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NICOLA ALEXANDER HANANIA

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Pulmonary
Address7200 Cambridge
HOUSTON TX 77030
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    Collapse Biography 
    Collapse awards and honors
    2016Elected Fellow of European Respiratory Society (FERS) , European Respiratory Society
    2016Thomas Petty, MD, Master ACCP Memorial Lecture in COPD, American College of Chest Physicians
    2013 - 2016Distinguished Scholar in Respiratory Health, American College of Chest Physicians
    2013 - 2014Member, ACCP/CTS Panel : Acute Exacerbations of COPD Guidelines, American College of Chest Physicians
    2011Member, ACP/ACCP/ATS/ERS Panel: Clinical Practice Guidelines of COPD, American College of Chest Physicians
    2009Donald Robert McCaffree Humanitarian Award, American College of Chest Physicians
    2005 - 2009Career Investigator Award (K23), National Institute of Health, NHLBI
    2003Fulbright and Jaworski L.L.P. Faculty Excellence Award for Teaching and Evaluation, Baylor College of Medicine
    2003Attending of the Year Award, Pulmonary Section, Baylor College of Medicine
    2003Award for Excellence in Teaching, Department of Medicine, Baylor College of Medicine
    2011 - NowElected to "Best Doctors in America"
    2003 - 2010Member, Academy of Distinguished Educators, , Baylor College of Medicine
    1994The Toronto Hospital, Department of Medicine, Resident's Research Award (first prize), University of Toronto
    1995Listed in Marquis Who's Who in America, 50th Edition,
    1994Dupont Pharmaceuticals / American College of Chest Physicians - Junior Investigator Award, American College of Chest Physicians
    1993The Toronto Hospital, Department of Medicine, Resident Research Award (third prize), University of Toronto
    1992University of Toronto, Department of Medicine, Research Award, University of Toronto

    Collapse Overview 
    Collapse overview
    Nicola (Nick) A. Hanania, MD, MS is Associate Professor of Medicine in the Section of Pulmonary and Critical Care Medicine and Director of the Airways Clinical Research Center at the Baylor College of Medicine in Houston, Texas, USA. He completed his medical training at the University of Jordan followed by residency in internal medicine and a fellowship in pulmonary medicine at the University of Toronto, Canada. He subsequently completed a fellowship in critical care medicine at Baylor College of Medicine, where he later earned a master’s degree in clinical investigation.

    Dr. Hanania is a fellow of the Royal College of Physicians and Surgeons of Canada, The American College of Chest Physicians, the American College of Physicians and the European Respiratory Society. As a Fellow of the American College of Chest Physicians, Dr. Hanania has served on the Board of Regents and as Chair of the Clinical Pulmonary, Airways Networks and Council of Networks for this organization. He has been on the Board of Trustees of the Chest Foundation since 2012. In addition, he served as a member of the Health Policy Committee of the American Thoracic Societ and on several guideline and workshop panels including the ACP/ATS/ACCP/ERS Clinical Practice guidelines on COPD and the CTS/ACCP COPD exacerbations guidelines.

    Dr. Hanania has received multiple awards. He is deputy editor of Respiratory Medicine and is Associate Editor of Therapeutic Advances in Respiratory Disease, Current Opinion in Pulmonary Medicine (Asthma Section) and Pulmonary Pharmacology and Therapeutics.

    Dr. Hanania’s research interests focus on the pharmacology and management of asthma and COPD. He has published more than 200 peer-reviewed papers, book chapters, editorials and reviews on these topics. He is actively involved in clinical trials investigating novel treatments. He is Principal Investigator for the American Lung Association Airway Clinical Research Center at Baylor College of Medicine, as well as Principal Investigator or Co-Investigator in several clinical trials in asthma and COPD. He has been invited and has lectured widely at local, regional, national and international meetings.

    Collapse Research 
    Collapse research activities and funding
    K23HL079054     (HANANIA, NICOLA A)Sep 6, 2005 - Aug 31, 2009
    NIH/NHLBI
    Response to Beta2-Agonists in Acute Severe Asthma
    Role: Principal Investigator

    U01AI095050     (HANANIA, NICOLA A)Aug 15, 2011 - Jul 31, 2015
    NIH/NIAID
    Efficacy and Safety of Beta-adrenoceptor Inverse Agonist, Nadolol in Mild Asthma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Iyer AS, Holm KE, Bhatt SP, Kim V, Kinney GL, Wamboldt FS, Jacobs MR, Regan EA, Armstrong HF, Lowe KE, Martinez CH, Dransfield MT, Foreman MG, Shinozaki G, Hanania NA, Wise RA, Make BJ, Hoth KF. Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - A cross sectional analysis of the COPDGene cohort. J Psychosom Res. 2019 Mar; 118:18-26. PMID: 30782350.
      View in: PubMed
    2. Baughman R, Drent M, Diamant Z, Hanania NA. Editorial introductions. Curr Opin Pulm Med. 2019 Jan; 25(1):v-vi. PMID: 30489334.
      View in: PubMed
    3. Diamant Z, Aalders W, Parulekar A, Bjermer L, Hanania NA. Targeting lipid mediators in asthma: time for reappraisal. Curr Opin Pulm Med. 2019 Jan; 25(1):121-127. PMID: 30422894.
      View in: PubMed
    4. Boulet LP, Hanania NA. The many faces of asthma-chronic obstructive pulmonary disease overlap. Curr Opin Pulm Med. 2019 Jan; 25(1):1-10. PMID: 30461532.
      View in: PubMed
    5. Hanania NA, Sethi S, Koltun A, Ward JK, Spanton J, Ng D. Long-term safety and efficacy of formoterol fumarate inhalation solution in patients with moderate-to-severe COPD. Int J Chron Obstruct Pulmon Dis. 2019; 14:117-127. PMID: 30643398.
      View in: PubMed
    6. Yohannes AM, Dryden S, Hanania NA. Validity and Responsiveness of the Depression Anxiety Stress Scales-21 (DASS-21) in COPD. Chest. 2018 Dec 27. PMID: 30594559.
      View in: PubMed
    7. Shaddox E, Peterson CB, Stingo FC, Hanania NA, Cruickshank-Quinn C, Kechris K, Bowler R, Vannucci M. Bayesian inference of networks across multiple sample groups and data types. Biostatistics. 2018 Dec 26. PMID: 30590505.
      View in: PubMed
    8. Hanania NA, Chipps BE, Griffin NM, Yoo B, Iqbal A, Casale TB. Omalizumab effectiveness in asthma-COPD overlap: Post hoc analysis of PROSPERO. J Allergy Clin Immunol. 2018 Dec 18. PMID: 30576755.
      View in: PubMed
    9. Han MK, Hanania NA, Martinez FJ. Confronting the Challenge of COPD: What Is New in the Approaches to Diagnosis, Treatment, and Patient Outcomes. Chest. 2018 Oct; 154(4):984-985. PMID: 30290933.
      View in: PubMed
    10. Skolnik N, Kaplan AG, Lake T, Hayden ML, Hanania NA. COPD Management in the Primary Care Setting. J Fam Pract. 2018 Oct; 67(10 Suppl):S27-S32. PMID: 30423008.
      View in: PubMed
    11. Calzetta L, Hanania NA, Dini FL, Goldstein MF, Fairweather WR, Howard WW, Cazzola M. Impact of doxofylline compared to theophylline in asthma: A pooled analysis of functional and clinical outcomes from two multicentre, double-blind, randomized studies (DOROTHEO 1 and DOROTHEO 2). Pulm Pharmacol Ther. 2018 12; 53:20-26. PMID: 30219705.
      View in: PubMed
    12. D'Urzo AD, Cazzola M, Hanania NA, Buhl R, Maleki-Yazdi MR. New developments in optimizing bronchodilator treatment of COPD: a focus on glycopyrrolate/formoterol combination formulated by co-suspension delivery technology. Int J Chron Obstruct Pulmon Dis. 2018; 13:2805-2819. PMID: 30233171.
