TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mejia R, Verocai GG, Mosley IA, Zhan B, Vongthavaravat L, Busselman RE, Hamer SA. Evaluation of a novel Tc-24 recombinant antigen ELISA for serologic testing for Trypanosoma cruzi in dogs. bioRxiv. 2024 Feb 14. PMID: 38405948; PMCID: PMC10888942.
    2. Jones KM, Zhan B, Ernste KJ, Villar MJ, Bisht N, Nguyen D, Chang LY, Poveda C, Robinson GJ, Trivedi AJ, Hofferek CJ, Decker WK, Konduri V. Immunomodulatory proteins from hookworms reduce cardiac inflammation and modulate regulatory responses in a mouse model of chronic Trypanosoma cruzi infection. Front Parasitol. 2023; 2. PMID: 38239430; PMCID: PMC10795693.
    3. Thimmiraju SR, Adhikari R, Villar MJ, Lee J, Liu Z, Kundu R, Chen YL, Sharma S, Ghei K, Keegan B, Versteeg L, Gillespie PM, Ciciriello A, Islam NY, Poveda C, Uzcategui N, Chen WH, Kimata JT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Pollet J. A Recombinant Protein XBB.1.5 RBD/Alum/CpG Vaccine Elicits High Neutralizing Antibody Titers against Omicron Subvariants of SARS-CoV-2. Vaccines (Basel). 2023 Oct 01; 11(10). PMID: 37896960; PMCID: PMC10610638.
      Citations: 2     
    4. MatRahim NA, Jones KM, Keegan BP, Strych U, Zhan B, Lee HY, AbuBakar S. TonB-Dependent Receptor Protein Displayed on Spores of Bacillus subtilis Stimulates Protective Immune Responses against Acinetobacter baumannii. Vaccines (Basel). 2023 Jun 16; 11(6). PMID: 37376495; PMCID: PMC10302887.
    5. Xian S, Chen L, Yan Y, Chen J, Yu G, Shao Y, Zhan B, Wang Y, Zhao L. Echinococcus multilocularis Calreticulin Interferes with C1q-Mediated Complement Activation. Trop Med Infect Dis. 2023 Jan 07; 8(1). PMID: 36668954; PMCID: PMC9864966.
      Citations: 2     
    6. Uzoechi SC, Rosa BA, Singh KS, Choi YJ, Bracken BK, Brindley PJ, Townsend RR, Sprung R, Zhan B, Bottazzi ME, Hawdon JM, Wong Y, Loukas A, Djuranovic S, Mitreva M. Excretory/Secretory Proteome of Females and Males of the Hookworm Ancylostoma ceylanicum. Pathogens. 2023 Jan 06; 12(1). PMID: 36678443; PMCID: PMC9865600.
    7. Hotez PJ, Adhikari R, Chen WH, Chen YL, Gillespie P, Islam NY, Keegan B, Tyagi Kundu R, Lee J, Liu Z, Kimata JT, Oezguen N, Pollet J, Poveda C, Razavi K, Ronca SE, Strych U, Thimmiraju SR, Versteeg L, Villar-Mondragon MJ, Wei J, Zhan B, Bottazzi ME. From concept to delivery: a yeast-expressed recombinant protein-based COVID-19 vaccine technology suitable for global access. Expert Rev Vaccines. 2023 Jan-Dec; 22(1):495-500. PMID: 37252854.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    8. Chen L, Cheng Z, Xian S, Zhan B, Xu Z, Yan Y, Chen J, Wang Y, Zhao L. Immunization with EmCRT-Induced Protective Immunity against Echinococcus multilocularis Infection in BALB/c Mice. Trop Med Infect Dis. 2022 Oct 01; 7(10). PMID: 36288020; PMCID: PMC9610995.
      Citations: 2     
    9. Demontis M, Cano J, Coppel RL, Chauhan V, Cavanagh D, Dutta S, Angov E, van Lieshout L, Zhan B, Santano R, Rubio R, Grau-Pujol B, Escola V, Muchisse O, Cuamba I, Vidal M, Ruiz-Olalla G, Aguilar R, Gandasegui J, Jamine JC, Cossa A, Sacoor C, Izquierdo L, Chitnis CE, Mu?oz J, Doba?o C, Moncunill G. Evaluation of antibody serology to determine current helminth and Plasmodium falciparum infections in a co-endemic area in Southern Mozambique. PLoS Negl Trop Dis. 2022 06; 16(6):e0010138. PMID: 35727821; PMCID: PMC9212154.
      Citations:    Fields:    Translation:HumansAnimals
    10. Li H, Qiu D, Yuan Y, Wang X, Wu F, Yang H, Wang S, Ma M, Qian Y, Zhan B, Yang X. Trichinella spiralis cystatin alleviates polymicrobial sepsis through activating regulatory macrophages. Int Immunopharmacol. 2022 Aug; 109:108907. PMID: 35691271.
      Citations:    Fields:    Translation:AnimalsCells
    11. Luu L, Hartley CS, Glover AF, Walsh TR, Lian LY, Zhan B, Bottazzi ME, Abraham D, Petrovsky N, Ayiseh RB, Mbah GE, Lustigman S, Makepeace BL, Graham-Brown J, Bah GS, Okah-Nnane NH, Bayang N, Tangwa B, Ekale DD, Tanya VN. Co-Administration of Adjuvanted Recombinant Ov-103 and Ov-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine Onchocerca ochengi Infection Model of Human Onchocerciasis. Vaccines (Basel). 2022 May 27; 10(6). PMID: 35746469; PMCID: PMC9229719.
    12. Pollet J, Strych U, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Jose Villar M, Rani Thimmiraju S, Lopez B, Gillespie PM, Ronca S, Kimata JT, Reers M, Paradkar V, Hotez PJ, Elena Bottazzi M. Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern. Vaccine. 2022 06 09; 40(26):3655-3663. PMID: 35568591; PMCID: PMC9080055.
      Citations:    Fields:    Translation:HumansAnimalsCells
    13. Zhan B, Bottazzi ME, Hotez PJ, Lustigman S. Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle With Onchocerca ochengi. Front Cell Infect Microbiol. 2022; 12:869039. PMID: 35444961; PMCID: PMC9015098.
      Citations:    Fields:    Translation:HumansAnimals
    14. Cheng Y, Yu Y, Zhuang Q, Wang L, Zhan B, Du S, Liu Y, Huang J, Hao J, Zhu X. Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization. iScience. 2022 Mar 18; 25(3):103979. PMID: 35281745; PMCID: PMC8914552.
      Citations: 1     
    15. Wei J, Hegde VL, Yanamandra AV, O'Hara MP, Keegan B, Jones KM, Strych U, Bottazzi ME, Zhan B, Sastry KJ, Hotez PJ. Mucosal Vaccination With Recombinant Tm-WAP49 Protein Induces Protective Humoral and Cellular Immunity Against Experimental Trichuriasis in AKR Mice. Front Immunol. 2022; 13:800295. PMID: 35197976; PMCID: PMC8859434.
      Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
    16. Nogueira DS, Coqueiro-Dos-Santos A, Carvalho SAP, Kraemer L, Fraga VG, Santos FV, de Castro JC, Russo RC, Bottazzi ME, Hotez PJ, Zhan B, Bartholomeu DC, Bueno LL, Fujiwara RT, Gazzinelli-Guimar?es AC, Amorim CCO, Oliveira FMS, Barbosa FS, Akamatsu MA, Ho PL. ASCVac-1, a Multi-Peptide Chimeric Vaccine, Protects Mice Against Ascaris suum Infection. Front Immunol. 2021; 12:788185. PMID: 34992603; PMCID: PMC8724438.
