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RADEK SKODA

TitleSenior Faculty
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
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    Other Positions
    TitleSenior Faculty
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleSenior Faculty
    InstitutionBaylor College of Medicine
    DepartmentDuncan Cancer Center
    DivisionCancer Center


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Schaefer T, Mittal N, Wang H, Ataman M, Candido S, L?tscher J, Velychko S, Tintignac L, Bock T, B?rsch A, Ba?ler J, Rao TN, Zmajkovic J, Roffeis S, L?liger J, Jacob F, Dumlin A, Sch?rch C, Schmidt A, Skoda RC, Wymann MP, Hess C, Sch?ler HR, Zaehres H, Hurt E, Zavolan M, Lengerke C. Nuclear and cytosolic fractions of SOX2 synergize as transcriptional and translational co-regulators of cell fate. Cell Rep. 2024 Oct 22; 43(10):114807. PMID: 39368083.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Usart M, Stetka J, Luque Paz D, Hansen N, Kimmerlin Q, Almeida Fonseca T, Lock M, Kubovcakova L, Karjalainen R, Hao-Shen H, B?rsch A, El Taher A, Schulz J, Leroux JC, Dirnhofer S, Skoda RC. Loss of Dnmt3a increases self-renewal and resistance to pegIFN-a in JAK2-V617F-positive myeloproliferative neoplasms. Blood. 2024 06 13; 143(24):2490-2503. PMID: 38493481; PMCID: PMC11208296.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Miao Y, Virtanen A, Zmajkovic J, Hilpert M, Skoda RC, Silvennoinen O, Haikarainen T. Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity. J Med Chem. 2024 Jun 27; 67(12):10012-10024. PMID: 38843875; PMCID: PMC11215726.
      Citations: 1     Fields:    Translation:HumansCells
    4. Usart M, Hansen N, Stetka J, Almeida Fonseca T, Guy A, Kimmerlin Q, Rai S, Hao-Shen H, Roux J, Dirnhofer S, Skoda RC. The glutaminase inhibitor CB-839 targets metabolic dependencies of JAK2-mutant hematopoiesis in MPN. Blood Adv. 2024 05 14; 8(9):2312-2325. PMID: 38295283; PMCID: PMC11117009.
      Citations: 3     Fields:    Translation:HumansAnimals
    5. Rai S, Zhang Y, Grockowiak E, Kimmerlin Q, Hansen N, Stoll CB, Usart M, Luque Paz D, Hao-Shen H, Zhu Y, Roux J, Bader MS, Dirnhofer S, Farady CJ, Schroeder T, M?ndez-Ferrer S, Skoda RC. IL-1? promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells. Blood Adv. 2024 03 12; 8(5):1234-1249. PMID: 38207211; PMCID: PMC10912850.
      Citations: 4     Fields:    Translation:AnimalsCells
    6. Wildschut MHE, Mena J, D?rdelmann C, van Oostrum M, Hale BD, Settelmeier J, Festl Y, Lysenko V, Sch?rch PM, Ring A, Severin Y, Bader MS, Pedrioli PGA, Goetze S, van Drogen A, Balabanov S, Skoda RC, Lopes M, Wollscheid B, Theocharides APA, Snijder B. Proteogenetic drug response profiling elucidates targetable vulnerabilities of myelofibrosis. Nat Commun. 2023 10 12; 14(1):6414. PMID: 37828014; PMCID: PMC10570306.
      Citations:    
    7. Luque Paz D, Bader MS, Nienhold R, Rai S, Almeida Fonseca T, Stetka J, Hao-Shen H, Mild-Schneider G, Passweg JR, Skoda RC. Impact of Clonal Architecture on Clinical Course and Prognosis in Patients With Myeloproliferative Neoplasms. Hemasphere. 2023 May; 7(5):e885. PMID: 37153874; PMCID: PMC10158927.
      Citations:    
    8. Stetka J, Usart M, Kubovcakova L, Rai S, Rao TN, Sutter J, Hao-Shen H, Dirnhofer S, Geier F, Bader MS, Passweg JR, Manolova V, D?rrenberger F, Ahmed N, Schroeder T, Ganz T, Nemeth E, Silvestri L, Nai A, Camaschella C, Skoda RC. Iron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms. Blood. 2023 04 27; 141(17):2127-2140. PMID: 36758212.
      Citations:    
    9. Luque Paz D, Kralovics R, Skoda RC. Genetic basis and molecular profiling in myeloproliferative neoplasms. Blood. 2023 04 20; 141(16):1909-1921. PMID: 36347013; PMCID: PMC10646774.
      Citations:    
    10. Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, D?hner H, Falini B, Garcia-Manero G, Haferlach T, Hellstr?m-Lindberg E, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanuil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Sol? F, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola M. Genomic profiling for clinical decision making in?myeloid neoplasms and acute leukemia. Blood. 2022 11 24; 140(21):2228-2247. PMID: 36130297; PMCID: PMC10488320.
      Citations:    
    11. Rai S, Grockowiak E, Hansen N, Luque Paz D, Stoll CB, Hao-Shen H, Mild-Schneider G, Dirnhofer S, Farady CJ, M?ndez-Ferrer S, Skoda RC. Inhibition of interleukin-1? reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm. Nat Commun. 2022 09 13; 13(1):5346. PMID: 36100613; PMCID: PMC9470591.
      Citations:    
    12. Sobas M, Kiladjian JJ, Beauverd Y, Curto-Garcia N, Sadjadian P, Shih LY, Devos T, Krochmalczyk D, Galli S, Bieniaszewska M, Seferynska I, McMullin MF, Armatys A, Spalek A, Waclaw J, Zdrenghea M, Legros L, Girodon F, Lewandowski K, Angona Figueras A, Samuelsson J, Abuin Blanco A, Cony-Makhoul P, Collins A, James C, Kusec R, Lauermannova M, Noya MS, Skowronek M, Szukalski L, Szmigielska-Kaplon A, Wondergem M, Dudchenko I, Gora Tybor J, Laribi K, Kulikowska de Nalecz A, Demory JL, Le Du K, Zweegman S, Besses Raebel C, Skoda R, Giraudier S, Griesshammer M, Harrison CN, Ianotto JC. Real-world study of children and young adults with myeloproliferative neoplasms: identifying risks and unmet needs. Blood Adv. 2022 09 13; 6(17):5171-5183. PMID: 35802458; PMCID: PMC9631631.
