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NORMAN SUSSMAN

TitleAssociate Professor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor Emeritus
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Surgery
    DivisionSurgery-Transplant Division


    Collapse Overview 
    Collapse overview
    Dr. Norman L. Sussman is leading an effort to improve medical resources in rural and underserved communities in Texas using a videoconference outreach model. He is also continuing to refine methods of assessing risk in patient with acute liver failure.

    Dr. Sussman is an active member of the Baylor - St. Luke’s Liver Center. He is Board Certified in Internal Medicine, Gastroenterology, and Transplant Hepatology. His clinical interests cover all aspects of liver disease, and his research interests include assessment and management of acute liver failure, artificial liver support, new agents to treat viral hepatitis, and complications of advanced cirrhosis.

    Collapse Research 
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    R29DK039552     (SUSSMAN, NORMAN L)Jan 1, 1989 - Dec 31, 1993
    NIH
    BIOSYNTHESIS OF LIVER ALKALINE PHOSPHATASE
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tujios SR, Rule JA, Sussman N, Rakela JL, Ganger D, Bass N, Reuben A, Stravitz RT, Kleiner D, Wang H, Choi EK, Peng L, Yeh M, Hatfield B, Yang GY, Gill R, Fontana RJ, Lee WM, Acute Liver Failure Study Group. Clinical and pathological spectrum of disease severity among patients with acute liver failure (ALF) undergoing deceased donor liver transplantation. Liver Transpl. 2025 May 06. PMID: 40341552.
      Citations:    Fields:    
    2. Liangpunsakul S, Krebs WB, Kwong AJ, Kwo PY, Brown RS, Lin W, Sussman NL. The impact of liver transplantation on endpoint selection in alcohol-associated hepatitis trials. Hepatol Commun. 2025 May 01; 9(5). PMID: 40304564; PMCID: PMC12045545.
      Citations:    Fields:    Translation:Humans
    3. Shiffman M, Da B, Goel A, Kwong A, Stein L, Moreno C, Nicoll A, Mehta A, Louvet A, Flamm S, Pyrsopoulos N, Satapathy S, Kuo A, Ganger D, Aloman C, Strasser SI, Tse E, Russo MW, Rockey D, Gray M, Mitchell M, Thursz M, Krebs W, Scott D, Blevins C, Ellis D, Brown J, Sussman N, Lin W. Larsucosterol for the Treatment of Alcohol-Associated Hepatitis. NEJM Evid. 2025 Feb; 4(2):EVIDoa2400243. PMID: 39873544.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    4. Rule JA, Ajayi F, James LP, Tujios SR, Sussman NL, Rakela JL, Ganger D, Bass NL, Reuben A, Stravitz RT, Lee WM, Acute Liver Failure Study Group. Differentiating Ischemic Hepatitis from Acetaminophen Overdose in Acute Liver Failure: Role of Acetaminophen Adducts-Ischemic Hepatitis vs Acetaminophen Overdose. Dig Dis Sci. 2024 Oct; 69(10):3952-3961. PMID: 39222204.
      Citations:    Fields:    Translation:Humans
    5. Lee BP, Witkiewitz K, Mellinger J, Anania FA, Bataller R, Cotter TG, Curtis B, Dasarathy S, DeMartini KS, Diamond I, Diazgranados N, DiMartini AF, Falk DE, Fernandez AC, German MN, Kamath PS, Kidwell KM, Leggio L, Litten R, Louvet A, Lucey MR, McCaul ME, Sanyal AJ, Singal AK, Sussman NL, Terrault NA, Thursz MR, Verna EC, Radaeva S, Nagy LE, Mitchell MC. Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement. Nat Rev Gastroenterol Hepatol. 2024 Sep; 21(9):626-645. PMID: 38849555; PMCID: PMC11829730.