      View in: PubMed
    13. Maselli DJ, Hanania NA. Asthma COPD overlap: Impact of associated comorbidities. Pulm Pharmacol Ther. 2018 10; 52:27-31. PMID: 30172866.
      View in: PubMed
    14. Maselli DJ, Hardin M, Christenson SA, Hanania NA, Hersh CP, Adams SG, Anzueto A, Peters JI, Han MK, Martinez FJ. Clinical Approach to the Therapy of Asthma-COPD Overlap. Chest. 2019 Jan; 155(1):168-177. PMID: 30077690.
      View in: PubMed
    15. Baker AM, Holbrook JT, Yohannes AM, Eakin MN, Sugar EA, Henderson RJ, Casper AS, Kaminsky DA, Rea AL, Mathews AM, Que LG, Ramsdell JW, Gerald LB, Wise RA, Hanania NA. Test Performance Characteristics of the AIR, GAD-7 and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2018 Jul 09. PMID: 29986152.
      View in: PubMed
    16. Braddock M, Hanania NA, Sharafkhaneh A, Colice G, Carlsson M. Potential Risks Related to Modulating Interleukin-13 and Interleukin-4 Signalling: A Systematic Review. Drug Saf. 2018 05; 41(5):489-509. PMID: 29411337.
      View in: PubMed
    17. Braman SS, Carlin BW, Hanania NA, Mahler DA, Ohar JA, Pinto-Plata V, Shah T, Eubanks D, Dhand R. Results of a Pulmonologist Survey Regarding Knowledge and Practices With Inhalation Devices for COPD. Respir Care. 2018 07; 63(7):840-848. PMID: 29717099.
      View in: PubMed
    18. Hanania NA, Massanari M, Jain N. Measurement of fractional exhaled nitric oxide in real-world clinical practice alters asthma treatment decisions. Ann Allergy Asthma Immunol. 2018 04; 120(4):414-418.e1. PMID: 29408317.
      View in: PubMed
    19. Hanania NA, Braman S, Adams SG, Adewuya R, Ari A, Brooks J, Mahler DA, Ohar JA, Peters J, Sanjar S. The Role of Inhalation Delivery Devices in COPD: Perspectives of Patients and Health Care Providers. Chronic Obstr Pulm Dis. 2018 Apr 01; 5(2):111-123. PMID: 30374449.
      View in: PubMed
    20. Dhand R, Mahler DA, Carlin BW, Hanania NA, Ohar JA, Pinto-Plata V, Shah T, Eubanks D, Braman SS. Results of a Patient Survey Regarding COPD Knowledge, Treatment Experiences, and Practices With Inhalation Devices. Respir Care. 2018 07; 63(7):833-839. PMID: 29559537.
      View in: PubMed
    21. Cazzola M, Calzetta L, Matera MG, Hanania NA, Rogliani P. How does race/ethnicity influence pharmacological response to asthma therapies? Expert Opin Drug Metab Toxicol. 2018 Apr; 14(4):435-446. PMID: 29528249.
      View in: PubMed
    22. Donohue JF, Bollu VK, Stull DE, Nelson LM, Williams VS, Stensland MD, Hanania NA. Long-term health-related quality-of-life and symptom response profiles with arformoterol in COPD: results from a 52-week trial. Int J Chron Obstruct Pulmon Dis. 2018; 13:499-508. PMID: 29440887.
      View in: PubMed
    23. Yohannes AM, Kaplan A, Hanania NA. Anxiety and Depression in Chronic Obstructive Pulmonary Disease: Recognition and Management. Cleve Clin J Med. 2018 Feb; 85(2 Suppl 1):S11-S18. PMID: 29494328.
      View in: PubMed
    24. Yohannes AM, Kaplan A, Hanania NA. COPD in Primary Care: Key Considerations for Optimized Management: Anxiety and Depression in Chronic Obstructive Pulmonary Disease: Recognition and Management. J Fam Pract. 2018 Feb; 67(2 Suppl):S11-S18. PMID: 29443332.
      View in: PubMed
    25. Humbert M, Busse W, Hanania NA. Controversies and opportunities in severe asthma. Curr Opin Pulm Med. 2018 01; 24(1):83-93. PMID: 29059087.
      View in: PubMed
    26. Hanania NA, Diamant Z. The road to precision medicine in asthma: challenges and opportunities. Curr Opin Pulm Med. 2018 01; 24(1):1-3. PMID: 29045293.
      View in: PubMed
    27. Parulekar AD, Kao CC, Diamant Z, Hanania NA. Targeting the interleukin-4 and interleukin-13 pathways in severe asthma: current knowledge and future needs. Curr Opin Pulm Med. 2018 01; 24(1):50-55. PMID: 29036019.
      View in: PubMed
    28. Bousquet J, Brusselle G, Buhl R, Busse WW, Cruz AA, Djukanovic R, Domingo C, Hanania NA, Humbert M, Menzies Gow A, Phipatanakul W, Wahn U, Wechsler ME. Care pathways for the selection of a biologic in severe asthma. Eur Respir J. 2017 12; 50(6). PMID: 29217605.
      View in: PubMed
    29. Narendra DK, Hanania NA. Procalcitonin in Chronic Obstructive Pulmonary Disease Exacerbations: Is It Ready for Primetime Use? Ann Am Thorac Soc. 2017 Dec; 14(12):1757-1758. PMID: 29192825.
      View in: PubMed
    30. Parulekar AD, Martinez C, Tsai CL, Locantore N, Atik M, Yohannes AM, Kao CC, Al-Azzawi H, Mohsin A, Wise RA, Foreman MG, Demeo DL, Regan EA, Make BJ, Boriek AM, Wiener LE, Hanania NA. Examining the Effects of Age on Health Outcomes of Chronic Obstructive Pulmonary Disease: Results From the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease Study and Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate Endpoints Cohorts. J Am Med Dir Assoc. 2017 Dec 01; 18(12):1063-1068. PMID: 29169736.
      View in: PubMed
    31. Rogers L, Sugar EA, Blake K, Castro M, Dimango E, Hanania NA, Happel KI, Peters SP, Reibman J, Saams J, Teague WG, Wise RA, Holbrook JT. Step-Down Therapy for Asthma Well Controlled on Inhaled Corticosteroid and Long-Acting Beta-Agonist: A Randomized Clinical Trial. J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2):633-643.e1. PMID: 28974349.
      View in: PubMed
    32. Casale TB, Chipps BE, Rosén K, Trzaskoma B, Haselkorn T, Omachi TA, Greenberg S, Hanania NA. Response to omalizumab using patient enrichment criteria from trials of novel biologics in asthma. Allergy. 2018 02; 73(2):490-497. PMID: 28859263.
      View in: PubMed
    33. Medrek SK, Parulekar AD, Hanania NA. Predictive Biomarkers for Asthma Therapy. Curr Allergy Asthma Rep. 2017 Sep 19; 17(10):69. PMID: 28929293.
      View in: PubMed
    34. Boriek AM, Lopez MA, Velasco C, Bakir AA, Frolov A, Wynd S, Babb TG, Hanania NA, Hoffman EA, Sharafkhaneh A. Obesity modulates diaphragm curvature in subjects with and without COPD. Am J Physiol Regul Integr Comp Physiol. 2017 Nov 01; 313(5):R620-R629. PMID: 28903915.
      View in: PubMed
    35. Mangold R, Salzman GA, Williams KB, Hanania NA. Factors associated with depressive symptoms in uncontrolled asthmatics. J Asthma. 2018 05; 55(5):555-560. PMID: 28759275.
      View in: PubMed
    36. Monaco TJ, Hanania NA. Emerging inhaled long-acting beta-2 adrenoceptor agonists for the treatment of COPD. Expert Opin Emerg Drugs. 2017 09; 22(3):285-299. PMID: 28868931.
