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Li-Yuan Yu-Lee

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Immunology, Allergy, Rheum
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionImmunology


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    R01DK044625     (YU-LEE, LI-YUAN)Mar 1, 1992 - Sep 30, 2000
    NIH/NIDDK
    IRF-1 AND PROLACTIN IN T CELL ACTIVATION
    Role: Principal Investigator

    R01DK053176     (YU-LEE, LI-YUAN)Mar 15, 1998 - Mar 31, 2010
    NIH/NIDDK
    Function of NudC, a Prolactin Regulated Gene
    Role: Principal Investigator

    R01CA174798     (LIN, SUE-HWA)Apr 1, 2013 - Nov 30, 2023
    NIH/NCI
    Endothelial-to-osteoblast transition in prostate cancer bone metastasis
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lin SC, Yu-Lee LY, Lin SH. Osteoblastic Factors in Prostate Cancer Bone Metastasis. Curr Osteoporos Rep. 2018 12; 16(6):642-647. PMID: 30203251.
      View in: PubMed
    2. Yu G, Cheng CJ, Lin SC, Lee YC, Frigo DE, Yu-Lee LY, Gallick GE, Titus MA, Nutt LK, Lin SH. Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II. Cancer Res. 2018 05 15; 78(10):2490-2502. PMID: 29535221.
      View in: PubMed
    3. Yu-Lee LY, Yu G, Lee YC, Lin SC, Pan J, Pan T, Yu KJ, Liu B, Creighton CJ, Rodriguez-Canales J, Villalobos PA, Wistuba II, de Nadal E, Posas F, Gallick GE, Lin SH. Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFßRIII-p38MAPK-pS249/T252RB Pathway. Cancer Res. 2018 06 01; 78(11):2911-2924. PMID: 29514796.
      View in: PubMed
    4. Pan T, Lin SC, Yu KJ, Yu G, Song JH, Lewis VO, Bird JE, Moon B, Lin PP, Tannir NM, Jonasch E, Wood CG, Gallick GE, Yu-Lee LY, Lin SH, Satcher RL. BIGH3 Promotes Osteolytic Lesions in Renal Cell Carcinoma Bone Metastasis by Inhibiting Osteoblast Differentiation. Neoplasia. 2018 01; 20(1):32-43. PMID: 29190493.
      View in: PubMed
    5. Yu KJ, Li JK, Lee YC, Yu G, Lin SC, Pan T, Satcher RL, Titus MA, Yu-Lee LY, Weng WH, Gallick GE, Lin SH. Cabozantinib-induced osteoblast secretome promotes survival and migration of metastatic prostate cancer cells in bone. Oncotarget. 2017 Sep 26; 8(43):74987-75006. PMID: 29088840.
      View in: PubMed
    6. Bilen MA, Pan T, Lee YC, Lin SC, Yu G, Pan J, Hawke D, Pan BF, Vykoukal J, Gray K, Satcher RL, Gallick GE, Yu-Lee LY, Lin SH. Proteomics Profiling of Exosomes from Primary Mouse Osteoblasts under Proliferation versus Mineralization Conditions and Characterization of Their Uptake into Prostate Cancer Cells. J Proteome Res. 2017 08 04; 16(8):2709-2728. PMID: 28675788.
      View in: PubMed
    7. Lockyer P, Mao H, Fan Q, Li L, Yu-Lee LY, Eissa NT, Patterson C, Xie L, Pi X. LRP1-Dependent BMPER Signaling Regulates Lipopolysaccharide-Induced Vascular Inflammation. Arterioscler Thromb Vasc Biol. 2017 08; 37(8):1524-1535. PMID: 28596374.
      View in: PubMed
    8. Lin SC, Lee YC, Yu G, Cheng CJ, Zhou X, Chu K, Murshed M, Le NT, Baseler L, Abe JI, Fujiwara K, deCrombrugghe B, Logothetis CJ, Gallick GE, Yu-Lee LY, Maity SN, Lin SH. Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer. Dev Cell. 2017 06 05; 41(5):467-480.e3. PMID: 28586644.
      View in: PubMed
    9. Zeng H, Ortiz A, Shen PF, Cheng CJ, Lee YC, Yu G, Lin SC, Creighton CJ, Yu-Lee LY, Lin SH. Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway. Oncotarget. 2017 Feb 07; 8(6):10145-10160. PMID: 28052036.
