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JESUS VALLEJO

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Infectious Diseases
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Heart Failure


    Collapse ORNG Applications 
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    Collapse Biography 
    Collapse awards and honors
    2003PIDS Young Investigator Award, Pediatric Infectious Diseases Society
    2013F & J Faculty Excellence Award, Baylor Collge of Medicine
    2013Research Mentor Award - Dept. of Pediatrics, Baylor College of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R01GM062474     (VALLEJO, JESUS G)Jul 2, 2001 - Jun 30, 2007
    NIH/NIGMS
    Cardiac Depression in Gram-Positive Sepsis--Role of TLR2
    Role: Principal Investigator

    R01HL083426     (VALLEJO, JESUS G)Apr 10, 2008 - Mar 31, 2013
    NIH/NHLBI
    Role of Toll-like Receptors 3 and 4 in Viral Heart Disease
    Role: Principal Investigator

    R21HL091223     (BOWLES, NEIL E)Jun 16, 2008 - May 31, 2011
    NIH/NHLBI
    Role of TLR3-TRIF Variants in host susceptibility to viral myocarditis
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. McNeil JC, Sommer LM, Boyle M, Hogan P, Vallejo JG, Hultén KG, Flores AR, Kaplan SL, Fritz S. Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children. Antimicrob Agents Chemother. 2020 Aug 20; 64(9). PMID: 32660989.
      View in: PubMed
    2. Orman G, Kralik SF, Desai N, Meoded A, Vallejo JG, Huisman TAGM, Tran BH. Imaging of Paranasal Sinus Infections in Children: A Review. J Neuroimaging. 2020 May 30. PMID: 32472739.
      View in: PubMed
    3. Orman G, Kukreja MK, Vallejo JG, Desai N, Huisman TAGM, Kralik SF. Accuracy of MR Imaging for Detection of Sensorineural Hearing Loss in Infants with Bacterial Meningitis. AJNR Am J Neuroradiol. 2020 06; 41(6):1081-1086. PMID: 32439638.
      View in: PubMed
    4. McNeil JC, Dunn JJ, Kaplan SL, Vallejo JG. Complications of Otitis Media and Sinusitis Caused by Streptococcus anginosus Group Organisms in Children. Pediatr Infect Dis J. 2020 02; 39(2):108-113. PMID: 31738321.
      View in: PubMed
    5. Kaplan J, Ikeda S, McNeil JC, Kaplan SL, Vallejo JG. Microbiology of Osteoarticular Infections in Patients with Sickle Hemoglobinopathies at Texas Children's Hospital, 2000-2018. Pediatr Infect Dis J. 2019 12; 38(12):1251-1253. PMID: 31738345.
      View in: PubMed
    6. McNeil JC, Vallejo JG, Kok EY, Sommer LM, Hultén KG, Kaplan SL. Clinical and Microbiologic Variables Predictive of Orthopedic Complications Following Staphylococcus aureus Acute Hematogenous Osteoarticular Infections in Children. Clin Infect Dis. 2019 11 13; 69(11):1955-1961. PMID: 30753346.
      View in: PubMed
    7. Vallejo JG, McNeil JC, Hultén KG, Sommer LM, Dunn JJ, Kaplan SL. Invasive Haemophilus influenzae Disease at Texas Children's Hospital, 2011 to 2018. Pediatr Infect Dis J. 2019 09; 38(9):900-905. PMID: 31107422.
      View in: PubMed
    8. Kralik SF, Kukreja MK, Paldino MJ, Desai NK, Vallejo JG. Comparison of CSF and MRI Findings among Neonates and Infants with E coli or Group B Streptococcal Meningitis. AJNR Am J Neuroradiol. 2019 08; 40(8):1413-1417. PMID: 31320464.
      View in: PubMed
    9. Celebi N, Vallejo JG, Eckstein OS, Geer J, Punia JN, Elenberg E. Persistent fever in a pediatric renal transplant patient: Answers. Pediatr Nephrol. 2019 05; 34(5):825-828. PMID: 30570689.