      View in: PubMed
    37. Cazzola M, Rogliani P, Calzetta L, Hanania NA, Matera MG. Impact of Mucolytic Agents on COPD Exacerbations: A Pair-wise and Network Meta-analysis. COPD. 2017 Oct; 14(5):552-563. PMID: 28753070.
      View in: PubMed
    38. Goto T, Faridi MK, Gibo K, Toh S, Hanania NA, Camargo CA, Hasegawa K. Trends in 30-day readmission rates after COPD hospitalization, 2006-2012. Respir Med. 2017 Sep; 130:92-97. PMID: 29206640.
      View in: PubMed
    39. Yohannes AM, Mülerová H, Lavoie K, Vestbo J, Rennard SI, Wouters E, Hanania NA. The Association of Depressive Symptoms With Rates of Acute Exacerbations in Patients With COPD: Results From a 3-year Longitudinal Follow-up of the ECLIPSE Cohort. J Am Med Dir Assoc. 2017 Nov 01; 18(11):955-959.e6. PMID: 28733182.
      View in: PubMed
    40. Kaminsky DA, Guntupalli KK, Lippmann J, Burns SM, Brock MA, Skelly J, DeSarno M, Pecott-Grimm H, Mohsin A, LaRock-McMahon C, Warren P, Whitney MC, Hanania NA. Effect of Yoga Breathing (Pranayama) on Exercise Tolerance in Patients with Chronic Obstructive Pulmonary Disease: A Randomized, Controlled Trial. J Altern Complement Med. 2017 Sep; 23(9):696-704. PMID: 28714735.
      View in: PubMed
    41. Sapir T, Moreo KF, Greene LS, Simone LC, Carter JD, Mateka JJL, Hanania NA. Assessing Patient and Provider Perceptions of Factors Associated with Patient Engagement in Asthma Care. Ann Am Thorac Soc. 2017 May; 14(5):659-666. PMID: 28128966.
      View in: PubMed
    42. Hanania NA, Lareau SC, Yawn BP. Safety of inhaled long-acting anti-muscarinic agents in COPD. Postgrad Med. 2017 Jun; 129(5):500-512. PMID: 28395575.
      View in: PubMed
    43. Sethi S, Fogarty C, Hanania NA, Martinez FJ, Rennard S, Fries M, Orevillo C, Darken P, St Rose E, Strom S, Fischer T, Golden M, Dwivedi S, Reisner C. Erratum: Erratum: Efficacy of Formoterol Fumarate Delivered by Metered Dose Inhaler Using Co-Suspension™ Delivery Technology Versus Foradil® Aerolizer® in Moderate-To-Severe COPD: A Randomized, Dose-Ranging Study. Chronic Obstr Pulm Dis. 2017 Apr 15; 4(3):258. PMID: 28853450.
      View in: PubMed
    44. Hanania NA, Tashkin DP, Kerwin EM, Donohue JF, Denenberg M, O'Donnell DE, Quinn D, Siddiqui S, Orevillo C, Maes A, Reisner C. Long-term safety and efficacy of glycopyrrolate/formoterol metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with chronic obstructive pulmonary disease. Respir Med. 2017 05; 126:105-115. PMID: 28427541.
      View in: PubMed
    45. Biswas R, Hanania NA, Sabharwal A. Factors Determining In Vitro Lung Deposition of Albuterol Aerosol Delivered by Ventolin Metered-Dose Inhaler. J Aerosol Med Pulm Drug Deliv. 2017 Aug; 30(4):256-266. PMID: 28157430.
      View in: PubMed
    46. Robinson D, Humbert M, Buhl R, Cruz AA, Inoue H, Korom S, Hanania NA, Nair P. Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy. 2017 Feb; 47(2):161-175. PMID: 28036144.
      View in: PubMed
    47. Parulekar AD, Diamant Z, Hanania NA. Role of biologics targeting type 2 airway inflammation in asthma: what have we learned so far? Curr Opin Pulm Med. 2017 01; 23(1):3-11. PMID: 27820746.
      View in: PubMed
    48. Diamant Z, Hanania NA. Generic medications in precision medicine in asthma. Curr Opin Pulm Med. 2017 01; 23(1):1-2. PMID: 27902500.
      View in: PubMed
    49. Medrek SK, Kao CC, Yang DH, Hanania NA, Parulekar AD. Fungal Sensitization Is Associated with Increased Risk of Life-Threatening Asthma. J Allergy Clin Immunol Pract. 2017 Jul - Aug; 5(4):1025-1031.e2. PMID: 28017627.
      View in: PubMed
    50. Sethi S, Fogarty C, Hanania NA, Martinez FJ, Rennard S, Fries M, Orevillo C, Darken P, St Rose E, Strom S, Fischer T, Golden M, Dwivedi S, Reisner C. Efficacy of Formoterol Fumarate Delivered by Metered Dose Inhaler Using Co-Suspension™ Delivery Technology Versus Foradil® Aerolizer® in Moderate-To-Severe COPD: A Randomized, Dose-Ranging Study. Chronic Obstr Pulm Dis. 2016 Nov 17; 4(1):21-33. PMID: 28848908.
      View in: PubMed
    51. Wise RA, Acevedo RA, Anzueto AR, Hanania NA, Martinez FJ, Ohar JA, Tashkin DP. Guiding Principles for the Use of Nebulized Long-Acting Beta2-Agonists in Patients with COPD: An Expert Panel Consensus. Chronic Obstr Pulm Dis. 2016 Nov 15; 4(1):7-20. PMID: 28848907.
      View in: PubMed
    52. Skloot GS, Busse PJ, Braman SS, Kovacs EJ, Dixon AE, Vaz Fragoso CA, Scichilone N, Prakash YS, Pabelick CM, Mathur SK, Hanania NA, Moore WC, Gibson PG, Zieman S, Ragless BB. An Official American Thoracic Society Workshop Report: Evaluation and Management of Asthma in the Elderly. Ann Am Thorac Soc. 2016 11; 13(11):2064-2077. PMID: 27831798.
      View in: PubMed
    53. Hanania NA, Korenblat P, Chapman KR, Bateman ED, Kopecky P, Paggiaro P, Yokoyama A, Olsson J, Gray S, Holweg CT, Eisner M, Asare C, Fischer SK, Peng K, Putnam WS, Matthews JG. Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials. Lancet Respir Med. 2016 10; 4(10):781-796. PMID: 27616196.
      View in: PubMed
    54. Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, Kinney GL, McDonald MN, Brigham EP, Wise RA, McCormack MC, Hansel NN. Obesity Is Associated With Increased Morbidity in Moderate to Severe COPD. Chest. 2017 Jan; 151(1):68-77. PMID: 27568229.
      View in: PubMed
    55. Sun W, Kechris K, Jacobson S, Drummond MB, Hawkins GA, Yang J, Chen TH, Quibrera PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Silverman EK, Woodruff PG, O'Neal WK, Bowler RP. Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet. 2016 Aug; 12(8):e1006011. PMID: 27532455.
      View in: PubMed
    56. Herscher ML, Wisnivesky JP, Busse PJ, Hanania NA, Sheng T, Wolf MS, Federman AD. Characteristics and outcomes of older adults with long-standing versus late-onset asthma. J Asthma. 2017 04; 54(3):223-229. PMID: 27459257.
      View in: PubMed
    57. Kim V, Zhao H, Boriek AM, Anzueto A, Soler X, Bhatt SP, Rennard SI, Wise R, Comellas A, Ramsdell JW, Kinney GL, Han MK, Martinez CH, Yen A, Black-Shinn J, Porszasz J, Criner GJ, Hanania NA, Sharafkhaneh A, Crapo JD, Make BJ, Silverman EK, Curtis JL. Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2016 07; 13(7):1016-25. PMID: 27158740.
