Institute for Clinical and Translational Research

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NORMAN LESLIE SUSSMAN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
DivisionSurgery-Transplant Division
Address6620 Main Stree, Suite 1425
Houston TX 77030
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    Dr. Norman L. Sussman is leading an effort to improve medical resources in rural and underserved communities in Texas using a videoconference outreach model. He is also continuing to refine methods of assessing risk in patient with acute liver failure.

    Dr. Sussman is an active member of the Baylor - St. Luke’s Liver Center. He is Board Certified in Internal Medicine, Gastroenterology, and Transplant Hepatology. His clinical interests cover all aspects of liver disease, and his research interests include assessment and management of acute liver failure, artificial liver support, new agents to treat viral hepatitis, and complications of advanced cirrhosis.

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    • Assessment and management of acute liver failure
    • Artificial liver support
    • Complications of advanced cirrhosis
    • New agents to treat viral hepatitis


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sussman NL, Kelly JH. Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial. Liver Transpl. 2018 05; 24(5):711. PMID: 29385313.
      View in: PubMed
    2. Rana A, Sigireddi RR, Halazun KJ, Kothare A, Wu MF, Liu H, Kueht ML, Vierling JM, Sussman NL, Mindikoglu AL, Miloh T, Galvan NTN, Cotton RT, O'Mahony CA, Goss JA. Predicting Liver Allograft Discard: The Discard Risk Index. Transplantation. 2018 Feb 26. PMID: 29485514.
      View in: PubMed
    3. Rana A, Ackah RL, Webb GJ, Halazun KJ, Vierling JM, Liu H, Wu MF, Yoeli D, Kueht M, Mindikoglu AL, Sussman NL, Galván NT, Cotton RT, O'Mahony CA, Goss JA. No Gains in Long-Term Survival After Liver Transplantation Over the Past Three Decades. Ann Surg. 2018 Jan 04. PMID: 29303806.
      View in: PubMed
    4. Rana A, Witte ED, Halazun KJ, Sood GK, Mindikoglu AL, Sussman NL, Vierling JM, Kueht ML, Galvan NTN, Cotton RT, O'Mahony CA, Goss JA. Liver transplant length of stay (LOS) index: A novel predictive score for hospital length of stay following liver transplantation. Clin Transplant. 2017 Dec; 31(12). PMID: 29044759.
      View in: PubMed
    5. Goss M, Reese J, Kueht M, Vierling JM, Mindikoglu AL, Sussman NL, Kaplan B, Wood RP, Rana AA. A Surge in Cadaveric Liver Donors and a National Narcotic Epidemic: Is There an Association? Liver Transpl. 2017 Mar 14. PMID: 28295986.
      View in: PubMed
    6. DuBrock HM, Goldberg DS, Sussman NL, Bartolome SD, Kadry Z, Salgia RJ, Mulligan DC, Kremers WK, Kawut SM, Krowka MJ, Channick RN. Predictors of Waitlist Mortality in Portopulmonary Hypertension. Transplantation. 2017 Feb 15. PMID: 28207639.
      View in: PubMed
    7. Sussman NL, Remien CH. The Headache of Acetaminophen Overdose: Getting the N-Acetylcysteine. Clin Gastroenterol Hepatol. 2016 Dec 23. PMID: 28017841.
      View in: PubMed
    8. Thornton K, Deming P, Manch RA, Moore A, Kohli A, Gish R, Sussman NL, Khaderi S, Scott J, Mera J, Box T, Qualls C, Sedillo M, Arora S. Is response guided therapy dead? Low cure rates in patients with detectable hepatitis C virus at week 4 of treatment. Hepatol Int. 2016 Jul; 10(4):624-31. PMID: 27098355.
      View in: PubMed
    9. Carrion AF, Khaderi SA, Sussman NL. Model for end-stage liver disease limbo, model for end-stage liver disease purgatory, and the dilemma of treating hepatitis C in patients awaiting liver transplantation. Liver Transpl. 2016 Mar; 22(3):279-80. PMID: 26663608.