      Citations:    
    13. Garc?a-Garc?a A, Klein T, Born G, Hilpert M, Scherberich A, Lengerke C, Skoda RC, Bourgine PE, Martin I. Culturing patient-derived malignant hematopoietic stem cells in engineered and fully humanized 3D niches. Proc Natl Acad Sci U S A. 2021 10 05; 118(40). PMID: 34580200; PMCID: PMC8501773.
      Citations:    
    14. Furrer R, Jauch AJ, Nageswara Rao T, Dilbaz S, Rhein P, Steurer SA, Recher M, Skoda RC, Handschin C. Remodeling of metabolism and inflammation by exercise ameliorates tumor-associated anemia. Sci Adv. 2021 Sep 10; 7(37):eabi4852. PMID: 34516881; PMCID: PMC8442918.
      Citations:    
    15. D?hner H, Malcovati L, Ossenkoppele GJ, Hochhaus A, Maria Vannucchi A, Bullinger L, Cervantes F, Craddock C, de Witte T, D?hner K, Dombret H, Fenaux P, Geissler J, Germing U, Guilhot F, Harrison C, Hellstr?m-Lindberg E, Passamonti F, Sierra J, Skoda R, Wierzbowska A. The EHA Research Roadmap: Malignant Myeloid Diseases. Hemasphere. 2021 Sep; 5(9):e635. PMID: 34476345; PMCID: PMC8389885.
      Citations:    
    16. Rao TN, Hansen N, Stetka J, Luque Paz D, Kalmer M, Hilfiker J, Endele M, Ahmed N, Kubovcakova L, Rybarikova M, Hao-Shen H, Geier F, Beisel C, Dirnhofer S, Schroeder T, Br?mmendorf TH, Wolf D, Koschmieder S, Skoda RC. JAK2-V617F and interferon-a induce megakaryocyte-biased stem cells characterized by decreased long-term functionality. Blood. 2021 04 22; 137(16):2139-2151. PMID: 33667305; PMCID: PMC8103999.
      Citations:    
    17. Luque Paz D, Ashcroft P, Skoda RC. Myeloproliferative Neoplasms: The Long Wait for JAK2-Mutant Clone Expansion. Cell Stem Cell. 2021 03 04; 28(3):359-361. PMID: 33667352.
      Citations:    
    18. Valent P, Orfao A, Kubicek S, Staber P, Haferlach T, Deininger M, Kollmann K, Lion T, Virgolini I, Winter G, Hantschel O, Kenner L, Zuber J, Grebien F, Moriggl R, Hoermann G, Andreeff M, Bock C, Mughal T, Kralovics R, Sexl V, Skoda R, Superti-Furga G, Hermine O, Constantinescu SN, J?ger U. Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions. Hemasphere. 2021 Mar; 5(3):e536. PMID: 33623882; PMCID: PMC7892291.
      Citations: 1     
    19. Stetka J, Skoda RC. Mouse models of myeloproliferative neoplasms for pre-clinical testing of novel therapeutic agents. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2021 Mar; 165(1):26-33. PMID: 33542546.
      Citations:    
    20. Nienhold R, Ashcroft P, Zmajkovic J, Rai S, Rao TN, Drexler B, Meyer SC, Lundberg P, Passweg JR, Lekovic D, Cokic V, Bonhoeffer S, Skoda RC. MPN patients with low mutant JAK2 allele burden show late expansion restricted to erythroid and megakaryocytic lineages. Blood. 2020 11 26; 136(22):2591-2595. PMID: 32698197.
      Citations:    
    21. ?bro NF, Grinfeld J, Belmonte M, Irvine M, Shepherd MS, Rao TN, Karow A, Riedel LM, Harris OB, Baxter EJ, Nangalia J, Godfrey A, Harrison CN, Li J, Skoda RC, Campbell PJ, Green AR, Kent DG. Longitudinal Cytokine Profiling Identifies GRO-a and EGF as Potential Biomarkers of Disease Progression in Essential Thrombocythemia. Hemasphere. 2020 Jun; 4(3):e371. PMID: 32647796; PMCID: PMC7306314.
      Citations:    
    22. Boettcher S, Wilk CM, Singer J, Beier F, Burcklen E, Beisel C, Ventura Ferreira MS, Gourri E, Gassner C, Frey BM, Schanz U, Skoda RC, Ebert BL, Brummendorf TH, Beerenwinkel N, Manz MG. Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation. Blood. 2020 04 30; 135(18):1548-1559. PMID: 32181816.
      Citations:    
    23. Rao TN, Hansen N, Hilfiker J, Rai S, Majewska JM, Lekovic D, Gezer D, Andina N, Galli S, Cassel T, Geier F, Delezie J, Nienhold R, Hao-Shen H, Beisel C, Di Palma S, Dimeloe S, Trebicka J, Wolf D, Gassmann M, Fan TW, Lane AN, Handschin C, Dirnhofer S, Kr?ger N, Hess C, Radimerski T, Koschmieder S, Cokic VP, Skoda RC. JAK2-mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms. Blood. 2019 11 21; 134(21):1832-1846. PMID: 31511238; PMCID: PMC6872961.
      Citations:    
    24. Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, DeBerardinis RJ, Xu J. Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation. Cancer Discov. 2019 09; 9(9):1228-1247. PMID: 31189531; PMCID: PMC6726547.
      Citations:    
    25. Skoda RC, Schwaller J. Dual roles of EZH2 in acute myeloid leukemia. J Exp Med. 2019 04 01; 216(4):725-727. PMID: 30890555; PMCID: PMC6446873.
