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BIN ZHAN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Tropical Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sun S, Li H, Yuan Y, Wang L, He W, Xie H, Gao S, Cheng R, Qian H, Jiang H, Wang X, Zhan B, Fang Q, Yang X. Preventive and therapeutic effects of Trichinella spiralis adult extracts on allergic inflammation in an experimental asthma mouse model. Parasit Vectors. 2019 Jun 28; 12(1):326. PMID: 31253164.
      View in: PubMed
    2. Barry MA, Versteeg L, Wang Q, Pollet J, Zhan B, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2019 05; 13(5):e0007413. PMID: 31145733.
      View in: PubMed
    3. Shao S, Sun X, Chen Y, Zhan B, Zhu X. Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host. Front Microbiol. 2019; 10:532. PMID: 30949145.
      View in: PubMed
    4. Wang L, Zou Y, Zhu X, Bottazzi ME, Hotez PJ, Zhan B. China's shifting neglected parasitic infections in an era of economic reform, urbanization, disease control, and the Belt and Road Initiative. PLoS Negl Trop Dis. 2019 01; 13(1):e0006946. PMID: 30677027.
      View in: PubMed
    5. Wang Z, Hao C, Huang J, Zhuang Q, Zhan B, Zhu X. Mapping of the complement C1q binding site on Trichinella spiralis paramyosin. Parasit Vectors. 2018 Dec 27; 11(1):666. PMID: 30587214.
      View in: PubMed
    6. Weatherhead JE, Porter P, Coffey A, Haydel D, Versteeg L, Zhan B, Gazzinelli Guimarães AC, Fujiwara R, Jaramillo AM, Bottazzi ME, Hotez PJ, Corry DB, Beaumier CM. Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice. Infect Immun. 2018 12; 86(12). PMID: 30249744.
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    7. Gazzinelli-Guimarães AC, Gazzinelli-Guimarães PH, Nogueira DS, Oliveira FMS, Barbosa FS, Amorim CCO, Cardoso MS, Kraemer L, Caliari MV, Akamatsu MA, Ho PL, Jones KM, Weatherhead J, Bottazzi ME, Hotez PJ, Zhan B, Bartholomeu DC, Russo RC, Bueno LL, Fujiwara RT. IgG Induced by Vaccination With Ascaris suum Extracts Is Protective Against Infection. Front Immunol. 2018; 9:2535. PMID: 30473693.
      View in: PubMed
    8. Zhan B, Arumugam S, Kennedy MW, Tricoche N, Lian LY, Asojo OA, Bennuru S, Bottazzi ME, Hotez PJ, Lustigman S, Klei TR. Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils. PLoS Negl Trop Dis. 2018 10; 12(10):e0006772. PMID: 30296268.
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    9. de la Cruz JJ, Villanueva-Lizama L, Dzul-Huchim V, Ramírez-Sierra MJ, Martinez-Vega P, Rosado-Vallado M, Ortega-Lopez J, Flores-Pucheta CI, Gillespie P, Zhan B, Bottazzi ME, Hotez PJ, Dumonteil E. Production of recombinant TSA-1 and evaluation of its potential for the immuno-therapeutic control of Trypanosoma cruzi infection in mice. Hum Vaccin Immunother. 2019; 15(1):210-219. PMID: 30192702.
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    10. Briggs N, Wei J, Versteeg L, Zhan B, Keegan B, Damania A, Pollet J, Hayes KS, Beaumier C, Seid CA, Leong J, Grencis RK, Bottazzi ME, Sastry KJ, Hotez PJ. Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm. PLoS Pathog. 2018 08; 14(8):e1007273. PMID: 30153307.
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    11. Cheng Y, Zhu X, Wang X, Zhuang Q, Huyan X, Sun X, Huang J, Zhan B, Zhu X. Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation. Front Immunol. 2018; 9:1566. PMID: 30093899.
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    12. Jain S, George PJ, Deng W, Koussa J, Parkhouse K, Hensley SE, Jiang J, Lu J, Liu Z, Wei J, Zhan B, Bottazzi ME, Shen H, Lustigman S. The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4+ T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway. Vaccine. 2018 06 14; 36(25):3650-3665. PMID: 29764680.
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    13. Zhang R, Sun Q, Chen Y, Sun X, Gu Y, Zhao Z, Cheng Y, Zhao L, Huang J, Zhan B, Zhu X. Ts-Hsp70 induces protective immunity against Trichinella spiralis infection in mouse by activating dendritic cells through TLR2 and TLR4. PLoS Negl Trop Dis. 2018 05; 12(5):e0006502. PMID: 29775453.
      View in: PubMed
    14. Hu Y, Nguyen TT, Lee ACY, Urban JF, Miller MM, Zhan B, Koch DJ, Noon JB, Abraham A, Fujiwara RT, Bowman DD, Ostroff GR, Aroian RV. Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure. Int J Parasitol Drugs Drug Resist. 2018 08; 8(2):287-294. PMID: 29772478.
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    15. Konduri V, Halpert MM, Liang D, Levitt JM, Cruz-Chan JV, Zhan B, Bottazzi ME, Hotez PJ, Jones KM, Decker WK. Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy. Infect Immun. 2017 09; 85(9). PMID: 28674032.