      View in: PubMed
    10. Cunningham CE, Li S, Vizeacoumar FS, Bhanumathy KK, Lee JS, Parameswaran S, Furber L, Abuhussein O, Paul JM, McDonald M, Templeton SD, Shukla H, El Zawily AM, Boyd F, Alli N, Mousseau DD, Geyer R, Bonham K, Anderson DH, Yan J, Yu-Lee LY, Weaver BA, Uppalapati M, Ruppin E, Sablina A, Freywald A, Vizeacoumar FJ. Therapeutic relevance of the protein phosphatase 2A in cancer. Oncotarget. 2016 Sep 20; 7(38):61544-61561. PMID: 27557495.
      View in: PubMed
    11. Weiderhold KN, Fadri-Moskwik M, Pan J, Nishino M, Chuang C, Deeraksa A, Lin SH, Yu-Lee LY. Dynamic Phosphorylation of NudC by Aurora B in Cytokinesis. PLoS One. 2016; 11(4):e0153455. PMID: 27074040.
      View in: PubMed
    12. Lee YC, Lin SC, Yu G, Cheng CJ, Liu B, Liu HC, Hawke DH, Parikh NU, Varkaris A, Corn P, Logothetis C, Satcher RL, Yu-Lee LY, Gallick GE, Lin SH. Identification of Bone-Derived Factors Conferring De Novo Therapeutic Resistance in Metastatic Prostate Cancer. Cancer Res. 2015 Nov 15; 75(22):4949-59. PMID: 26530902.
      View in: PubMed
    13. Satcher RL, Pan T, Bilen MA, Li X, Lee YC, Ortiz A, Kowalczyk AP, Yu-Lee LY, Lin SH. Cadherin-11 endocytosis through binding to clathrin promotes cadherin-11-mediated migration in prostate cancer cells. J Cell Sci. 2015 Dec 15; 128(24):4629-41. PMID: 26519476.
      View in: PubMed
    14. Lee YC, Gajdosik MS, Josic D, Clifton JG, Logothetis C, Yu-Lee LY, Gallick GE, Maity SN, Lin SH. Secretome analysis of an osteogenic prostate tumor identifies complex signaling networks mediating cross-talk of cancer and stromal cells within the tumor microenvironment. Mol Cell Proteomics. 2015 Mar; 14(3):471-83. PMID: 25527621.
      View in: PubMed
    15. Ortiz A, Lee YC, Yu G, Liu HC, Lin SC, Bilen MA, Cho H, Yu-Lee LY, Lin SH. Angiomotin is a novel component of cadherin-11/ß-catenin/p120 complex and is critical for cadherin-11-mediated cell migration. FASEB J. 2015 Mar; 29(3):1080-91. PMID: 25466890.
      View in: PubMed
    16. Karlin KL, Mondal G, Hartman JK, Tyagi S, Kurley SJ, Bland CS, Hsu TY, Renwick A, Fang JE, Migliaccio I, Callaway C, Nair A, Dominguez-Vidana R, Nguyen DX, Osborne CK, Schiff R, Yu-Lee LY, Jung SY, Edwards DP, Hilsenbeck SG, Rosen JM, Zhang XH, Shaw CA, Couch FJ, Westbrook TF. The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor. Cell Rep. 2014 Nov 20; 9(4):1318-32. PMID: 25453754.
      View in: PubMed
    17. Yu G, Lee YC, Cheng CJ, Wu CF, Song JH, Gallick GE, Yu-Lee LY, Kuang J, Lin SH. RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival. Mol Cancer Res. 2015 Feb; 13(2):348-57. PMID: 25189355.
      View in: PubMed
    18. Lee PH, Puppi M, Schluns KS, Yu-Lee LY, Dong C, Lacorazza HD. The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage. J Immunol. 2014 Jan 01; 192(1):178-88. PMID: 24259505.
      View in: PubMed
    19. Chuang C, Pan J, Hawke DH, Lin SH, Yu-Lee LY. NudC deacetylation regulates mitotic progression. PLoS One. 2013; 8(9):e73841. PMID: 24069238.
      View in: PubMed
    20. Lee YC, Bilen MA, Yu G, Lin SC, Huang CF, Ortiz A, Cho H, Song JH, Satcher RL, Kuang J, Gallick GE, Yu-Lee LY, Huang W, Lin SH. Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis. Mol Cancer Res. 2013 Nov; 11(11):1401-11. PMID: 23913163.
      View in: PubMed
    21. Lee YC, Jin JK, Cheng CJ, Huang CF, Song JH, Huang M, Brown WS, Zhang S, Yu-Lee LY, Yeh ET, McIntyre BW, Logothetis CJ, Gallick GE, Lin SH. Targeting constitutively activated ß1 integrins inhibits prostate cancer metastasis. Mol Cancer Res. 2013 Apr; 11(4):405-17. PMID: 23339185.
