InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Other Positions
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Heart Failure

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    Collapse Biography 
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    2003PIDS Young Investigator Award, Pediatric Infectious Diseases Society
    2013F & J Faculty Excellence Award, Baylor Collge of Medicine
    2013Research Mentor Award - Dept. of Pediatrics, Baylor College of Medicine

    Collapse Overview 

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    R01GM062474     (VALLEJO, JESUS G)Jul 2, 2001 - Jun 30, 2007
    Cardiac Depression in Gram-Positive Sepsis--Role of TLR2
    Role: Principal Investigator

    R01HL083426     (VALLEJO, JESUS G)Apr 10, 2008 - Mar 31, 2013
    Role of Toll-like Receptors 3 and 4 in Viral Heart Disease
    Role: Principal Investigator

    R21HL091223     (BOWLES, NEIL E)Jun 16, 2008 - May 31, 2011
    Role of TLR3-TRIF Variants in host susceptibility to viral myocarditis
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cardenas-Comfort C, Kaplan SL, Vallejo JG, McNeil JC. Follow-up Blood Cultures in Children With Staphylococcus aureus Bacteremia. Pediatrics. 2020 12; 146(6). PMID: 33239473.
      Citations:    Fields:    Translation:HumansCells
    2. McNeil JC, Sommer LM, Boyle M, Hogan P, Vallejo JG, Hultén KG, Flores AR, Kaplan SL, Fritz S. Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children. Antimicrob Agents Chemother. 2020 08 20; 64(9). PMID: 32660989.
      Citations: 2     Fields:    
    3. Orman G, Kralik SF, Desai N, Meoded A, Vallejo JG, Huisman TAGM, Tran BH. Imaging of Paranasal Sinus Infections in Children: A Review. J Neuroimaging. 2020 09; 30(5):572-586. PMID: 32472739.
      Citations:    Fields:    
    4. Orman G, Kukreja MK, Vallejo JG, Desai N, Huisman TAGM, Kralik SF. Accuracy of MR Imaging for Detection of Sensorineural Hearing Loss in Infants with Bacterial Meningitis. AJNR Am J Neuroradiol. 2020 06; 41(6):1081-1086. PMID: 32439638.
      Citations:    Fields:    Translation:Humans
    5. McNeil JC, Dunn JJ, Kaplan SL, Vallejo JG. Complications of Otitis Media and Sinusitis Caused by Streptococcus anginosus Group Organisms in Children. Pediatr Infect Dis J. 2020 02; 39(2):108-113. PMID: 31738321.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    6. Kaplan J, Ikeda S, McNeil JC, Kaplan SL, Vallejo JG. Microbiology of Osteoarticular Infections in Patients with Sickle Hemoglobinopathies at Texas Children's Hospital, 2000-2018. Pediatr Infect Dis J. 2019 12; 38(12):1251-1253. PMID: 31738345.
      Citations: 1     Fields:    Translation:HumansCells
    7. McNeil JC, Vallejo JG, Kok EY, Sommer LM, Hultén KG, Kaplan SL. Clinical and Microbiologic Variables Predictive of Orthopedic Complications Following Staphylococcus aureus Acute Hematogenous Osteoarticular Infections in Children. Clin Infect Dis. 2019 11 13; 69(11):1955-1961. PMID: 30753346.
      Citations: 3     Fields:    Translation:HumansCells
    8. Vallejo JG, McNeil JC, Hultén KG, Sommer LM, Dunn JJ, Kaplan SL. Invasive Haemophilus influenzae Disease at Texas Children's Hospital, 2011 to 2018. Pediatr Infect Dis J. 2019 09; 38(9):900-905. PMID: 31107422.
      Citations: 2     Fields:    Translation:HumansCells
    9. Kralik SF, Kukreja MK, Paldino MJ, Desai NK, Vallejo JG. Comparison of CSF and MRI Findings among Neonates and Infants with E coli or Group B Streptococcal Meningitis. AJNR Am J Neuroradiol. 2019 08; 40(8):1413-1417. PMID: 31320464.
      Citations:    Fields:    Translation:HumansCells
    10. Celebi N, Vallejo JG, Eckstein OS, Geer J, Punia JN, Elenberg E. Persistent fever in a pediatric renal transplant patient: Answers. Pediatr Nephrol. 2019 05; 34(5):825-828. PMID: 30570689.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Celebi N, Vallejo JG, Eckstein OS, Geer J, Punia JN, Elenberg E. Persistent fever in a pediatric renal transplant patient: Questions. Pediatr Nephrol. 2019 05; 34(5):823-824. PMID: 30570688.