      Citations:    Fields:    Translation:HumansAnimalsCells
    17. Demontis M, Cano J, Chitnis CE, Coppel RL, Chauhan V, Cavanagh D, Dutta S, Angov E, Gaur D, van Lieshout L, Zhan B, Santano R, Rubio R, Grau-Pujol B, Escola V, Muchisse O, Cuamba I, Vidal M, Cister? P, Ruiz-Olalla G, Aguilar R, Jamine JC, Cossa A, Sacoor C, Izquierdo L, Mu?oz J, Moncunill G, Doba?o C. Plasmodium falciparum and Helminth Coinfections Increase IgE and Parasite-Specific IgG Responses. Microbiol Spectr. 2021 12 22; 9(3):e0110921. PMID: 34878303; PMCID: PMC8653825.
      Citations: 1     Fields:    Translation:HumansAnimals
    18. Yang H, Li H, Chen W, Mei Z, Yuan Y, Wang X, Chu L, Xu Y, Sun Y, Li D, Gao H, Zhan B, Li H, Yang X. Therapeutic Effect of Schistosoma japonicum Cystatin on Atherosclerotic Renal Damage. Front Cell Dev Biol. 2021; 9:760980. PMID: 34901005; PMCID: PMC8656285.
    19. Chen WH, Pollet J, Strych U, Lee J, Liu Z, Kundu RT, Versteeg L, Villar MJ, Adhikari R, Wei J, Poveda C, Keegan B, Bailey AO, Chen YL, Gillespie PM, Kimata JT, Zhan B, Hotez PJ, Bottazzi ME. Yeast-expressed recombinant SARS-CoV-2 receptor binding domain RBD203-N1 as a COVID-19 protein vaccine candidate. Protein Expr Purif. 2022 02; 190:106003. PMID: 34688919; PMCID: PMC8529586.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    20. Liang Z, Liu D, Zhan B, Yao Q, Chen C, L? JM. Two Antibody-Guided Lactic-co-Glycolic Acid-Polyethylenimine (LGA-PEI) Nanoparticle Delivery Systems for Therapeutic Nucleic Acids. Pharmaceuticals (Basel). 2021 Aug 25; 14(9). PMID: 34577541; PMCID: PMC8470087.
      Citations: 2     
    21. Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, Suthar MS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP. A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates. Sci Immunol. 2021 07 15; 6(61). PMID: 34266981; PMCID: PMC9119307.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    22. Hao C, Wang W, Zhan B, Wang Z, Huang J, Sun X, Zhu X. Trichinella spiralis Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease. Front Cell Dev Biol. 2021; 9:695015. PMID: 34336843; PMCID: PMC8320175.
    23. Lee J, Liu Z, Chen WH, Wei J, Kundu R, Adhikari R, Rivera JA, Gillespie PM, Strych U, Zhan B, Hotez PJ, Bottazzi ME. Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1. Appl Microbiol Biotechnol. 2021 May; 105(10):4153-4165. PMID: 33959781; PMCID: PMC8102132.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    24. Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Altieri Rivera J, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME. SARS-CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice. Hum Vaccin Immunother. 2021 08 03; 17(8):2356-2366. PMID: 33847226; PMCID: PMC8054496.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    25. Hayon J, Weatherhead J, Hotez PJ, Bottazzi ME, Zhan B. Advances in vaccine development for human trichuriasis. Parasitology. 2021 Mar 24; 1-12. PMID: 33757603.
      Citations: 3     Fields:    
    26. Li H, Qiu D, Yang H, Yuan Y, Wu L, Chu L, Zhan B, Wang X, Sun Y, Xu W, Yang X. Therapeutic Efficacy of Excretory-Secretory Products of Trichinella spiralis Adult Worms on Sepsis-Induced Acute Lung Injury in a Mouse Model. Front Cell Infect Microbiol. 2021; 11:653843. PMID: 33842398; PMCID: PMC8024484.
      Citations: 4     Fields:    Translation:Animals
    27. Chen WH, Wei J, Kundu RT, Adhikari R, Liu Z, Lee J, Versteeg L, Poveda C, Keegan B, Villar MJ, de Araujo Leao AC, Rivera JA, Gillespie PM, Pollet J, Strych U, Zhan B, Hotez PJ, Bottazzi ME. Genetic modification to design a stable yeast-expressed recombinant SARS-CoV-2 receptor binding domain as a COVID-19 vaccine candidate. Biochim Biophys Acta Gen Subj. 2021 06; 1865(6):129893. PMID: 33731300; PMCID: PMC7955913.
      Citations: 10     Fields:    Translation:AnimalsCells
    28. Xie H, Wu L, Chen X, Gao S, Li H, Yuan Y, Liang J, Wang X, Wang S, Xu C, Chu L, Zhan B, Zhou R, Yang X. Schistosoma japonicum Cystatin Alleviates Sepsis Through Activating Regulatory Macrophages. Front Cell Infect Microbiol. 2021; 11:617461. PMID: 33718268; PMCID: PMC7943722.
      Citations: 2     Fields:    Translation:AnimalsCells
    29. Ryan NM, Hess JA, de Villena FP, Leiby BE, Shimada A, Yu L, Yarmahmoodi A, Petrovsky N, Zhan B, Bottazzi ME, Makepeace BL, Lustigman S, Abraham D. Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice. NPJ Vaccines. 2021 Jan 26; 6(1):17. PMID: 33500417; PMCID: PMC7838260.
      Citations: 4     
    30. Zhan B, Bottazzi ME, Hotez PJ, de Castro JC, de Almeida LV, Cardoso MS, Oliveira FMS, Nogueira DS, Reis-Cunha JL, Magalhaes LMD, Bueno LL, Bartholomeu DC, Fujiwara RT. Vaccination with chimeric protein induces protection in murine model against ascariasis. Vaccine. 2021 01 08; 39(2):394-401. PMID: 33248854.
      Citations: 3     Fields:    Translation:AnimalsPHPublic Health
    31. Shao S, Hao C, Zhan B, Zhuang Q, Zhao L, Chen Y, Huang J, Zhu X. Trichinella spiralis Calreticulin S-Domain Binds to Human Complement C1q to Interfere With C1q-Mediated Immune Functions. Front Immunol. 2020; 11:572326. PMID: 33329535; PMCID: PMC7710684.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    32. Wu Y, Tian X, Song N, Huang M, Wu Z, Li S, Waterfield NR, Zhan B, Wang L, Yang G. Application of Quantitative PCR in the Diagnosis and Evaluating Treatment Efficacy of Leishmaniasis. Front Cell Infect Microbiol. 2020; 10:581639. PMID: 33117735; PMCID: PMC7575730.
      Citations: 3     Fields:    Translation:HumansCells
    33. Wang Z, Hao C, Zhuang Q, Zhan B, Sun X, Huang J, Cheng Y, Zhu X. Excretory/Secretory Products From Trichinella spiralis Adult Worms Attenuated DSS-Induced Colitis in Mice by Driving PD-1-Mediated M2 Macrophage Polarization. Front Immunol. 2020; 11:563784. PMID: 33117347; PMCID: PMC7575908.
      Citations: 10     Fields:    Translation:AnimalsCells
    34. Liu Z, Kundu R, Biter AB, Nyon MP, Chen WH, Zhan B, Strych U, Hotez PJ, Bottazzi ME, Damena S. A scalable and reproducible manufacturing process for Phlebotomus papatasi salivary protein PpSP15, a vaccine candidate for leishmaniasis. Protein Expr Purif. 2021 01; 177:105750. PMID: 32920041.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    35. Mekonnen GG, Tedla BA, Pickering D, Becker L, Wang L, Zhan B, Bottazzi ME, Loukas A, Sotillo J, Pearson MS. Schistosoma haematobium Extracellular Vesicle Proteins Confer Protection in a Heterologous Model of Schistosomiasis. Vaccines (Basel). 2020 Jul 24; 8(3). PMID: 32722279; PMCID: PMC7563238.