      View in: PubMed
    58. Banerji D, Mahler DA, Hanania NA. Efficacy and safety of LABA/LAMA fixed-dose combinations approved in the US for the management of COPD. Expert Rev Respir Med. 2016 07; 10(7):767-80. PMID: 27223863.
      View in: PubMed
    59. Bujarski S, Parulekar AD, Hanania NA. Lebrikizumab in the treatment of asthma. Expert Opin Biol Ther. 2016 May 10. PMID: 27161908.
      View in: PubMed
    60. Buhl R, Korn S, Menzies-Gow A, Aubier M, Chapman KR, Canonica GW, Picado C, Martin N, Escobar RA, Korom S, Hanania NA. Assessing biomarkers in a real-world severe asthma study (ARIETTA). Respir Med. 2016 06; 115:7-12. PMID: 27215497.
      View in: PubMed
    61. Yohannes AM, Dryden S, Hanania NA. The Responsiveness of the Anxiety Inventory for Respiratory Disease Scale Following Pulmonary Rehabilitation. Chest. 2016 07; 150(1):188-95. PMID: 26953219.
      View in: PubMed
    62. Yohannes AM, Müllerová H, Hanania NA, Lavoie K, Tal-Singer R, Vestbo J, Rennard SI, Wouters EF. Long-term Course of Depression Trajectories in Patients With COPD: A 3-Year Follow-up Analysis of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Cohort. Chest. 2016 Apr; 149(4):916-26. PMID: 26836938.
      View in: PubMed
    63. Diamant Z, Hanania NA. Editorial: The new look on asthma: linking phenotypes, endotypes and biomarkers to asthma management. Curr Opin Pulm Med. 2016 Jan; 22(1):1-2. PMID: 26574722.
      View in: PubMed
    64. Parulekar AD, Diamant Z, Hanania NA. Role of T2 inflammation biomarkers in severe asthma. Curr Opin Pulm Med. 2016 Jan; 22(1):59-68. PMID: 26574724.
      View in: PubMed
    65. Martinez CH, Diaz AA, Parulekar AD, Rennard SI, Kanner RE, Hansel NN, Couper D, Holm KE, Hoth KF, Curtis JL, Martinez FJ, Hanania NA, Regan EA, Paine R, Cigolle CT, Han MK. Age-Related Differences in Health-Related Quality of Life in COPD: An Analysis of the COPDGene and SPIROMICS Cohorts. Chest. 2016 Apr; 149(4):927-35. PMID: 26836895.
      View in: PubMed
    66. Checkley W, Foreman MG, Bhatt SP, Dransfield MT, Han M, Hanania NA, Hansel NN, Regan EA, Wise RA. Differences between absolute and predicted values of forced expiratory volumes to classify ventilatory impairment in chronic obstructive pulmonary disease. Respir Med. 2016 Feb; 111:30-8. PMID: 26712569; PMCID: PMC4955626 [Available on 02/01/17].
    67. Douglas IS, Albertson TE, Folan P, Hanania NA, Tashkin DP, Upson DJ, Leone FT. Implications of Marijuana Decriminalization on the Practice of Pulmonary, Critical Care, and Sleep Medicine. A Report of the American Thoracic Society Marijuana Workgroup. Ann Am Thorac Soc. 2015 Nov; 12(11):1700-10. PMID: 26540421.
      View in: PubMed
    68. Djukanovic R, Hanania N, Busse W, Price D. IgE-mediated asthma: New revelations and future insights. Respir Med. 2016 Mar; 112:128-9. PMID: 26577335.
      View in: PubMed
    69. Hanania NA, Noonan M, Corren J, Korenblat P, Zheng Y, Fischer SK, Cheu M, Putnam WS, Murray E, Scheerens H, Holweg CT, Maciuca R, Gray S, Doyle R, McClintock D, Olsson J, Matthews JG, Yen K. Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies. Thorax. 2015 Aug; 70(8):748-56. PMID: 26001563.
      View in: PubMed
    70. Cazzola M, Hanania NA, MacNee W, Rüdell K, Hackford C, Tamimi N. A review of the most common patient-reported outcomes in COPD--revisiting current knowledge and estimating future challenges. Int J Chron Obstruct Pulmon Dis. 2015; 10:725-38. PMID: 25897216; PMCID: PMC4396518.
    71. Criner GJ, Bourbeau J, Diekemper RL, Ouellette DR, Goodridge D, Hernandez P, Curren K, Balter MS, Bhutani M, Camp PG, Celli BR, Dechman G, Dransfield MT, Fiel SB, Foreman MG, Hanania NA, Ireland BK, Marchetti N, Marciniuk DD, Mularski RA, Ornelas J, Road JD, Stickland MK. Prevention of acute exacerbations of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline. Chest. 2015 Apr; 147(4):894-942. PMID: 25321320; PMCID: PMC4388124.
    72. Criner GJ, Bourbeau J, Diekemper RL, Ouellette DR, Goodridge D, Hernandez P, Curren K, Balter MS, Bhutani M, Camp PG, Celli BR, Dechman G, Dransfield MT, Fiel SB, Foreman MG, Hanania NA, Ireland BK, Marchetti N, Marciniuk DD, Mularski RA, Ornelas J, Road JD, Stickland MK. Executive summary: prevention of acute exacerbation of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline. Chest. 2015 Apr; 147(4):883-893. PMID: 25320966; PMCID: PMC4388123.
    73. Chow L, Parulekar AD, Hanania NA. Hospital management of acute exacerbations of chronic obstructive pulmonary disease. J Hosp Med. 2015 May; 10(5):328-39. PMID: 25820201.
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    74. Bujarski S, Parulekar AD, Sharafkhaneh A, Hanania NA. The asthma COPD overlap syndrome (ACOS). Curr Allergy Asthma Rep. 2015 Mar; 15(3):509. PMID: 25712010.
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    75. Parulekar AD, Diamant Z, Hanania NA. Antifungals in severe asthma. Curr Opin Pulm Med. 2015 Jan; 21(1):48-54. PMID: 25415408.
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    76. Rogers L, Hanania NA. Role of anticholinergics in asthma management: recent evidence and future needs. Curr Opin Pulm Med. 2015 Jan; 21(1):103-8. PMID: 25415409.
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    77. Crim C, Dransfield MT, Bourbeau J, Jones PW, Hanania NA, Mahler DA, Vestbo J, Wachtel A, Martinez FJ, Barnhart F, Lettis S, Calverley PM. Pneumonia risk with inhaled fluticasone furoate and vilanterol compared with vilanterol alone in patients with COPD. Ann Am Thorac Soc. 2015 Jan; 12(1):27-34. PMID: 25490706.
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    78. Putcha N, Puhan MA, Drummond MB, Han MK, Regan EA, Hanania NA, Martinez CH, Foreman M, Bhatt SP, Make B, Ramsdell J, DeMeo DL, Barr RG, Rennard SI, Martinez F, Silverman EK, Crapo J, Wise RA, Hansel NN. A simplified score to quantify comorbidity in COPD. PLoS One. 2014; 9(12):e114438. PMID: 25514500.
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    79. Donohue JF, Hanania NA, Make B, Miles MC, Mahler DA, Curry L, Tosiello R, Wheeler A, Tashkin DP. One-year safety and efficacy study of arformoterol tartrate in patients with moderate to severe COPD. Chest. 2014 Dec; 146(6):1531-1542. PMID: 25451347; PMCID: PMC4251615.
    80. Qureshi H, Sharafkhaneh A, Hanania NA. Chronic obstructive pulmonary disease exacerbations: latest evidence and clinical implications. Ther Adv Chronic Dis. 2014 Sep; 5(5):212-27. PMID: 25177479; PMCID: PMC4131503.
