Receptors, Prostaglandin E, EP4 Subtype
"Receptors, Prostaglandin E, EP4 Subtype" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of prostaglandin E receptors that specifically couples to GS ALPHA GTP-BINDING PROTEIN SUBUNITS and subsequently activates ADENYLYL CYCLASES. The receptor may also signal through the activation of PHOSPHATIDYLINOSITOL 3-KINASE.
| Descriptor ID |
D058309
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| MeSH Number(s) |
D12.776.543.750.695.200.700.600.400
|
| Concept/Terms |
Receptors, Prostaglandin E, EP4 Subtype- Receptors, Prostaglandin E, EP4 Subtype
- Prostaglandin E Receptor 4
- Prostaglandin EP4 Receptors
- EP4 Receptors, Prostaglandin
- Receptors, Prostaglandin EP4
- Prostanoid Receptor EP4
- EP4, Prostanoid Receptor
- Receptor EP4, Prostanoid
- Receptor, Prostaglandin EP4
- EP4 Receptor, Prostaglandin
- Prostaglandin EP4 Receptor
- PGE Receptor, EP4 Subtype
- Prostaglandin E2 Receptor, EP4 Subtype
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Prostaglandin E, EP4 Subtype".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Prostaglandin E, EP4 Subtype".
This graph shows the total number of publications written about "Receptors, Prostaglandin E, EP4 Subtype" by people in this website by year, and whether "Receptors, Prostaglandin E, EP4 Subtype" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptors, Prostaglandin E, EP4 Subtype" by people in Profiles.
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Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. Am J Hum Genet. 2021 03 04; 108(3):431-445.
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First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers. J Immunother Cancer. 2020 06; 8(1).
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Inhibition of PGE2/EP4 receptor signaling enhances oxaliplatin efficacy in resistant colon cancer cells through modulation of oxidative stress. Sci Rep. 2019 03 20; 9(1):4954.
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Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology. 2017 01; 152(1):206-217.e2.
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The tumor promoting activity of the EP4 receptor for prostaglandin E2 in murine skin. Mol Oncol. 2014 Dec; 8(8):1626-39.
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Combined targeting of STAT3/NF-?B/COX-2/EP4 for effective management of pancreatic cancer. Clin Cancer Res. 2014 Mar 01; 20(5):1259-73.
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The expression of prostaglandin receptors EP3 and EP4 in human cervix in post-term pregnancy differs between failed and successful labor induction. Acta Obstet Gynecol Scand. 2014 Feb; 93(2):159-67.
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Prostaglandin E2 regulates pancreatic stellate cell activity via the EP4 receptor. Pancreas. 2013 Apr; 42(3):467-74.
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New bronchodilators. Curr Opin Pharmacol. 2012 Jun; 12(3):238-45.
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The induction of S100p expression by the Prostaglandin E2 (PGE2)/EP4 receptor signaling pathway in colon cancer cells. Cancer Biol Ther. 2010 Nov 15; 10(10):1056-66.