      Citations: 4     Fields:    
    6. Patel PV, Livingston S, Rakela JL, Stravitz RT, Reuben A, Bass NM, Tujios SR, Larson AM, Sussman NL, Rule JA, Durkalski-Mauldin VL, Lee WM, Ganger DR, Acute Liver Failure Study Group (ALFSG). Indeterminate etiology of acute liver failure in North America: Less common, still grave prognosis. Clin Transplant. 2023 12; 37(12):e15128. PMID: 37705387; PMCID: PMC11459373.
      Citations:    Fields:    Translation:Humans
    7. Enke T, Livingston S, Rule J, Stravitz T, Rakela J, Bass N, Reuben A, Tujios S, Larson A, Sussman N, Durkalski V, Lee W, Ganger D. Autoimmune hepatitis presenting as acute liver failure: A 20-year retrospective review of North America. Liver Transpl. 2023 06 01; 29(6):570-580. PMID: 36825579; PMCID: PMC10192052.
      Citations: 1     Fields:    Translation:Humans
    8. Myneedu K, Chavez LO, Sussman NL, Michael M, Padilla A, Zuckerman MJ. Autoimmune Hepatitis in a Patient With Common Variable Immunodeficiency. ACG Case Rep J. 2021 Mar; 8(3):e00547. PMID: 34549051; PMCID: PMC8443823.
      Citations:    
    9. Darr U, Sussman NL. Drug-Induced Liver Injury in the Setting of Analgesic Use. Clin Liver Dis. 2020 02; 24(1):121-129. PMID: 31753245.
      Citations: 4     Fields:    Translation:Humans
    10. DuBrock HM, Salgia RJ, Sussman NL, Bartolome SD, Kadry Z, Mulligan DC, Jenkins S, Lackore K, Channick RN, Kawut SM, Krowka MJ. Portopulmonary Hypertension: A Survey of Practice Patterns and Provider Attitudes. Transplant Direct. 2019 Jun; 5(6):e456. PMID: 31321292; PMCID: PMC6553621.
      Citations: 2     
    11. Shiffman ML, Sussman NL, Ravendhran N, Ditmyer M, Kowdley KV, Kugelmas M. Financial Compensation For Hepatologists in Different Practice Settings. Hepatology. 2019 06; 69(6):2664-2671. PMID: 30586171.
      Citations: 2     Fields:    Translation:Humans
    12. Sussman NL, Lucey MR. Alcohol and Alcoholic Liver Disease. Clin Liver Dis. 2019 02; 23(1):xiii-xiv. PMID: 30454837.
      Citations: 3     Fields:    Translation:Humans
    13. Villarreal JA, Sussman NL. Extracorporeal Liver Support in Patients with Acute Liver Failure. Tex Heart Inst J. 2019 02; 46(1):67-68. PMID: 30833847; PMCID: PMC6379009.
      Citations:    Fields:    Translation:HumansAnimals
    14. Rana A, Ackah RL, Webb GJ, Halazun KJ, Vierling JM, Liu H, Wu MF, Yoeli D, Kueht M, Mindikoglu AL, Sussman NL, Cotton RT, O'Mahony CA, Goss JA, Galv?n NT. No Gains in Long-term Survival After Liver Transplantation Over the Past Three Decades. Ann Surg. 2019 01; 269(1):20-27. PMID: 29303806.
      Citations: 19     Fields:    Translation:Humans
    15. Chhatwal J, Sussman NL. Universal Screening for Hepatitis C: An Important Step in Virus Elimination. Clin Gastroenterol Hepatol. 2019 04; 17(5):835-837. PMID: 30528843.
      Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
    16. Khaderi S, Sussman N, Kanwal F. Project ECHO: The Specialist Will See You Now. Hepatology. 2018 12; 68(6):2066-2068. PMID: 30033576.
      Citations: 1     Fields:    Translation:Humans
    17. Grome L, Jalalabadi F, Fordis CM, Sussman NL, Reece EM. Bootstrapping Your Telehealth Program. Semin Plast Surg. 2018 Nov; 32(4):162-165. PMID: 30357035; PMCID: PMC6197872.