    81. Sharafkhaneh A, Altan AE, Colice GL, Hanania NA, Donohue JF, Kurlander JL, Rodriguez-Roisin R, Altman PR. A simple rule to identify patients with chronic obstructive pulmonary disease who may need treatment reevaluation. Respir Med. 2014 Sep; 108(9):1310-20. PMID: 25130680.
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    82. Humbert M, Busse W, Hanania NA, Lowe PJ, Canvin J, Erpenbeck VJ, Holgate S. Omalizumab in asthma: an update on recent developments. J Allergy Clin Immunol Pract. 2014 Sep-Oct; 2(5):525-36.e1. PMID: 25213045.
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    83. Hanania NA. The Saudi guidelines for chronic obstructive pulmonary disease: A fresh "Real-World" approach to COPD. Ann Thorac Med. 2014 Apr; 9(2):53-4. PMID: 24791167; PMCID: PMC4005163.
    84. Koshy S, Huq R, Tanner MR, Atik MA, Porter PC, Khan FS, Pennington MW, Hanania NA, Corry DB, Beeton C. Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma. J Biol Chem. 2014 May 02; 289(18):12623-32. PMID: 24644290; PMCID: PMC4007452.
    85. Parulekar AD, Atik MA, Hanania NA. Periostin, a novel biomarker of TH2-driven asthma. Curr Opin Pulm Med. 2014 Jan; 20(1):60-5. PMID: 24247042.
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    86. Putcha N, Han MK, Martinez CH, Foreman MG, Anzueto AR, Casaburi R, Cho MH, Hanania NA, Hersh CP, Kinney GL, Make BJ, Steiner RM, Lutz SM, Thomashow BM, Williams AA, Bhatt SP, Beaty TH, Bowler RP, Ramsdell JW, Curtis JL, Everett D, Hokanson JE, Lynch DA, Sutherland ER, Silverman EK, Crapo JD, Wise RA, Regan EA, Hansel NN. Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans. Chronic Obstr Pulm Dis. 2014; 1(1):105-114. PMID: 25695106.
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    87. Hanania NA. Evaluating the safety of COPD medications: an evidence-based review. Chest. 2013 Oct; 144(4):1357-1367. PMID: 24081347.
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    88. Hanania NA, Calverley PM, Dransfield MT, Karpel JP, Brose M, Zhu H, Goehring UM, Rowe P. Pooled subpopulation analyses of the effects of roflumilast on exacerbations and lung function in COPD. Respir Med. 2014 Feb; 108(2):366-75. PMID: 24120253.
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    89. Wechsler ME, Laviolette M, Rubin AS, Fiterman J, Lapa e Silva JR, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Hales JB, McEvoy C, Slebos DJ, Holmes M, Phillips MJ, Erzurum SC, Hanania NA, Sumino K, Kraft M, Cox G, Sterman DH, Hogarth K, Kline JN, Mansur AH, Louie BE, Leeds WM, Barbers RG, Austin JH, Shargill NS, Quiring J, Armstrong B, Castro M. Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma. J Allergy Clin Immunol. 2013 Dec; 132(6):1295-302. PMID: 23998657; PMCID: PMC4114404.
    90. Hanania NA, Wenzel S, Rosén K, Hsieh HJ, Mosesova S, Choy DF, Lal P, Arron JR, Harris JM, Busse W. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):804-11. PMID: 23471469.
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    91. Dransfield MT, Bourbeau J, Jones PW, Hanania NA, Mahler DA, Vestbo J, Wachtel A, Martinez FJ, Barnhart F, Sanford L, Lettis S, Crim C, Calverley PM. Once-daily inhaled fluticasone furoate and vilanterol versus vilanterol only for prevention of exacerbations of COPD: two replicate double-blind, parallel-group, randomised controlled trials. Lancet Respir Med. 2013 May; 1(3):210-23. PMID: 24429127.
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    92. Sharafkhaneh A, Wolf RA, Goodnight S, Hanania NA, Make BJ, Tashkin DP. Perceptions and attitudes toward the use of nebulized therapy for COPD: patient and caregiver perspectives. COPD. 2013 Aug; 10(4):482-92. PMID: 23875742.
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    93. Yohannes AM, Connolly MJ, Hanania NA. Ten years of tiotropium: clinical impact and patient perspectives. Int J Chron Obstruct Pulmon Dis. 2013; 8:117-25. PMID: 23515335; PMCID: PMC3600941.
    94. Spencer P, Hanania NA. Optimizing safety of COPD treatments: role of the nurse practitioner. J Multidiscip Healthc. 2013; 6:53-63. PMID: 23459224; PMCID: PMC3583441.
    95. Tsai CL, Lee WY, Delclos GL, Hanania NA, Camargo CA. Comparative effectiveness of noninvasive ventilation vs invasive mechanical ventilation in chronic obstructive pulmonary disease patients with acute respiratory failure. J Hosp Med. 2013 Apr; 8(4):165-72. PMID: 23401469.
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    96. Tsai CL, Delclos GL, Huang JS, Hanania NA, Camargo CA. Age-related differences in asthma outcomes in the United States, 1988-2006. Ann Allergy Asthma Immunol. 2013 Apr; 110(4):240-6, 246.e1. PMID: 23535086.
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    97. Hansel NN, Washko GR, Foreman MG, Han MK, Hoffman EA, DeMeo DL, Barr RG, Van Beek EJ, Kazerooni EA, Wise RA, Brown RH, Black-Shinn J, Hokanson JE, Hanania NA, Make B, Silverman EK, Crapo JD, Dransfield MT. Racial differences in CT phenotypes in COPD. COPD. 2013 Feb; 10(1):20-7. PMID: 23413893; PMCID: PMC4321889.
    98. Decramer ML, Hanania NA, Lötvall JO, Yawn BP. The safety of long-acting ß2-agonists in the treatment of stable chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2013; 8:53-64. PMID: 23378756; PMCID: PMC3558319.
    99. Parulekar AD, Alobaidy A, Hanania NA. Asthma outcomes revisited. Curr Opin Pulm Med. 2013 Jan; 19(1):6-12. PMID: 23196270.
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    100. Hanania NA. Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Respir Med. 2012 Dec; 106 Suppl 2:S1-2. PMID: 23290699.
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    101. Adams SG, Pitts J, Wynne J, Yawn BP, Diamond EJ, Lee S, Dellert E, Hanania NA. Effect of a primary care continuing education program on clinical practice of chronic obstructive pulmonary disease: translating theory into practice. Mayo Clin Proc. 2012 Sep; 87(9):862-70. PMID: 22958990.
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    102. Al-shair K, Muellerova H, Yorke J, Rennard SI, Wouters EF, Hanania NA, Sharafkhaneh A, Vestbo J. Examining fatigue in COPD: development, validity and reliability of a modified version of FACIT-F scale. Health Qual Life Outcomes. 2012 Aug 23; 10:100. PMID: 22913289; PMCID: PMC3491053.
    103. Hanania NA, Feldman G, Zachgo W, Shim JJ, Crim C, Sanford L, Lettis S, Barnhart F, Haumann B. The efficacy and safety of the novel long-acting ß2 agonist vilanterol in patients with COPD: a randomized placebo-controlled trial. Chest. 2012 Jul; 142(1):119-127. PMID: 22241764.
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    104. Mak G, Hanania NA. New bronchodilators. Curr Opin Pharmacol. 2012 Jun; 12(3):238-45. PMID: 22445544.
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    105. Barr RG, Berkowitz EA, Bigazzi F, Bode F, Bon J, Bowler RP, Chiles C, Crapo JD, Criner GJ, Curtis JL, Dass C, Dirksen A, Dransfield MT, Edula G, Erikkson L, Friedlander A, Galperin-Aizenberg M, Gefter WB, Gierada DS, Grenier PA, Goldin J, Han MK, Hanania NA, Hansel NN, Jacobson FL, Kauczor HU, Kinnula VL, Lipson DA, Lynch DA, MacNee W, Make BJ, Mamary AJ, Mann H, Marchetti N, Mascalchi M, McLennan G, Murphy JR, Naidich D, Nath H, Newell JD, Pistolesi M, Regan EA, Reilly JJ, Sandhaus R, Schroeder JD, Sciurba F, Shaker S, Sharafkhaneh A, Silverman EK, Steiner RM, Strange C, Sverzellati N, Tashjian JH, van Beek EJ, Washington L, Washko GR, Westney G, Wood SA, Woodruff PG. A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD. 2012 Apr; 9(2):151-9. PMID: 22429093; PMCID: PMC3752926.
