FONG LAM

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6621 FANNIN
Houston, TX 77030
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    Collapse Biography 
    Collapse awards and honors
    2016 - 2017Alkek Award for Pilot Projects on Experimental Therapeutics, Baylor College of Medicine
    2017 - 2018Travel Award for Outstanding Young Investigators, The Microcirculatory Society
    2014 - 2015Micahel E. DeBakey Veterans Affairs Seed Award, Michael E. DeBakey Veterans Affairs Medical Center
    2017 - 2022NIGMS K08, National Institutes of Health

    Collapse Overview 
    Collapse overview
    My clinical and research interests lie in the interactions between neutrophils, platelets, and endothelial cells in the microcirculation. These interactions lead to both the inflammation and thrombosis that occur in patients with inflammatory diseases. I am interested in understanding the mechanisms by which inflammation and thrombosis influence each other in order to develop novel therapies to reduce the morbidity and mortality from pathologic inflammation (such as sepsis, acute lung injury, trauma, and extracorporeal devices)

    Collapse Research 
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    K08GM123261     (LAM, FONG WILSON)Apr 1, 2017 - Mar 31, 2022
    NIH
    UTILIZING SOLUBLE VIMENTIN AND ITS COMPONENTS TO ATTENUATE INFLAMMATION
    Role: Principal Investigator

    R01DK122708     (JU, CYNTHIA)Sep 17, 2019 - Aug 31, 2024
    NIH
    Role of chitinase-3-like-1 (Chi3l1) in acetaminophen-induced liver injury
    Role: Co-Investigator

    Pilot/Feasibility Award     (Fong Lam)Jan 1, 2020 - Dec 31, 2020
    Texas Medical Center Digestive Diseases Core
    Platelets in APAP-induced hepatotoxicity
    Role Description: To identify the role of platelets in the development, progression, and resolution of acetaminophen induced liver injury using a combination of intravital microscopy, standard histology, and serum biochemical analyses.
    Role: Principal Investigator