      Citations:    
    26. Kaasinen E, Kuismin O, Rajam?ki K, Ristolainen H, Aavikko M, Kondelin J, Saarinen S, Berta DG, Katainen R, Hirvonen EAM, Karhu A, Taira A, Tanskanen T, Alkodsi A, Taipale M, Morgunova E, Franssila K, Lehtonen R, M?kinen M, Aittom?ki K, Palotie A, Kurki MI, Pietil?inen O, Hilpert M, Saarentaus E, Niinim?ki J, Junttila J, Kaikkonen K, Vahteristo P, Skoda RC, Sepp?nen MRJ, Eklund KK, Taipale J, Kilpivaara O, Aaltonen LA. Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans. Nat Commun. 2019 03 19; 10(1):1252. PMID: 30890702; PMCID: PMC6424975.
      Citations:    
    27. Stivala S, Codilupi T, Brkic S, Baerenwaldt A, Ghosh N, Hao-Shen H, Dirnhofer S, Dettmer MS, Simillion C, Kaufmann BA, Chiu S, Keller M, Kleppe M, Hilpert M, Buser AS, Passweg JR, Radimerski T, Skoda RC, Levine RL, Meyer SC. Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms. J Clin Invest. 2019 03 04; 129(4):1596-1611. PMID: 30730307; PMCID: PMC6436863.
      Citations:    
    28. Meyer SC, Drexler B, Skoda RC. [Myeloproliferative neoplasms - Update on diagnosis and treatment]. Ther Umsch. 2019; 76(9):487-495. PMID: 32157965.
      Citations:    
    29. Skoda RC. Accelerating myelofibrosis through loss of Dnmt3a. Blood. 2018 12 27; 132(26):2703-2704. PMID: 30591541.
      Citations:    
    30. Drexler B, Passweg JR, Tzankov A, Bigler M, Theocharides AP, Cantoni N, Keller P, Stussi G, Ruefer A, Benz R, Favre G, Lundberg P, Nienhold R, Fuhrer A, Biaggi C, Manz MG, Bargetzi M, Mendez-Ferrer S, Skoda RC, Swiss Group for Clinical Cancer Research (SAKK). The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14. Haematologica. 2019 04; 104(4):710-716. PMID: 30409796; PMCID: PMC6442970.
      Citations:    
    31. Bourgine PE, Klein T, Paczulla AM, Shimizu T, Kunz L, Kokkaliaris KD, Coutu DL, Lengerke C, Skoda R, Schroeder T, Martin I. In vitro biomimetic engineering of a human hematopoietic niche with functional properties. Proc Natl Acad Sci U S A. 2018 06 19; 115(25):E5688-E5695. PMID: 29866839; PMCID: PMC6016789.
      Citations:    
    32. Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval JL, Lacout C, Cordonnier M, Rodrigues-Lima F, Chanteloup G, Mosca M, Chr?tien ML, Bastie JN, Audia S, Sagot P, Ramla S, Martin L, Gleave M, Mezger V, Skoda R, Plo I, Garrido C, Girodon F, de Thonel A. HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Nat Commun. 2018 04 12; 9(1):1431. PMID: 29650953; PMCID: PMC5897330.
      Citations:    
    33. Zmajkovic J, Lundberg P, Nienhold R, Torgersen ML, Sundan A, Waage A, Skoda RC. A Gain-of-Function Mutation in EPO in Familial Erythrocytosis. N Engl J Med. 2018 03 08; 378(10):924-930. PMID: 29514032.
      Citations:    
    34. Nieborowska-Skorska M, Maifrede S, Dasgupta Y, Sullivan K, Flis S, Le BV, Solecka M, Belyaeva EA, Kubovcakova L, Nawrocki M, Kirschner M, Zhao H, Prchal JT, Piwocka K, Moliterno AR, Wasik M, Koschmieder S, Green TR, Skoda RC, Skorski T. Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms. Blood. 2017 12 28; 130(26):2848-2859. PMID: 29042365; PMCID: PMC5746670.
      Citations:    
    35. Meyer SC, Steinmann E, Lehmann T, Muesser P, Passweg JR, Skoda RC, Tsakiris DA. Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera. Biomed Res Int. 2017; 2017:9876819. PMID: 28698883; PMCID: PMC5494054.
      Citations:    
    36. Lekovic D, Gotic M, Skoda R, Beleslin-Cokic B, Milic N, Mitrovic-Ajtic O, Nienhold R, Sefer D, Suboticki T, Buac M, Markovic D, Diklic M, Cokic VP. Bone marrow microvessel density and plasma angiogenic factors in myeloproliferative neoplasms: clinicopathological and molecular correlations. Ann Hematol. 2017 Mar; 96(3):393-404. PMID: 27924369.
      Citations:    
    37. Pastor V, Hirabayashi S, Karow A, Wehrle J, Kozyra EJ, Nienhold R, Ruzaike G, Lebrecht D, Yoshimi A, Niewisch M, Ripperger T, G?hring G, Baumann I, Schwarz S, Strahm B, Flotho C, Skoda RC, Niemeyer CM, Wlodarski MW. Mutational landscape in children with myelodysplastic syndromes is distinct from adults: specific somatic drivers and novel germline variants. Leukemia. 2017 03; 31(3):759-762. PMID: 27876779.
      Citations:    
    38. Shimizu T, Kubovcakova L, Nienhold R, Zmajkovic J, Meyer SC, Hao-Shen H, Geier F, Dirnhofer S, Guglielmelli P, Vannucchi AM, Feenstra JD, Kralovics R, Orkin SH, Skoda RC. Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis. J Exp Med. 2016 07 25; 213(8):1479-96. PMID: 27401344; PMCID: PMC4986524.
      Citations:    
    39. Suboticki T, Mitrovic Ajtic O, Beleslin-Cokic BB, Nienhold R, Diklic M, Djikic D, Lekovic D, Bulat T, Markovic D, Gotic M, Noguchi CT, Schechter AN, Skoda RC, Cokic VP. Angiogenic factors are increased in circulating granulocytes and CD34+ cells of myeloproliferative neoplasms. Mol Carcinog. 2017 02; 56(2):567-579. PMID: 27341002; PMCID: PMC7286093.