      Citations: 1     
    18. Jalalabadi F, Shultz KP, Sussman NL, Fisher WE, Reece EM. Initiating Telehealth in a Complex Organization. Semin Plast Surg. 2018 Nov; 32(4):159-161. PMID: 30357052; PMCID: PMC6197881.
      Citations: 2     
    19. Rana A, Sigireddi RR, Halazun KJ, Kothare A, Wu MF, Liu H, Kueht ML, Vierling JM, Sussman NL, Mindikoglu AL, Miloh T, Galvan NTN, Cotton RT, O'Mahony CA, Goss JA. Predicting Liver Allograft Discard: The Discard Risk Index. Transplantation. 2018 09; 102(9):1520-1529. PMID: 29485514.
      Citations: 4     Fields:    Translation:Humans
    20. Ganger DR, Rule J, Rakela J, Bass N, Reuben A, Stravitz RT, Sussman N, Larson AM, James L, Chiu C, Lee WM, Acute Liver Failure Study Group. Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by An Expert Committee to Establish Causality. Am J Gastroenterol. 2018 09; 113(9):1319. PMID: 29946176; PMCID: PMC9252260.
      Citations: 24     Fields:    Translation:HumansCells
    21. Sussman NL, Kelly JH. Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial. Liver Transpl. 2018 05; 24(5):711. PMID: 29385313.
      Citations: 1     Fields:    Translation:Humans
    22. Rana A, Witte ED, Halazun KJ, Sood GK, Mindikoglu AL, Sussman NL, Vierling JM, Kueht ML, Galvan NTN, Cotton RT, O'Mahony CA, Goss JA. Liver transplant length of stay (LOS) index: A novel predictive score for hospital length of stay following liver transplantation. Clin Transplant. 2017 Dec; 31(12). PMID: 29044759.
      Citations: 4     Fields:    Translation:Humans
    23. DuBrock HM, Goldberg DS, Sussman NL, Bartolome SD, Kadry Z, Salgia RJ, Mulligan DC, Kremers WK, Kawut SM, Krowka MJ, Channick RN. Predictors of Waitlist Mortality in Portopulmonary Hypertension. Transplantation. 2017 07; 101(7):1609-1615. PMID: 28207639; PMCID: PMC5481480.
      Citations: 12     Fields:    Translation:Humans
    24. Goss M, Reese J, Kueht M, Vierling JM, Mindikoglu AL, Sussman NL, Kaplan B, Wood RP, Rana AA. A Surge in cadaveric liver donors and a national narcotic epidemic: Is there an association? Liver Transpl. 2017 05; 23(5):698-700. PMID: 28295986.
      Citations: 3     Fields:    Translation:Humans
    25. Sussman NL, Remien CH. The Headache of Acetaminophen Overdose: Getting the NAC. Clin Gastroenterol Hepatol. 2017 04; 15(4):563-564. PMID: 28017841.
      Citations: 1     Fields:    Translation:Humans
    26. Thornton K, Deming P, Manch RA, Moore A, Kohli A, Gish R, Sussman NL, Khaderi S, Scott J, Mera J, Box T, Qualls C, Sedillo M, Arora S. Is response guided therapy dead? Low cure rates in patients with detectable hepatitis C virus at week 4 of treatment. Hepatol Int. 2016 Jul; 10(4):624-31. PMID: 27098355.
      Citations: 8     Fields:    Translation:HumansCells
    27. Carrion AF, Khaderi SA, Sussman NL. Model for end-stage liver disease limbo, model for end-stage liver disease purgatory, and the dilemma of treating hepatitis C in patients awaiting liver transplantation. Liver Transpl. 2016 Mar; 22(3):279-80. PMID: 26663608.
      Citations: 11     Fields:    Translation:HumansCells
    28. Sussman NL. Treatment of Overt Hepatic Encephalopathy. Clin Liver Dis. 2015 Aug; 19(3):551-63. PMID: 26195208.
      Citations: 1     Fields:    Translation:Humans
    29. Khaderi SA, Sussman NL. Screening for malignancy in primary sclerosing cholangitis (PSC). Curr Gastroenterol Rep. 2015 Apr; 17(4):17. PMID: 25786901.