      View in: PubMed
    10. Sussman NL. Treatment of Overt Hepatic Encephalopathy. Clin Liver Dis. 2015 Aug; 19(3):551-63. PMID: 26195208.
      View in: PubMed
    11. Khaderi SA, Sussman NL. Screening for malignancy in primary sclerosing cholangitis (PSC). Curr Gastroenterol Rep. 2015 Apr; 17(4):17. PMID: 25786901.
      View in: PubMed
    12. Sussman NL, Kelly JH. Artificial liver. Clin Gastroenterol Hepatol. 2014 Sep; 12(9):1439-42. PMID: 24909908.
      View in: PubMed
    13. Khaderi S, Khan R, Safdar Z, Stribling R, Vierling JM, Goss JA, Sussman NL. Long-term follow-up of portopulmonary hypertension patients after liver transplantation. Liver Transpl. 2014 Jun; 20(6):724-7. PMID: 24648168.
      View in: PubMed
    14. Sussman NL, Remien CH, Kanwal F. The end of hepatitis C. Clin Gastroenterol Hepatol. 2014 Apr; 12(4):533-6. PMID: 24480676.
      View in: PubMed
    15. Remien CH, Sussman NL, Adler FR. Mathematical modelling of chronic acetaminophen metabolism and liver injury. Math Med Biol. 2014 Sep; 31(3):302-17. PMID: 23788256.
      View in: PubMed
    16. Remien CH, Adler FR, Box TD, Waddoups L, Sussman NL. Reply:. Hepatology. 2012 Dec; 56(6):2428-9. PMID: 22806412.
      View in: PubMed
    17. Safdar Z, Bartolome S, Sussman N. Portopulmonary hypertension: an update. Liver Transpl. 2012 Aug; 18(8):881-91. PMID: 22674534.
      View in: PubMed
    18. Remien CH, Adler FR, Waddoups L, Box TD, Sussman NL. Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death. Hepatology. 2012 Aug; 56(2):727-34. PMID: 22331703.
      View in: PubMed
    19. Sussman NL, Kochar R, Fallon MB. Pulmonary complications in cirrhosis. Curr Opin Organ Transplant. 2011 Jun; 16(3):281-8. PMID: 21543981.
      View in: PubMed
    20. Salek J, Byrne J, Box T, Longo N, Sussman N. Recurrent liver failure in a 25-year-old female. Liver Transpl. 2010 Sep; 16(9):1049-53. PMID: 20818742.
      View in: PubMed
    21. Sussman NL, McGuire BM, Kelly JH. Hepatic assist devices: will they ever be successful? Curr Gastroenterol Rep. 2009 Feb; 11(1):64-8. PMID: 19166661.
      View in: PubMed
    22. Sussman NL, Lee PL, Dries AM, Schwartz MR, Barton JC. Multi-organ iron overload in an African-American man with ALAS2 R452S and SLC40A1 R561G. Acta Haematol. 2008; 120(3):168-73. PMID: 19066423.
      View in: PubMed
    23. Sussman N. Interpreting antidepressant clinical trials. Ann Clin Psychiatry. 2007 Oct-Dec; 19(4):215-20. PMID: 18058279.
      View in: PubMed
    24. Agha A, Sussman N. Acute hepatic dysfunction with abdominal pain and ascites. MedGenMed. 2007; 9(2):31. PMID: 17955086; PMCID: PMC1994833.
      View in: PubMed, PubMed Central
    25. Sussman N. Translating Science Into Service: Lessons Learned From the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Study. Prim Care Companion J Clin Psychiatry. 2007; 9(5):331-7. PMID: 17998951; PMCID: PMC2040279.
      View in: PubMed, PubMed Central
    26. Sussman N, Kaza V, Barshes N, Stribling R, Goss J, O'Mahony C, Zhang E, Vierling J, Frost A. Successful liver transplantation following medical management of portopulmonary hypertension: a single-center series. Am J Transplant. 2006 Sep; 6(9):2177-82. PMID: 16796721.
      View in: PubMed
    27. Stribling R, Sussman N, Vierling JM. Treatment of hepatitis C infection. Gastroenterol Clin North Am. 2006 Jun; 35(2):463-86. PMID: 16880075.