      Citations:    Fields:    Translation:Humans
    12. McNeil JC, Vallejo JG, Hultén KG, Kaplan SL. Osteoarticular Infections Following Open or Penetrating Trauma in Children in the Post-Community-Acquired Methicillin-resistant Staphylococcus aureus Era: The Impact of Enterobacter cloacae. Pediatr Infect Dis J. 2018 12; 37(12):1204-1210. PMID: 29570590.
      Citations: 5     Fields:    Translation:HumansCells
    13. Kok EY, Vallejo JG, Sommer LM, Rosas L, Kaplan SL, Hulten KG, McNeil JC. Association of Vancomycin MIC and Molecular Characteristics with Clinical Outcomes in Methicillin-Susceptible Staphylococcus aureus Acute Hematogenous Osteoarticular Infections in Children. Antimicrob Agents Chemother. 2018 05; 62(5). PMID: 29530845.
      Citations: 9     Fields:    Translation:HumansCells
    14. Gibson A, Kaplan SL, Vallejo JG. Impact of Serum Vancomycin Trough Levels in the Treatment of Central Nervous System Shunt Infections Caused by Coagulase-Negative Staphylococci. Pediatr Neurosurg. 2018; 53(4):243-246. PMID: 29698961.
      Citations:    Fields:    Translation:HumansCells
    15. Vallejo JG, Cain AN, Mason EO, Kaplan SL, Hultén KG. Staphylococcus aureus Central Nervous System Infections in Children. Pediatr Infect Dis J. 2017 Oct; 36(10):947-951. PMID: 28399057.
      Citations:    Fields:    Translation:HumansCells
    16. McNeil JC, Kaplan SL, Vallejo JG. The Influence of the Route of Antibiotic Administration, Methicillin Susceptibility, Vancomycin Duration and Serum Trough Concentration on Outcomes of Pediatric Staphylococcus aureus Bacteremic Osteoarticular Infection. Pediatr Infect Dis J. 2017 06; 36(6):572-577. PMID: 28027279.
      Citations: 10     Fields:    Translation:HumansCells
    17. Branson J, Vallejo JG, Flores AR, Hulten KG, Mason EO, Kaplan SL, McNeil JC. The Contemporary Microbiology and Rates of Concomitant Osteomyelitis in Acute Septic Arthritis. Pediatr Infect Dis J. 2017 03; 36(3):267-273. PMID: 27870814.
      Citations: 7     Fields:    Translation:HumansCells
    18. McNeil JC, Forbes AR, Vallejo JG, Flores AR, Hultén KG, Mason EO, Kaplan SL. Role of Operative or Interventional Radiology-Guided Cultures for Osteomyelitis. Pediatrics. 2016 05; 137(5). PMID: 27244827.
      Citations: 10     Fields:    Translation:Humans
    19. McNeil JC, Kok EY, Forbes AR, Lamberth L, Hulten KG, Vallejo JG, Mason EO, Kaplan SL. Healthcare-associated Staphylococcus aureus Bacteremia in Children: Evidence for Reverse Vancomycin Creep and Impact of Vancomycin Trough Values on Outcome. Pediatr Infect Dis J. 2016 Mar; 35(3):263-8. PMID: 26646549.
      Citations: 9     Fields:    Translation:HumansCells
    20. McNeil JC, Kok EY, Vallejo JG, Campbell JR, Hulten KG, Mason EO, Kaplan SL. Clinical and Molecular Features of Decreased Chlorhexidine Susceptibility among Nosocomial Staphylococcus aureus Isolates at Texas Children's Hospital. Antimicrob Agents Chemother. 2016 Feb; 60(2):1121-8. PMID: 26666947.
      Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
    21. Patel A, Mao KR, McNeil JC, Kaplan SL, Vallejo JG. Fever and Reversible Laboratory Abnormalities Associated with Prolonged Use of Piperacillin-Tazobactam in Children. Pediatr Infect Dis J. 2015 Aug; 34(8):849-50. PMID: 25961892.
