, Young NL. Early butyrate induced acetylation of histone H4 is proteoform specific and linked to methylation state. Epigenetics. 2018; 13(5):519-535. PMID: 29940793.
      Citations: 10     Fields:    Translation:HumansCells
    13. Wang T, Holt MV, Young NL. The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance. Epigenetics Chromatin. 2018 06 07; 11(1):29. PMID: 29880017.
      Citations: 7     Fields:    Translation:HumansCells
    14. Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B. How many human proteoforms are there? Nat Chem Biol. 2018 02 14; 14(3):206-214. PMID: 29443976.
      Citations: 137     Fields:    Translation:HumansCells
    15. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 33441849.
      Citations: 2     Fields:    Translation:Cells
    16. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 29667342.
      Citations: 8     Fields:    Translation:HumansCells
    17. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 24644084.
      Citations: 34     Fields:    Translation:HumansCells
    18. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 20577673.
      Citations: 14     Fields:    Translation:HumansCells
    19. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 28241071.
      Citations: 6     Fields:    Translation:AnimalsCells
    20. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 20683756.
      Citations: 41     Fields:    Translation:HumansCells
    21. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 26209608.
      Citations: 11     Fields:    Translation:HumansCells
    22. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 21774791.
      Citations: 33     Fields:    
    23. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 19158276.
      Citations: 68     Fields:    Translation:HumansCells
    24. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 24496597.
      Citations: 1     Fields:    Translation:HumansCells
    25. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 22343720.
      Citations: 23     Fields:    Translation:AnimalsCells
    26. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 22722849.
      Citations: 203     Fields:    Translation:HumansAnimalsCells
    27. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 20202861.
      Citations: 8     Fields:    Translation:HumansCells
    28. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 20103568.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    29. Zhuang H, Bai J, Chang JY, Yuan Z, Wang P. MTOR inhibition reversed drug resistance after combination radiation with erlotinib in lung adenocarcinoma. Oncotarget. 2016 Dec 20; 7(51):84688-84694. PMID: 34242617.
      Citations: 1     Fields:    
    30. Dang X, Singh A, Spetman BD, Nolan KD, Isaacs JS, Dennis JH, Dalton S, Marshall AG, Young NL. Label-Free Relative Quantitation of Isobaric and Isomeric Human Histone H2A and H2B Variants by Fourier Transform Ion Cyclotron Resonance Top-Down MS/MS. J Proteome Res. 2016 09 02; 15(9):3196-203. PMID: 27431976.
      Citations: 11     Fields:    Translation:HumansCells
    31. Harshman SW, Young NL, Parthun MR, Freitas MA. H1 histones: current perspectives and challenges. Nucleic Acids Res. 2013 Nov; 41(21):9593-609. PMID: 23945933.
      Citations: 82     Fields:    Translation:Cells
    32. Zhang Q, Noble KA, Mao Y, Young NL, Sathe SK, Roux KH, Marshall AG. Rapid screening for potential epitopes reactive with a polycolonal antibody by solution-phase H/D exchange monitored by FT-ICR mass spectrometry. J Am Soc Mass Spectrom. 2013 Jul; 24(7):1016-25. PMID: 23681851.
      Citations: 4     Fields:    Translation:AnimalsCells
    33. Voigt P, LeRoy G, Drury WJ, Zee BM, Son J, Beck DB, Young NL, Garcia BA, Reinberg D. Asymmetrically modified nucleosomes. Cell. 2012 Sep 28; 151(1):181-93. PMID: 23021224.
      Citations: 178     Fields:    Translation:HumansAnimalsCells
    34. Torrente MP, Zee BM, Young NL, Baliban RC, LeRoy G, Floudas CA, Hake SB, Garcia BA. Proteomic interrogation of human chromatin. PLoS One. 2011; 6(9):e24747. PMID: 21935452.
      Citations: 16     Fields:    Translation:HumansCells
    35. Yan K, Cao Q, Reilly CM, Young NL, Garcia BA, Mishra N. Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunity. J Biol Chem. 2011 Aug 19; 286(33):28833-28843. PMID: 21708950.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    36. Young NL, Plazas-Mayorca MD, Garcia BA. Systems-wide proteomic characterization of combinatorial post-translational modification patterns. Expert Rev Proteomics. 2010 Feb; 7(1):79-92. PMID: 20121478.
      Citations: 21     Fields:    Translation:Cells
    37. Plazas-Mayorca MD, Zee BM, Young NL, Fingerman IM, LeRoy G, Briggs SD, Garcia BA. One-pot shotgun quantitative mass spectrometry characterization of histones. J Proteome Res. 2009 Nov; 8(11):5367-74. PMID: 19764812.
      Citations: 75     Fields:    Translation:HumansCells
    38. DiMaggio PA, Young NL, Baliban RC, Garcia BA, Floudas CA. A mixed integer linear optimization framework for the identification and quantification of targeted post-translational modifications of highly modified proteins using multiplexed electron transfer dissociation tandem mass spectrometry. Mol Cell Proteomics. 2009 Nov; 8(11):2527-43. PMID: 19666874.
      Citations: 45     Fields:    Translation:HumansCells
    39. Young NL, DiMaggio PA, Plazas-Mayorca MD, Baliban RC, Floudas CA, Garcia BA. High throughput characterization of combinatorial histone codes. Mol Cell Proteomics. 2009 Oct; 8(10):2266-84. PMID: 19654425.
      Citations: 141     Fields:    Translation:HumansCells
    40. LeRoy G, Weston JT, Zee BM, Young NL, Plazas-Mayorca MD, Garcia BA. Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications. Mol Cell Proteomics. 2009 Nov; 8(11):2432-42. PMID: 19567367.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    41. Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M. Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol Cell. 2009 Feb 27; 33(4):417-27. PMID: 19250903.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
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