      Citations:    
    40. Grisouard J, Li S, Kubovcakova L, Rao TN, Meyer SC, Lundberg P, Hao-Shen H, Romanet V, Murakami M, Radimerski T, Dirnhofer S, Skoda RC. JAK2 exon 12 mutant mice display isolated erythrocytosis and changes in iron metabolism favoring increased erythropoiesis. Blood. 2016 08 11; 128(6):839-51. PMID: 27288519.
      Citations:    
    41. Theocharides AP, Lundberg P, Lakkaraju AK, Lysenko V, Myburgh R, Aguzzi A, Skoda RC, Manz MG. Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency. Blood. 2016 06 23; 127(25):3253-9. PMID: 27013444.
      Citations:    
    42. Ashcheulov P, Skoda R, Skarohl?d J, Taylor A, Fendrych F, Kratochv?lov? I. Layer Protecting the Surface of Zirconium Used in Nuclear Reactors. Recent Pat Nanotechnol. 2016; 10(1):59-65. PMID: 27018273.
      Citations:    
    43. Karow A, Nienhold R, Lundberg P, Peroni E, Putti MC, Randi ML, Skoda RC. Mutational profile of childhood myeloproliferative neoplasms. Leukemia. 2015 Dec; 29(12):2407-9. PMID: 26223499.
      Citations:    
    44. Skoda RC, Duek A, Grisouard J. Pathogenesis of myeloproliferative neoplasms. Exp Hematol. 2015 Aug; 43(8):599-608. PMID: 26209551.
      Citations:    
    45. Hammar?n HM, Ungureanu D, Grisouard J, Skoda RC, Hubbard SR, Silvennoinen O. ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4642-7. PMID: 25825724; PMCID: PMC4403165.
      Citations:    
    46. Holbro A, Skoda R, Lundberg P, Passweg J, Buser A, Lehmann T. Erythropoietin receptor mutation--a rush of blood to the head? Ann Hematol. 2015 Jul; 94(7):1229-31. PMID: 25772631.
      Citations:    
    47. Grisouard J, Shimizu T, Duek A, Kubovcakova L, Hao-Shen H, Dirnhofer S, Skoda RC. Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN. Blood. 2015 Mar 26; 125(13):2131-40. PMID: 25595737.
      Citations:    
    48. S?nchez-Aguilera A, Arranz L, Mart?n-P?rez D, Garc?a-Garc?a A, Stavropoulou V, Kubovcakova L, Isern J, Mart?n-Salamanca S, Langa X, Skoda RC, Schwaller J, M?ndez-Ferrer S. Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis. Cell Stem Cell. 2014 Dec 04; 15(6):791-804. PMID: 25479752.
      Citations:    
    49. Santisakultarm TP, Paduano CQ, Stokol T, Southard TL, Nishimura N, Skoda RC, Olbricht WL, Schafer AI, Silver RT, Schaffer CB. Stalled cerebral capillary blood flow in mouse models of essential thrombocythemia and polycythemia vera revealed by in vivo two-photon imaging. J Thromb Haemost. 2014 Dec; 12(12):2120-30. PMID: 25263265.
      Citations:    
    50. Strassel C, Kubovcakova L, Mangin PH, Ravanat C, Freund M, Skoda RC, Denis CV, Dupuis A, Herbrecht R, Gachet C, Lanza F. Haemorrhagic and thrombotic diatheses in mouse models with thrombocytosis. Thromb Haemost. 2015 Feb; 113(2):414-25. PMID: 25298269.
      Citations:    
    51. Lundberg P, Takizawa H, Kubovcakova L, Guo G, Hao-Shen H, Dirnhofer S, Orkin SH, Manz MG, Skoda RC. Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. J Exp Med. 2014 Oct 20; 211(11):2213-30. PMID: 25288396; PMCID: PMC4203945.
      Citations:    
    52. Skoda RC. Less Jak2 makes more platelets. Blood. 2014 Oct 02; 124(14):2168-9. PMID: 25278567.
      Citations:    
    53. Arranz L, S?nchez-Aguilera A, Mart?n-P?rez D, Isern J, Langa X, Tzankov A, Lundberg P, Munti?n S, Tzeng YS, Lai DM, Schwaller J, Skoda RC, M?ndez-Ferrer S. Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms. Nature. 2014 Aug 07; 512(7512):78-81. PMID: 25043017.
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    54. Duek A, Lundberg P, Shimizu T, Grisouard J, Karow A, Kubovcakova L, Hao-Shen H, Dirnhofer S, Skoda RC. Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F-driven mouse model of MPNs. Blood. 2014 Jun 19; 123(25):3943-50. PMID: 24820309.
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    55. Lundberg P, Nienhold R, Ambrosetti A, Cervantes F, P?rez-Encinas MM, Skoda RC. Somatic mutations in calreticulin can be found in pedigrees with familial predisposition to myeloproliferative neoplasms. Blood. 2014 Apr 24; 123(17):2744-5. PMID: 24764562.
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    56. Grisouard J, Hao-Shen H, Dirnhofer S, Wagner KU, Skoda RC. Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia. Haematologica. 2014 Apr; 99(4):e52-4. PMID: 24510341; PMCID: PMC3971094.
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    57. Lundberg P, Karow A, Nienhold R, Looser R, Hao-Shen H, Nissen I, Girsberger S, Lehmann T, Passweg J, Stern M, Beisel C, Kralovics R, Skoda RC. Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms. Blood. 2014 Apr 03; 123(14):2220-8. PMID: 24478400.
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    58. Grisouard J, Ojeda-Uribe M, Looser R, Hao-Shen H, Lundberg P, Duek A, Jeandidier E, Karow A, Skoda RC. Complex subclone structure that responds differentially to therapy in a patient with essential thrombocythemia and chronic myeloid leukemia. Blood. 2013 Nov 21; 122(22):3694-6. PMID: 24263960.
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    59. Medinger M, Muesser P, Girsberger S, Skoda R, Tzankov A, Buser A, Passweg J, Tsakiris D?. Dkk3 levels in patients with myeloproliferative neoplasms. Thromb Res. 2014 Feb; 133(2):218-21. PMID: 24309205.