      View in: PubMed
    10. Celebi N, Vallejo JG, Eckstein OS, Geer J, Punia JN, Elenberg E. Persistent fever in a pediatric renal transplant patient: Questions. Pediatr Nephrol. 2019 05; 34(5):823-824. PMID: 30570688.
      View in: PubMed
    11. McNeil JC, Vallejo JG, Hultén KG, Kaplan SL. Osteoarticular Infections Following Open or Penetrating Trauma in Children in the Post-Community-Acquired Methicillin-resistant Staphylococcus aureus Era: The Impact of Enterobacter cloacae. Pediatr Infect Dis J. 2018 12; 37(12):1204-1210. PMID: 29570590.
      View in: PubMed
    12. Kok EY, Vallejo JG, Sommer LM, Rosas L, Kaplan SL, Hulten KG, McNeil JC. Association of Vancomycin MIC and Molecular Characteristics with Clinical Outcomes in Methicillin-Susceptible Staphylococcus aureus Acute Hematogenous Osteoarticular Infections in Children. Antimicrob Agents Chemother. 2018 05; 62(5). PMID: 29530845.
      View in: PubMed
    13. Gibson A, Kaplan SL, Vallejo JG. Impact of Serum Vancomycin Trough Levels in the Treatment of Central Nervous System Shunt Infections Caused by Coagulase-Negative Staphylococci. Pediatr Neurosurg. 2018; 53(4):243-246. PMID: 29698961.
      View in: PubMed
    14. Vallejo JG, Cain AN, Mason EO, Kaplan SL, Hultén KG. Staphylococcus aureus Central Nervous System Infections in Children. Pediatr Infect Dis J. 2017 Oct; 36(10):947-951. PMID: 28399057.
      View in: PubMed
    15. McNeil JC, Kaplan SL, Vallejo JG. The Influence of the Route of Antibiotic Administration, Methicillin Susceptibility, Vancomycin Duration and Serum Trough Concentration on Outcomes of Pediatric Staphylococcus aureus Bacteremic Osteoarticular Infection. Pediatr Infect Dis J. 2017 06; 36(6):572-577. PMID: 28027279.
      View in: PubMed
    16. Branson J, Vallejo JG, Flores AR, Hulten KG, Mason EO, Kaplan SL, McNeil JC. The Contemporary Microbiology and Rates of Concomitant Osteomyelitis in Acute Septic Arthritis. Pediatr Infect Dis J. 2017 03; 36(3):267-273. PMID: 27870814.
      View in: PubMed
    17. McNeil JC, Forbes AR, Vallejo JG, Flores AR, Hultén KG, Mason EO, Kaplan SL. Role of Operative or Interventional Radiology-Guided Cultures for Osteomyelitis. Pediatrics. 2016 05; 137(5). PMID: 27244827.
      View in: PubMed
    18. McNeil JC, Kok EY, Forbes AR, Lamberth L, Hulten KG, Vallejo JG, Mason EO, Kaplan SL. Healthcare-associated Staphylococcus aureus Bacteremia in Children: Evidence for Reverse Vancomycin Creep and Impact of Vancomycin Trough Values on Outcome. Pediatr Infect Dis J. 2016 Mar; 35(3):263-8. PMID: 26646549.
      View in: PubMed
    19. McNeil JC, Kok EY, Vallejo JG, Campbell JR, Hulten KG, Mason EO, Kaplan SL. Clinical and Molecular Features of Decreased Chlorhexidine Susceptibility among Nosocomial Staphylococcus aureus Isolates at Texas Children's Hospital. Antimicrob Agents Chemother. 2016 Feb; 60(2):1121-8. PMID: 26666947.
      View in: PubMed
    20. Patel A, Mao KR, McNeil JC, Kaplan SL, Vallejo JG. Fever and Reversible Laboratory Abnormalities Associated with Prolonged Use of Piperacillin-Tazobactam in Children. Pediatr Infect Dis J. 2015 Aug; 34(8):849-50. PMID: 25961892.