      Citations: 14     
    36. Gao S, Li H, Xie H, Wu S, Yuan Y, Chu L, Sun S, Yang H, Wu L, Bai Y, Zhou Q, Wang X, Zhan B, Cui H, Yang X. Therapeutic efficacy of Schistosoma japonicum cystatin on sepsis-induced cardiomyopathy in a mouse model. Parasit Vectors. 2020 May 18; 13(1):260. PMID: 32423469; PMCID: PMC7236195.
      Citations: 12     Fields:    Translation:Animals
    37. Versteeg L, Wei J, Liu Z, Keegan B, Fujiwara RT, Jones KM, Asojo O, Strych U, Bottazzi ME, Hotez PJ, Zhan B. Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection. PLoS Negl Trop Dis. 2020 02; 14(2):e0008057. PMID: 32053593; PMCID: PMC7017989.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    38. Gu Y, Sun X, Huang J, Zhan B, Zhu X. A Multiple Antigen Peptide Vaccine Containing CD4+ T Cell Epitopes Enhances Humoral Immunity against Trichinella spiralis Infection in Mice. J Immunol Res. 2020; 2020:2074803. PMID: 32377530; PMCID: PMC7199560.
      Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    39. Sun XM, Guo K, Hao CY, Zhan B, Huang JJ, Zhu X. Trichinella spiralis Excretory-Secretory Products Stimulate Host Regulatory T Cell Differentiation through Activating Dendritic Cells. Cells. 2019 11 07; 8(11). PMID: 31703440; PMCID: PMC6912532.
      Citations: 9     Fields:    Translation:AnimalsCells
    40. George PJ, Hess JA, Jain S, Patton JB, Zhan T, Tricoche N, Zhan B, Bottazzi ME, Hotez PJ, Abraham D, Lustigman S. Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans. PLoS Negl Trop Dis. 2019 09; 13(9):e0007730. PMID: 31525197; PMCID: PMC6762197.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    41. Sun S, Li H, Yuan Y, Wang L, He W, Xie H, Gao S, Cheng R, Qian H, Jiang H, Wang X, Zhan B, Fang Q, Yang X. Preventive and therapeutic effects of Trichinella spiralis adult extracts on allergic inflammation in an experimental asthma mouse model. Parasit Vectors. 2019 Jun 28; 12(1):326. PMID: 31253164; PMCID: PMC6599242.
      Citations: 11     Fields:    Translation:AnimalsCells
    42. Barry MA, Versteeg L, Wang Q, Pollet J, Zhan B, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2019 05; 13(5):e0007413. PMID: 31145733; PMCID: PMC6542517.
      Citations: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    43. Shao S, Sun X, Chen Y, Zhan B, Zhu X. Complement Evasion: An Effective Strategy That Parasites Utilize to Survive in the Host. Front Microbiol. 2019; 10:532. PMID: 30949145; PMCID: PMC6435963.
      Citations: 16     
    44. Wang L, Zou Y, Zhu X, Bottazzi ME, Hotez PJ, Zhan B. China's shifting neglected parasitic infections in an era of economic reform, urbanization, disease control, and the Belt and Road Initiative. PLoS Negl Trop Dis. 2019 01; 13(1):e0006946. PMID: 30677027; PMCID: PMC6345419.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    45. Wang Z, Hao C, Huang J, Zhuang Q, Zhan B, Zhu X. Mapping of the complement C1q binding site on Trichinella spiralis paramyosin. Parasit Vectors. 2018 Dec 27; 11(1):666. PMID: 30587214; PMCID: PMC6307294.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    46. Weatherhead JE, Porter P, Coffey A, Haydel D, Versteeg L, Zhan B, Fujiwara R, Jaramillo AM, Bottazzi ME, Hotez PJ, Corry DB, Beaumier CM, Gazzinelli Guimar?es AC. Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice. Infect Immun. 2018 12; 86(12). PMID: 30249744; PMCID: PMC6246907.
      Citations: 15     Fields:    Translation:AnimalsCells
    47. Jones KM, Weatherhead J, Bottazzi ME, Hotez PJ, Zhan B, Gazzinelli-Guimar?es AC, Gazzinelli-Guimar?es PH, Nogueira DS, Oliveira FMS, Barbosa FS, Amorim CCO, Cardoso MS, Kraemer L, Caliari MV, Akamatsu MA, Ho PL, Bartholomeu DC, Russo RC, Bueno LL, Fujiwara RT. IgG Induced by Vaccination With Ascaris suum Extracts Is Protective Against Infection. Front Immunol. 2018; 9:2535. PMID: 30473693; PMCID: PMC6238660.
      Citations: 17     Fields:    Translation:AnimalsPHPublic Health
    48. Zhan B, Arumugam S, Kennedy MW, Tricoche N, Lian LY, Asojo OA, Bennuru S, Bottazzi ME, Hotez PJ, Lustigman S, Klei TR. Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils. PLoS Negl Trop Dis. 2018 10; 12(10):e0006772. PMID: 30296268; PMCID: PMC6193737.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    49. Gillespie P, Zhan B, Bottazzi ME, Hotez PJ, Dumonteil E, de la Cruz JJ, Villanueva-Lizama L, Dzul-Huchim V, Ram?rez-Sierra MJ, Martinez-Vega P, Rosado-Vallado M, Ortega-Lopez J, Flores-Pucheta CI. Production of recombinant TSA-1 and evaluation of its potential for the immuno-therapeutic control of Trypanosoma cruzi infection in mice. Hum Vaccin Immunother. 2019; 15(1):210-219. PMID: 30192702; PMCID: PMC6363145.
      Citations: 11     Fields:    Translation:AnimalsCells
    50. Briggs N, Wei J, Versteeg L, Zhan B, Keegan B, Damania A, Pollet J, Hayes KS, Beaumier C, Seid CA, Leong J, Grencis RK, Bottazzi ME, Sastry KJ, Hotez PJ. Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm. PLoS Pathog. 2018 08; 14(8):e1007273. PMID: 30153307; PMCID: PMC6130879.
      Citations: 10     Fields:    Translation:AnimalsPHPublic Health
    51. Cheng Y, Zhu X, Wang X, Zhuang Q, Huyan X, Sun X, Huang J, Zhan B, Zhu X. Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation. Front Immunol. 2018; 9:1566. PMID: 30093899; PMCID: PMC6070611.
      Citations: 10     Fields:    Translation:Animals
    52. Jain S, George PJ, Deng W, Koussa J, Parkhouse K, Hensley SE, Jiang J, Lu J, Liu Z, Wei J, Zhan B, Bottazzi ME, Shen H, Lustigman S. The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4+ T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway. Vaccine. 2018 06 14; 36(25):3650-3665. PMID: 29764680; PMCID: PMC6595497.
      Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    53. Zhang R, Sun Q, Chen Y, Sun X, Gu Y, Zhao Z, Cheng Y, Zhao L, Huang J, Zhan B, Zhu X. Ts-Hsp70 induces protective immunity against Trichinella spiralis infection in mouse by activating dendritic cells through TLR2 and TLR4. PLoS Negl Trop Dis. 2018 05; 12(5):e0006502. PMID: 29775453; PMCID: PMC5979045.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    54. Hu Y, Nguyen TT, Lee ACY, Urban JF, Miller MM, Zhan B, Koch DJ, Noon JB, Abraham A, Bowman DD, Ostroff GR, Aroian RV, Fujiwara RT. Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure. Int J Parasitol Drugs Drug Resist. 2018 08; 8(2):287-294. PMID: 29772478; PMCID: PMC6039361.