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    16. Liu Z, Kelleher A, Tabb S, Wei J, Pollet J, Hotez PJ, Bottazzi ME, Zhan B, Asojo OA. Identification, Characterization, and Structure of Tm16 from Trichuris muris. J Parasitol Res. 2017; 2017:4342789. PMID: 28884022.
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    17. Gu Y, Sun X, Li B, Huang J, Zhan B, Zhu X. Vaccination with a Paramyosin-Based Multi-Epitope Vaccine Elicits Significant Protective Immunity against Trichinella spiralis Infection in Mice. Front Microbiol. 2017; 8:1475. PMID: 28824599.
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    18. Wang L, Sun X, Huang J, Zhan B, Zhu X. Heterologous Prime-Boost Vaccination Enhances TsPmy's Protective Immunity against Trichinella spiralis Infection in a Murine Model. Front Microbiol. 2017; 8:1394. PMID: 28785255.
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    19. Wei J, Versteeg L, Liu Z, Keegan B, Gazzinelli-Guimarães AC, Fujiwara RT, Briggs N, Jones KM, Strych U, Beaumier CM, Bottazzi ME, Hotez PJ, Zhan B. Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005769. PMID: 28708895.
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    20. Gunter SM, Jones KM, Seid CA, Essigmann HT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Brown EL. Mutations to Cysteine Residues in the Trypanosoma cruzi B-Cell Superantigen Tc24 Diminish Susceptibility to IgM-Mediated Hydrolysis. J Parasitol. 2017 10; 103(5):579-583. PMID: 28581897.
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    21. Zhao L, Shao S, Chen Y, Sun X, Sun R, Huang J, Zhan B, Zhu X. Trichinella spiralis Calreticulin Binds Human Complement C1q As an Immune Evasion Strategy. Front Immunol. 2017; 8:636. PMID: 28620388.
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    22. Li H, Wang S, Zhan B, He W, Chu L, Qiu D, Li N, Wan Y, Zhang H, Chen X, Fang Q, Shen J, Yang X. Therapeutic effect of Schistosoma japonicum cystatin on bacterial sepsis in mice. Parasit Vectors. 2017 May 08; 10(1):222. PMID: 28482922.
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    23. Asojo OA, Kelleher A, Liu Z, Pollet J, Hudspeth EM, Rezende WC, Groen MJ, Seid CA, Abdeladhim M, Townsend S, de Castro W, Mendes-Sousa A, Bartholomeu DC, Fujiwara RT, Bottazzi ME, Hotez PJ, Zhan B, Oliveira F, Kamhawi S, Valenzuela JG. Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis. PLoS Negl Trop Dis. 2017 03; 11(3):e0005374. PMID: 28278244.
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    24. Versteeg L, Le Guezennec X, Zhan B, Liu Z, Angagaw M, Woodhouse JD, Biswas S, Beaumier CM. Transferring Luminex® cytokine assays to a wall-less plate technology: Validation and comparison study with plasma and cell culture supernatants. J Immunol Methods. 2017 01; 440:74-82. PMID: 27840065.
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    25. Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A, Hotez PJ, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda CR, Upham JW, Julia V, Giacomin PR, Loukas A. Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Sci Transl Med. 2016 10 26; 8(362):362ra143. PMID: 27797959.
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    26. McAtee CP, Seid CA, Hammond M, Hudspeth E, Keegan BP, Liu Z, Wei J, Zhan B, Arjona-Sabido R, Cruz-Chan V, Dumonteil E, Hotez PJ, Bottazzi ME. Expression, purification, immunogenicity and protective efficacy of a recombinant nucleoside hydrolase from Leishmania donovani, a vaccine candidate for preventing cutaneous leishmaniasis. Protein Expr Purif. 2017 02; 130:129-136. PMID: 27773761.
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    27. Seid CA, Jones KM, Pollet J, Keegan B, Hudspeth E, Hammond M, Wei J, McAtee CP, Versteeg L, Gutierrez A, Liu Z, Zhan B, Respress JL, Strych U, Bottazzi ME, Hotez PJ. Cysteine mutagenesis improves the production without abrogating antigenicity of a recombinant protein vaccine candidate for human chagas disease. Hum Vaccin Immunother. 2017 03 04; 13(3):621-633. PMID: 27737611.
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    28. Wei J, Damania A, Gao X, Liu Z, Mejia R, Mitreva M, Strych U, Bottazzi ME, Hotez PJ, Zhan B. The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates. Parasit Vectors. 2016 Sep 27; 9(1):518. PMID: 27677574.
      View in: PubMed
    29. Wang L, Wang X, Bi K, Sun X, Yang J, Gu Y, Huang J, Zhan B, Zhu X. Oral Vaccination with Attenuated Salmonella typhimurium-Delivered TsPmy DNA Vaccine Elicits Protective Immunity against Trichinella spiralis in BALB/c Mice. PLoS Negl Trop Dis. 2016 09; 10(9):e0004952. PMID: 27589591.
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    30. Hess JA, Zhan B, Torigian AR, Patton JB, Petrovsky N, Zhan T, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D. The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice. PLoS Negl Trop Dis. 2016 07; 10(7):e0004797. PMID: 27387453.