      View in: PubMed
    21. Vallejo JG. JD Cherry, GJ Demmler, P Hotez, SL Kaplan (eds), Feigin & Cherry’s Textbook of Pediatric Infectious Diseases. Myocarditis. 2013.
    22. Kaplan SL, Vallejo, JG. JD Cherry, GJ Demmler, P Hotez, SL Kaplan (eds), Feigin & Cherry’s Textbook of Pediatric Infectious Diseases. Bacteremia and septic shock. 2013.
    23. Gorbea C, Rechsteiner M, Vallejo JG, Bowles NE. Depletion of the 26S proteasome adaptor Ecm29 increases Toll-like receptor 3 signaling. Sci Signal. 2013 Oct 01; 6(295):ra86. PMID: 24084648.
      View in: PubMed
    24. Cabrera AG, Khan MS, Morales DL, Chen DW, Moffett BS, Price JF, Dreyer WJ, Denfield SW, Jeewa A, Fraser CD, Vallejo JG. Infectious complications and outcomes in children supported with left ventricular assist devices. J Heart Lung Transplant. 2013 May; 32(5):518-24. PMID: 23489988.
      View in: PubMed
    25. Philip J, Xu Z, Bowles NE, Vallejo JG. Cardiac-specific overexpression of melanoma differentiation-associated gene-5 protects mice from lethal viral myocarditis. Circ Heart Fail. 2013 Mar; 6(2):326-34. PMID: 23271791.
      View in: PubMed
    26. Moghimpour Bijani F, Vallejo JG, Rezaei N. Toll-like receptor signaling pathways in cardiovascular diseases: challenges and opportunities. Int Rev Immunol. 2012 Oct; 31(5):379-95. PMID: 23083347.
      View in: PubMed
    27. Xu Z, Desai M, Philip J, Sivsubramanian N, Bowles NE, Vallejo JG. Conditional transgenic expression of TIR-domain-containing adaptor-inducing interferon-ß (TRIF) in the adult mouse heart is protective in acute viral myocarditis. Basic Res Cardiol. 2011 Nov; 106(6):1159-71. PMID: 21956162.
      View in: PubMed
    28. Vallejo JG. Role of toll-like receptors in cardiovascular diseases. Clin Sci (Lond). 2011 Jul; 121(1):1-10. PMID: 21413930.
      View in: PubMed
    29. Ghose R, Guo T, Vallejo JG, Gandhi A. Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. Drug Metab Dispos. 2011 May; 39(5):874-81. PMID: 21303924.
      View in: PubMed
    30. Gorbea C, Makar KA, Pauschinger M, Pratt G, Bersola JL, Varela J, David RM, Banks L, Huang CH, Li H, Schultheiss HP, Towbin JA, Vallejo JG, Bowles NE. A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy. J Biol Chem. 2010 Jul 23; 285(30):23208-23. PMID: 20472559.
      View in: PubMed
    31. Dong JW, Vallejo JG, Tzeng HP, Thomas JA, Mann DL. Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways. Am J Physiol Heart Circ Physiol. 2010 Mar; 298(3):H1079-87. PMID: 20061547.
      View in: PubMed
    32. Vallejo JG, Mann DL. Inflammatory cardiomyopathy-pathogenesis and therapy. Schultheiss, Heinz-Peter; Noutsias, Michel. The role of cytokines in inflammation induced cardiomyopathy. Pathogenesis and therapeutic implications. 2010.
    33. Huang CH, Vallejo JG, Kollias G, Mann DL. Role of the innate immune system in acute viral myocarditis. Basic Res Cardiol. 2009 May; 104(3):228-37. PMID: 19159057.
      View in: PubMed
    34. Desai MS, Mariscalco MM, Tawil A, Vallejo JG, Smith CW. Atherogenic diet-induced hepatitis is partially dependent on murine TLR4. J Leukoc Biol. 2008 Jun; 83(6):1336-44. PMID: 18334542.