      Citations: 8     Fields:    Translation:AnimalsCells
    55. Konduri V, Halpert MM, Liang D, Levitt JM, Cruz-Chan JV, Zhan B, Bottazzi ME, Hotez PJ, Jones KM, Decker WK. Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy. Infect Immun. 2017 09; 85(9). PMID: 28674032; PMCID: PMC5563592.
      Citations: 7     Fields:    Translation:AnimalsCells
    56. Liu Z, Kelleher A, Tabb S, Wei J, Pollet J, Hotez PJ, Bottazzi ME, Zhan B, Asojo OA. Identification, Characterization, and Structure of Tm16 from Trichuris muris. J Parasitol Res. 2017; 2017:4342789. PMID: 28884022; PMCID: PMC5573103.
      Citations: 3     
    57. Gu Y, Sun X, Li B, Huang J, Zhan B, Zhu X. Vaccination with a Paramyosin-Based Multi-Epitope Vaccine Elicits Significant Protective Immunity against Trichinella spiralis Infection in Mice. Front Microbiol. 2017; 8:1475. PMID: 28824599; PMCID: PMC5540943.
      Citations: 31     
    58. Wang L, Sun X, Huang J, Zhan B, Zhu X. Heterologous Prime-Boost Vaccination Enhances TsPmy's Protective Immunity against Trichinella spiralis Infection in a Murine Model. Front Microbiol. 2017; 8:1394. PMID: 28785255; PMCID: PMC5519575.
      Citations: 6     
    59. Wei J, Versteeg L, Liu Z, Keegan B, Fujiwara RT, Briggs N, Jones KM, Strych U, Beaumier CM, Bottazzi ME, Hotez PJ, Zhan B, Gazzinelli-Guimar?es AC. Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005769. PMID: 28708895; PMCID: PMC5529013.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    60. Gunter SM, Jones KM, Seid CA, Essigmann HT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Brown EL. Mutations to Cysteine Residues in the Trypanosoma cruzi B-Cell Superantigen Tc24 Diminish Susceptibility to IgM-Mediated Hydrolysis. J Parasitol. 2017 10; 103(5):579-583. PMID: 28581897.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    61. Zhao L, Shao S, Chen Y, Sun X, Sun R, Huang J, Zhan B, Zhu X. Trichinella spiralis Calreticulin Binds Human Complement C1q As an Immune Evasion Strategy. Front Immunol. 2017; 8:636. PMID: 28620388; PMCID: PMC5449505.
      Citations: 13     Fields:    
    62. Li H, Wang S, Zhan B, He W, Chu L, Qiu D, Li N, Wan Y, Zhang H, Chen X, Fang Q, Shen J, Yang X. Therapeutic effect of Schistosoma japonicum cystatin on bacterial sepsis in mice. Parasit Vectors. 2017 May 08; 10(1):222. PMID: 28482922; PMCID: PMC5422996.
      Citations: 16     Fields:    Translation:AnimalsCells
    63. Asojo OA, Kelleher A, Liu Z, Pollet J, Hudspeth EM, Rezende WC, Groen MJ, Seid CA, Abdeladhim M, Townsend S, de Castro W, Mendes-Sousa A, Bottazzi ME, Hotez PJ, Zhan B, Oliveira F, Kamhawi S, Valenzuela JG, Bartholomeu DC, Fujiwara RT. Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis. PLoS Negl Trop Dis. 2017 03; 11(3):e0005374. PMID: 28278244; PMCID: PMC5344329.
      Citations: 3     Fields:    Translation:AnimalsCells
    64. Versteeg L, Le Guezennec X, Zhan B, Liu Z, Angagaw M, Woodhouse JD, Biswas S, Beaumier CM. Transferring Luminex? cytokine assays to a wall-less plate technology: Validation and comparison study with plasma and cell culture supernatants. J Immunol Methods. 2017 01; 440:74-82. PMID: 27840065.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    65. Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A, Hotez PJ, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda CR, Upham JW, Giacomin PR, Loukas A, Julia V. Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Sci Transl Med. 2016 10 26; 8(362):362ra143. PMID: 27797959.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    66. McAtee CP, Seid CA, Hammond M, Hudspeth E, Keegan BP, Liu Z, Wei J, Zhan B, Hotez PJ, Bottazzi ME, Arjona-Sabido R, Cruz-Chan V, Dumonteil E. Expression, purification, immunogenicity and protective efficacy of a recombinant nucleoside hydrolase from Leishmania donovani, a vaccine candidate for preventing cutaneous leishmaniasis. Protein Expr Purif. 2017 02; 130:129-136. PMID: 27773761.
      Citations: 5     Fields:    Translation:Animals
    67. Seid CA, Jones KM, Pollet J, Keegan B, Hudspeth E, Hammond M, Wei J, McAtee CP, Versteeg L, Gutierrez A, Liu Z, Zhan B, Respress JL, Strych U, Bottazzi ME, Hotez PJ. Cysteine mutagenesis improves the production without abrogating antigenicity of a recombinant protein vaccine candidate for human chagas disease. Hum Vaccin Immunother. 2017 03 04; 13(3):621-633. PMID: 27737611; PMCID: PMC5360114.
      Citations: 15     Fields:    Translation:AnimalsCells
    68. Wei J, Damania A, Gao X, Liu Z, Mejia R, Mitreva M, Strych U, Bottazzi ME, Hotez PJ, Zhan B. The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates. Parasit Vectors. 2016 Sep 27; 9(1):518. PMID: 27677574; PMCID: PMC5039805.
      Citations: 10     Fields:    
    69. Wang L, Wang X, Bi K, Sun X, Yang J, Gu Y, Huang J, Zhan B, Zhu X. Oral Vaccination with Attenuated Salmonella typhimurium-Delivered TsPmy DNA Vaccine Elicits Protective Immunity against Trichinella spiralis in BALB/c Mice. PLoS Negl Trop Dis. 2016 09; 10(9):e0004952. PMID: 27589591; PMCID: PMC5010209.
      Citations: 24     Fields:    Translation:AnimalsCellsPHPublic Health
    70. Hess JA, Zhan B, Torigian AR, Patton JB, Petrovsky N, Zhan T, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D. The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice. PLoS Negl Trop Dis. 2016 07; 10(7):e0004797. PMID: 27387453; PMCID: PMC4936747.
      Citations: 13     Fields:    Translation:HumansAnimalsPHPublic Health
    71. Yang J, Zhu W, Huang J, Wang X, Sun X, Zhan B, Zhu X. Partially protective immunity induced by the 14-3-3 protein from Trichinella spiralis. Vet Parasitol. 2016 Nov 15; 231:63-68. PMID: 27387374.
      Citations: 13     Fields:    Translation:Animals
    72. Gu Y, Huang J, Wang X, Wang L, Yang J, Zhan B, Zhu X. Identification and characterization of CD4+ T cell epitopes present in Trichinella spiralis paramyosin. Vet Parasitol. 2016 Nov 15; 231:59-62. PMID: 27353726.
      Citations: 5     Fields:    Translation:AnimalsCells
    73. Arumugam S, Wei J, Liu Z, Abraham D, Bell A, Bottazzi ME, Hotez PJ, Zhan B, Lustigman S, Klei TR. Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection. PLoS Negl Trop Dis. 2016 Apr; 10(4):e0004586. PMID: 27045170; PMCID: PMC4821550.
      Citations: 14     Fields:    Translation:Animals
    74. Barry MA, Wang Q, Jones KM, Heffernan MJ, Buhaya MH, Beaumier CM, Keegan BP, Zhan B, Bottazzi ME, Hotez PJ, Dumonteil E. A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease. Hum Vaccin Immunother. 2016 04 02; 12(4):976-87. PMID: 26890466; PMCID: PMC4962947.