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    60. Hussein K, Percy M, McMullin MF, Schwarz J, Schnittger S, Porret N, Martinez-Aviles LM, Paricio BB, Giraudier S, Skoda R, Lippert E, Hermouet S, Cario H. Clinical utility gene card for: hereditary thrombocythemia. Eur J Hum Genet. 2014 Feb; 22(2). PMID: 23736217; PMCID: PMC3895637.
      Citations:    
    61. Kubovcakova L, Lundberg P, Grisouard J, Hao-Shen H, Romanet V, Andraos R, Murakami M, Dirnhofer S, Wagner KU, Radimerski T, Skoda RC. Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model. Blood. 2013 Feb 14; 121(7):1188-99. PMID: 23264594.
      Citations:    
    62. Girsberger S, Karow A, Lundberg P, Dirnhofer S, Lehmann T, Passweg JR, Tichelli A, Skoda R, Rov? A. JAK2 V617F-mutated myeloproliferative neoplasia developing five years after wild-type JAK2 acute myeloid leukemia: a case report. Acta Haematol. 2013; 129(1):23-5. PMID: 23006959.
      Citations:    
    63. de Wit TD, Borkhardt A, Chomienne C, D?hner H, Fibbe WE, Fo? R, Hagenbeek A, Skoda RC, Smand CR, J?ger U. Raising hematology's European voice: the importance of calling yourself a hematologist. Haematologica. 2012 Apr; 97(4):476-8. PMID: 22492289; PMCID: PMC3347677.
      Citations:    
    64. Lai JC, Ponti S, Pan D, Kohler H, Skoda RC, Matthias P, Nagamine Y. The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis. Blood. 2012 May 03; 119(18):4291-300. PMID: 22422825.
      Citations:    
    65. Lundberg P, Skoda R. Hematology Testing in Mice. Curr Protoc Mouse Biol. 2011 Sep 01; 1(3):323-46. PMID: 26069057.
      Citations:    
    66. Ungureanu D, Wu J, Pekkala T, Niranjan Y, Young C, Jensen ON, Xu CF, Neubert TA, Skoda RC, Hubbard SR, Silvennoinen O. The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Nat Struct Mol Biol. 2011 Aug 14; 18(9):971-6. PMID: 21841788; PMCID: PMC4504201.
      Citations:    
    67. Zhang G, Xiang B, Dong A, Skoda RC, Daugherty A, Smyth SS, Du X, Li Z. Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood. 2011 Sep 29; 118(13):3670-9. PMID: 21803853; PMCID: PMC3186338.
      Citations:    
    68. Chagraoui H, Kassouf M, Banerjee S, Goardon N, Clark K, Atzberger A, Pearce AC, Skoda RC, Ferguson DJ, Watson SP, Vyas P, Porcher C. SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis. Blood. 2011 Jul 21; 118(3):723-35. PMID: 21596846.
      Citations:    
    69. Skoda RC, Schwaller J. HiJAKing the methylosome in myeloproliferative disorders. Cancer Cell. 2011 Feb 15; 19(2):161-3. PMID: 21316597.
      Citations:    
    70. Schaub FX, Lehmann T, Looser R, Hao-Shen H, Tichelli A, Skoda RC. Transition to homozygosity does not appear to provide a clonal advantage to hematopoietic progenitors carrying mutations in TET2. Blood. 2011 Feb 10; 117(6):2075-6. PMID: 21310937.
      Citations:    
    71. Passamonti F, Elena C, Schnittger S, Skoda RC, Green AR, Girodon F, Kiladjian JJ, McMullin MF, Ruggeri M, Besses C, Vannucchi AM, Lippert E, Gisslinger H, Rumi E, Lehmann T, Ortmann CA, Pietra D, Pascutto C, Haferlach T, Cazzola M. Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations. Blood. 2011 Mar 10; 117(10):2813-6. PMID: 21224469.
      Citations:    
    72. Posthuma HL, Skoda RC, Jacob FA, van der Maas AP, Valk PJ, Posthuma EF. Hereditary thrombocytosis not as innocent as thought? Development into acute leukemia and myelofibrosis. Blood. 2010 Oct 28; 116(17):3375-6. PMID: 21030572.
      Citations:    
    73. Skoda RC. JAK2 impairs stem cell function? Blood. 2010 Sep 02; 116(9):1392-3. PMID: 20813904.
      Citations:    
    74. Bertozzi CC, Schmaier AA, Mericko P, Hess PR, Zou Z, Chen M, Chen CY, Xu B, Lu MM, Zhou D, Sebzda E, Santore MT, Merianos DJ, Stadtfeld M, Flake AW, Graf T, Skoda R, Maltzman JS, Koretzky GA, Kahn ML. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010 Jul 29; 116(4):661-70. PMID: 20363774; PMCID: PMC3324297.
      Citations:    
    75. Schaub FX, Looser R, Li S, Hao-Shen H, Lehmann T, Tichelli A, Skoda RC. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood. 2010 Mar 11; 115(10):2003-7. PMID: 20061559.
      Citations:    
    76. Skoda RC. Hereditary myeloproliferative disorders. Haematologica. 2010 Jan; 95(1):6-8. PMID: 20065077; PMCID: PMC2805753.
      Citations:    
    77. Cemp?rek J, Skoda R, Z?k Z. Sodium scandium diphosphate, NaScP(2)O(7), isotypic with a-NaTi(III)P(2)O(7). Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 07; 65(Pt 12):i86. PMID: 21578541; PMCID: PMC2971830.
      Citations:    
    78. Tefferi A, Skoda R, Vardiman JW. Myeloproliferative neoplasms: contemporary diagnosis using histology and genetics. Nat Rev Clin Oncol. 2009 Nov; 6(11):627-37. PMID: 19806146.
      Citations:    
    79. Goldman JM, Green AR, Holyoake T, Jamieson C, Mesa R, Mughal T, Pellicano F, Perrotti D, Skoda R, Vannucchi AM. Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues. Leukemia. 2009 Oct; 23(10):1708-15. PMID: 19641523.