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    31. Yang J, Zhu W, Huang J, Wang X, Sun X, Zhan B, Zhu X. Partially protective immunity induced by the 14-3-3 protein from Trichinella spiralis. Vet Parasitol. 2016 Nov 15; 231:63-68. PMID: 27387374.
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    32. Gu Y, Huang J, Wang X, Wang L, Yang J, Zhan B, Zhu X. Identification and characterization of CD4+ T cell epitopes present in Trichinella spiralis paramyosin. Vet Parasitol. 2016 Nov 15; 231:59-62. PMID: 27353726.
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    33. Arumugam S, Wei J, Liu Z, Abraham D, Bell A, Bottazzi ME, Hotez PJ, Zhan B, Lustigman S, Klei TR. Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection. PLoS Negl Trop Dis. 2016 Apr; 10(4):e0004586. PMID: 27045170.
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    34. Barry MA, Wang Q, Jones KM, Heffernan MJ, Buhaya MH, Beaumier CM, Keegan BP, Zhan B, Dumonteil E, Bottazzi ME, Hotez PJ. A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease. Hum Vaccin Immunother. 2016 04 02; 12(4):976-87. PMID: 26890466.
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    35. Hudspeth EM, Wang Q, Seid CA, Hammond M, Wei J, Liu Z, Zhan B, Pollet J, Heffernan MJ, McAtee CP, Engler DA, Matsunami RK, Strych U, Asojo OA, Hotez PJ, Bottazzi ME. Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic properties. Hum Vaccin Immunother. 2016 07 02; 12(7):1707-20. PMID: 26839079.
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    36. Sun R, Zhao X, Wang Z, Yang J, Zhao L, Zhan B, Zhu X. Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation. PLoS Negl Trop Dis. 2015 Dec; 9(12):e0004310. PMID: 26720603.
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    37. Zhan B, Ajmera R, Geiger SM, Gonçalves MT, Liu Z, Wei J, Wilkins PP, Fujiwara R, Gazzinelli-Guimaraes PH, Bottazzi ME, Hotez P. Identification of immunodominant antigens for the laboratory diagnosis of toxocariasis. Trop Med Int Health. 2015 Dec; 20(12):1787-96. PMID: 26426162.
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    38. Anderson JP, Rascoe LN, Levert K, Chastain HM, Reed MS, Rivera HN, McAuliffe I, Zhan B, Wiegand RE, Hotez PJ, Wilkins PP, Pohl J, Handali S. Development of a Luminex Bead Based Assay for Diagnosis of Toxocariasis Using Recombinant Antigens Tc-CTL-1 and Tc-TES-26. PLoS Negl Trop Dis. 2015; 9(10):e0004168. PMID: 26485145.
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    39. Rey-Burusco MF, Ibáñez-Shimabukuro M, Gabrielsen M, Franchini GR, Roe AJ, Griffiths K, Zhan B, Cooper A, Kennedy MW, Córsico B, Smith BO. Diversity in the structures and ligand-binding sites of nematode fatty acid and retinol-binding proteins revealed by Na-FAR-1 from Necator americanus. Biochem J. 2015 Nov 01; 471(3):403-14. PMID: 26318523.
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    40. Bi K, Yang J, Wang L, Gu Y, Zhan B, Zhu X. Partially Protective Immunity Induced by a 20 kDa Protein Secreted by Trichinella spiralis Stichocytes. PLoS One. 2015; 10(8):e0136189. PMID: 26288365.
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    41. Martinez-Campos V, Martinez-Vega P, Ramirez-Sierra MJ, Rosado-Vallado M, Seid CA, Hudspeth EM, Wei J, Liu Z, Kwityn C, Hammond M, Ortega-López J, Zhan B, Hotez PJ, Bottazzi ME, Dumonteil E. Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice. Vaccine. 2015 Aug 26; 33(36):4505-12. PMID: 26192358.
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    42. Kelleher A, Liu Z, Seid CA, Zhan B, Asojo OA. Expression, purification, crystallization and crystallographic study of Lutzomyia longipalpis LJL143. Acta Crystallogr F Struct Biol Commun. 2015 Jul; 71(Pt 7):925-8. PMID: 26144240.
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    43. Hotez PJ, Bottazzi ME, Zhan B, Makepeace BL, Klei TR, Abraham D, Taylor DW, Lustigman S. The Onchocerciasis Vaccine for Africa--TOVA--Initiative. PLoS Negl Trop Dis. 2015 Jan; 9(1):e0003422. PMID: 25634641.
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    44. Knight JM, Zingales B, Bottazzi ME, Hotez P, Zhan B. Limited antigenic variation in the Trypanosoma cruzi candidate vaccine antigen TSA-1. Parasite Immunol. 2014 Dec; 36(12):708-12. PMID: 25040249.
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    45. Gu Y, Zhan B, Yang Y, Yang X, Zhao X, Wang L, Yang J, Bi K, Wang Y, Zhu X. Protective effect of a prime-boost strategy with the Ts87 vaccine against Trichinella spiralis infection in mice. Biomed Res Int. 2014; 2014:326860. PMID: 25250316.