      Citations: 13     Fields:    Translation:Humans
    30. Sussman NL, Kelly JH. Artificial liver. Clin Gastroenterol Hepatol. 2014 Sep; 12(9):1439-42. PMID: 24909908.
      Citations: 6     Fields:    Translation:Humans
    31. Khaderi S, Khan R, Safdar Z, Stribling R, Vierling JM, Goss JA, Sussman NL. Long-term follow-up of portopulmonary hypertension patients after liver transplantation. Liver Transpl. 2014 Jun; 20(6):724-7. PMID: 24648168.
      Citations: 12     Fields:    Translation:Humans
    32. Sussman NL, Remien CH, Kanwal F. The end of hepatitis C. Clin Gastroenterol Hepatol. 2014 Apr; 12(4):533-6. PMID: 24480676.
      Citations: 15     Fields:    Translation:HumansPHPublic Health
    33. Remien CH, Sussman NL, Adler FR. Mathematical modelling of chronic acetaminophen metabolism and liver injury. Math Med Biol. 2014 Sep; 31(3):302-17. PMID: 23788256.
      Citations: 2     Fields:    Translation:Humans
    34. Safdar Z, Bartolome S, Sussman N. Portopulmonary hypertension: an update. Liver Transpl. 2012 Aug; 18(8):881-91. PMID: 22674534.
      Citations: 19     Fields:    Translation:Humans
    35. Remien CH, Adler FR, Waddoups L, Box TD, Sussman NL. Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death. Hepatology. 2012 Aug; 56(2):727-34. PMID: 22331703.
      Citations: 18     Fields:    Translation:HumansCells
    36. Sussman NL, Kochar R, Fallon MB. Pulmonary complications in cirrhosis. Curr Opin Organ Transplant. 2011 Jun; 16(3):281-8. PMID: 21543981.
      Citations: 7     Fields:    Translation:Humans
    37. Salek J, Byrne J, Box T, Longo N, Sussman N. Recurrent liver failure in a 25-year-old female. Liver Transpl. 2010 Sep; 16(9):1049-53. PMID: 20818742.
      Citations: 7     Fields:    Translation:HumansCells
    38. Sussman NL, McGuire BM, Kelly JH. Hepatic assist devices: will they ever be successful? Curr Gastroenterol Rep. 2009 Feb; 11(1):64-8. PMID: 19166661.
      Citations: 3     Fields:    Translation:HumansCells
    39. Sussman NL, Lee PL, Dries AM, Schwartz MR, Barton JC. Multi-organ iron overload in an African-American man with ALAS2 R452S and SLC40A1 R561G. Acta Haematol. 2008; 120(3):168-73. PMID: 19066423.
      Citations: 6     Fields:    Translation:HumansCells
    40. Agha A, Sussman N. Acute hepatic dysfunction with abdominal pain and ascites. MedGenMed. 2007 May 09; 9(2):31. PMID: 17955086; PMCID: PMC1994833.
      Citations:    Fields:    Translation:Humans
    41. Sussman N, Kaza V, Barshes N, Stribling R, Goss J, O'Mahony C, Zhang E, Vierling J, Frost A. Successful liver transplantation following medical management of portopulmonary hypertension: a single-center series. Am J Transplant. 2006 Sep; 6(9):2177-82. PMID: 16796721.
      Citations: 26     Fields:    Translation:Humans
    42. Stribling R, Sussman N, Vierling JM. Treatment of hepatitis C infection. Gastroenterol Clin North Am. 2006 Jun; 35(2):463-86. PMID: 16880075.
      Citations: 4     Fields:    Translation:Humans
    43. Woofter A, Sussman N. Jaundice in a traveler returning from India. MedGenMed. 2006 Feb 16; 8(1):48. PMID: 16915178; PMCID: PMC1681962.