      Citations: 25     Fields:    Translation:AnimalsCells
    75. Hudspeth EM, Wang Q, Seid CA, Hammond M, Wei J, Liu Z, Zhan B, Pollet J, Heffernan MJ, McAtee CP, Engler DA, Strych U, Asojo OA, Hotez PJ, Bottazzi ME, Matsunami RK. Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic properties. Hum Vaccin Immunother. 2016 07 02; 12(7):1707-20. PMID: 26839079; PMCID: PMC4964838.
      Citations: 5     Fields:    Translation:AnimalsCells
    76. Sun R, Zhao X, Wang Z, Yang J, Zhao L, Zhan B, Zhu X. Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation. PLoS Negl Trop Dis. 2015 Dec; 9(12):e0004310. PMID: 26720603; PMCID: PMC4697845.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    77. Zhan B, Ajmera R, Geiger SM, Liu Z, Wei J, Wilkins PP, Fujiwara R, Gazzinelli-Guimaraes PH, Bottazzi ME, Hotez P, Gon?alves MT. Identification of immunodominant antigens for the laboratory diagnosis of toxocariasis. Trop Med Int Health. 2015 Dec; 20(12):1787-96. PMID: 26426162.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    78. Anderson JP, Rascoe LN, Levert K, Chastain HM, Reed MS, Rivera HN, McAuliffe I, Zhan B, Wiegand RE, Hotez PJ, Wilkins PP, Pohl J, Handali S. Development of a Luminex Bead Based Assay for Diagnosis of Toxocariasis Using Recombinant Antigens Tc-CTL-1 and Tc-TES-26. PLoS Negl Trop Dis. 2015; 9(10):e0004168. PMID: 26485145; PMCID: PMC4618131.
      Citations: 12     Fields:    Translation:HumansCells
    79. Gabrielsen M, Roe AJ, Griffiths K, Zhan B, Cooper A, Kennedy MW, Smith BO, Rey-Burusco MF, Ib??ez-Shimabukuro M, Franchini GR, C?rsico B. Diversity in the structures and ligand-binding sites of nematode fatty acid and retinol-binding proteins revealed by Na-FAR-1 from Necator americanus. Biochem J. 2015 Nov 01; 471(3):403-14. PMID: 26318523; PMCID: PMC4613501.
      Citations: 15     Fields:    Translation:AnimalsCells
    80. Bi K, Yang J, Wang L, Gu Y, Zhan B, Zhu X. Partially Protective Immunity Induced by a 20 kDa Protein Secreted by Trichinella spiralis Stichocytes. PLoS One. 2015; 10(8):e0136189. PMID: 26288365; PMCID: PMC4545582.
      Citations: 8     Fields:    Translation:AnimalsCells
    81. Seid CA, Hudspeth EM, Wei J, Liu Z, Kwityn C, Hammond M, Zhan B, Hotez PJ, Bottazzi ME, Martinez-Campos V, Martinez-Vega P, Ramirez-Sierra MJ, Rosado-Vallado M, Ortega-L?pez J, Dumonteil E. Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice. Vaccine. 2015 Aug 26; 33(36):4505-12. PMID: 26192358.
      Citations: 19     Fields:    Translation:AnimalsCells
    82. Kelleher A, Liu Z, Seid CA, Zhan B, Asojo OA. Expression, purification, crystallization and crystallographic study of Lutzomyia longipalpis LJL143. Acta Crystallogr F Struct Biol Commun. 2015 Jul; 71(Pt 7):925-8. PMID: 26144240; PMCID: PMC4498716.
      Citations:    Fields:    Translation:AnimalsCells
    83. Hotez PJ, Bottazzi ME, Zhan B, Makepeace BL, Klei TR, Abraham D, Taylor DW, Lustigman S. The Onchocerciasis Vaccine for Africa--TOVA--Initiative. PLoS Negl Trop Dis. 2015 Jan; 9(1):e0003422. PMID: 25634641; PMCID: PMC4310604.
      Citations: 16     Fields:    
    84. Knight JM, Zingales B, Bottazzi ME, Hotez P, Zhan B. Limited antigenic variation in the Trypanosoma cruzi candidate vaccine antigen TSA-1. Parasite Immunol. 2014 Dec; 36(12):708-12. PMID: 25040249.
      Citations: 3     Fields:    Translation:HumansAnimals
    85. Gu Y, Zhan B, Yang Y, Yang X, Zhao X, Wang L, Yang J, Bi K, Wang Y, Zhu X. Protective effect of a prime-boost strategy with the Ts87 vaccine against Trichinella spiralis infection in mice. Biomed Res Int. 2014; 2014:326860. PMID: 25250316; PMCID: PMC4164511.
      Citations: 6     Fields:    Translation:Animals
    86. Fang L, Sun L, Yang J, Gu Y, Zhan B, Huang J, Zhu X. Heat shock protein 70 from Trichinella spiralis induces protective immunity in BALB/c mice by activating dendritic cells. Vaccine. 2014 Jul 31; 32(35):4412-4419. PMID: 24962751.
      Citations: 10     Fields:    Translation:AnimalsCells
    87. Hotez PJ, Bottazzi ME, Tseng CT, Zhan B, Lustigman S, Du L, Jiang S. Calling for rapid development of a safe and effective MERS vaccine. Microbes Infect. 2014 Jul; 16(7):529-31. PMID: 24931059; PMCID: PMC7128618.
      Citations: 21     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    88. Arumugam S, Wei J, Ward D, Abraham D, Lustigman S, Zhan B, Klei TR. Vaccination with a genetically modified Brugia malayi cysteine protease inhibitor-2 reduces adult parasite numbers and affects the fertility of female worms following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae. Int J Parasitol. 2014 Sep; 44(10):675-9. PMID: 24929131; PMCID: PMC5335902.
      Citations: 14     Fields:    Translation:Animals
    89. Hess JA, Zhan B, Deckman JM, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D, Bonne-Ann?e S. Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model. Int J Parasitol. 2014 Aug; 44(9):637-46. PMID: 24907553; PMCID: PMC4118642.
      Citations: 17     Fields:    Translation:Animals
    90. Yang X, Yang Y, Wang Y, Zhan B, Gu Y, Cheng Y, Zhu X. Excretory/secretory products from Trichinella spiralis adult worms ameliorate DSS-induced colitis in mice. PLoS One. 2014; 9(5):e96454. PMID: 24788117; PMCID: PMC4008629.
      Citations: 32     Fields:    Translation:AnimalsCells
    91. Tang YT, Gao X, Rosa BA, Abubucker S, Hallsworth-Pepin K, Martin J, Tyagi R, Heizer E, Zhang X, Bhonagiri-Palsikar V, Minx P, Warren WC, Wang Q, Zhan B, Hotez PJ, Sternberg PW, Dougall A, Gaze ST, Mulvenna J, Sotillo J, Ranganathan S, Wilson RW, Felgner PL, Bethony J, Hawdon JM, Gasser RB, Loukas A, Mitreva M, Rabelo EM. Genome of the human hookworm Necator americanus. Nat Genet. 2014 Mar; 46(3):261-269. PMID: 24441737; PMCID: PMC3978129.
      Citations: 87     Fields:    Translation:HumansAnimals
    92. Zhan B, Beaumier CM, Briggs N, Jones KM, Keegan BP, Bottazzi ME, Hotez PJ. Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections. Expert Rev Vaccines. 2014 Mar; 13(3):321-31. PMID: 24392641; PMCID: PMC3934375.
      Citations: 25     Fields:    Translation:HumansAnimals
    93. Chen WH, Du L, Chag SM, Ma C, Tricoche N, Tao X, Seid CA, Hudspeth EM, Lustigman S, Tseng CT, Bottazzi ME, Hotez PJ, Zhan B, Jiang S. Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate. Hum Vaccin Immunother. 2014; 10(3):648-58. PMID: 24355931; PMCID: PMC4130269.