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    46. Fang L, Sun L, Yang J, Gu Y, Zhan B, Huang J, Zhu X. Heat shock protein 70 from Trichinella spiralis induces protective immunity in BALB/c mice by activating dendritic cells. Vaccine. 2014 Jul 31; 32(35):4412-9. PMID: 24962751.
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    47. Arumugam S, Wei J, Ward D, Abraham D, Lustigman S, Zhan B, Klei TR. Vaccination with a genetically modified Brugia malayi cysteine protease inhibitor-2 reduces adult parasite numbers and affects the fertility of female worms following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae. Int J Parasitol. 2014 Sep; 44(10):675-9. PMID: 24929131.
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    48. Hotez PJ, Bottazzi ME, Tseng CT, Zhan B, Lustigman S, Du L, Jiang S. Calling for rapid development of a safe and effective MERS vaccine. Microbes Infect. 2014 Jul; 16(7):529-31. PMID: 24931059.
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    49. Hess JA, Zhan B, Bonne-Année S, Deckman JM, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D. Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model. Int J Parasitol. 2014 Aug; 44(9):637-46. PMID: 24907553.
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    50. Yang X, Yang Y, Wang Y, Zhan B, Gu Y, Cheng Y, Zhu X. Excretory/secretory products from Trichinella spiralis adult worms ameliorate DSS-induced colitis in mice. PLoS One. 2014; 9(5):e96454. PMID: 24788117.
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    51. Tang YT, Gao X, Rosa BA, Abubucker S, Hallsworth-Pepin K, Martin J, Tyagi R, Heizer E, Zhang X, Bhonagiri-Palsikar V, Minx P, Warren WC, Wang Q, Zhan B, Hotez PJ, Sternberg PW, Dougall A, Gaze ST, Mulvenna J, Sotillo J, Ranganathan S, Rabelo EM, Wilson RW, Felgner PL, Bethony J, Hawdon JM, Gasser RB, Loukas A, Mitreva M. Genome of the human hookworm Necator americanus. Nat Genet. 2014 Mar; 46(3):261-269. PMID: 24441737.
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    52. Zhan B, Beaumier CM, Briggs N, Jones KM, Keegan BP, Bottazzi ME, Hotez PJ. Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections. Expert Rev Vaccines. 2014 Mar; 13(3):321-31. PMID: 24392641.
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    53. Chen WH, Du L, Chag SM, Ma C, Tricoche N, Tao X, Seid CA, Hudspeth EM, Lustigman S, Tseng CT, Bottazzi ME, Hotez PJ, Zhan B, Jiang S. Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate. Hum Vaccin Immunother. 2014; 10(3):648-58. PMID: 24355931.
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    54. Curti E, Kwityn C, Zhan B, Gillespie P, Brelsford J, Deumic V, Plieskatt J, Rezende WC, Tsao E, Kalampanayil B, Hotez PJ, Bottazzi ME. Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoni TSP-2 recombinant protein: a vaccine candidate for human intestinal schistosomiasis. Hum Vaccin Immunother. 2013 Nov; 9(11):2342-50. PMID: 23899507.
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    55. Kelleher A, Zhan B, Asojo OA. Structure of monomeric Na-GST-3, a glutathione S-transferase from the major human hookworm parasite Necator americanus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Aug; 69(Pt 8):839-43. PMID: 23908024.
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    56. Hu Y, Zhan B, Keegan B, Yiu YY, Miller MM, Jones K, Aroian RV. Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms. PLoS Negl Trop Dis. 2012; 6(11):e1900. PMID: 23145203.
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    57. Dumonteil E, Bottazzi ME, Zhan B, Heffernan MJ, Jones K, Valenzuela JG, Kamhawi S, Ortega J, de Leon Rosales SP, Lee BY, Bacon KM, Fleischer B, Slingsby BT, Cravioto MB, Tapia-Conyer R, Hotez PJ. Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects. Expert Rev Vaccines. 2012 Sep; 11(9):1043-55. PMID: 23151163.
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    58. Zhan B, Santiago H, Keegan B, Gillespie P, Xue J, Bethony J, de Oliveira LM, Jiang D, Diemert D, Xiao SH, Jones K, Feng X, Hotez PJ, Bottazzi ME. Fusion of Na-ASP-2 with human immunoglobulin Fc? abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE. Parasite Immunol. 2012 Aug-Sep; 34(8-9):404-11. PMID: 22651670.
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    59. Goud GN, Deumic V, Gupta R, Brelsford J, Zhan B, Gillespie P, Plieskatt JL, Tsao EI, Hotez PJ, Bottazzi ME. Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen. Protein Expr Purif. 2012 Jun; 83(2):145-51. PMID: 22503665.
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    60. Jiang D, Zhan B, Mayor RS, Gillespie P, Keegan B, Bottazzi ME, Hotez P. Ac-AP-12, a novel factor Xa anticoagulant peptide from the esophageal glands of adult Ancylostoma caninum. Mol Biochem Parasitol. 2011 May; 177(1):42-8. PMID: 21251931.
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    61. Zhan B, Perally S, Brophy PM, Xue J, Goud G, Liu S, Deumic V, de Oliveira LM, Bethony J, Bottazzi ME, Jiang D, Gillespie P, Xiao SH, Gupta R, Loukas A, Ranjit N, Lustigman S, Oksov Y, Hotez P. Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanus. Infect Immun. 2010 Apr; 78(4):1552-63. PMID: 20145100.