      Citations: 1     Fields:    Translation:Humans
    22. Vallejo JG. JD Cherry, GJ Demmler, P Hotez, SL Kaplan (eds), Feigin & Cherry’s Textbook of Pediatric Infectious Diseases. Myocarditis. 2013.
    23. Kaplan SL, Vallejo, JG. JD Cherry, GJ Demmler, P Hotez, SL Kaplan (eds), Feigin & Cherry’s Textbook of Pediatric Infectious Diseases. Bacteremia and septic shock. 2013.
    24. Gorbea C, Rechsteiner M, Vallejo JG, Bowles NE. Depletion of the 26S proteasome adaptor Ecm29 increases Toll-like receptor 3 signaling. Sci Signal. 2013 Oct 01; 6(295):ra86. PMID: 24084648.
      Citations: 7     Fields:    Translation:HumansCells
    25. Cabrera AG, Khan MS, Morales DL, Chen DW, Moffett BS, Price JF, Dreyer WJ, Denfield SW, Jeewa A, Fraser CD, Vallejo JG. Infectious complications and outcomes in children supported with left ventricular assist devices. J Heart Lung Transplant. 2013 May; 32(5):518-24. PMID: 23489988.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    26. Philip J, Xu Z, Bowles NE, Vallejo JG. Cardiac-specific overexpression of melanoma differentiation-associated gene-5 protects mice from lethal viral myocarditis. Circ Heart Fail. 2013 Mar; 6(2):326-34. PMID: 23271791.
      Citations: 4     Fields:    Translation:AnimalsCells
    27. Moghimpour Bijani F, Vallejo JG, Rezaei N. Toll-like receptor signaling pathways in cardiovascular diseases: challenges and opportunities. Int Rev Immunol. 2012 Oct; 31(5):379-95. PMID: 23083347.
      Citations: 18     Fields:    Translation:HumansCells
    28. Xu Z, Desai M, Philip J, Sivsubramanian N, Bowles NE, Vallejo JG. Conditional transgenic expression of TIR-domain-containing adaptor-inducing interferon-ß (TRIF) in the adult mouse heart is protective in acute viral myocarditis. Basic Res Cardiol. 2011 Nov; 106(6):1159-71. PMID: 21956162.
      Citations: 2     Fields:    Translation:AnimalsCells
    29. Vallejo JG. Role of toll-like receptors in cardiovascular diseases. Clin Sci (Lond). 2011 Jul; 121(1):1-10. PMID: 21413930.
      Citations: 34     Fields:    Translation:AnimalsCells
    30. Ghose R, Guo T, Vallejo JG, Gandhi A. Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. Drug Metab Dispos. 2011 May; 39(5):874-81. PMID: 21303924.
      Citations: 15     Fields:    Translation:AnimalsCells
    31. Gorbea C, Makar KA, Pauschinger M, Pratt G, Bersola JL, Varela J, David RM, Banks L, Huang CH, Li H, Schultheiss HP, Towbin JA, Vallejo JG, Bowles NE. A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy. J Biol Chem. 2010 Jul 23; 285(30):23208-23. PMID: 20472559.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    32. Dong JW, Vallejo JG, Tzeng HP, Thomas JA, Mann DL. Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways. . 2010 Mar; 298(3):H1079-87. PMID: 20061547.
    33. Vallejo JG, Mann DL. Inflammatory cardiomyopathy-pathogenesis and therapy. Schultheiss, Heinz-Peter; Noutsias, Michel. The role of cytokines in inflammation induced cardiomyopathy. Pathogenesis and therapeutic implications. 2010.
    34. Huang CH, Vallejo JG, Kollias G, Mann DL. Role of the innate immune system in acute viral myocarditis. Basic Res Cardiol. 2009 May; 104(3):228-37. PMID: 19159057.
      Citations: 8     Fields:    Translation:AnimalsCells
    35. Desai MS, Mariscalco MM, Tawil A, Vallejo JG, Smith CW. Atherogenic diet-induced hepatitis is partially dependent on murine TLR4. J Leukoc Biol. 2008 Jun; 83(6):1336-44. PMID: 18334542.
      Citations: 23     Fields:    Translation:Animals
    36. Breinholt JP, Vallejo JG, Gates CM, Clunie SK, Kearney DL, Dreyer WJ, Towbin JA, Bowles NE. Myocardial pro-inflammatory cytokine expression and cellular rejection in pediatric heart transplant recipients. J Heart Lung Transplant. 2008 Mar; 27(3):317-24. PMID: 18342755.