      Citations: 57     Fields:    Translation:AnimalsCells
    94. Curti E, Kwityn C, Zhan B, Gillespie P, Brelsford J, Deumic V, Plieskatt J, Rezende WC, Tsao E, Kalampanayil B, Hotez PJ, Bottazzi ME. Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoni TSP-2 recombinant protein: a vaccine candidate for human intestinal schistosomiasis. Hum Vaccin Immunother. 2013 Nov; 9(11):2342-50. PMID: 23899507; PMCID: PMC3981843.
      Citations: 13     Fields:    Translation:Animals
    95. Kelleher A, Zhan B, Asojo OA. Structure of monomeric Na-GST-3, a glutathione S-transferase from the major human hookworm parasite Necator americanus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Aug; 69(Pt 8):839-43. PMID: 23908024; PMCID: PMC3729155.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    96. Hu Y, Zhan B, Keegan B, Yiu YY, Miller MM, Jones K, Aroian RV. Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms. PLoS Negl Trop Dis. 2012; 6(11):e1900. PMID: 23145203; PMCID: PMC3493396.
      Citations: 19     Fields:    Translation:Animals
    97. Bottazzi ME, Zhan B, Heffernan MJ, Jones K, Valenzuela JG, Kamhawi S, Lee BY, Bacon KM, Fleischer B, Slingsby BT, Cravioto MB, Tapia-Conyer R, Hotez PJ, Dumonteil E, Ortega J, de Leon Rosales SP. Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects. Expert Rev Vaccines. 2012 Sep; 11(9):1043-55. PMID: 23151163; PMCID: PMC3819810.
      Citations: 47     Fields:    Translation:HumansAnimalsPHPublic Health
    98. Zhan B, Santiago H, Keegan B, Gillespie P, Xue J, Bethony J, de Oliveira LM, Jiang D, Diemert D, Xiao SH, Jones K, Feng X, Hotez PJ, Bottazzi ME. Fusion of Na-ASP-2 with human immunoglobulin Fc? abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE. Parasite Immunol. 2012 Aug-Sep; 34(8-9):404-11. PMID: 22651670.
      Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    99. Goud GN, Deumic V, Gupta R, Brelsford J, Zhan B, Gillespie P, Plieskatt JL, Tsao EI, Hotez PJ, Bottazzi ME. Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen. Protein Expr Purif. 2012 Jun; 83(2):145-51. PMID: 22503665.
      Citations: 13     Fields:    Translation:Animals
    100. Jiang D, Zhan B, Mayor RS, Gillespie P, Keegan B, Bottazzi ME, Hotez P. Ac-AP-12, a novel factor Xa anticoagulant peptide from the esophageal glands of adult Ancylostoma caninum. Mol Biochem Parasitol. 2011 May; 177(1):42-8. PMID: 21251931.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    101. Zhan B, Perally S, Brophy PM, Xue J, Goud G, Liu S, Deumic V, de Oliveira LM, Bethony J, Bottazzi ME, Jiang D, Gillespie P, Xiao SH, Gupta R, Loukas A, Ranjit N, Lustigman S, Oksov Y, Hotez P. Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanus. Infect Immun. 2010 Apr; 78(4):1552-63. PMID: 20145100; PMCID: PMC2849424.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    102. Zhan B, Gupta R, Wong SP, Bier S, Jiang D, Goud G, Hotez P. Molecular cloning and characterization of Ac-TMP-2, a tissue inhibitor of metalloproteinase secreted by adult Ancylostoma caninum. Mol Biochem Parasitol. 2008 Dec; 162(2):142-8. PMID: 18804124.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    103. Fujiwara RT, Zhan B, Mendez S, Loukas A, Bueno LL, Wang Y, Plieskatt J, Oksov Y, Lustigman S, Bottazzi ME, Hotez P, Bethony JM. Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16. Clin Vaccine Immunol. 2007 Mar; 14(3):281-7. PMID: 17267592; PMCID: PMC1828853.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    104. Feng J, Zhan B, Liu Y, Liu S, Williamson A, Goud G, Loukas A, Hotez P. Molecular cloning and characterization of Ac-MTP-2, an astacin-like metalloprotease released by adult Ancylostoma caninum. Mol Biochem Parasitol. 2007 Apr; 152(2):132-8. PMID: 17280728.
      Citations: 7     Fields:    Translation:AnimalsCells
    105. Williamson AL, Lustigman S, Oksov Y, Deumic V, Plieskatt J, Mendez S, Zhan B, Bottazzi ME, Hotez PJ, Loukas A. Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration. Infect Immun. 2006 Feb; 74(2):961-7. PMID: 16428741; PMCID: PMC1360348.
      Citations: 42     Fields:    Translation:Animals
    106. Zhan B, Liu S, Perally S, Xue J, Fujiwara R, Brophy P, Xiao S, Liu Y, Feng J, Williamson A, Wang Y, Bueno LL, Mendez S, Goud G, Bethony JM, Hawdon JM, Loukas A, Jones K, Hotez PJ. Biochemical characterization and vaccine potential of a heme-binding glutathione transferase from the adult hookworm Ancylostoma caninum. Infect Immun. 2005 Oct; 73(10):6903-11. PMID: 16177370; PMCID: PMC1230892.
      Citations: 38     Fields:    Translation:AnimalsCells
    107. Goud GN, Bottazzi ME, Zhan B, Mendez S, Deumic V, Plieskatt J, Liu S, Wang Y, Bueno L, Fujiwara R, Samuel A, Ahn SY, Solanki M, Asojo OA, Wang J, Bethony JM, Loukas A, Roy M, Hotez PJ. Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials. Vaccine. 2005 Sep 15; 23(39):4754-64. PMID: 16054275.
      Citations: 33     Fields:    Translation:HumansAnimalsPHPublic Health
    108. Fujiwara RT, Loukas A, Mendez S, Williamson AL, Bueno LL, Wang Y, Samuel A, Zhan B, Bottazzi ME, Hotez PJ, Bethony JM. Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs. Vaccine. 2006 Jan 23; 24(4):501-9. PMID: 16140437.
      Citations: 20     Fields:    Translation:AnimalsCellsPHPublic Health
    109. Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Plieskatt J, Goud G, Bottazzi ME, Zhan B, Wang Y, Williamson A, Lustigman S, Correa-Oliveira R, Xiao S, Hotez PJ. Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals. FASEB J. 2005 Oct; 19(12):1743-5. PMID: 16037096.
      Citations: 64     Fields:    Translation:HumansAnimals
    110. Mendez S, Zhan B, Goud G, Ghosh K, Dobardzic A, Wu W, Liu S, Deumic V, Dobardzic R, Liu Y, Bethony J, Hotez PJ. Effect of combining the larval antigens Ancylostoma secreted protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicum. Vaccine. 2005 May 02; 23(24):3123-30. PMID: 15837211.
      Citations: 20     Fields:    Translation:AnimalsCells
    111. Zhan B, Wang Y, Liu Y, Williamson A, Loukas A, Hawdon JM, Xue HC, Xiao SH, Hotez PJ. Ac-SAA-1, an immunodominant 16 kDa surface-associated antigen of infective larvae and adults of Ancylostoma caninum. Int J Parasitol. 2004 Aug; 34(9):1037-45. PMID: 15313130.
      Citations: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    112. Loukas A, Bethony JM, Williamson AL, Goud GN, Mendez S, Zhan B, Hawdon JM, Elena Bottazzi M, Brindley PJ, Hotez PJ. Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms. J Infect Dis. 2004 May 15; 189(10):1952-61. PMID: 15122534.