    106. Tsai CL, Lee WY, Hanania NA, Camargo CA. Age-related differences in clinical outcomes for acute asthma in the United States, 2006-2008. J Allergy Clin Immunol. 2012 May; 129(5):1252-1258.e1. PMID: 22385630.
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    107. Kuhl K, Hanania NA. Targeting IgE in asthma. Curr Opin Pulm Med. 2012 Jan; 18(1):1-5. PMID: 22139745.
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    108. Tamimi A, Serdarevic D, Hanania NA. The effects of cigarette smoke on airway inflammation in asthma and COPD: therapeutic implications. Respir Med. 2012 Mar; 106(3):319-28. PMID: 22196881.
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    109. Hanania NA, Crater GD, Morris AN, Emmett AH, O'Dell DM, Niewoehner DE. Benefits of adding fluticasone propionate/salmeterol to tiotropium in moderate to severe COPD. Respir Med. 2012 Jan; 106(1):91-101. PMID: 22040533.
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    110. Kao CC, Hsu JW, Bandi V, Hanania NA, Kheradmand F, Jahoor F. Glucose and pyruvate metabolism in severe chronic obstructive pulmonary disease. J Appl Physiol (1985). 2012 Jan; 112(1):42-7. PMID: 22016370; PMCID: PMC3290418.
    111. Dalal AA, Shah M, Lunacsek O, Hanania NA. Clinical and economic burden of patients diagnosed with COPD with comorbid cardiovascular disease. Respir Med. 2011 Oct; 105(10):1516-22. PMID: 21684731.
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    112. Hanania NA, Celli BR, Donohue JF, Martin UJ. Bronchodilator reversibility in COPD. Chest. 2011 Oct; 140(4):1055-1063. PMID: 21972384.
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    113. Gross NJ, Hanania NA. The COPD Pipeline XII. COPD. 2011 Oct; 8(5):387-91. PMID: 21905763.
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    114. Hanania NA, King MJ, Braman SS, Saltoun C, Wise RA, Enright P, Falsey AR, Mathur SK, Ramsdell JW, Rogers L, Stempel DA, Lima JJ, Fish JE, Wilson SR, Boyd C, Patel KV, Irvin CG, Yawn BP, Halm EA, Wasserman SI, Sands MF, Ershler WB, Ledford DK. Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshop. J Allergy Clin Immunol. 2011 Sep; 128(3 Suppl):S4-24. PMID: 21872730; PMCID: PMC3164961.
    115. Hanania NA, Marciniuk DD. A unified front against COPD: clinical practice guidelines from the American College of Physicians, the American College of Chest Physicians, the American Thoracic Society, and the European Respiratory Society. Chest. 2011 Sep; 140(3):565-566. PMID: 21896511.
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    116. Dalal AA, Shah M, Lunacsek O, Hanania NA. Clinical and economic burden of depression/anxiety in chronic obstructive pulmonary disease patients within a managed care population. COPD. 2011 Aug; 8(4):293-9. PMID: 21827298.
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    117. Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, Harris JM, Scheerens H, Wu LC, Su Z, Mosesova S, Eisner MD, Bohen SP, Matthews JG. Lebrikizumab treatment in adults with asthma. N Engl J Med. 2011 Sep 22; 365(12):1088-98. PMID: 21812663.
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    118. Qaseem A, Wilt TJ, Weinberger SE, Hanania NA, Criner G, van der Molen T, Marciniuk DD, Denberg T, Schünemann H, Wedzicha W, MacDonald R, Shekelle P. Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society. Ann Intern Med. 2011 Aug 02; 155(3):179-91. PMID: 21810710.
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    119. Han MK, Kazerooni EA, Lynch DA, Liu LX, Murray S, Curtis JL, Criner GJ, Kim V, Bowler RP, Hanania NA, Anzueto AR, Make BJ, Hokanson JE, Crapo JD, Silverman EK, Martinez FJ, Washko GR. Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology. 2011 Oct; 261(1):274-82. PMID: 21788524.
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    120. Kim YI, Schroeder J, Lynch D, Newell J, Make B, Friedlander A, Estépar RS, Hanania NA, Washko G, Murphy JR, Wilson C, Hokanson JE, Zach J, Butterfield K, Bowler RP. Gender differences of airway dimensions in anatomically matched sites on CT in smokers. COPD. 2011 Aug; 8(4):285-92. PMID: 21756032; PMCID: PMC3703311.
    121. Han MK, Curran-Everett D, Dransfield MT, Criner GJ, Zhang L, Murphy JR, Hansel NN, DeMeo DL, Hanania NA, Regan EA, Make BJ, Martinez FJ, Westney GE, Foreman MG. Racial differences in quality of life in patients with COPD. Chest. 2011 Nov; 140(5):1169-1176. PMID: 21636665; PMCID: PMC3205846.
    122. Drexel C, Jacobson A, Hanania NA, Whitfield B, Katz J, Sullivan T. Measuring the impact of a live, case-based, multiformat, interactive continuing medical education program on improving clinician knowledge and competency in evidence-based COPD care. Int J Chron Obstruct Pulmon Dis. 2011; 6:297-307. PMID: 21697994.
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    123. Kao CC, Hsu JW, Bandi V, Hanania NA, Kheradmand F, Jahoor F. Resting energy expenditure and protein turnover are increased in patients with severe chronic obstructive pulmonary disease. Metabolism. 2011 Oct; 60(10):1449-55. PMID: 21550084; PMCID: PMC3176951.
    124. Hanania NA, Alpan O, Hamilos DL, Condemi JJ, Reyes-Rivera I, Zhu J, Rosen KE, Eisner MD, Wong DA, Busse W. Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial. Ann Intern Med. 2011 May 03; 154(9):573-82. PMID: 21536936.
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    125. Mintz ML, Yawn BP, Mannino DM, Donohue JF, Hanania NA, Grellet CA, Gilsenan AW, McLeod LD, Dalal AA, Raphiou IH, Prillaman BA, Crater GD, Cicale MJ, Mapel DW. Prevalence of airway obstruction assessed by lung function questionnaire. Mayo Clin Proc. 2011 May; 86(5):375-81. PMID: 21531880; PMCID: PMC3084639.
    126. Hanania NA. Safety of chronic obstructive pulmonary disease medications: a primary care perspective. Postgrad Med. 2011 May; 123(3):72-9. PMID: 21566417.
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    127. Walker JK, Penn RB, Hanania NA, Dickey BF, Bond RA. New perspectives regarding ß(2) -adrenoceptor ligands in the treatment of asthma. Br J Pharmacol. 2011 May; 163(1):18-28. PMID: 21175591; PMCID: PMC3085865.
    128. Castro M, Rubin A, Laviolette M, Hanania NA, Armstrong B, Cox G. Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma. Ann Allergy Asthma Immunol. 2011 Jul; 107(1):65-70. PMID: 21704887.
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    129. Hanania NA, Sharafkhaneh A, Celli B, Decramer M, Lystig T, Kesten S, Tashkin D. Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trial. Respir Res. 2011 Jan 11; 12:6. PMID: 21219660; PMCID: PMC3027109.
    130. Mak G, Hanania NA. Vitamin D and asthma. Curr Opin Pulm Med. 2011 Jan; 17(1):1-5. PMID: 21045696.
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    131. Hanania NA, Sharma G, Sharafkhaneh A. COPD in the elderly patient. Semin Respir Crit Care Med. 2010 Oct; 31(5):596-606. PMID: 20941660.