      View in: PubMed
    22. Fadri-Moskwik M, Weiderhold KN, Deeraksa A, Chuang C, Pan J, Lin SH, Yu-Lee LY. Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells. FASEB J. 2012 Oct; 26(10):4057-67. PMID: 22751009.
      View in: PubMed
    23. Chuang C, Yu-Lee LY. Identifying acetylated proteins in mitosis. Methods Mol Biol. 2012; 909:181-204. PMID: 22903717.
      View in: PubMed
    24. Ye X, Lee YC, Choueiri M, Chu K, Huang CF, Tsai WW, Kobayashi R, Logothetis CJ, Yu-Lee LY, Lin SH. Aberrant expression of katanin p60 in prostate cancer bone metastasis. Prostate. 2012 Feb; 72(3):291-300. PMID: 21681775.
      View in: PubMed
    25. Lee YC, Cheng CJ, Bilen MA, Lu JF, Satcher RL, Yu-Lee LY, Gallick GE, Maity SN, Lin SH. BMP4 promotes prostate tumor growth in bone through osteogenesis. Cancer Res. 2011 Aug 01; 71(15):5194-203. PMID: 21670081.
      View in: PubMed
    26. Qin J, Chen X, Yu-Lee LY, Tsai MJ, Tsai SY. Nuclear receptor COUP-TFII controls pancreatic islet tumor angiogenesis by regulating vascular endothelial growth factor/vascular endothelial growth factor receptor-2 signaling. Cancer Res. 2010 Nov 01; 70(21):8812-21. PMID: 20978203.
      View in: PubMed
    27. Chuang C, Lin SH, Huang F, Pan J, Josic D, Yu-Lee LY. Acetylation of RNA processing proteins and cell cycle proteins in mitosis. J Proteome Res. 2010 Sep 03; 9(9):4554-64. PMID: 20812760.
      View in: PubMed
    28. Huang CF, Lira C, Chu K, Bilen MA, Lee YC, Ye X, Kim SM, Ortiz A, Wu FL, Logothetis CJ, Yu-Lee LY, Lin SH. Cadherin-11 increases migration and invasion of prostate cancer cells and enhances their interaction with osteoblasts. Cancer Res. 2010 Jun 01; 70(11):4580-9. PMID: 20484040.
      View in: PubMed
    29. Lee YC, Cheng CJ, Huang M, Bilen MA, Ye X, Navone NM, Chu K, Kao HH, Yu-Lee LY, Wang Z, Lin SH. Androgen depletion up-regulates cadherin-11 expression in prostate cancer. J Pathol. 2010 May; 221(1):68-76. PMID: 20191612.
      View in: PubMed
    30. Kurasawa Y, Yu-Lee LY. PICH and cotargeted Plk1 coordinately maintain prometaphase chromosome arm architecture. Mol Biol Cell. 2010 Apr 01; 21(7):1188-99. PMID: 20130082.
      View in: PubMed
    31. Yamada M, Toba S, Takitoh T, Yoshida Y, Mori D, Nakamura T, Iwane AH, Yanagida T, Imai H, Yu-Lee LY, Schroer T, Wynshaw-Boris A, Hirotsune S. mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1. EMBO J. 2010 Feb 03; 29(3):517-31. PMID: 20019668.
      View in: PubMed
    32. Chu K, Cheng CJ, Ye X, Lee YC, Zurita AJ, Chen DT, Yu-Lee LY, Zhang S, Yeh ET, Hu MC, Logothetis CJ, Lin SH. Cadherin-11 promotes the metastasis of prostate cancer cells to bone. Mol Cancer Res. 2008 Aug; 6(8):1259-67. PMID: 18708358.
      View in: PubMed
    33. Yan J, Erdem H, Li R, Cai Y, Ayala G, Ittmann M, Yu-Lee LY, Tsai SY, Tsai MJ. Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression. Cancer Res. 2008 Jul 01; 68(13):5460-8. PMID: 18593949.
      View in: PubMed
    34. Lin SH, Lee YC, Choueiri MB, Wen S, Mathew P, Ye X, Do KA, Navone NM, Kim J, Tu SM, Yu-Lee LY, Logothetis CJ. Soluble ErbB3 levels in bone marrow and plasma of men with prostate cancer. Clin Cancer Res. 2008 Jun 15; 14(12):3729-36. PMID: 18559590.
      View in: PubMed
    35. Ishii S, Kurasawa Y, Wong J, Yu-Lee LY. Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Proc Natl Acad Sci U S A. 2008 Mar 18; 105(11):4179-84. PMID: 18326024.