      View in: PubMed
    28. Woofter A, Sussman N. Jaundice in a traveler returning from India. MedGenMed. 2006; 8(1):48. PMID: 16915178; PMCID: PMC1681962.
      View in: PubMed, PubMed Central
    29. Clark RD, Wolohan PR, Hodgkin EE, Kelly JH, Sussman NL. Modelling in vitro hepatotoxicity using molecular interaction fields and SIMCA. J Mol Graph Model. 2004 Jul; 22(6):487-97. PMID: 15182808.
      View in: PubMed
    30. Sussman N. The implications of weight changes with antipsychotic treatment. J Clin Psychopharmacol. 2003 Jun; 23(3 Suppl 1):S21-6. PMID: 12832946.
      View in: PubMed
    31. Dunner DL, Laird LK, Zajecka J, Bailey L, Sussman N, Seabolt JL. Six-year perspectives on the safety and tolerability of nefazodone. J Clin Psychiatry. 2002; 63 Suppl 1:32-41. PMID: 11890563.
      View in: PubMed
    32. Sussman N, Ginsberg DL, Bikoff J. Effects of nefazodone on body weight: a pooled analysis of selective serotonin reuptake inhibitor- and imipramine-controlled trials. J Clin Psychiatry. 2001 Apr; 62(4):256-60. PMID: 11379839.
      View in: PubMed
    33. Sussman N. Review of atypical antipsychotics and weight gain. J Clin Psychiatry. 2001; 62 Suppl 23:5-12. PMID: 11603886.
      View in: PubMed
    34. Kelly JH, Sussman NL. A fluorescent cell-based assay for cytochrome P-450 isozyme 1A2 induction and inhibition. J Biomol Screen. 2000 Aug; 5(4):249-54. PMID: 10992045.
      View in: PubMed
    35. Sussman N. Venlafaxine XR therapy for major depression and anxiety disorders. The clinical implications that its advantages pose. Postgrad Med. 1999 Nov; 106(6 Suppl):31-6. PMID: 19667502.
      View in: PubMed
    36. Castaneda R, Sussman N, Levy R, Trujillo M. A Treatment Algorithm for Attention Deficit Hyperactivity Disorder in Cocaine-Dependent Adults: A One-Year Private Practice Study with Long-Acting Stimulants, Fluoxetine, and Bupropion. Subst Abus. 1999 Mar; 20(1):59-71. PMID: 12511821.
      View in: PubMed
    37. Sussman N, Joffe RT. Introduction: augmentation of antidepressant medication. J Clin Psychiatry. 1998; 59 Suppl 5:3-4; discussion 70-3. PMID: 9635542.
      View in: PubMed
    38. Sussman N, Joffe RT. Antidepressant augmentation: conclusions and recommendations. J Clin Psychiatry. 1998; 59 Suppl 5:70-3. PMID: 9635551.
      View in: PubMed
    39. Sussman N. Anxiolytic antidepressant augmentation. J Clin Psychiatry. 1998; 59 Suppl 5:42-8; discussion 49-50. PMID: 9635547.
      View in: PubMed
    40. Castaneda R, Sussman N, Levy R, O'Malley M, Westreich L. A review of the effects of moderate alcohol intake on psychiatric and sleep disorders. Recent Dev Alcohol. 1998; 14:197-226. PMID: 9751947.
      View in: PubMed
    41. Sussman NL, Kelly JH. Extracorporeal liver support: cell-based therapy for the failing liver. Am J Kidney Dis. 1997 Nov; 30(5 Suppl 4):S66-71. PMID: 9372981.
      View in: PubMed
    42. Sussman N, Stahl S. Update in the pharmacotherapy of depression. Am J Med. 1996 Dec 30; 101(6A):26S-36S. PMID: 9012608.
      View in: PubMed
    43. Ellis AJ, Hughes RD, Wendon JA, Dunne J, Langley PG, Kelly JH, Gislason GT, Sussman NL, Williams R. Pilot-controlled trial of the extracorporeal liver assist device in acute liver failure. Hepatology. 1996 Dec; 24(6):1446-51. PMID: 8938179.