      Citations: 1     Fields:    Translation:HumansCells
    37. Tzeng HP, Fan J, Vallejo JG, Dong JW, Chen X, Houser SR, Mann DL. Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes. . 2008 Mar; 294(3):H1490-6. PMID: 18223193.
    38. Ramabadran RS, Chancey A, Vallejo JG, Barger PM, Sivasubramanian N, Mann DL. Targeted gene silencing of tumor necrosis factor attenuates the negative inotropic effects of lipopolysaccharide in isolated contracting cardiac myocytes. Tex Heart Inst J. 2008; 35(1):16-21. PMID: 18427645.
      Citations: 1     Fields:    Translation:HumansCells
    39. Ghose R, White D, Guo T, Vallejo J, Karpen SJ. Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. Drug Metab Dispos. 2008 Jan; 36(1):95-101. PMID: 17932222.
      Citations: 14     Fields:    Translation:AnimalsCells
    40. Sakata Y, Dong JW, Vallejo JG, Huang CH, Baker JS, Tracey KJ, Tacheuchi O, Akira S, Mann DL. Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury. . 2007 Jan; 292(1):H503-9. PMID: 16980352.
    41. Hardarson HS, Baker JS, Yang Z, Purevjav E, Huang CH, Alexopoulou L, Li N, Flavell RA, Bowles NE, Vallejo JG. Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. . 2007 Jan; 292(1):H251-8. PMID: 16936008.
    42. Hardarson HS, Bowels NE, Vallejo JG. Heart failure in children and young adults: from molecular mechanisms to medical and surgical strategies. JA Towbin, AC Chang. Innate immune responses in inflammatory heart disease. 2006.
    43. Syed FM, Hahn HS, Odley A, Guo Y, Vallejo JG, Lynch RA, Mann DL, Bolli R, Dorn GW. Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia. Circ Res. 2005 May 27; 96(10):1103-9. PMID: 15845887.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    44. Vallejo JG, Nemoto S, Ishiyama M, Yu B, Knuefermann P, Diwan A, Baker JS, Defreitas G, Tweardy DJ, Mann DL. Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock. . 2005 Mar; 288(3):H1272-7. PMID: 15706046.
    45. Knuefermann P, Sakata Y, Baker JS, Huang CH, Sekiguchi K, Hardarson HS, Takeuchi O, Akira S, Vallejo JG. Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart. Circulation. 2004 Dec 14; 110(24):3693-8. PMID: 15569836.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    46. Knuefermann P, Vallejo J, Mann DL. The role of innate immune responses in the heart in health and disease. Trends Cardiovasc Med. 2004 Jan; 14(1):1-7. PMID: 14720467.
      Citations: 6     Fields:    Translation:HumansAnimals
    47. Misra A, Haudek SB, Knuefermann P, Vallejo JG, Chen ZJ, Michael LH, Sivasubramanian N, Olson EN, Entman ML, Mann DL. Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction. Circulation. 2003 Dec 23; 108(25):3075-8. PMID: 14676146.
      Citations: 36     Fields:    Translation:AnimalsCells
    48. Vallejo J, Mann DL. Antiinflammatory therapy in myocarditis. Curr Opin Cardiol. 2003 May; 18(3):189-93. PMID: 12826819.
      Citations: 3     Fields:    Translation:Humans
    49. Bowles NE, Vallejo J. Viral causes of cardiac inflammation. Curr Opin Cardiol. 2003 May; 18(3):182-8. PMID: 12826818.
      Citations: 6     Fields:    Translation:HumansCells
    50. Knuefermann P, Nemoto S, Misra A, Nozaki N, Defreitas G, Goyert SM, Carabello BA, Mann DL, Vallejo JG. CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction. Circulation. 2002 Nov 12; 106(20):2608-15. PMID: 12427659.
      Citations: 36     Fields:    Translation:Animals
    51. Nemoto S, Vallejo JG, Knuefermann P, Misra A, Defreitas G, Carabello BA, Mann DL. Escherichia coli LPS-induced LV dysfunction: role of toll-like receptor-4 in the adult heart. . 2002 Jun; 282(6):H2316-23. PMID: 12003842.