    R01HL151858     (SHEVKOPLYAS, SERGEY S)May 1, 2020 - Apr 30, 2024
    NIH
    Enabling pediatric leukapheresis with high-throughput microfluidic technology
    Role: Co-Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Onyearugbulem C, Coss-Bu J, Gazzaneo MC, Melicoff E, Das S, Lam F, Mallory GB, Munoz FM. Infections Within the First Month After Pediatric Lung Transplantation: Epidemiology and Impact on Outcomes. J Pediatric Infect Dis Soc. 2021 Apr 03; 10(3):245-251. PMID: 32533840.
      Citations:    Fields:    
    2. Mendelson AA, Lam F, Peirce SM, Murfee WL. Clinical Perspectives on the Microcirculation. Microcirculation. 2021 Feb 24; e12688. PMID: 33629399.
      Citations:    Fields:    
    3. Bashir DA, Da Q, Pradhan S, Sekhar N, Valladolid C, Lam F, Guffey D, Goldman J, Desai MS, Cruz MA, Allen C, Nguyen TC, Vijayan KV. Secretion of von Willebrand Factor and Suppression of ADAMTS-13 Activity by Markedly High Concentration of Ferritin. Clin Appl Thromb Hemost. 2021 Jan-Dec; 27:1076029621992128. PMID: 33539188.
      Citations:    Fields:    Translation:HumansCells
    4. Godfrey E, Desai M, Lam F, Goss J, Rana A, Miloh T. Higher Waitlist Mortality in Pediatric Acute-on-chronic Liver Failure in the UNOS Database. J Pediatr Gastroenterol Nutr. 2021 Jan 01; 72(1):80-87. PMID: 32796428.
      Citations:    Fields:    
    5. Lam FW, Brown CA, Valladolid C, Emebo DC, Palzkill TG, Cruz MA. The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium. PLoS One. 2020; 15(10):e0240164. PMID: 33048962.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Courson JA, Hanlon SD, Bray MA, Lam FW, Burns AR, Rumbaut RE. Serial block-face scanning electron microscopy: A provocative technique to define 3-dimensional ultrastructure of microvascular thrombosis. Thromb Res. 2020 12; 196:519-522. PMID: 33099176.
      Citations:    Fields:    
    7. Valladolid C, Martinez-Vargas M, Sekhar N, Lam F, Brown C, Palzkill T, Tischer A, Auton M, Vijayan KV, Rumbaut RE, Nguyen TC, Cruz MA. Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation. Blood Adv. 2020 04 14; 4(7):1340-1349. PMID: 32259201.
      Citations: 1     Fields:    
    8. Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, Byrd TT, Mukherjee M, Marrelli SP, Orange JS, Joseph SK, Sorensen PH, Taylor MD, Hegde M, Mamonkin M, Jain RK, El-Naggar S, Ahmed N. Retraction Note: A homing system targets therapeutic T cells to brain cancer. Nature. 2019 03; 567(7746):132. PMID: 30787441.
      Citations:    Fields:    
    9. Gorgis NM, Kennedy C, Lam F, Thompson K, Coss-Bu J, Akcan Arikan A, Nguyen T, Hosek K, Miloh T, Karpen SJ, Penny DJ, Goss J, Desai MS. Clinical Consequences of Cardiomyopathy in Children With Biliary Atresia Requiring Liver Transplantation. Hepatology. 2019 03; 69(3):1206-1218. PMID: 30076624.
      Citations: 1     Fields:    Translation:Humans
    10. Onyearugbulem C, Williams L, Zhu H, Gazzaneo MC, Melicoff E, Das S, Coss-Bu J, Lam F, Mallory G, Munoz FM. Risk factors for infection after pediatric lung transplantation. Transpl Infect Dis. 2018 Dec; 20(6):e13000. PMID: 30221817.
      Citations: 2     Fields:    Translation:Humans
    11. Goldman J, Desai MS, McClain KL, Tcharmtchi MH, Kennedy CE, Thompson K, Lam F, Bashir DA, Chinn IK, Goldberg BR, Allen CE, Nguyen TC. Hepatobiliary Dysfunction and Disseminated Intravascular Coagulation Increase Risk of Mortality in Pediatric Hemophagocytic Lymphohistiocytosis. Pediatr Crit Care Med. 2018 10; 19(10):e522-e530. PMID: 30113519.
      Citations: 3     Fields:    Translation:Humans
    12. Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, Byrd TT, Mukherjee M, Marrelli SP, Orange JS, Joseph SK, Sorensen PH, Taylor MD, Hegde M, Mamonkin M, Jain RK, El-Naggar S, Ahmed N. A homing system targets therapeutic T cells to brain cancer. Nature. 2018 09; 561(7723):331-337. PMID: 30185905.
      Citations: 7     Fields:    
    13. Akcan Arikan A, Srivaths P, Himes RW, Tufan Pekkucuksen N, Lam F, Nguyen T, Miloh T, Braun M, Goss J, Desai MS. Hybrid Extracorporeal Therapies as a Bridge to Pediatric Liver Transplantation. Pediatr Crit Care Med. 2018 07; 19(7):e342-e349. PMID: 29652753.
