TitleAssociate Professor. Assistant Dean of Graduate Programs
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
AddressHealth 2 4849 Calhoun Road, Room 6007D
Houston, TX 77204-5039
Houston TX 77204-5039
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    Collapse Research 
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    R56AI079236     (BOND, RICHARD AGUSTIN)Apr 15, 2012 - Sep 30, 2014
    Mechanisms of Beta-blocker Induced Improvements in Asthma
    Role: Co-Principal Investigator

    R01HL057445     (KNOLL, BRIAN J)Dec 7, 1998 - Nov 30, 2001
    Role: Principal Investigator

    R01HL050047     (KNOLL, BRIAN J)Jul 10, 1994 - May 31, 2004
    Role: Principal Investigator

    R01CA046763     (KNOLL, BRIAN J)Feb 1, 1988 - Aug 31, 1991
    Role: Principal Investigator

    R01CA039792     (KNOLL, BRIAN J)Apr 1, 1985 - Mar 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nguyen LP, Al-Sawalha NA, Parra S, Pokkunuri I, Omoluabi O, Okulate AA, Windham Li E, Hazen M, Gonzalez-Granado JM, Daly CJ, McGrath JC, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. ?2-Adrenoceptor signaling in airway epithelial cells promotes eosinophilic inflammation, mucous metaplasia, and airway contractility. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):E9163-E9171. PMID: 29073113; PMCID: PMC5664525.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    2. Joshi R, Valdez D, Kim H, Eikenburg DC, Knoll BJ, Bond RA. Effects of ?-blockers on house dust mite-driven murine models pre- and post-development of an asthma phenotype. Pulm Pharmacol Ther. 2017 Oct; 46:30-40. PMID: 28729042; PMCID: PMC5612908.
      Citations: 2     Fields:    Translation:AnimalsCells
    3. Forkuo GS, Kim H, Thanawala VJ, Al-Sawalha N, Valdez D, Joshi R, Parra S, Pera T, Gonnella PA, Knoll BJ, Walker JK, Penn RB, Bond RA. Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by ?2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice. Am J Respir Cell Mol Biol. 2016 08; 55(2):234-42. PMID: 26909542; PMCID: PMC4979368.
      Citations: 10     Fields:    Translation:AnimalsCells
    4. Thanawala VJ, Valdez DJ, Joshi R, Forkuo GS, Parra S, Knoll BJ, Leff P, Bond RA, Bouvier M. ?-Blockers have differential effects on the murine asthma phenotype. Br J Pharmacol. 2015 Oct; 172(20):4833-46. PMID: 26211486; PMCID: PMC4621987.
      Citations: 13     Fields:    Translation:Animals
    5. Al-Sawalha N, Pokkunuri I, Omoluabi O, Kim H, Thanawala VJ, Hernandez A, Bond RA, Knoll BJ. Epinephrine Activation of the ?2-Adrenoceptor Is Required for IL-13-Induced Mucin Production in Human Bronchial Epithelial Cells. PLoS One. 2015; 10(7):e0132559. PMID: 26161982; PMCID: PMC4498766.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    6. . Epinephrine activation of the β2-adrenoceptor is required for IL-13 induced mucin production in human bronchial epithelial cells. PLoS One. 2015; 10(7):E0132559.
    7. Thanawala JT, Forkuo GS, Al-Sawalha N, Azzegagh Z, Nguyen LP, Eriksen JL, Tuvim MJ, Lowder TW, Dickey BF, KNOLL BJ, Walker JKL, Bond RA. β2-adrenoceptor agonists are required for development of the asthma phenotype in a murine model. Am. J. Resp. Cell Molec. Biol. 2013; 48:220-229.
    8. Peng H, Bond RA, Knoll BJ. The effects of acute and chronic nadolol treatment on ?2AR signaling in HEK293 cells. Naunyn Schmiedebergs Arch Pharmacol. 2011 Feb; 383(2):209-16. PMID: 21225244.
      Citations: 2     Fields:    Translation:HumansCells
    9. Awwad HO, Millman EE, Alpizar-Foster E, Moore RH, Knoll BJ. Mutating the dileucine motif of the human beta(2)-adrenoceptor reduces the high initial rate of receptor phosphorylation by GRK without affecting postendocytic sorting. Eur J Pharmacol. 2010 Jun 10; 635(1-3):9-15. PMID: 20193676; PMCID: PMC3132186.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Nguyen LP, Lin R, Parra S, Omoluabi O, Hanania NA, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2435-40. PMID: 19171883; PMCID: PMC2650174.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    11. Millman EE, Zhang H, Zhang H, Godines V, Bean AJ, Knoll BJ, Moore RH. Rapid recycling of beta-adrenergic receptors is dependent on the actin cytoskeleton and myosin Vb. Traffic. 2008 Nov; 9(11):1958-71. PMID: 18785920; PMCID: PMC2684784.
      Citations: 20     Fields:    Translation:HumansCells