      Citations: 32     Fields:    Translation:AnimalsPHPublic Health
    113. Goud GN, Zhan B, Ghosh K, Loukas A, Hawdon J, Dobardzic A, Deumic V, Liu S, Dobardzic R, Zook BC, Jin Q, Liu Y, Hoffman L, Chung-Debose S, Patel R, Mendez S, Hotez PJ. Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicum. J Infect Dis. 2004 Mar 01; 189(5):919-29. PMID: 14976610.
      Citations: 37     Fields:    Translation:AnimalsCells
    114. Hotez PJ, Zhan B, Bethony JM, Loukas A, Williamson A, Goud GN, Hawdon JM, Dobardzic A, Dobardzic R, Ghosh K, Bottazzi ME, Mendez S, Zook B, Wang Y, Liu S, Essiet-Gibson I, Chung-Debose S, Xiao S, Knox D, Meagher M, Inan M, Correa-Oliveira R, Vilk P, Shepherd HR, Brandt W, Russell PK. Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative. Int J Parasitol. 2003 Sep 30; 33(11):1245-58. PMID: 13678639.
      Citations: 45     Fields:    Translation:HumansAnimals
    115. Hotez PJ, Ashcom J, Zhan B, Bethony J, Loukas A, Hawdon J, Wang Y, Jin Q, Jones KC, Dobardzic A, Dobardzic R, Bolden J, Essiet I, Brandt W, Russell PK, Zook BC, Howard B, Chacon M. Effect of vaccination with a recombinant fusion protein encoding an astacinlike metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvae. J Parasitol. 2003 Aug; 89(4):853-5. PMID: 14533704.
      Citations: 16     Fields:    Translation:AnimalsPHPublic Health
    116. Zhan B, Liu Y, Badamchian M, Williamson A, Feng J, Loukas A, Hawdon JM, Hotez PJ. Molecular characterisation of the Ancylostoma-secreted protein family from the adult stage of Ancylostoma caninum. Int J Parasitol. 2003 Aug; 33(9):897-907. PMID: 12906874.
      Citations: 43     Fields:    Translation:AnimalsCells
    117. Basavaraju SV, Basavaraju S, Zhan B, Kennedy MW, Liu Y, Hawdon J, Hotez PJ. Ac-FAR-1, a 20 kDa fatty acid- and retinol-binding protein secreted by adult Ancylostoma caninum hookworms: gene transcription pattern, ligand binding properties and structural characterisation. Mol Biochem Parasitol. 2003 Jan; 126(1):63-71. PMID: 12554085.
      Citations: 45     Fields:    Translation:AnimalsCells
    118. Bethony J, Chen J, Lin S, Xiao S, Zhan B, Li S, Xue H, Xing F, Humphries D, Yan W, Chen G, Foster V, Hawdon JM, Hotez PJ. Emerging patterns of hookworm infection: influence of aging on the intensity of Necator infection in Hainan Province, People's Republic of China. Clin Infect Dis. 2002 Dec 01; 35(11):1336-44. PMID: 12439796.
      Citations: 52     Fields:    Translation:HumansAnimals
    119. Hotez PJ, Ashcom J, Bin Z, Bethony J, Williamson A, Hawdon JM, Jianjun F, Dobardzic A, Rizo I, Bolden J, Jin Q, Yan W, Dobardzic R, Chung-Debose S, Crowell M, Datu B, Delaney A, Dragonovski D, Jiang Y, Yueyuan L, Ghosh K, Loukas A, Brandt W, Russell PK, Zook BC. Effect of vaccinations with recombinant fusion proteins on Ancylostoma caninum habitat selection in the canine intestine. J Parasitol. 2002 Aug; 88(4):684-90. PMID: 12197114.
      Citations: 10     Fields:    Translation:AnimalsPHPublic Health
    120. Zhan B, Hotez PJ, Wang Y, Hawdon JM. A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases. Mol Biochem Parasitol. 2002 Apr 09; 120(2):291-6. PMID: 11897134.
      Citations: 26     Fields:    Translation:AnimalsCells
    121. Zhan B, Badamchian M, Meihua B, Ashcom J, Feng J, Hawdon J, Shuhua X, Hotez PJ. Molecular cloning and purification of Ac-TMP, a developmentally regulated putative tissue inhibitor of metalloprotease released in relative abundance by adult Ancylostoma hookworms. Am J Trop Med Hyg. 2002 Mar; 66(3):238-44. PMID: 12139214.
      Citations: 19     Fields:    Translation:AnimalsCells
    122. Zhan B, Li T, Xiao S, Zheng F, Hawdon JM. Species-specific identification of human hookworms by PCR of the mitochondrial cytochrome oxidase I gene. J Parasitol. 2001 Oct; 87(5):1227-9. PMID: 11695411.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    123. Hawdon JM, Li T, Zhan B, Blouin MS. Genetic structure of populations of the human hookworm, Necator americanus, in China. Mol Ecol. 2001 Jun; 10(6):1433-7. PMID: 11412366.
      Citations: 14     Fields:    Translation:Animals
    124. Franke F, Sanning C. [Synthesis of hyaluronidase in erysipelothrix]. Berl Munch Tierarztl Wochenschr. 1971 Jan 15; 84(2):28-30. PMID: 5540943.
      Citations: 1     Fields:    
    125. Klainer AS, Gorbach S, Weinstein L. Studies of intestinal microflora. VII. Effect of diet and fecal microbial flora on survival of animals exposed to x irradiation. J Bacteriol. 1967 Aug; 94(2):383-7. PMID: 6039361; PMCID: PMC315051.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    126. . Detection of Plasmodium falciparum by Polymerase Chain Reaction. Chinese J. Parasitol & Parasitic Dis. 12(2):111.
    127. . Further Report on Application of DNA Probe in Diagnosis of Vivax Malaria Infection. Chinese J. Parasitol & Parasitic Dis. 11:86.
    128. . Observation on Interfering Factors in detection of Falciparum Malaria Patients in Co-endemic Areas by IFA Test. Chinese J. Parasitol & Parasitic Dis. 12(2):151.
    129. . Application of PCR on the Diagnosis of Falciparum Malaria in a Malaria endemic field. Chinese J. Parasitol & Parasitic Dis. 12(1):37.
    130. . Longitudinal Surveillance of Chloroquine Resistance of Plasmodium falciparum after Cessation of Medication in South Yunnan. Chinese J. Parasitol & Parasitic Dis. 12(1):31-3.
    131. . Sensitivity of Plasmodium falciparum to seven anti-malaria Medicines in vitro. Chinese J. Parasitol & Parasitic Dis. 13(2):111-3.
    132. Application of Plasmodium falciparum DNA Extracted from Dried Blood Spot of Falciparum Malaria Patients for Polymerase Chain Reaction. Chinese J. Parasitol & Parasitic Dis. 13(2):120-2.
    133. . DNA Sequence Analysis of Apical Membrane Antigen-1 from a Plasmodium falciparum Isolate Collected from Meng-Peng Township, Yun-Nan. Chinese J. Parasitol & Parasitic Dis. 13(3):203-8.
    134. Sun FH, Wu ZX, Qian YX, Cao HG, Xue HC, Xiao SH, Ren HN, ZHAN B, Hawdon JM, Hotez PJ. Epidemiology of human intestinal nematode infection in Wujiang and Pizhou counties, Jiangsu Province, China. Southeast Asian J. Trop. Publ. Health. 17(2):81-83.
    135. Li Tiehua, ZHAN Bin, John M Hawdon, Gong Xin, Xiao Shuhua, Shan Qiang, Feng Zheng, Peter J Hotez. Sequencing of Cytochrome C Oxidatase I Gene of Ancylostoma duodenale and Necator americanus. Chinese J Parasitol & Parasitic Dis. 17(2):81-83.
    136. Peter J Hotez, Ghosh K, Hawdon JM, Narasimhan S, Johes B, Xiao SH, Liu S, ZHAN B, Xue HC, Ren HN, Wang H and Koski RA. Experimental approaches to the development of a recombinant hookworm vaccine. Immunological Reviews. 171:163-171.