      View in: PubMed
    44. Sussman NL, Kelly JH. Artificial liver support. Clin Invest Med. 1996 Oct; 19(5):393-9. PMID: 8889280.
      View in: PubMed
    45. Castañeda R, Levy R, Westreich LM, Sussman N. Drug craving and other negative reactions after abrupt substitution of nefazodone for other serotonergic agents. J Clin Psychiatry. 1996 Oct; 57(10):485-6. PMID: 8909335.
      View in: PubMed
    46. Castaneda R, Sussman N, Westreich L, Levy R, O'Malley M. A review of the effects of moderate alcohol intake on the treatment of anxiety and mood disorders. J Clin Psychiatry. 1996 May; 57(5):207-12. PMID: 8626352.
      View in: PubMed
    47. Sussman NL, Lake JR. Treatment of hepatic failure--1996: current concepts and progress toward liver dialysis. Am J Kidney Dis. 1996 May; 27(5):605-21. PMID: 8629619.
      View in: PubMed
    48. French JA, Mosier M, Walker S, Sommerville K, Sussman N. A double-blind, placebo-controlled study of vigabatrin three g/day in patients with uncontrolled complex partial seizures. Vigabatrin Protocol 024 Investigative Cohort. Neurology. 1996 Jan; 46(1):54-61. PMID: 8559421.
      View in: PubMed
    49. Lake JR, Sussman NL. Determining prognosis in patients with fulminant hepatic failure: when you absolutely, positively have to know the answer. Hepatology. 1995 Mar; 21(3):879-82. PMID: 7875687.
      View in: PubMed
    50. Sussman NL, Finegold MJ, Barish JP, Kelly JH. A case of syncytial giant-cell hepatitis treated with an extracorporeal liver assist device. Am J Gastroenterol. 1994 Jul; 89(7):1077-82. PMID: 7517100.
      View in: PubMed
    51. Silberman EK, Sussman N, Skillings G, Callanan M. Aura phenomena and psychopathology: a pilot investigation. Epilepsia. 1994 Jul-Aug; 35(4):778-84. PMID: 8082622.
      View in: PubMed
    52. Sussman NL, Gislason GT, Kelly JH. Extracorporeal liver support. Application to fulminant hepatic failure. J Clin Gastroenterol. 1994 Jun; 18(4):320-4. PMID: 8071519.
      View in: PubMed
    53. Sussman NL, Gislason GT, Conlin CA, Kelly JH. The Hepatix extracorporeal liver assist device: initial clinical experience. Artif Organs. 1994 May; 18(5):390-6. PMID: 8037614.
      View in: PubMed
    54. Gislason GT, Lobdell DD, Kelly JH, Sussman NL. A treatment system for implementing an extracorporeal liver assist device. Artif Organs. 1994 May; 18(5):385-9. PMID: 8037613.
      View in: PubMed
    55. Sussman N. The potential benefits of serotonin receptor-specific agents. J Clin Psychiatry. 1994 Feb; 55 Suppl:45-51. PMID: 7521327.
      View in: PubMed
    56. Kelly JH, Sussman NL. The hepatix extracorporeal liver assist device in the treatment of fulminant hepatic failure. ASAIO J. 1994 Jan-Mar; 40(1):83-5. PMID: 7514459.
      View in: PubMed
    57. Wood RP, Katz SM, Ozaki CF, Monsour HP, Gislason GT, Kelly JH, Sussman NL. Extracorporeal liver assist device (ELAD): a preliminary report. Transplant Proc. 1993 Aug; 25(4 Suppl 3):53-4. PMID: 8351720.
      View in: PubMed
    58. Sussman NL, Kelly JH. Artificial liver: a forthcoming attraction. Hepatology. 1993 Jun; 17(6):1163-4. PMID: 8514267.
      View in: PubMed
    59. Sussman N. Treating anxiety while minimizing abuse and dependence. J Clin Psychiatry. 1993 May; 54 Suppl:44-51. PMID: 8099577.