      Citations: 1     Fields:    Translation:Humans
    14. Da Q, Derry PJ, Lam FW, Rumbaut RE. Fluorescent labeling of endogenous platelets for intravital microscopy: Effects on platelet function. Microcirculation. 2018 08; 25(6):e12457. PMID: 29701894.
      Citations: 2     Fields:    Translation:AnimalsCells
    15. Wulff J, Margolin J, Coleman NE, Demmler-Harrison G, Lam F, Shah MD. A Severe Case of Murine Typhus Presenting With Anemia and Severe Thrombocytopenia. J Pediatr Hematol Oncol. 2018 04; 40(3):e185-e190. PMID: 29200167.
      Citations: 1     Fields:    Translation:Humans
    16. Lam FW, Da Q, Guillory B, Cruz MA. Recombinant Human Vimentin Binds to P-Selectin and Blocks Neutrophil Capture and Rolling on Platelets and Endothelium. J Immunol. 2018 03 01; 200(5):1718-1726. PMID: 29335256.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    17. Krennerich E, Sitler CG, Shah M, Lam F, Graf J. Retrospective Review of Pediatric Transport: Where Do Our Patients Go After Transport? Air Med J. 2017 Nov - Dec; 36(6):332-338. PMID: 29132597.
      Citations:    Fields:    Translation:Humans
    18. Rana A, Kueht M, Desai M, Lam F, Miloh T, Moffett J, Galvan NT, Cotton R, O'Mahony C, Goss J. No Child Left Behind: Liver Transplantation in Critically Ill Children. J Am Coll Surg. 2017 Apr; 224(4):671-677. PMID: 28167225.
      Citations: 1     Fields:    Translation:Humans
    19. Lam FW, Cruz MA, Parikh K, Rumbaut RE. Histones stimulate von Willebrand factor release in vitro and in vivo. Haematologica. 2016 07; 101(7):e277-9. PMID: 27013650.
      Citations: 6     Fields:    Translation:HumansAnimals
    20. Lam FW, Rumbaut RE. Platelets mediate acetaminophen hepatotoxicity. Blood. 2015 Oct 08; 126(15):1738-9. PMID: 26450954.
      Citations:    Fields:    Translation:AnimalsCells
    21. Lam FW, Vijayan KV, Rumbaut RE. Platelets and Their Interactions with Other Immune Cells. Compr Physiol. 2015 Jul 01; 5(3):1265-80. PMID: 26140718.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    22. Lam FW, Phillips J, Landry P, Magadi S, Smith CW, Rumbaut RE, Burns AR. Platelet recruitment promotes keratocyte repopulation following corneal epithelial abrasion in the mouse. PLoS One. 2015; 10(3):e0118950. PMID: 25775402.
      Citations:    Fields:    Translation:AnimalsCells
    23. Lam FW, Rumbaut RE, Burns AR. The Neutrophil: New Outlook for Old Cells, Edited by Dmitry Gabrilovich. Mechanisms of neutrophil migration. 2013; 129-188.
    24. Lam FW, Cruz MA, Leung HC, Parikh KS, Smith CW, Rumbaut RE. Histone induced platelet aggregation is inhibited by normal albumin. Thromb Res. 2013 Jul; 132(1):69-76. PMID: 23673386.
      Citations: 22     Fields:    Translation:HumansCells
    25. Nguyen T, Kyle UG, Jaimon N, Tcharmtchi MH, Coss-Bu JA, Lam F, Teruya J, Loftis L. Coinfection with Staphylococcus aureus increases risk of severe coagulopathy in critically ill children with influenza A (H1N1) virus infection. Crit Care Med. 2012 Dec; 40(12):3246-50. PMID: 22971587.
      Citations: 16     Fields:    Translation:HumansCells
    26. Stark RJ, Naik-Mathuria BJ, Lam FW, Olutoye OO, Sutton VR, Shekerdemian LS. Extracorporeal membrane oxygenation support of a severe metabolic crisis in a child with methylmalonic acidemia. ASAIO J. 2012 Jul-Aug; 58(4):438-9. PMID: 22711065.
      Citations: 1     Fields:    Translation:Humans
    27. Lam FW, Burns AR, Smith CW, Rumbaut RE. Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1. Am J Physiol Heart Circ Physiol. 2011 Feb; 300(2):H468-75. PMID: 21169400.
      Citations: 28     Translation:HumansAnimalsCells
    28. Desai MS, Shabier Z, Taylor M, Lam F, Thevananther S, Kosters A, Karpen SJ. Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis. Hepatology. 2010 Jun; 51(6):2097-107. PMID: 20512997.
      Citations: 23     Fields:    Translation:AnimalsCells
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