    137. Wang Y, Shen GJ, Wu WT, Xiao SH, Hotez PJ, Li QY, Xue HC, Yi XM, Liu XM, ZHAN B, Hawdon JM, Chou L, Ji Hong, Hu CM, Feng Z. Epidemiology of human ancylostomiasis among rural villagers in Nanlin County (Zhongzhou village), Anhui Province, China: age-associated prevalence, intensity and hookworm species identification. Southeast Asian J Trop Med Public Health. 30(4):692-7.
    138. Liu CH, Zhang XR, Qiu DC, Xiao SH, Hotez PJ, Zheng DF, Xue HC, Zhen HL, Li MG, Ren HN, ZHAN B, Hawdon JM, Feng Z. Epidemiology of human hookworm infections among adult rural villagers in Heijiang and Santai counties, Sichuan province, China. Acta Tropica. 73:243-249.
    139. ZHAN Bin, John Hawdon, Shan Qiang, Ren Hainan, Qiang Huiqing, Hu Wei, Xiao Shu-hua, Li Tiehua, Gong Xin, Feng Zheng, Peter Hotez. Ancylostoma-secreted Protein 1 (ASP-1) Homologues in Human Hookworms. Mol Biochem Parasitol. 98:143-149.
    140. ZHAN Bin, John Hawdon, Shan Qiang, Ren Hainan, Qiang Huiqing, Xiao Shu-hua, Li Tiehua, Feng Zheng, Peter Hotez. Construction and analysis of cDNA Library of the third stage larvae of Necator americanus. Chinese J Parasitol & Parasitic Dis. 18(1):26-29.
    141. Shan Qiang, ZHAN Bin, Xiao shu-hua, Feng Zheng, Peter Hotez, and John M. Hawdon. Variation between ASP-1molecules from Ancylostoma caninum in China and the United States. J. Parasitol. 86(1):181-5.
    142. Liu Sen, Kashinath Ghosh, ZHAN Bin, Shan Qiang , Thompson MG, Hawdon JM, Koski RA, Shuhua X, Hotez PJ. Hookworm burden reductions in BALB/c mice vaccinated with recombinant Ancylostoma secreted proteins (ASPs) from Ancylostoma duodenale, Ancylostoma caninum and Necator americanus. Vaccine. 18(11-12):1096-1102.
    143. . Epidemiology of human geohelminth infections (ascariasis, trichuriasis and necatoriasis) in Lushui and Puer Counties, Yunnan Province, China. Southeast Asian J Trop Med Public Health. 31(3):448-53.
    144. . Current prevalence and vaccine development of hookworm. Chinese J Parasitol & Parsitic Dis 2000. 18(3):182-5.
    145. Xue Haichou, Wang Yan, Xiao Shuhua, Liu Sen, Wang Yong, Shen Guangjin, Wu Weituo, ZHAN Bin, L Drake, Feng Zheng and Peter J Hotez. Epidemiology of human ancylostomiasis among rural villagers in Nanlin County (Zhongzhou village), Anhui Province, China: II. Seroepidemiological studies of the age relationships of serum antibody levels and infection status. Southeast Asian J Trop Med Public Health 2000. 31(4):736-741.
    146. Nishiena S. Gandhi, Chen Jizhang, Kaveh Khoshnood, Xing Fuying, Li Shanwen, Liu Yaoruo, ZHAN Bin, Xue Haichou, Tong Chougjin, Wang Yan, Wang Wensen, He Dungxing, Chen Chong, Xiao Shuhua, John M. Hawdon, Peter J. Hawdon. Epidemiology of Necator americanus hookworm infections in Xiulongkan Village, Hainan Province, China: High Prevalence and Intensity Among Middle-aged and Elderly. J. Parasitol. 87(4):739-43.
    147. . Species-specific Identification of Human Hookworms by PCR of the Mitochondrial Cytochrome Oxidase I Gene. J. Parasitol. 87(5):1227.
    148. . Helminth infections in China and southeast Asia: Their diseases burden in childhood and novel approaches to their control and diagnosis. Asian Journal of Pediatric Practice. 5(2):51-62.
    149. Xiao Shuhua, Peter J. Hotez, Sen Binggui, Liu Sen, Qiang Huiqing, Xue Haichou, ZHAN Bin, Feng Zheng. Electron and light microscopy of neutrophil responses in mice vaccinated and challenged with third-stage infective hookworm (Ancylostoma caninum) larvae. Parasitology International. 50:241-8.
    150. . Genetic structure of populations of the human hookworm, Necator americanus, in China. Molecular Ecology. 10(6):1433-7.
    151. Peter J. Hotez, ZHAN Bin, Jeffrey Bethony, Qun Jin, John M. Hawdon, HeatherA. Young, Samuel Simmens, Richard Hitzelberg, and Bernard C. Zook . Natural history of primary canine hookworm infections after three different oral doses of third-stage infective larvae of Ancylostoma caninum. . Comparative Parasitolog. 69(1):72-80.
    152. Peter J. Hotez, James Ashcom, ZHAN Bin, Jeff Bethony, Angela Williamson, John M. Hawdon, Feng Jianjun, Azra Dobardzic, Ivania Rizo, Janelle Bolder, Qun Jin, Wang Yan, Reshad Dobardzic, Sophia Chung-Debose, Melissa Crowell, Bennett Datu, Angela Delaney, Dilyan Dragonovski, Yang Jiang, Liu Yueyuan, Kshinath Ghosh, Alex Loukas, Walter Brandt, Philip K. Russell, and Bernard C. Zook. Effect of vaccinations with recombinant fusion protein on Ancylostoma caninum habitat selection in the canine intestine. J.Parasitol. 88(4):684-690.
    153. Xue Jian, Xiao Shu-Hua, Qiang Hui-qing, Liu Sen, Peter Hotez, Shen Bing-Gui, Xue Hai-Chou, Li Tie-Hua and ZHAN Bin. Necator americanus: maintenance through one hundred generations in golden hamsters (Mesocricetus auratus). II. Morphological development of the adult and its comparison with humans. Exp. Parasitol. 105(3-4):192-200.
    154. Li TH, Guo XR, Xue J, Hu L, Qiang HQ, Xue HC, ZHAN B, Hawdon JM, Xiao SH. Comparison of mitochondrial cytochrome oxidase 1 DNA sequences from Necator americanus hookworms maintained for 100 generations in golden hamsters (Mesocricetus auratus) and hookworms from natural human infections. Acta Trop. 92(1):71-5.
    155. Jian X, Jun-Min Y, Hai-Chou X, Hui-Qing Q, Hai-Nan R, Hotez P, ZHAN B, Shu-Hua X. Protective immunity elicited by ultraviolet-irradiated third-stage infective hookworm (Necator americanus and Ancylostoma caninum) larvae in mice and hamsters. Southeast Asian J Trop Med Public Health. 37(5):885-95.
    156. . Analyses on the Protein Composition and Antigenicity of Leishmania gerbilli Promastigotes. Endemic Diseases Bulletin. 5(3):63-6.
    157. . Detection of RESA Antibody in Falciparum Malaria Patients by Double RESA-IFA Method. Shanghai J. Immunology. 11:295.
    158. . Study on Relationship between Antibodies to Plasmodium falciparum and Clinical Immunity to infection in Falciparum Malaria Patients in Hyperendemic Areas. Shanghai J. Immunology. 11:279-81.
    159. . Detection of Anti-RESA antibody in Population of Endemic Malaria Area. Chinese J. Parasitic Diseases Control. 5(3):167.
    160. . Study on the Detection of Plasmodium vivax by a Specific DNA Probe. Chinese J.Parasitol & Parasitic Dis. 11:141.
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