      View in: PubMed
    36. Lee SH, Kunz J, Lin SH, Yu-Lee LY. 16-kDa prolactin inhibits endothelial cell migration by down-regulating the Ras-Tiam1-Rac1-Pak1 signaling pathway. Cancer Res. 2007 Nov 15; 67(22):11045-53. PMID: 18006851.
      View in: PubMed
    37. Chen N, Ye XC, Chu K, Navone NM, Sage EH, Yu-Lee LY, Logothetis CJ, Lin SH. A secreted isoform of ErbB3 promotes osteonectin expression in bone and enhances the invasiveness of prostate cancer cells. Cancer Res. 2007 Jul 15; 67(14):6544-8. PMID: 17638862.
      View in: PubMed
    38. Cheng CJ, Ye XC, Vakar-Lopez F, Kim J, Tu SM, Chen DT, Navone NM, Yu-Lee LY, Lin SH, Hu MC. Bone microenvironment and androgen status modulate subcellular localization of ErbB3 in prostate cancer cells. Mol Cancer Res. 2007 Jul; 5(7):675-84. PMID: 17634423.
      View in: PubMed
    39. Choueiri MB, Tu SM, Yu-Lee LY, Lin SH. The central role of osteoblasts in the metastasis of prostate cancer. Cancer Metastasis Rev. 2006 Dec; 25(4):601-9. PMID: 17160554.
      View in: PubMed
    40. Nishino M, Kurasawa Y, Evans R, Lin SH, Brinkley BR, Yu-Lee LY. NudC is required for Plk1 targeting to the kinetochore and chromosome congression. Curr Biol. 2006 Jul 25; 16(14):1414-21. PMID: 16860740.
      View in: PubMed
    41. Lee SH, Nishino M, Mazumdar T, Garcia GE, Galfione M, Lee FL, Lee CL, Liang A, Kim J, Feng L, Eissa NT, Lin SH, Yu-Lee LY. 16-kDa prolactin down-regulates inducible nitric oxide synthase expression through inhibition of the signal transducer and activator of transcription 1/IFN regulatory factor-1 pathway. Cancer Res. 2005 Sep 01; 65(17):7984-92. PMID: 16140971.
      View in: PubMed
    42. Vakar-Lopez F, Cheng CJ, Kim J, Shi GG, Troncoso P, Tu SM, Yu-Lee LY, Lin SH. Up-regulation of MDA-BF-1, a secreted isoform of ErbB3, in metastatic prostate cancer cells and activated osteoblasts in bone marrow. J Pathol. 2004 Jun; 203(2):688-95. PMID: 15141384.
      View in: PubMed
    43. Phan D, Cheng CJ, Galfione M, Vakar-Lopez F, Tunstead J, Thompson NE, Burgess RR, Najjar SM, Yu-Lee LY, Lin SH. Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis. Cancer Res. 2004 May 01; 64(9):3072-8. PMID: 15126343.
      View in: PubMed
    44. Lin SH, Nishino M, Luo W, Aumais JP, Galfione M, Kuang J, Yu-Lee LY. Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein. Oncogene. 2004 Apr 01; 23(14):2499-506. PMID: 14676831.
      View in: PubMed
    45. Zhou T, Aumais JP, Liu X, Yu-Lee LY, Erikson RL. A role for Plk1 phosphorylation of NudC in cytokinesis. Dev Cell. 2003 Jul; 5(1):127-38. PMID: 12852857.
      View in: PubMed
    46. Galfione M, Luo W, Kim J, Hawke D, Kobayashi R, Clapp C, Yu-Lee LY, Lin SH. Expression and purification of the angiogenesis inhibitor 16-kDa prolactin fragment from insect cells. Protein Expr Purif. 2003 Apr; 28(2):252-8. PMID: 12699689.
      View in: PubMed
    47. Aumais JP, Williams SN, Luo W, Nishino M, Caldwell KA, Caldwell GA, Lin SH, Yu-Lee LY. Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. J Cell Sci. 2003 May 15; 116(Pt 10):1991-2003. PMID: 12679384.
      View in: PubMed
    48. Kim J, Luo W, Chen DT, Earley K, Tunstead J, Yu-Lee LY, Lin SH. Antitumor activity of the 16-kDa prolactin fragment in prostate cancer. Cancer Res. 2003 Jan 15; 63(2):386-93. PMID: 12543792.
      View in: PubMed
    49. Stewart MD, Choi Y, Johnson GA, Yu-Lee LY, Bazer FW, Spencer TE. Roles of Stat1, Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1. Biol Reprod. 2002 Feb; 66(2):393-400. PMID: 11804954.
      View in: PubMed
    50. Yu-Lee LY. Prolactin modulation of immune and inflammatory responses. Recent Prog Horm Res. 2002; 57:435-55. PMID: 12017556.
      View in: PubMed
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