      Citations: 1     Fields:    Translation:Humans
    44. Clark RD, Wolohan PR, Hodgkin EE, Kelly JH, Sussman NL. Modelling in vitro hepatotoxicity using molecular interaction fields and SIMCA. J Mol Graph Model. 2004 Jul; 22(6):487-97. PMID: 15182808.
      Citations: 4     Fields:    Translation:HumansCells
    45. Dunner DL, Laird LK, Zajecka J, Bailey L, Sussman N, Seabolt JL. Six-year perspectives on the safety and tolerability of nefazodone. J Clin Psychiatry. 2002; 63 Suppl 1:32-41. PMID: 11890563.
      Citations: 1     Fields:    Translation:Humans
    46. Kelly JH, Sussman NL. A fluorescent cell-based assay for cytochrome P-450 isozyme 1A2 induction and inhibition. J Biomol Screen. 2000 Aug; 5(4):249-54. PMID: 10992045.
      Citations: 7     Fields:    Translation:HumansCells
    47. Sussman NL, Kelly JH. Extracorporeal liver support: cell-based therapy for the failing liver. Am J Kidney Dis. 1997 Nov; 30(5 Suppl 4):S66-71. PMID: 9372981.
      Citations: 6     Fields:    Translation:HumansAnimals
    48. Ellis AJ, Hughes RD, Wendon JA, Dunne J, Langley PG, Kelly JH, Gislason GT, Sussman NL, Williams R. Pilot-controlled trial of the extracorporeal liver assist device in acute liver failure. Hepatology. 1996 Dec; 24(6):1446-51. PMID: 8938179.
      Citations: 71     Fields:    Translation:HumansCTClinical Trials
    49. Sussman NL, Kelly JH. Artificial liver support. Clin Invest Med. 1996 Oct; 19(5):393-9. PMID: 8889280.
      Citations:    Fields:    Translation:HumansAnimals
    50. Sussman NL, Lake JR. Treatment of hepatic failure--1996: current concepts and progress toward liver dialysis. Am J Kidney Dis. 1996 May; 27(5):605-21. PMID: 8629619.
      Citations: 3     Fields:    Translation:Humans
    51. Lake JR, Sussman NL. Determining prognosis in patients with fulminant hepatic failure: when you absolutely, positively have to know the answer. Hepatology. 1995 Mar; 21(3):879-82. PMID: 7875687.
      Citations: 4     Fields:    Translation:Humans
    52. Sussman NL, Finegold MJ, Barish JP, Kelly JH. A case of syncytial giant-cell hepatitis treated with an extracorporeal liver assist device. Am J Gastroenterol. 1994 Jul; 89(7):1077-82. PMID: 7517100.
      Citations: 3     Fields:    Translation:HumansCells
    53. Sussman NL, Gislason GT, Kelly JH. Extracorporeal liver support. Application to fulminant hepatic failure. J Clin Gastroenterol. 1994 Jun; 18(4):320-4. PMID: 8071519.
      Citations: 8     Fields:    Translation:HumansAnimals
    54. Sussman NL, Gislason GT, Conlin CA, Kelly JH. The Hepatix extracorporeal liver assist device: initial clinical experience. Artif Organs. 1994 May; 18(5):390-6. PMID: 8037614.
      Citations: 28     Fields:    Translation:Humans
    55. Gislason GT, Lobdell DD, Kelly JH, Sussman NL. A treatment system for implementing an extracorporeal liver assist device. Artif Organs. 1994 May; 18(5):385-9. PMID: 8037613.
      Citations: 4     Fields:    Translation:HumansAnimals
    56. Kelly JH, Sussman NL. The hepatix extracorporeal liver assist device in the treatment of fulminant hepatic failure. ASAIO J. 1994 Jan-Mar; 40(1):83-5. PMID: 7514459.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    57. Wood RP, Katz SM, Ozaki CF, Monsour HP, Gislason GT, Kelly JH, Sussman NL. Extracorporeal liver assist device (ELAD): a preliminary report. Transplant Proc. 1993 Aug; 25(4 Suppl 3):53-4. PMID: 8351720.
