"Aurora Kinase B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. It mediates proper CHROMOSOME SEGREGATION and contractile ring function during CYTOKINESIS.
| Descriptor ID |
D064107
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.103.750 D12.776.167.049.750
|
| Concept/Terms |
Aurora Kinase B- Aurora Kinase B
- Serine-Threonine Protein Kinase 12
- Serine Threonine Protein Kinase 12
- Aurora-Related Kinase 2
- Aurora Related Kinase 2
- Aurora B Kinases
- Aurora Kinases B
|
Below are MeSH descriptors whose meaning is more general than "Aurora Kinase B".
Below are MeSH descriptors whose meaning is more specific than "Aurora Kinase B".
This graph shows the total number of publications written about "Aurora Kinase B" by people in this website by year, and whether "Aurora Kinase B" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 5 | 5 |
| 2009 | 0 | 4 | 4 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 6 | 6 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Aurora Kinase B" by people in Profiles.
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Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer. Clin Cancer Res. 2023 08 15; 29(16):3237-3249.
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Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2022 12 02; 82(23):4444-4456.
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Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity. Cancer Immunol Immunother. 2021 Apr; 70(4):1101-1113.
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The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling. Gastroenterology. 2020 12; 159(6):2146-2162.e33.
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Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages. Dev Cell. 2018 05 07; 45(3):376-391.e5.
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Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis. Oncotarget. 2017 Jul 25; 8(30):48671-48687.
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Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex. PLoS One. 2016; 11(6):e0157305.
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Dynamic Phosphorylation of NudC by Aurora B in Cytokinesis. PLoS One. 2016; 11(4):e0153455.
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Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma. Oncotarget. 2015 Nov 03; 6(34):35247-62.
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Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases. Mol Cancer Ther. 2015 Dec; 14(12):2687-99.