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    62. Zhan B, Gupta R, Wong SP, Bier S, Jiang D, Goud G, Hotez P. Molecular cloning and characterization of Ac-TMP-2, a tissue inhibitor of metalloproteinase secreted by adult Ancylostoma caninum. Mol Biochem Parasitol. 2008 Dec; 162(2):142-8. PMID: 18804124.
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    63. Fujiwara RT, Zhan B, Mendez S, Loukas A, Bueno LL, Wang Y, Plieskatt J, Oksov Y, Lustigman S, Bottazzi ME, Hotez P, Bethony JM. Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16. Clin Vaccine Immunol. 2007 Mar; 14(3):281-7. PMID: 17267592.
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    64. Feng J, Zhan B, Liu Y, Liu S, Williamson A, Goud G, Loukas A, Hotez P. Molecular cloning and characterization of Ac-MTP-2, an astacin-like metalloprotease released by adult Ancylostoma caninum. Mol Biochem Parasitol. 2007 Apr; 152(2):132-8. PMID: 17280728.
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    65. Williamson AL, Lustigman S, Oksov Y, Deumic V, Plieskatt J, Mendez S, Zhan B, Bottazzi ME, Hotez PJ, Loukas A. Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration. Infect Immun. 2006 Feb; 74(2):961-7. PMID: 16428741.
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    66. Zhan B, Liu S, Perally S, Xue J, Fujiwara R, Brophy P, Xiao S, Liu Y, Feng J, Williamson A, Wang Y, Bueno LL, Mendez S, Goud G, Bethony JM, Hawdon JM, Loukas A, Jones K, Hotez PJ. Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum. Infect Immun. 2005 Oct; 73(10):6903-11. PMID: 16177370.
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    67. Goud GN, Bottazzi ME, Zhan B, Mendez S, Deumic V, Plieskatt J, Liu S, Wang Y, Bueno L, Fujiwara R, Samuel A, Ahn SY, Solanki M, Asojo OA, Wang J, Bethony JM, Loukas A, Roy M, Hotez PJ. Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials. Vaccine. 2005 Sep 15; 23(39):4754-64. PMID: 16054275.
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    68. Fujiwara RT, Loukas A, Mendez S, Williamson AL, Bueno LL, Wang Y, Samuel A, Zhan B, Bottazzi ME, Hotez PJ, Bethony JM. Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs. Vaccine. 2006 Jan 23; 24(4):501-9. PMID: 16140437.
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    69. Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Plieskatt J, Goud G, Bottazzi ME, Zhan B, Wang Y, Williamson A, Lustigman S, Correa-Oliveira R, Xiao S, Hotez PJ. Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals. FASEB J. 2005 Oct; 19(12):1743-5. PMID: 16037096.
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    70. Mendez S, Zhan B, Goud G, Ghosh K, Dobardzic A, Wu W, Liu S, Deumic V, Dobardzic R, Liu Y, Bethony J, Hotez PJ. Effect of combining the larval antigens Ancylostoma secreted protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicum. Vaccine. 2005 May 02; 23(24):3123-30. PMID: 15837211.
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    71. Zhan B, Wang Y, Liu Y, Williamson A, Loukas A, Hawdon JM, Xue HC, Xiao SH, Hotez PJ. Ac-SAA-1, an immunodominant 16 kDa surface-associated antigen of infective larvae and adults of Ancylostoma caninum. Int J Parasitol. 2004 Aug; 34(9):1037-45. PMID: 15313130.
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    72. Loukas A, Bethony JM, Williamson AL, Goud GN, Mendez S, Zhan B, Hawdon JM, Elena Bottazzi M, Brindley PJ, Hotez PJ. Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms. J Infect Dis. 2004 May 15; 189(10):1952-61. PMID: 15122534.
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    73. Goud GN, Zhan B, Ghosh K, Loukas A, Hawdon J, Dobardzic A, Deumic V, Liu S, Dobardzic R, Zook BC, Jin Q, Liu Y, Hoffman L, Chung-Debose S, Patel R, Mendez S, Hotez PJ. Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicum. J Infect Dis. 2004 Mar 01; 189(5):919-29. PMID: 14976610.
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    74. Hotez PJ, Zhan B, Bethony JM, Loukas A, Williamson A, Goud GN, Hawdon JM, Dobardzic A, Dobardzic R, Ghosh K, Bottazzi ME, Mendez S, Zook B, Wang Y, Liu S, Essiet-Gibson I, Chung-Debose S, Xiao S, Knox D, Meagher M, Inan M, Correa-Oliveira R, Vilk P, Shepherd HR, Brandt W, Russell PK. Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative. Int J Parasitol. 2003 Sep 30; 33(11):1245-58. PMID: 13678639.
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    75. Hotez PJ, Ashcom J, Zhan B, Bethony J, Loukas A, Hawdon J, Wang Y, Jin Q, Jones KC, Dobardzic A, Dobardzic R, Bolden J, Essiet I, Brandt W, Russell PK, Zook BC, Howard B, Chacon M. Effect of vaccination with a recombinant fusion protein encoding an astacinlike metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvae. J Parasitol. 2003 Aug; 89(4):853-5. PMID: 14533704.