    12. Nguyen LP, Omoluabi O, Parra S, Frieske JM, Clement C, Ammar-Aouchiche Z, Ho SB, Ehre C, Kesimer M, Knoll BJ, Tuvim MJ, Dickey BF, Bond RA. Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):256-62. PMID: 18096872; PMCID: PMC2258446.
      Citations: 66     Fields:    Translation:Animals
    13. Lin R, Peng H, Nguyen LP, Dudekula NB, Shardonofsky F, Knoll BJ, Parra S, Bond RA. Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulm Pharmacol Ther. 2008; 21(1):115-24. PMID: 17689122; PMCID: PMC2775056.
      Citations: 36     Fields:    Translation:Animals
    14. Awwad HO, Iyer V, Rosenfeld JL, Millman EE, Foster E, Moore RH, Knoll BJ. Inhibitors of phosphoinositide 3-kinase cause defects in the postendocytic sorting of beta2-adrenergic receptors. Exp Cell Res. 2007 Jul 15; 313(12):2586-96. PMID: 17553490; PMCID: PMC2034330.
      Citations: 5     Fields:    Translation:HumansCells
    15. Tran TM, Friedman J, Baameur F, Knoll BJ, Moore RH, Clark RB. Characterization of beta2-adrenergic receptor dephosphorylation: Comparison with the rate of resensitization. Mol Pharmacol. 2007 Jan; 71(1):47-60. PMID: 17012621.
      Citations: 29     Fields:    Translation:HumansCells
    16. Moore RH, Millman EE, Godines V, Hanania NA, Tran TM, Peng H, Dickey BF, Knoll BJ, Clark RB. Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):254-61. PMID: 16980556; PMCID: PMC1899312.
      Citations: 28     Fields:    Translation:HumansCells
    17. Iyer V, Tran TM, Foster E, Dai W, Clark RB, Knoll BJ. Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356. Br J Pharmacol. 2006 Feb; 147(3):249-59. PMID: 16331289; PMCID: PMC1751300.
      Citations: 30     Fields:    Translation:HumansCells
    18. Vaughan DJ, Millman EE, Godines V, Friedman J, Tran TM, Dai W, Knoll BJ, Clark RB, Moore RH. Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. J Biol Chem. 2006 Mar 17; 281(11):7684-92. PMID: 16407241.
      Citations: 38     Fields:    Translation:HumansCells
    19. Callaerts-Vegh Z, Evans KL, Dudekula N, Cuba D, Knoll BJ, Callaerts PF, Giles H, Shardonofsky FR, Bond RA. Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4948-53. PMID: 15069206; PMCID: PMC387354.
      Citations: 69     Fields:    Translation:AnimalsCells
    20. Moore RH, Millman EE, Alpizar-Foster E, Dai W, KNOLL BJ. Rab11 regulates the recycling and lysosome targeting of β2-adrenergic receptors. J. Cell Sci. 2004; 117:3107-3117.
    21. Millman EE, Rosenfeld JL, Vaughan DJ, Nguyen J, Dai W, Alpizar-Foster E, Clark RB, Knoll BJ, Moore RH. Endosome sorting of beta 2-adrenoceptors is GRK5 independent. Br J Pharmacol. 2004 Jan; 141(2):277-84. PMID: 14691047; PMCID: PMC1574185.
      Citations: 7     Fields:    Translation:HumansCells
    22. Liu Q, Reubi JC, Wang Y, Knoll BJ, Schonbrunn A. In vivo phosphorylation of the somatostatin 2A receptor in human tumors. J Clin Endocrinol Metab. 2003 Dec; 88(12):6073-9. PMID: 14671213.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    23. . Therapeutic Targets in Airway Inflammation (Eissa NT, Huston D, eds). Cellular Trafficking of β2-adrenergic Receptors. 2003.
    24. . Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Molec. Carcinog. 1995; 13:104-111.
    25. Mathew, J., KNOLL BJ, Pillai, A, Durham, D, Sell S. . Discrete cell-type specific enhancer regions 5' of the rat alphafetoprotein gene: Identification of a highly active distal enhancer. J. Tumor Marker Oncology. 1994; 9:21-28.
    26. . The Role of Cell Types in Hepatocarcinogenesis (Sirica, AE, ed). Transgenic mouse models of hepatocarcinogenesis. 1992; 299-321.
    27. . Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases. Gene. 1987; 60:267-276.
    28. . Preferential cleavage of phage lamdda repressor monomers by recA protease. . Nature. 1981; 294:182-184.
    29. Colbert DA, Knoll BJ, Woo SL, Mace ML, Tsai MJ, O'Malley BW. Differential hormonal responsiveness of the ovalbumin gene and its pseudogenes in the chick oviduct. Biochemistry. 1980 Nov 25; 19(24):5586-92. PMID: 6257282.
      Citations: 7     Fields:    Translation:AnimalsCells
    30. . An analysis of repressor overproduction by the lambda cIIIs mutant. J. Molec. Biol. 1979; 132:551-555.
    31. . Isolation and characterization of mutations in the cIII gene of bacteriophage lambda which increase the efficiency of lysogenization of Escherichia coli K-12. J. Virology. 1979; 92(518):531.
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