      View in: PubMed
    35. Breinholt JP, Vallejo JG, Gates CM, Clunie SK, Kearney DL, Dreyer WJ, Towbin JA, Bowles NE. Myocardial pro-inflammatory cytokine expression and cellular rejection in pediatric heart transplant recipients. J Heart Lung Transplant. 2008 Mar; 27(3):317-24. PMID: 18342755.
      View in: PubMed
    36. Tzeng HP, Fan J, Vallejo JG, Dong JW, Chen X, Houser SR, Mann DL. Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1490-6. PMID: 18223193.
      View in: PubMed
    37. Ramabadran RS, Chancey A, Vallejo JG, Barger PM, Sivasubramanian N, Mann DL. Targeted gene silencing of tumor necrosis factor attenuates the negative inotropic effects of lipopolysaccharide in isolated contracting cardiac myocytes. Tex Heart Inst J. 2008; 35(1):16-21. PMID: 18427645.
      View in: PubMed
    38. Ghose R, White D, Guo T, Vallejo J, Karpen SJ. Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. Drug Metab Dispos. 2008 Jan; 36(1):95-101. PMID: 17932222.
      View in: PubMed
    39. Sakata Y, Dong JW, Vallejo JG, Huang CH, Baker JS, Tracey KJ, Tacheuchi O, Akira S, Mann DL. Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H503-9. PMID: 16980352.
      View in: PubMed
    40. Hardarson HS, Baker JS, Yang Z, Purevjav E, Huang CH, Alexopoulou L, Li N, Flavell RA, Bowles NE, Vallejo JG. Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H251-8. PMID: 16936008.
      View in: PubMed
    41. Hardarson HS, Bowels NE, Vallejo JG. Heart failure in children and young adults: from molecular mechanisms to medical and surgical strategies. JA Towbin, AC Chang. Innate immune responses in inflammatory heart disease. 2006.
    42. Syed FM, Hahn HS, Odley A, Guo Y, Vallejo JG, Lynch RA, Mann DL, Bolli R, Dorn GW. Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia. Circ Res. 2005 May 27; 96(10):1103-9. PMID: 15845887.
      View in: PubMed
    43. Vallejo JG, Nemoto S, Ishiyama M, Yu B, Knuefermann P, Diwan A, Baker JS, Defreitas G, Tweardy DJ, Mann DL. Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1272-7. PMID: 15706046.
      View in: PubMed
    44. Knuefermann P, Sakata Y, Baker JS, Huang CH, Sekiguchi K, Hardarson HS, Takeuchi O, Akira S, Vallejo JG. Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart. Circulation. 2004 Dec 14; 110(24):3693-8. PMID: 15569836.
      View in: PubMed
    45. Knuefermann P, Vallejo J, Mann DL. The role of innate immune responses in the heart in health and disease. Trends Cardiovasc Med. 2004 Jan; 14(1):1-7. PMID: 14720467.
      View in: PubMed
    46. Misra A, Haudek SB, Knuefermann P, Vallejo JG, Chen ZJ, Michael LH, Sivasubramanian N, Olson EN, Entman ML, Mann DL. Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction. Circulation. 2003 Dec 23; 108(25):3075-8. PMID: 14676146.
      View in: PubMed
    47. Vallejo J, Mann DL. Antiinflammatory therapy in myocarditis. Curr Opin Cardiol. 2003 May; 18(3):189-93. PMID: 12826819.
      View in: PubMed
    48. Bowles NE, Vallejo J. Viral causes of cardiac inflammation. Curr Opin Cardiol. 2003 May; 18(3):182-8. PMID: 12826818.
      View in: PubMed
    49. Knuefermann P, Nemoto S, Misra A, Nozaki N, Defreitas G, Goyert SM, Carabello BA, Mann DL, Vallejo JG. CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction. Circulation. 2002 Nov 12; 106(20):2608-15. PMID: 12427659.
      View in: PubMed
    50. Nemoto S, Vallejo JG, Knuefermann P, Misra A, Defreitas G, Carabello BA, Mann DL. Escherichia coli LPS-induced LV dysfunction: role of toll-like receptor-4 in the adult heart. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2316-23. PMID: 12003842.