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    76. Zhan B, Liu Y, Badamchian M, Williamson A, Feng J, Loukas A, Hawdon JM, Hotez PJ. Molecular characterisation of the Ancylostoma-secreted protein family from the adult stage of Ancylostoma caninum. Int J Parasitol. 2003 Aug; 33(9):897-907. PMID: 12906874.
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    77. Basavaraju SV, Basavaraju S, Zhan B, Kennedy MW, Liu Y, Hawdon J, Hotez PJ. Ac-FAR-1, a 20 kDa fatty acid- and retinol-binding protein secreted by adult Ancylostoma caninum hookworms: gene transcription pattern, ligand binding properties and structural characterisation. Mol Biochem Parasitol. 2003 Jan; 126(1):63-71. PMID: 12554085.
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    78. Bethony J, Chen J, Lin S, Xiao S, Zhan B, Li S, Xue H, Xing F, Humphries D, Yan W, Chen G, Foster V, Hawdon JM, Hotez PJ. Emerging patterns of hookworm infection: influence of aging on the intensity of Necator infection in Hainan Province, People's Republic of China. Clin Infect Dis. 2002 Dec 01; 35(11):1336-44. PMID: 12439796.
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    79. Hotez PJ, Ashcom J, Bin Z, Bethony J, Williamson A, Hawdon JM, Jianjun F, Dobardzic A, Rizo I, Bolden J, Jin Q, Yan W, Dobardzic R, Chung-Debose S, Crowell M, Datu B, Delaney A, Dragonovski D, Jiang Y, Yueyuan L, Ghosh K, Loukas A, Brandt W, Russell PK, Zook BC. Effect of vaccinations with recombinant fusion proteins on Ancylostoma caninum habitat selection in the canine intestine. J Parasitol. 2002 Aug; 88(4):684-90. PMID: 12197114.
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    80. Zhan B, Hotez PJ, Wang Y, Hawdon JM. A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases. Mol Biochem Parasitol. 2002 Apr 09; 120(2):291-6. PMID: 11897134.
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    81. Zhan B, Badamchian M, Meihua B, Ashcom J, Feng J, Hawdon J, Shuhua X, Hotez PJ. Molecular cloning and purification of Ac-TMP, a developmentally regulated putative tissue inhibitor of metalloprotease released in relative abundance by adult Ancylostoma hookworms. Am J Trop Med Hyg. 2002 Mar; 66(3):238-44. PMID: 12139214.
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    82. Zhan B, Li T, Xiao S, Zheng F, Hawdon JM. Species-specific identification of human hookworms by PCR of the mitochondrial cytochrome oxidase I gene. J Parasitol. 2001 Oct; 87(5):1227-9. PMID: 11695411.
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    83. Hawdon JM, Li T, Zhan B, Blouin MS. Genetic structure of populations of the human hookworm, Necator americanus, in China. Mol Ecol. 2001 Jun; 10(6):1433-7. PMID: 11412366.
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    84. Franke F, Sanning C. [Synthesis of hyaluronidase in erysipelothrix]. Berl Munch Tierarztl Wochenschr. 1971 Jan 15; 84(2):28-30. PMID: 5540943.
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    85. Klainer AS, Gorbach S, Weinstein L. Studies of intestinal microflora. VII. Effect of diet and fecal microbial flora on survival of animals exposed to x irradiation. J Bacteriol. 1967 Aug; 94(2):383-7. PMID: 6039361.
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    86. Zhan, B. and J. Wang. Analyses on the Protein Composition and Antigenicity of Leishmania gerbilli Promastigotes. Endemic Diseases Bulletin. 5(3):63-6.
    87. Zhang, L.X., B. Zhan, X.P. Feng and J. Wang. Detection of RESA Antibody in Falciparum Malaria Patients by Double RESA-IFA Method. Shanghai J. Immunology. 11:295.
    88. Zhang, L.X., B, Zhan, X.P. Feng and J. Wang. Study on Relationship between Antibodies to Plasmodium falciparum and Clinical Immunity to infection in Falciparum Malaria Patients in Hyperendemic Areas. Shanghai J. Immunology. 11:279-81.
    89. Zhan, B., L.X. Zhang, X.P. Feng and W.H. Huang. Detection of Anti-RESA antibody in Population of Endemic Malaria Area. Chinese J. Parasitic Diseases Control. 5(3):167.
    90. Zhang, L.X., J.H. Chai, B. Zhan, X.P. Feng and J. Wang. Study on the Detection of Plasmodium vivax by a Specific DNA Probe. Chinese J.Parasitol & Parasitic Dis. 11:141.
    91. Zhan, B., L.X. Zhang, J.J. Wang and X.P. Feng. Detection of Plasmodium falciparum by Polymerase Chain Reaction. Chinese J. Parasitol & Parasitic Dis. 12(2):111.
    92. Zhang, L.X., J.H. Chai, B. Zhan, X.P. Feng and J.J. Wang. Further Report on Application of DNA Probe in Diagnosis of Vivax Malaria Infection. Chinese J. Parasitol & Parasitic Dis. 11:86.