    52. Knuefermann P, Nemoto S, Baumgarten G, Misra A, Sivasubramanian N, Carabello BA, Vallejo JG. Cardiac inflammation and innate immunity in septic shock: is there a role for toll-like receptors? Chest. 2002 Apr; 121(4):1329-36. PMID: 11948070.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    53. Baumgarten G, Knuefermann P, Nozaki N, Sivasubramanian N, Mann DL, Vallejo JG. In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis. 2001 Jun 01; 183(11):1617-24. PMID: 11343210.
      Citations: 51     Fields:    Translation:AnimalsCells
    54. Vallejo JG, Knuefermann P, Mann DL, Sivasubramanian N. Group B Streptococcus induces TNF-alpha gene expression and activation of the transcription factors NF-kappa B and activator protein-1 in human cord blood monocytes. J Immunol. 2000 Jul 01; 165(1):419-25. PMID: 10861080.
      Citations: 17     Fields:    Translation:HumansCells
    55. Albanyan EA, Vallejo JG, Smith CW, Edwards MS. Nonopsonic binding of type III Group B Streptococci to human neutrophils induces interleukin-8 release mediated by the p38 mitogen-activated protein kinase pathway. Infect Immun. 2000 Apr; 68(4):2053-60. PMID: 10722601.
      Citations: 14     Fields:    Translation:HumansCells
    56. Albanyan EA, Morad AB, Vallejo JG. Vibrio vulnificus sepsis in a child with Diamond-Blackfan syndrome. Pediatr Infect Dis J. 1997 Aug; 16(8):818-20. PMID: 9271048.
      Citations: 1     Fields:    Translation:Humans
    57. Vallejo JG, Baker CJ, Edwards MS. Roles of the bacterial cell wall and capsule in induction of tumor necrosis factor alpha by type III group B streptococci. Infect Immun. 1996 Dec; 64(12):5042-6. PMID: 8945544.
      Citations: 15     Fields:    Translation:HumansCells
    58. Vallejo JG, Starke JR. Intrathoracic tuberculosis in children. Semin Respir Infect. 1996 Sep; 11(3):184-95. PMID: 8883176.
      Citations: 1     Fields:    Translation:Humans
    59. Vallejo JG, Baker CJ, Edwards MS. Interleukin-6 production by human neonatal monocytes stimulated by type III group B streptococci. J Infect Dis. 1996 Aug; 174(2):332-7. PMID: 8699063.
      Citations: 10     Fields:    Translation:HumansCells
    60. Vallejo JG, Stevens AM, Dutton RV, Kaplan SL. Hepatosplenic abscesses due to Brucella melitensis: report of a case involving a child and review of the literature. Clin Infect Dis. 1996 Mar; 22(3):485-9. PMID: 8852967.
      Citations: 14     Fields:    Translation:HumansCells
    61. Vallejo JG, Ong LT, Starke JR. Tuberculous osteomyelitis of the long bones in children. Pediatr Infect Dis J. 1995 Jun; 14(6):542-6. PMID: 7667061.
      Citations: 9     Fields:    Translation:Humans
    62. Vallejo JG, Baker CJ, Edwards MS. Demonstration of circulating group B streptococcal immune complexes in neonates with meningitis. J Clin Microbiol. 1994 Sep; 32(9):2041-5. PMID: 7814522.
      Citations:    Fields:    Translation:HumansCells
    63. Vallejo JG, Ong LT, Starke JR. Clinical features, diagnosis, and treatment of tuberculosis in infants. Pediatrics. 1994 Jul; 94(1):1-7. PMID: 8008511.
      Citations: 26     Fields:    Translation:HumansCells
    64. Vallejo JG, Englund JA, Garcia-Prats JA, Demmler GJ. Ganciclovir treatment of steroid-associated cytomegalovirus disease in a congenitally infected neonate. Pediatr Infect Dis J. 1994 Mar; 13(3):239-41. PMID: 8177639.
      Citations: 5     Fields:    Translation:Humans
    65. Vallejo JG, Starke JR. Tuberculosis and pregnancy. Clin Chest Med. 1992 Dec; 13(4):693-707. PMID: 1478028.
      Citations: 7     Fields:    Translation:Humans
    66. Vallejo JG, Kaplan SL, Mason EO. Treatment of meningitis and other infections due to ampicillin-resistant Haemophilus influenzae type b in children. Rev Infect Dis. 1991 Mar-Apr; 13(2):197-200. PMID: 2041948.
      Citations: 1     Fields:    Translation:HumansCells
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