      View in: PubMed
    60. Sussman N. How to manage anxious patients who are depressed. J Clin Psychiatry. 1993 May; 54 Suppl:8-16; discussion 17-20. PMID: 8099581.
      View in: PubMed
    61. Sussman NL, Kelly JH. Improved liver function following treatment with an extracorporeal liver assist device. Artif Organs. 1993 Jan; 17(1):27-30. PMID: 8422230.
      View in: PubMed
    62. Sussman NL, Kelly JH. Liver assist devices (LADs) will not be used to treat fulminant hepatic failure (FHF), but its consequences, namely hepatic encephalopathy (HE) Artif Organs. 1993 Jan; 17(1):43-5. PMID: 8422234.
      View in: PubMed
    63. Sussman NL, Kelly JH. Extracorporeal liver assist in the treatment of fulminant hepatic failure. Blood Purif. 1993; 11(3):170-4. PMID: 8280439.
      View in: PubMed
    64. Kelly JH, Koussayer T, He D, Chong MG, Shang TA, Whisennand HH, Sussman NL. Assessment of an extracorporeal liver assist device in anhepatic dogs. Artif Organs. 1992 Aug; 16(4):418-22. PMID: 10078286.
      View in: PubMed
    65. Sussman NL, Chong MG, Koussayer T, He DE, Shang TA, Whisennand HH, Kelly JH. Reversal of fulminant hepatic failure using an extracorporeal liver assist device. Hepatology. 1992 Jul; 16(1):60-5. PMID: 1618484.
      View in: PubMed
    66. Kelly JH, Koussayer T, He DE, Chong MG, Shang TA, Whisennand HH, Sussman NL. An improved model of acetaminophen-induced fulminant hepatic failure in dogs. Hepatology. 1992 Feb; 15(2):329-35. PMID: 1735538.
      View in: PubMed
    67. Ballenger JC, McDonald S, Noyes R, Rickels K, Sussman N, Woods S, Patin J, Singer J. The first double-blind, placebo-controlled trial of a partial benzodiazepine agonist abecarnil (ZK 112-119) in generalized anxiety disorder. Psychopharmacol Bull. 1991; 27(2):171-9. PMID: 1681563.
      View in: PubMed
    68. Sussman N, Cancro R. Improving results with antidepressant drug therapy. Compr Ther. 1990 Feb; 16(2):12-23. PMID: 2311358.
      View in: PubMed
    69. Sussman NL, Eliakim R, Rubin D, Perlmutter DH, DeSchryver-Kecskemeti K, Alpers DH. Intestinal alkaline phosphatase is secreted bidirectionally from villous enterocytes. Am J Physiol. 1989 Jul; 257(1 Pt 1):G14-23. PMID: 2546440.
      View in: PubMed
    70. Go MF, Schonfeld G, Pfleger B, Cole TG, Sussman NL, Alpers DH. Regulation of intestinal and hepatic apoprotein synthesis after chronic fat and cholesterol feeding. J Clin Invest. 1988 May; 81(5):1615-20. PMID: 3130399; PMCID: PMC442597.
      View in: PubMed, PubMed Central
    71. Seetharam S, Sussman NL, Komoda T, Alpers DH. The mechanism of elevated alkaline phosphatase activity after bile duct ligation in the rat. Hepatology. 1986 May-Jun; 6(3):374-80. PMID: 3710426.
      View in: PubMed
    72. Sussman NL, Seetharam S, Blaufuss MC, Alpers DH. Translation of rat intestinal RNA yields two alkaline phosphatases. Biochem J. 1986 Mar 15; 234(3):563-8. PMID: 2424431; PMCID: PMC1146608.
      View in: PubMed, PubMed Central
    73. SUSSMAN N. The autonomic nervous system in rheumatoid arthritis; a preliminary report on the use of D.H.E.-45. Med Times. 1952 Sep; 80(9):560-3. PMID: 12992244.
      View in: PubMed
    74. SUSSMAN N. ACTH sensitivity. Med Times. 1952 Mar; 80(3):154-5. PMID: 14909997.
      View in: PubMed
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