    93. Zhang, L.X., B. Zhan, X.P. Feng and J.J. Wang. Observation on Interfering Factors in detection of Falciparum Malaria Patients in Co-endemic Areas by IFA Test. Chinese J. Parasitol & Parasitic Dis. 12(2):151.
    94. Zhan, B., L.X. Zhang, J.J. Wang and X.P. Feng. Application of PCR on the Diagnosis of Falciparum Malaria in a Malaria endemic field. Chinese J. Parasitol & Parasitic Dis. 12(1):37.
    95. Yang, H.L., P.F. Yang, Y. Dong, L.G. Che, W.C. Chen, H. He, D.Q. Liu, R.J. Liu, B. Zhan, C.Y. Zhang, D.Q. Gao. Longitudinal Surveillance of Chloroquine Resistance of Plasmodium falciparum after Cessation of Medication in South Yunnan. Chinese J. Parasitol & Parasitic Dis. 12(1):31-3.
    96. Yang, H.L., D.Q. Liu, Y. Dong, R.J. Liu, B. Zhan, C.Y. Zhang. Sensitivity of Plasmodium falciparum to seven anti-malaria Medicines in vitro. Chinese J. Parasitol & Parasitic Dis. 13(2):111-3.
    97. Zhang, L.X., R.L. Coppel, V.M. Marshall, B. Zhan, X.P. Feng and J.J. Wang. Application of Plasmodium falciparum DNA Extracted from Dried Blood Spot of Falciparum Malaria Patients for Polymerase Chain Reaction. Chinese J. Parasitol & Parasitic Dis. 13(2):120-2.
    98. Zhang, L.X., R.L.Coppel, V.M.Marshall, B.Zhan, X.P.Feng and J.J.Wang. DNA Sequence Analysis of Apical Membrane Antigen-1 from a Plasmodium falciparum Isolate Collected from Meng-Peng Township, Yun-Nan. Chinese J. Parasitol & Parasitic Dis. 13(3):203-8.
    99. Sun FH, Wu ZX, Qian YX, Cao HG, Xue HC, Xiao SH, Ren HN, Zhan B, Hawdon JM, Hotez PJ. Epidemiology of human intestinal nematode infection in Wujiang and Pizhou counties, Jiangsu Province, China. Southeast Asian J. Trop. Publ. Health. 17(2):81-83.
    100. Li Tiehua, Zhan Bin, John M Hawdon, Gong Xin, Xiao Shuhua, Shan Qiang, Feng Zheng, Peter J Hotez. Sequencing of Cytochrome C Oxidatase I Gene of Ancylostoma duodenale and Necator americanus. Chinese J Parasitol & Parasitic Dis. 17(2):81-83.
    101. Peter J Hotez, Ghosh K, Hawdon JM, Narasimhan S, Johes B, Xiao SH, Liu S, Zhan B, Xue HC, Ren HN, Wang H and Koski RA. Experimental approaches to the development of a recombinant hookworm vaccine. Immunological Reviews. 171:163-171.
    102. Wang Y, Shen GJ, Wu WT, Xiao SH, Hotez PJ, Li QY, Xue HC, Yi XM, Liu XM, Zhan B, Hawdon JM, Chou L, Ji Hong, Hu CM, Feng Z. Epidemiology of human ancylostomiasis among rural villagers in Nanlin County (Zhongzhou village), Anhui Province, China: age-associated prevalence, intensity and hookworm species identification. Southeast Asian J Trop Med Public Health. 30(4):692-7.
    103. Liu CH, Zhang XR, Qiu DC, Xiao SH, Hotez PJ, Zheng DF, Xue HC, Zhen HL, Li MG, Ren HN, Zhan B, Hawdon JM, Feng Z. Epidemiology of human hookworm infections among adult rural villagers in Heijiang and Santai counties, Sichuan province, China. Acta Tropica. 73:243-249.
    104. Zhan Bin, John Hawdon, Shan Qiang, Ren Hainan, Qiang Huiqing, Hu Wei, Xiao Shu-hua, Li Tiehua, Gong Xin, Feng Zheng, Peter Hotez. Ancylostoma-secreted Protein 1 (ASP-1) Homologues in Human Hookworms. Mol Biochem Parasitol. 98:143-149.
    105. Zhan Bin, John Hawdon, Shan Qiang, Ren Hainan, Qiang Huiqing, Xiao Shu-hua, Li Tiehua, Feng Zheng, Peter Hotez. Construction and analysis of cDNA Library of the third stage larvae of Necator americanus. Chinese J Parasitol & Parasitic Dis. 18(1):26-29.
    106. Shan Qiang, Zhan Bin, Xiao shu-hua, Feng Zheng, Peter Hotez, and John M. Hawdon. Variation between ASP-1molecules from Ancylostoma caninum in China and the United States. J. Parasitol. 86(1):181-5.
    107. Liu Sen, Kashinath Ghosh, Zhan Bin, Shan Qiang , Thompson MG, Hawdon JM, Koski RA, Shuhua X, Hotez PJ. Hookworm burden reductions in BALB/c mice vaccinated with recombinant Ancylostoma secreted proteins (ASPs) from Ancylostoma duodenale, Ancylostoma caninum and Necator americanus. Vaccine. 18(11-12):1096-1102.