      View in: PubMed
    51. Knuefermann P, Nemoto S, Baumgarten G, Misra A, Sivasubramanian N, Carabello BA, Vallejo JG. Cardiac inflammation and innate immunity in septic shock: is there a role for toll-like receptors? Chest. 2002 Apr; 121(4):1329-36. PMID: 11948070.
      View in: PubMed
    52. Baumgarten G, Knuefermann P, Nozaki N, Sivasubramanian N, Mann DL, Vallejo JG. In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis. 2001 Jun 01; 183(11):1617-24. PMID: 11343210.
      View in: PubMed
    53. Vallejo JG, Knuefermann P, Mann DL, Sivasubramanian N. Group B Streptococcus induces TNF-alpha gene expression and activation of the transcription factors NF-kappa B and activator protein-1 in human cord blood monocytes. J Immunol. 2000 Jul 01; 165(1):419-25. PMID: 10861080.
      View in: PubMed
    54. Albanyan EA, Vallejo JG, Smith CW, Edwards MS. Nonopsonic binding of type III Group B Streptococci to human neutrophils induces interleukin-8 release mediated by the p38 mitogen-activated protein kinase pathway. Infect Immun. 2000 Apr; 68(4):2053-60. PMID: 10722601.
      View in: PubMed
    55. Albanyan EA, Morad AB, Vallejo JG. Vibrio vulnificus sepsis in a child with Diamond-Blackfan syndrome. Pediatr Infect Dis J. 1997 Aug; 16(8):818-20. PMID: 9271048.
      View in: PubMed
    56. Vallejo JG, Baker CJ, Edwards MS. Roles of the bacterial cell wall and capsule in induction of tumor necrosis factor alpha by type III group B streptococci. Infect Immun. 1996 Dec; 64(12):5042-6. PMID: 8945544.
      View in: PubMed
    57. Vallejo JG, Starke JR. Intrathoracic tuberculosis in children. Semin Respir Infect. 1996 Sep; 11(3):184-95. PMID: 8883176.
      View in: PubMed
    58. Vallejo JG, Baker CJ, Edwards MS. Interleukin-6 production by human neonatal monocytes stimulated by type III group B streptococci. J Infect Dis. 1996 Aug; 174(2):332-7. PMID: 8699063.
      View in: PubMed
    59. Vallejo JG, Stevens AM, Dutton RV, Kaplan SL. Hepatosplenic abscesses due to Brucella melitensis: report of a case involving a child and review of the literature. Clin Infect Dis. 1996 Mar; 22(3):485-9. PMID: 8852967.
      View in: PubMed
    60. Vallejo JG, Ong LT, Starke JR. Tuberculous osteomyelitis of the long bones in children. Pediatr Infect Dis J. 1995 Jun; 14(6):542-6. PMID: 7667061.
      View in: PubMed
    61. Vallejo JG, Baker CJ, Edwards MS. Demonstration of circulating group B streptococcal immune complexes in neonates with meningitis. J Clin Microbiol. 1994 Sep; 32(9):2041-5. PMID: 7814522.
      View in: PubMed
    62. Vallejo JG, Ong LT, Starke JR. Clinical features, diagnosis, and treatment of tuberculosis in infants. Pediatrics. 1994 Jul; 94(1):1-7. PMID: 8008511.
      View in: PubMed
    63. Vallejo JG, Englund JA, Garcia-Prats JA, Demmler GJ. Ganciclovir treatment of steroid-associated cytomegalovirus disease in a congenitally infected neonate. Pediatr Infect Dis J. 1994 Mar; 13(3):239-41. PMID: 8177639.
      View in: PubMed
    64. Vallejo JG, Starke JR. Tuberculosis and pregnancy. Clin Chest Med. 1992 Dec; 13(4):693-707. PMID: 1478028.
      View in: PubMed
    65. Vallejo JG, Kaplan SL, Mason EO. Treatment of meningitis and other infections due to ampicillin-resistant Haemophilus influenzae type b in children. Rev Infect Dis. 1991 Mar-Apr; 13(2):197-200. PMID: 2041948.
      View in: PubMed
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