      Citations: 2     Fields:    Translation:Humans
    58. Sussman NL, Kelly JH. Artificial liver: a forthcoming attraction. Hepatology. 1993 Jun; 17(6):1163-4. PMID: 8514267.
      Citations: 10     Fields:    Translation:Humans
    59. Sussman NL, Kelly JH. Improved liver function following treatment with an extracorporeal liver assist device. Artif Organs. 1993 Jan; 17(1):27-30. PMID: 8422230.
      Citations: 12     Fields:    Translation:Humans
    60. Sussman NL, Kelly JH. Liver assist devices (LADs) will not be used to treat fulminant hepatic failure (FHF), but its consequences, namely hepatic encephalopathy (HE) Artif Organs. 1993 Jan; 17(1):43-5. PMID: 8422234.
      Citations: 1     Fields:    Translation:Humans
    61. Sussman NL, Kelly JH. Extracorporeal liver assist in the treatment of fulminant hepatic failure. Blood Purif. 1993; 11(3):170-4. PMID: 8280439.
      Citations:    Fields:    Translation:HumansAnimalsCells
    62. Kelly JH, Koussayer T, He D, Chong MG, Shang TA, Whisennand HH, Sussman NL. Assessment of an extracorporeal liver assist device in anhepatic dogs. Artif Organs. 1992 Aug; 16(4):418-22. PMID: 10078286.
      Citations: 3     Fields:    Translation:Animals
    63. Sussman NL, Chong MG, Koussayer T, He DE, Shang TA, Whisennand HH, Kelly JH. Reversal of fulminant hepatic failure using an extracorporeal liver assist device. Hepatology. 1992 Jul; 16(1):60-5. PMID: 1618484.
      Citations: 34     Fields:    Translation:HumansAnimals
    64. Kelly JH, Koussayer T, He DE, Chong MG, Shang TA, Whisennand HH, Sussman NL. An improved model of acetaminophen-induced fulminant hepatic failure in dogs. Hepatology. 1992 Feb; 15(2):329-35. PMID: 1735538.
      Citations: 15     Fields:    Translation:AnimalsCells
    65. Ballenger JC, McDonald S, Noyes R, Rickels K, Sussman N, Woods S, Patin J, Singer J. The first double-blind, placebo-controlled trial of a partial benzodiazepine agonist abecarnil (ZK 112-119) in generalized anxiety disorder. Psychopharmacol Bull. 1991; 27(2):171-9. PMID: 1681563.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    66. Sussman NL, Eliakim R, Rubin D, Perlmutter DH, DeSchryver-Kecskemeti K, Alpers DH. Intestinal alkaline phosphatase is secreted bidirectionally from villous enterocytes. Am J Physiol. 1989 Jul; 257(1 Pt 1):G14-23. PMID: 2546440.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    67. Go MF, Schonfeld G, Pfleger B, Cole TG, Sussman NL, Alpers DH. Regulation of intestinal and hepatic apoprotein synthesis after chronic fat and cholesterol feeding. J Clin Invest. 1988 May; 81(5):1615-20. PMID: 3130399; PMCID: PMC442597.
      Citations: 3     Fields:    Translation:Animals
    68. Seetharam S, Sussman NL, Komoda T, Alpers DH. The mechanism of elevated alkaline phosphatase activity after bile duct ligation in the rat. Hepatology. 1986 May-Jun; 6(3):374-80. PMID: 3710426.
      Citations: 9     Fields:    Translation:AnimalsCells
    69. Sussman NL, Seetharam S, Blaufuss MC, Alpers DH. Translation of rat intestinal RNA yields two alkaline phosphatases. Biochem J. 1986 Mar 15; 234(3):563-8. PMID: 2424431; PMCID: PMC1146608.
      Citations: 4     Fields:    Translation:AnimalsCells
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