      Citations:    
    80. Liu K, Martini M, Rocca B, Amos CI, Teofili L, Giona F, Ding J, Komatsu H, Larocca LM, Skoda RC. Evidence for a founder effect of the MPL-S505N mutation in eight Italian pedigrees with hereditary thrombocythemia. Haematologica. 2009 Oct; 94(10):1368-74. PMID: 19608689; PMCID: PMC2754952.
      Citations: 16     Fields:    Translation:HumansCells
    81. Medinger M, Skoda R, Gratwohl A, Theocharides A, Buser A, Heim D, Dirnhofer S, Tichelli A, Tzankov A. Angiogenesis and vascular endothelial growth factor-/receptor expression in myeloproliferative neoplasms: correlation with clinical parameters and JAK2-V617F mutational status. Br J Haematol. 2009 Jul; 146(2):150-7. PMID: 19466975.
      Citations:    
    82. Olcaydu D, Skoda RC, Looser R, Li S, Cazzola M, Pietra D, Passamonti F, Lippert E, Carillo S, Girodon F, Vannucchi A, Reading NS, Prchal JT, Ay C, Pabinger I, Gisslinger H, Kralovics R. The 'GGCC' haplotype of JAK2 confers susceptibility to JAK2 exon 12 mutation-positive polycythemia vera. Leukemia. 2009 Oct; 23(10):1924-6. PMID: 19440215.
      Citations:    
    83. Skoda RC. Thrombocytosis. Hematology Am Soc Hematol Educ Program. 2009; 159-67. PMID: 20008195.
      Citations:    
    84. Schaub FX, J?ger R, Looser R, Hao-Shen H, Hermouet S, Girodon F, Tichelli A, Gisslinger H, Kralovics R, Skoda RC. Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the predisposing mutations for JAK2-V617F. Blood. 2009 Feb 26; 113(9):2022-7. PMID: 19047681.
      Citations:    
    85. Lippert E, Girodon F, Hammond E, Jelinek J, Reading NS, Fehse B, Hanlon K, Hermans M, Richard C, Swierczek S, Ugo V, Carillo S, Harrivel V, Marzac C, Pietra D, Sobas M, Mounier M, Migeon M, Ellard S, Kr?ger N, Herrmann R, Prchal JT, Skoda RC, Hermouet S. Concordance of assays designed for the quantification of JAK2V617F: a multicenter study. Haematologica. 2009 Jan; 94(1):38-45. PMID: 19001280; PMCID: PMC2625411.
      Citations:    
    86. Cross NC, Daley GQ, Green AR, Hughes TP, Jamieson C, Manley P, Mughal T, Perrotti D, Radich J, Skoda R, Soverini S, Vainchenker W, Verstovsek S, Villeval JL, Goldman JM. BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features. Leukemia. 2008 Nov; 22(11):1975-89. PMID: 19002192.
      Citations: 5     Fields:    Translation:Humans
    87. Tiedt R, Coers J, Ziegler S, Wiestner A, Hao-Shen H, Bornmann C, Schenkel J, Karakhanova S, de Sauvage FJ, Jackson CW, Skoda RC. Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood. 2009 Feb 19; 113(8):1768-77. PMID: 18845793.
      Citations:    
    88. Theocharides A, Passweg JR, Medinger M, Looser R, Li S, Hao-Shen H, Buser AS, Gratwohl A, Tichelli A, Skoda RC. The allele burden of JAK2 mutations remains stable over several years in patients with myeloproliferative disorders. Haematologica. 2008 Dec; 93(12):1890-3. PMID: 18790796.
      Citations:    
    89. Skoda RC. Can we control JAK? Blood. 2008 Jun 15; 111(12):5419-20. PMID: 18544689.
      Citations:    
    90. Liu K, Kralovics R, Rudzki Z, Grabowska B, Buser AS, Olcaydu D, Gisslinger H, Tiedt R, Frank P, Oko? K, van der Maas AP, Skoda RC. A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family. Haematologica. 2008 May; 93(5):706-14. PMID: 18367486.
      Citations:    
    91. Pasqualucci L, Li S, Meloni G, Schnittger S, Gattenlohner S, Liso A, Di Ianni M, Martelli MP, Pescarmona E, Foa R, Haferlach T, Skoda RC, Falini B. NPM1-mutated acute myeloid leukaemia occurring in JAK2-V617F+ primary myelofibrosis: de-novo origin? Leukemia. 2008 Jul; 22(7):1459-63. PMID: 18200037.
      Citations:    
    92. Li S, Kralovics R, De Libero G, Theocharides A, Gisslinger H, Skoda RC. Clonal heterogeneity in polycythemia vera patients with JAK2 exon12 and JAK2-V617F mutations. Blood. 2008 Apr 01; 111(7):3863-6. PMID: 18195094.
      Citations:    
    93. Schmitt-Graeff AH, Teo SS, Olschewski M, Schaub F, Haxelmans S, Kirn A, Reinecke P, Germing U, Skoda RC. JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis. Haematologica. 2008 Jan; 93(1):34-40. PMID: 18166783.
      Citations:    
    94. Tiedt R, Hao-Shen H, Sobas MA, Looser R, Dirnhofer S, Schwaller J, Skoda RC. Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood. 2008 Apr 15; 111(8):3931-40. PMID: 18160670.
      Citations:    
    95. Petrich BG, Marchese P, Ruggeri ZM, Spiess S, Weichert RA, Ye F, Tiedt R, Skoda RC, Monkley SJ, Critchley DR, Ginsberg MH. Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med. 2007 Dec 24; 204(13):3103-11. PMID: 18086863; PMCID: PMC2150986.
      Citations:    
    96. Pietra D, Li S, Brisci A, Passamonti F, Rumi E, Theocharides A, Ferrari M, Gisslinger H, Kralovics R, Cremonesi L, Skoda R, Cazzola M. Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders. Blood. 2008 Feb 01; 111(3):1686-9. PMID: 17984312.