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    132. Sharafkhaneh A, Mattewal AS, Abraham VM, Dronavalli G, Hanania NA. Budesonide/formoterol combination in COPD: a US perspective. Int J Chron Obstruct Pulmon Dis. 2010 Oct 05; 5:357-66. PMID: 21037960; PMCID: PMC2962302.
    133. Hanania NA, Mannava B, Franklin AE, Lipworth BJ, Williamson PA, Garner WJ, Dickey BF, Bond RA. Response to salbutamol in patients with mild asthma treated with nadolol. Eur Respir J. 2010 Oct; 36(4):963-5. PMID: 20889466.
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    134. Hanania NA, Müllerova H, Locantore NW, Vestbo J, Watkins ML, Wouters EF, Rennard SI, Sharafkhaneh A. Determinants of depression in the ECLIPSE chronic obstructive pulmonary disease cohort. Am J Respir Crit Care Med. 2011 Mar 01; 183(5):604-11. PMID: 20889909.
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    135. Dickey BF, Walker JK, Hanania NA, Bond RA. beta-Adrenoceptor inverse agonists in asthma. Curr Opin Pharmacol. 2010 Jun; 10(3):254-9. PMID: 20399707; PMCID: PMC2905467.
    136. Sharafkhaneh A, Petersen NJ, Yu HJ, Dalal AA, Johnson ML, Hanania NA. Burden of COPD in a government health care system: a retrospective observational study using data from the US Veterans Affairs population. Int J Chron Obstruct Pulmon Dis. 2010 May 06; 5:125-32. PMID: 20461144; PMCID: PMC2866562.
    137. Cazzola M, Hanania NA, Matera MG. Arformoterol tartrate in the treatment of COPD. Expert Rev Respir Med. 2010 Apr; 4(2):155-62. PMID: 20406080.
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    138. Hanania NA, Mannino DM, Yawn BP, Mapel DW, Martinez FJ, Donohue JF, Kosinski M, Rendas-Baum R, Mintz M, Samuels S, Jhingran P, Dalal AA. Predicting risk of airflow obstruction in primary care: Validation of the lung function questionnaire (LFQ). Respir Med. 2010 Aug; 104(8):1160-70. PMID: 20226647.
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    139. Yawn BP, Mapel DW, Mannino DM, Martinez FJ, Donohue JF, Hanania NA, Kosinski M, Rendas-Baum R, Mintz M, Samuels S, Dalal AA. Development of the Lung Function Questionnaire (LFQ) to identify airflow obstruction. Int J Chron Obstruct Pulmon Dis. 2010 Feb 18; 5:1-10. PMID: 20368906; PMCID: PMC2846155.
    140. Hanania NA, Donohue JF, Nelson H, Sciarappa K, Goodwin E, Baumgartner RA, Hanrahan JP. The safety and efficacy of arformoterol and formoterol in COPD. COPD. 2010 Feb; 7(1):17-31. PMID: 20214460.
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    141. Cully JA, Stanley MA, Deswal A, Hanania NA, Phillips LL, Kunik ME. Cognitive-behavioral therapy for chronic cardiopulmonary conditions: preliminary outcomes from an open trial. Prim Care Companion J Clin Psychiatry. 2010; 12(4). PMID: 21085552; PMCID: PMC2983462.
    142. King MJ, Hanania NA. Asthma in the elderly: current knowledge and future directions. Curr Opin Pulm Med. 2010 Jan; 16(1):55-9. PMID: 19844181.
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    143. Hanania NA, Dickey BF, Bond RA. Clinical implications of the intrinsic efficacy of beta-adrenoceptor drugs in asthma: full, partial and inverse agonism. Curr Opin Pulm Med. 2010 Jan; 16(1):1-5. PMID: 19887938; PMCID: PMC2855430.
    144. Tashkin DP, Hanania NA, McGinty J, Denis-Mize K, Chaudry I. Nebulized formoterol provides added benefits to tiotropium treatment in chronic obstructive pulmonary disease. Adv Ther. 2009 Nov; 26(11):1024-34. PMID: 19953349.
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    145. Sharma G, Hanania NA, Shim YM. The aging immune system and its relationship to the development of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 01; 6(7):573-80. PMID: 19934352.
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    146. Bailey WC, Sciurba FC, Hanania NA, Donohue JF, Ferguson GT, Zibrak JD, Sharafkhaneh A, Marcus P, Rosa K, Piault EC, Martinez FJ. Development and validation of the Chronic Obstructive Pulmonary Disease Assessment Questionnaire (COPD-AQ). Prim Care Respir J. 2009 Sep; 18(3):198-207. PMID: 19492178.
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    147. Hanania NA, Boota A, Kerwin E, Tomlinson L, Denis-Mize K. Efficacy and safety of nebulized formoterol as add-on therapy in COPD patients receiving maintenance tiotropium bromide: Results from a 6-week, randomized, placebo-controlled, clinical trial. Drugs. 2009 Jun 18; 69(9):1205-16. PMID: 19537837.
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    148. Nguyen LP, Lin R, Parra S, Omoluabi O, Hanania NA, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2435-40. PMID: 19171883.
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    149. Hanania NA. Asthma control: a new perspective on the management of asthma. Curr Opin Pulm Med. 2009 Jan; 15(1):1-3. PMID: 19077698.
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    150. Guntupalli KK, Reddy RM, Loutfi RH, Alapat PM, Bandi VD, Hanania NA. Evaluation of obstructive lung disease with vibration response imaging. J Asthma. 2008 Dec; 45(10):923-30. PMID: 19085584.
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    151. Maurer J, Rebbapragada V, Borson S, Goldstein R, Kunik ME, Yohannes AM, Hanania NA. Anxiety and depression in COPD: current understanding, unanswered questions, and research needs. Chest. 2008 Oct; 134(4 Suppl):43S-56S. PMID: 18842932; PMCID: PMC2849676.
    152. Donohue JF, Hanania NA, Fogarty C, Campbell SC, Rinehart M, Denis-Mize K. Long-term safety of nebulized formoterol: results of a twelve-month open-label clinical trial. Ther Adv Respir Dis. 2008 Aug; 2(4):199-208. PMID: 19124372.
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    153. Cazzola M, Hanania NA, Jones PW, Mahler DA, Make B, Ohar J, Rennard S. It's about time--directing our attention toward modifying the course of COPD. Respir Med. 2008 Jun; 102 Suppl 1:S37-48. PMID: 18582796.
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    154. Sharafkhaneh A, Hanania NA, Kim V. Pathogenesis of emphysema: from the bench to the bedside. Proc Am Thorac Soc. 2008 May 01; 5(4):475-7. PMID: 18453358; PMCID: PMC2645322.
    155. Hanania NA. Targeting airway inflammation in asthma: current and future therapies. Chest. 2008 Apr; 133(4):989-98. PMID: 18398119.
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    156. Donohue JF, Hanania NA, Sciarappa KA, Goodwin E, Grogan DR, Baumgartner RA, Hanrahan JP. Arformoterol and salmeterol in the treatment of chronic obstructive pulmonary disease: a one year evaluation of safety and tolerance. Ther Adv Respir Dis. 2008 Apr; 2(2):37-48. PMID: 19124357.
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    157. Hanrahan JP, Hanania NA, Calhoun WJ, Sahn SA, Sciarappa K, Baumgartner RA. Effect of nebulized arformoterol on airway function in COPD: results from two randomized trials. COPD. 2008 Feb; 5(1):25-34. PMID: 18259972.
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    158. Hanania NA. The impact of inhaled corticosteroid and long-acting beta-agonist combination therapy on outcomes in COPD. Pulm Pharmacol Ther. 2008; 21(3):540-50. PMID: 18280761.