    108. Lili Z, Bingxiang Z, Hong T, Shuhua X, Hotez P, Bin Zhan, Yangzhong L, Ying L, Haichou X, Hawdon J, Hui Y, Huizhen W, Zhen F. Epidemiology of human geohelminth infections (ascariasis, trichuriasis and necatoriasis) in Lushui and Puer Counties, Yunnan Province, China. Southeast Asian J Trop Med Public Health. 31(3):448-53.
    109. Bin Zhan, Shuhua Xiao, Tiehua Li and Meihua Bo. Current prevalence and vaccine development of hookworm. Chinese J Parasitol & Parsitic Dis 2000. 18(3):182-5.
    110. Xue Haichou, Wang Yan, Xiao Shuhua, Liu Sen, Wang Yong, Shen Guangjin, Wu Weituo, Zhan Bin, L Drake, Feng Zheng and Peter J Hotez. Epidemiology of human ancylostomiasis among rural villagers in Nanlin County (Zhongzhou village), Anhui Province, China: II. Seroepidemiological studies of the age relationships of serum antibody levels and infection status. Southeast Asian J Trop Med Public Health 2000. 31(4):736-741.
    111. Nishiena S. Gandhi, Chen Jizhang, Kaveh Khoshnood, Xing Fuying, Li Shanwen, Liu Yaoruo, Zhan Bin, Xue Haichou, Tong Chougjin, Wang Yan, Wang Wensen, He Dungxing, Chen Chong, Xiao Shuhua, John M. Hawdon, Peter J. Hawdon. Epidemiology of Necator americanus hookworm infections in Xiulongkan Village, Hainan Province, China: High Prevalence and Intensity Among Middle-aged and Elderly. J. Parasitol. 87(4):739-43.
    112. Bin Zhan, Tiehua Li Shuhua Xiao, Zheng Feng and John M Hawdon. Species-specific Identification of Human Hookworms by PCR of the Mitochondrial Cytochrome Oxidase I Gene. J. Parasitol. 87(5):1227.
    113. Menfo A. Imoisili, Ekopimo Ibia, Ariel R. Porcalla, Xiao Shuhua, Bin Zhan, Sridhar Basavaraju, George M. Davis, Peter J. Hotez. Helminth infections in China and southeast Asia: Their diseases burden in childhood and novel approaches to their control and diagnosis. Asian Journal of Pediatric Practice. 5(2):51-62.
    114. Xiao Shuhua, Peter J. Hotez, Sen Binggui, Liu Sen, Qiang Huiqing, Xue Haichou, Zhan Bin, Feng Zheng. Electron and light microscopy of neutrophil responses in mice vaccinated and challenged with third-stage infective hookworm (Ancylostoma caninum) larvae. Parasitology International. 50:241-8.
    115. J.M. Hawdon, T. Li, B. Zhan, and M.S. Blouin. Genetic structure of populations of the human hookworm, Necator americanus, in China. Molecular Ecology. 10(6):1433-7.
    116. Peter J. Hotez, Zhan Bin, Jeffrey Bethony, Qun Jin, John M. Hawdon, HeatherA. Young, Samuel Simmens, Richard Hitzelberg, and Bernard C. Zook . Natural history of primary canine hookworm infections after three different oral doses of third-stage infective larvae of Ancylostoma caninum. . Comparative Parasitolog. 69(1):72-80.
    117. Peter J. Hotez, James Ashcom, Zhan Bin, Jeff Bethony, Angela Williamson, John M. Hawdon, Feng Jianjun, Azra Dobardzic, Ivania Rizo, Janelle Bolder, Qun Jin, Wang Yan, Reshad Dobardzic, Sophia Chung-Debose, Melissa Crowell, Bennett Datu, Angela Delaney, Dilyan Dragonovski, Yang Jiang, Liu Yueyuan, Kshinath Ghosh, Alex Loukas, Walter Brandt, Philip K. Russell, and Bernard C. Zook. Effect of vaccinations with recombinant fusion protein on Ancylostoma caninum habitat selection in the canine intestine. J.Parasitol. 88(4):684-690.
    118. Xue Jian, Xiao Shu-Hua, Qiang Hui-qing, Liu Sen, Peter Hotez, Shen Bing-Gui, Xue Hai-Chou, Li Tie-Hua and Zhan Bin. Necator americanus: maintenance through one hundred generations in golden hamsters (Mesocricetus auratus). II. Morphological development of the adult and its comparison with humans. Exp. Parasitol. 105(3-4):192-200.
    119. Li TH, Guo XR, Xue J, Hu L, Qiang HQ, Xue HC, Zhan B, Hawdon JM, Xiao SH. Comparison of mitochondrial cytochrome oxidase 1 DNA sequences from Necator americanus hookworms maintained for 100 generations in golden hamsters (Mesocricetus auratus) and hookworms from natural human infections. Acta Trop. 92(1):71-5.
    120. Jian X, Jun-Min Y, Hai-Chou X, Hui-Qing Q, Hai-Nan R, Hotez P, Zhan B, Shu-Hua X. Protective immunity elicited by ultraviolet-irradiated third-stage infective hookworm (Necator americanus and Ancylostoma caninum) larvae in mice and hamsters. Southeast Asian J Trop Med Public Health. 37(5):885-95.
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