      Citations:    
    97. Skoda R. Update on the impact of the JAK2 mutation on signalling pathways in myeloproliferative disorders. Eur J Haematol Suppl. 2007 Oct; (68):5-8. PMID: 17727557.
      Citations:    
    98. Skoda R, Barbui T, Reilly JT. Myeloproliferative disorders: a time of new definitions. Outflow from New Horizons in Haematology Meeting, 9-10 March 2007. Eur J Haematol Suppl. 2007 Oct; (68):1. PMID: 17727555.
      Citations:    
    99. Skoda R. Advances in the understanding and management of myeloproliferative disorders. Eur J Haematol Suppl. 2007 Oct; (68):2-4. PMID: 17727556.
      Citations:    
    100. L?on C, Eckly A, Hechler B, Aleil B, Freund M, Ravanat C, Jourdain M, Nonne C, Weber J, Tiedt R, Gratacap MP, Severin S, Cazenave JP, Lanza F, Skoda R, Gachet C. Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. Blood. 2007 Nov 01; 110(9):3183-91. PMID: 17664350.
      Citations:    
    101. Pan D, Schomber T, Kalberer CP, Terracciano LM, Hafen K, Krenger W, Hao-Shen H, Deng C, Skoda RC. Normal erythropoiesis but severe polyposis and bleeding anemia in Smad4-deficient mice. Blood. 2007 Oct 15; 110(8):3049-55. PMID: 17638848.
      Citations:    
    102. Theocharides A, Boissinot M, Girodon F, Garand R, Teo SS, Lippert E, Talmant P, Tichelli A, Hermouet S, Skoda RC. Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation. Blood. 2007 Jul 01; 110(1):375-9. PMID: 17363731.
      Citations:    
    103. Skoda R. The genetic basis of myeloproliferative disorders. Hematology Am Soc Hematol Educ Program. 2007; 1-10. PMID: 18024602.
      Citations:    
    104. Tiedt R, Schomber T, Hao-Shen H, Skoda RC. Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood. 2007 Feb 15; 109(4):1503-6. PMID: 17032923.
      Citations:    
    105. Lippert E, Boissinot M, Kralovics R, Girodon F, Dobo I, Praloran V, Boiret-Dupr? N, Skoda RC, Hermouet S. The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera. Blood. 2006 Sep 15; 108(6):1865-7. PMID: 16728702.
      Citations:    
    106. Kralovics R, Teo SS, Li S, Theocharides A, Buser AS, Tichelli A, Skoda RC. Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders. Blood. 2006 Aug 15; 108(4):1377-80. PMID: 16675710.
      Citations:    
    107. Luft T, Rodionova E, Maraskovsky E, Kirsch M, Hess M, Buchholtz C, Goerner M, Schnurr M, Skoda R, Ho AD. Adaptive functional differentiation of dendritic cells: integrating the network of extra- and intracellular signals. Blood. 2006 Jun 15; 107(12):4763-9. PMID: 16527899.
      Citations:    
    108. Skoda R, Prchal JT. Chronic myeloproliferative disorders--introduction. Semin Hematol. 2005 Oct; 42(4):181-3. PMID: 16210031.
      Citations:    
    109. Skoda R, Prchal JT. Lessons from familial myeloproliferative disorders. Semin Hematol. 2005 Oct; 42(4):266-73. PMID: 16210040.
      Citations:    
    110. Kralovics R, Teo SS, Buser AS, Brutsche M, Tiedt R, Tichelli A, Passamonti F, Pietra D, Cazzola M, Skoda RC. Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2. Blood. 2005 Nov 15; 106(10):3374-6. PMID: 16081684.
      Citations:    
    111. Cazzola M, Skoda R. Gain of function, loss of control - a molecular basis for chronic myeloproliferative disorders. Haematologica. 2005 Jul; 90(7):871-4. PMID: 15996923.
      Citations:    
    112. Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005 Apr 28; 352(17):1779-90. PMID: 15858187.
      Citations:    
    113. Kralovics R, Skoda RC. Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders. Blood Rev. 2005 Jan; 19(1):1-13. PMID: 15572213.
      Citations:    
    114. Coers J, Ranft C, Skoda RC. A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation. J Biol Chem. 2004 Aug 27; 279(35):36397-404. PMID: 15210714.
      Citations:    
    115. Luft T, Maraskovsky E, Schnurr M, Knebel K, Kirsch M, G?rner M, Skoda R, Ho AD, Nawroth P, Bierhaus A. Tuning the volume of the immune response: strength and persistence of stimulation determine migration and cytokine secretion of dendritic cells. Blood. 2004 Aug 15; 104(4):1066-74. PMID: 15113760.
      Citations:    
    116. Schomber T, Kalberer CP, Wodnar-Filipowicz A, Skoda RC. Gene silencing by lentivirus-mediated delivery of siRNA in human CD34+ cells. Blood. 2004 Jun 15; 103(12):4511-3. PMID: 14988151.
      Citations:    
    117. Skoda RC. Chronic myeloproliferative disorders: molecular markers and pathogenesis. Hematol J. 2004; 5 Suppl 3:S122-5. PMID: 15190293.
      Citations:    
    118. Kralovics R, Buser AS, Teo SS, Coers J, Tichelli A, van der Maas AP, Skoda RC. Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders. Blood. 2003 Sep 01; 102(5):1869-71. PMID: 12730106.
      Citations: 20     Fields:    Translation:HumansCells
    119. Ziegler S, B?rki K, Skoda RC. A 2-kb c-mpl promoter fragment is sufficient to direct expression to the megakaryocytic lineage and sites of embryonic hematopoiesis in transgenic mice. Blood. 2002 Aug 01; 100(3):1072-4. PMID: 12130527.
      Citations: 3     Fields:    Translation:AnimalsCells
    120. Wiestner A, Padosch SA, Ghilardi N, Cesar JM, Odriozola J, Shapiro A, Skoda RC. Hereditary thrombocythaemia is a genetically heterogeneous disorder: exclusion of TPO and MPL in two families with hereditary thrombocythaemia. Br J Haematol. 2000 Jul; 110(1):104-9. PMID: 10930985.