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    159. Donohue JF, Hanania NA, Ciubotaru RL, Noe L, Pasta DJ, Schaefer K, Claus R, Andrews WT, Roach J. Comparison of levalbuterol and racemic albuterol in hospitalized patients with acute asthma or COPD: a 2-week, multicenter, randomized, open-label study. Clin Ther. 2008; 30 Spec No:989-1002. PMID: 18640474.
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    160. Sharafkhaneh A, Velamuri S, Badmaev V, Lan C, Hanania N. The potential role of natural agents in treatment of airway inflammation. Ther Adv Respir Dis. 2007 Dec; 1(2):105-20. PMID: 19124352.
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    161. Braman SS, Hanania NA. Asthma in older adults. Clin Chest Med. 2007 Dec; 28(4):685-702, v. PMID: 17967288.
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    162. Hanania NA, Donohue JF. Pharmacologic interventions in chronic obstructive pulmonary disease: bronchodilators. Proc Am Thorac Soc. 2007 Oct 01; 4(7):526-34. PMID: 17878465.
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    163. Hanania NA. Optimizing maintenance therapy for chronic obstructive pulmonary disease: strategies for improving patient-centered outcomes. Clin Ther. 2007 Oct; 29(10):2121-33. PMID: 18042470.
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    164. Hanania NA, Sharafkhaneh A. Update on the pharmacologic therapy for chronic obstructive pulmonary disease. Clin Chest Med. 2007 Sep; 28(3):589-607, vi-vii. PMID: 17720046.
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    165. Hanania NA, Singh S, El-Wali R, Flashner M, Franklin AE, Garner WJ, Dickey BF, Parra S, Ruoss S, Shardonofsky F, O'Connor BJ, Page C, Bond RA. The safety and effects of the beta-blocker, nadolol, in mild asthma: an open-label pilot study. Pulm Pharmacol Ther. 2008; 21(1):134-41. PMID: 17703976; PMCID: PMC2254137.
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    168. Baumgartner RA, Hanania NA, Calhoun WJ, Sahn SA, Sciarappa K, Hanrahan JP. Nebulized arformoterol in patients with COPD: a 12-week, multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled trial. Clin Ther. 2007 Feb; 29(2):261-78. PMID: 17472819.
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    173. Nowak R, Emerman C, Hanrahan JP, Parsey MV, Hanania NA, Claus R, Schaefer K, Baumgartner RA. A comparison of levalbuterol with racemic albuterol in the treatment of acute severe asthma exacerbations in adults. Am J Emerg Med. 2006 May; 24(3):259-67. PMID: 16635694.
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    174. Hanania NA, Atmar RL, Castro M. Influenza vaccine in patients with asthma. Expert Rev Vaccines. 2006 Feb; 5(1):111-8. PMID: 16451113.
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    175. Cazzola M, Hanania NA. The role of combination therapy with corticosteroids and long-acting beta2-agonists in the prevention of exacerbations in COPD. Int J Chron Obstruct Pulmon Dis. 2006; 1(4):345-54. PMID: 18044091.
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    178. Hanania NA. The challenge of differentiating asthma from chronic obstructive pulmonary disease. Manag Care. 2005 Jul; 14(7 Suppl Obstructie Lung):9-15; discussion 24-6. PMID: 18564559.
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    179. Make B, Hanania NA, ZuWallack R, Kalberg C, Emmett A, Brown CP, Knobil K. The efficacy and safety of inhaled fluticasone propionate/salmeterol and ipratropium/albuterol for the treatment of chronic obstructive pulmonary disease: an eight-week, multicenter, randomized, double-blind, double-dummy, parallel-group study. Clin Ther. 2005 May; 27(5):531-42. PMID: 15978302.
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    180. Soto FJ, Hanania NA. Selective phosphodiesterase-4 inhibitors in chronic obstructive lung disease. Curr Opin Pulm Med. 2005 Mar; 11(2):129-34. PMID: 15699784.
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    183. Hanania NA, Moore RH. Anti-inflammatory activities of beta2-agonists. Curr Drug Targets Inflamm Allergy. 2004 Sep; 3(3):271-7. PMID: 15379595.
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    184. Hanania NA, Sockrider M, Castro M, Holbrook JT, Tonascia J, Wise R, Atmar RL. Immune response to influenza vaccination in children and adults with asthma: effect of corticosteroid therapy. J Allergy Clin Immunol. 2004 Apr; 113(4):717-24. PMID: 15100679.
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    186. Rodriguez W, Hanania N, Guy E, Guntupalli J. Pulmonary-renal syndromes in the intensive care unit. Crit Care Clin. 2002 Oct; 18(4):881-95, x. PMID: 12418445.
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    187. Hanania NA, Sharafkhaneh A, Barber R, Dickey BF. Beta-agonist intrinsic efficacy: measurement and clinical significance. Am J Respir Crit Care Med. 2002 May 15; 165(10):1353-8. PMID: 12016095.
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    188. Nasta SD, Carrum GM, Shahab I, Hanania NA, Udden MM. Regression of a plasmablastic lymphoma in a patient with HIV on highly active antiretroviral therapy. Leuk Lymphoma. 2002 Feb; 43(2):423-6. PMID: 11999580.
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    189. Hanania NA, Zimmerman JL. Accidental hypothermia. Crit Care Clin. 1999 Apr; 15(2):235-49. PMID: 10331126.
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    190. Hanania NA, Pope C, Guntupalli KK. Acute respiratory distress syndrome. Inhaled nitric oxide. Respir Care Clin N Am. 1998 Dec; 4(4):695-709. PMID: 9881400.
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    191. Jain S, Hanania NA, Guntupalli KK. Ventilation of patients with asthma and obstructive lung disease. Crit Care Clin. 1998 Oct; 14(4):685-705. PMID: 9891633.
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    192. Zimmerman JL, Hanania NA. Vasodilators in mechanical ventilation. Crit Care Clin. 1998 Oct; 14(4):611-27. PMID: 9891630.
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    193. Hanania NA, Tarlo SM, Silverman F, Urch B, Senathirajah N, Zamel N, Corey P. Effect of exposure to low levels of ozone on the response to inhaled allergen in allergic asthmatic patients. Chest. 1998 Sep; 114(3):752-6. PMID: 9743162.
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    194. Hanania NA, David-Wang A, Kesten S, Chapman KR. Factors associated with emergency department dependence of patients with asthma. Chest. 1997 Feb; 111(2):290-5. PMID: 9041971.
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    195. Rebuck DA, Hanania NA, D'Urzo AD, Chapman KR. The accuracy of a handheld portable spirometer. Chest. 1996 Jan; 109(1):152-7. PMID: 8549178.
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    196. Hanania NA, Chapman KR, Sturtridge WC, Szalai JP, Kesten S. Dose-related decrease in bone density among asthmatic patients treated with inhaled corticosteroids. J Allergy Clin Immunol. 1995 Nov; 96(5 Pt 1):571-9. PMID: 7499672.
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    197. Kesten S, Chew R, Hanania NA. Health-care utilization after near-fatal asthma. Chest. 1995 Jun; 107(6):1564-9. PMID: 7781347.
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    198. Hanania NA, Chapman KR, Kesten S. Adverse effects of inhaled corticosteroids. Am J Med. 1995 Feb; 98(2):196-208. PMID: 7847437.
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    199. Hanania NA, Wittman R, Kesten S, Chapman KR. Medical personnel's knowledge of and ability to use inhaling devices. Metered-dose inhalers, spacing chambers, and breath-actuated dry powder inhalers. Chest. 1994 Jan; 105(1):111-6. PMID: 8275720.
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    200. Hanania N, Hoffstein V. Tuberculosis presenting with generalized lymphadenopathy, pulmonary infiltrates, and bone destruction in a young man. Arch Intern Med. 1993 May 24; 153(10):1265-7. PMID: 8494479.
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