NLR Family, Pyrin Domain-Containing 3 Protein
"NLR Family, Pyrin Domain-Containing 3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
| Descriptor ID |
D000071199
|
| MeSH Number(s) |
D12.644.360.539.250
|
| Concept/Terms |
NLR Family, Pyrin Domain-Containing 3 Protein- NLR Family, Pyrin Domain-Containing 3 Protein
- NLR Family, Pyrin Domain Containing 3 Protein
- Cold Autoinflammatory Syndrome 1 Protein
- NACHT, LRR and PYD Domains-Containing Protein 3
- NACHT, LRR and PYD Domains Containing Protein 3
- NLRP3 Protein
|
Below are MeSH descriptors whose meaning is more general than "NLR Family, Pyrin Domain-Containing 3 Protein".
Below are MeSH descriptors whose meaning is more specific than "NLR Family, Pyrin Domain-Containing 3 Protein".
This graph shows the total number of publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in this website by year, and whether "NLR Family, Pyrin Domain-Containing 3 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 3 | 3 |
| 2014 | 0 | 6 | 6 |
| 2015 | 0 | 2 | 2 |
| 2016 | 5 | 2 | 7 |
| 2017 | 6 | 3 | 9 |
| 2018 | 4 | 0 | 4 |
| 2019 | 1 | 4 | 5 |
| 2020 | 6 | 0 | 6 |
| 2021 | 4 | 3 | 7 |
| 2022 | 1 | 3 | 4 |
| 2023 | 2 | 5 | 7 |
| 2024 | 0 | 1 | 1 |
| 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in Profiles.
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Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia. Fluids Barriers CNS. 2025 Jun 03; 22(1):55.
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NLRP3 Inflammasome Activation Expands the Immunosuppressive Myeloid Stroma and Antagonizes the Therapeutic Benefit of STING Activation in Glioblastoma. Cancer Res Commun. 2025 Jun 01; 5(6):960-972.
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Mitigation of nicotine-induced podocyte injury through inhibition of thioredoxin interacting protein. Biomed Pharmacother. 2025 Jun; 187:118110.
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IRE1a silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer. Cell. 2024 Dec 12; 187(25):7248-7266.e34.
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Role of hypoxia-mediated pyroptosis?in the development of extending knee joint contracture in rats. Eur J Med Res. 2024 May 27; 29(1):298.
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Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis. Cell Mol Biol Lett. 2024 Apr 27; 29(1):61.
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D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1?-driven pyroptotic uroepithelial cell shedding in the murine bladder. Dev Cell. 2024 01 08; 59(1):33-47.e5.
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Contribution of membrane raft redox signalling to visfatin-induced inflammasome activation and podocyte injury. Aging (Albany NY). 2023 11 17; 15(22):12738-12748.
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Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation. J Clin Invest. 2023 10 02; 133(19).
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The genetic and clinical characteristics and effects of Canakinumab on cryopyrin-associated periodic syndrome: a large pediatric cohort study from China. Front Immunol. 2023; 14:1267933.