      Citations: 2     Fields:    Translation:Humans
    121. Brodmann S, Passweg JR, Gratwohl A, Tichelli A, Skoda RC. Myeloproliferative disorders: complications, survival and causes of death. Ann Hematol. 2000 Jun; 79(6):312-8. PMID: 10901610.
      Citations: 10     Fields:    Translation:Humans
    122. Cazzola M, Skoda RC. Translational pathophysiology: a novel molecular mechanism of human disease. Blood. 2000 Jun 01; 95(11):3280-8. PMID: 10828006.
      Citations: 53     Fields:    Translation:HumansCells
    123. Ghilardi N, Wiestner A, Kikuchi M, Ohsaka A, Skoda RC. Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene. Br J Haematol. 1999 Nov; 107(2):310-6. PMID: 10583217.
      Citations: 36     Fields:    Translation:Humans
    124. Ghilardi N, Skoda RC. A single-base deletion in the thrombopoietin (TPO) gene causes familial essential thrombocythemia through a mechanism of more efficient translation of TPO mRNA. Blood. 1999 Aug 15; 94(4):1480-2. PMID: 10484635.
      Citations: 17     Fields:    Translation:HumansCells
    125. Smith M, Herrell S, Lusher M, Lako L, Simpson C, Wiestner A, Skoda R, Ireland M, Strachan T. Genomic organisation of the human chordin gene and mutation screening of candidate Cornelia de Lange syndrome genes. Hum Genet. 1999 Jul-Aug; 105(1-2):104-11. PMID: 10480362.
      Citations: 5     Fields:    Translation:HumansCells
    126. Stoffel R, Ziegler S, Ghilardi N, Ledermann B, de Sauvage FJ, Skoda RC. Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decisions in vivo. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):698-702. PMID: 9892696; PMCID: PMC15199.
      Citations: 13     Fields:    Translation:AnimalsCells
    127. Skoda RC. Specificity of signaling by hematopoietic cytokine receptors: instructive versus permissive effects. J Recept Signal Transduct Res. 1999 Jan-Jul; 19(1-4):741-72. PMID: 10071797.
      Citations:    Fields:    Translation:HumansAnimalsCells
    128. Ghilardi N, Wiestner A, Skoda RC. Thrombopoietin production is inhibited by a translational mechanism. Blood. 1998 Dec 01; 92(11):4023-30. PMID: 9834204.
      Citations: 30     Fields:    Translation:AnimalsCells
    129. Harrison CN, Gale RE, Wiestner AC, Skoda RC, Linch DC. The activating splice mutation in intron 3 of the thrombopoietin gene is not found in patients with non-familial essential thrombocythaemia. Br J Haematol. 1998 Sep; 102(5):1341-3. PMID: 9753068.
      Citations: 4     Fields:    Translation:Humans
    130. H?kansson ML, Brown H, Ghilardi N, Skoda RC, Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci. 1998 Jan 01; 18(1):559-72. PMID: 9412531; PMCID: PMC6793379.
      Citations: 145     Fields:    Translation:AnimalsCells
    131. Wiestner A, Schlemper RJ, van der Maas AP, Skoda RC. An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia. Nat Genet. 1998 Jan; 18(1):49-52. PMID: 9425899.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    132. Skoda RC, Tichelli A, Tyndall A, Hoffmann T, Gillessen S, Gratwohl A. Autologous peripheral blood stem cell transplantation in a patient with chronic autoimmune thrombocytopenia. Br J Haematol. 1997 Oct; 99(1):56-7. PMID: 9359502.
      Citations: 4     Fields:    Translation:Humans
    133. Ghilardi N, Skoda RC. The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol. 1997 Apr; 11(4):393-9. PMID: 9092791.
      Citations: 69     Fields:    Translation:AnimalsCells
    134. Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6231-5. PMID: 8692797; PMCID: PMC39004.
      Citations: 149     Fields:    Translation:HumansAnimalsCells
    135. Stoffel R, Wiestner A, Skoda RC. Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood. 1996 Jan 15; 87(2):567-73. PMID: 8555478.
      Citations: 37     Fields:    Translation:AnimalsCellsPHPublic Health
    136. Skoda RC, Tsai SF, Orkin SH, Leder P. Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. J Exp Med. 1995 May 01; 181(5):1603-13. PMID: 7722440; PMCID: PMC2191979.
      Citations: 18     Fields:    Translation:AnimalsCells
    137. Shen MM, Skoda RC, Cardiff RD, Campos-Torres J, Leder P, Ornitz DM. Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. EMBO J. 1994 Mar 15; 13(6):1375-85. PMID: 8137821; PMCID: PMC394955.
      Citations: 18     Fields:    Translation:AnimalsCells
    138. Skoda RC, Seldin DC, Chiang MK, Peichel CL, Vogt TF, Leder P. Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J. 1993 Jul; 12(7):2645-53. PMID: 8334987; PMCID: PMC413511.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    139. Skoda RC, Gonzalez FJ, Demierre A, Meyer UA. Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5240-3. PMID: 2899325; PMCID: PMC281725.
      Citations: 49     Fields:    Translation:HumansCells
    140. Gonzalez FJ, Skoda RC, Kimura S, Umeno M, Zanger UM, Nebert DW, Gelboin HV, Hardwick JP, Meyer UA. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature. 1988 Feb 04; 331(6155):442-6. PMID: 3123997.
      Citations: 148     Fields:    Translation:HumansCells
    141. Christen P, Jaussi R, Sonderegger P, Gehring H, Graf-Hausner U, Behra R, Fl?ckiger J, Skoda RC. Biosynthesis of aspartate aminotransferases. Prog Clin Biol Res. 1984; 144B:17-25. PMID: 6718400.
      Citations:    Fields:    Translation:AnimalsCells
    142. Horak F, Skoda R. [Immuneglobin-D-serum level with healthy test persons and patients with diseases of the respiratory tract (author's transl)]. Laryngol Rhinol Otol (Stuttg). 1978 Sep; 57(9):850-6. PMID: 745490.
      Citations: 1     Fields:    Translation:Humans
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