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Stephen Pflugfelder

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Ophthalmology
DivisionOphthalmology
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    R03EY008193     (PFLUGFELDER, STEPHEN CARL)Mar 1, 1989 - Feb 28, 1990
    NIH/NEI
    DETECTION OF EPSTEIN-BARR VIRAL DNA IN OCULAR SPECIMENS
    Role: Principal Investigator

    R01EY008711     (PFLUGFELDER, STEPHEN CARL)Aug 1, 1990 - Jul 31, 1994
    NIH/NEI
    EBV AND OCULAR PATHOLOGY IN SJOGREN'S SYNDROME
    Role: Principal Investigator

    R01EY011915     (PFLUGFELDER, STEPHEN C)Aug 1, 1997 - Jul 31, 2020
    NIH/NEI
    Pathogenesis of Conjunctival Squamous Metaplasia
    Role: Principal Investigator

    R01EY018090     (PFLUGFELDER, STEPHEN CARL)Aug 1, 2009 - Jul 31, 2011
    NIH/NEI
    Environmentally-Induced Ocular Surface Inflammation Mimicking Sjogren's Syndrome
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Trujillo-Vargas CM, Schaefer L, Alam J, Pflugfelder SC, Britton RA, de Paiva CS. The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome. Ocul Surf. 2019 Oct 20. PMID: 31644955.
      View in: PubMed
    2. Wang C, Schaefer L, Bian F, Yu Z, Pflugfelder SC, Britton RA, de Paiva CS. Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide. Invest Ophthalmol Vis Sci. 2019 Oct 01; 60(13):4224-4233. PMID: 31618426.
      View in: PubMed
    3. de Paiva CS, Pflugfelder SC, Ng SM, Akpek EK. Topical cyclosporine A therapy for dry eye syndrome. Cochrane Database Syst Rev. 2019 09 13; 9:CD010051. PMID: 31517988.
      View in: PubMed
    4. Hsu JI, Pflugfelder SC, Kim SJ. Ocular complications of atopic dermatitis. Cutis. 2019 Sep; 104(3):189-193. PMID: 31675394.
      View in: PubMed
    5. Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R. Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial. Ophthalmology. 2019 Aug 26. PMID: 31585826.
      View in: PubMed
    6. Deng R, Chen X, Zhang Y, Bian F, Gao N, Hu J, Wang C, de Souza RG, Lu F, Pflugfelder SC, Li DQ. Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation. Mucosal Immunol. 2019 09; 12(5):1141-1149. PMID: 31350466.
      View in: PubMed
    7. Bian F, Xiao Y, Barbosa FL, de Souza RG, Hernandez H, Yu Z, Pflugfelder SC, de Paiva CS. Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. Mucosal Immunol. 2019 07; 12(4):897-908. PMID: 30696983.
      View in: PubMed
    8. Chen X, Deng R, Chi W, Hua X, Lu F, Bian F, Gao N, Li Z, Pflugfelder SC, de Paiva CS, Li DQ. IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model. Allergy. 2019 May; 74(5):910-921. PMID: 30515838.
      View in: PubMed
    9. Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams AR, Pflugfelder SC, de Paiva CS. Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome. Int J Mol Sci. 2018 Nov 30; 19(12). PMID: 30513621.
      View in: PubMed
    10. Stamer WD, Williams AM, Pflugfelder S, Coupland SE. Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members. Invest Ophthalmol Vis Sci. 2018 10 01; 59(12):4783-4792. PMID: 30304462.
      View in: PubMed
    11. Xiao Y, de Paiva CS, Yu Z, de Souza RG, Li DQ, Pflugfelder SC. Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol. 2018 09 25; 30(10):457-470. PMID: 30010888.
      View in: PubMed
    12. Pflugfelder SC, Bian F, Gumus K, Farley W, Stern ME, De Paiva CS. Severity of Sjögren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells. Int J Mol Sci. 2018 Sep 14; 19(9). PMID: 30223431.
      View in: PubMed
    13. Guimaraes de Souza R, Yu Z, Stern ME, Pflugfelder SC, de Paiva CS. Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast. J Ocul Pharmacol Ther. 2018 09; 34(7):543-549. PMID: 29958030.
      View in: PubMed
    14. Zaheer M, Wang C, Bian F, Yu Z, Hernandez H, de Souza RG, Simmons KT, Schady D, Swennes AG, Pflugfelder SC, Britton RA, de Paiva CS. Protective role of commensal bacteria in Sjögren Syndrome. J Autoimmun. 2018 09; 93:45-56. PMID: 29934134.
      View in: PubMed
    15. Patel SN, Shetlar DJ, Pflugfelder SC. Bilateral Candida parapsilosis infiltration of nonhealing indolent epithelial defects in a diabetic patient with neurotrophic keratopathy. Can J Ophthalmol. 2018 12; 53(6):e224-e226. PMID: 30502998.
      View in: PubMed
    16. Yang J, Chandwani R, Gopinatth V, Boyce T, Pflugfelder SC, Huang D, Liu G. Near-infrared laser thermal conjunctivoplasty. Sci Rep. 2018 03 01; 8(1):3863. PMID: 29497112.
      View in: PubMed
    17. Wang C, Zaheer M, Bian F, Quach D, Swennes AG, Britton RA, Pflugfelder SC, de Paiva CS. Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci. 2018 Feb 13; 19(2). PMID: 29438346.
      View in: PubMed
    18. Ko BY, Xiao Y, Barbosa FL, de Paiva CS, Pflugfelder SC. Goblet cell loss abrogates ocular surface immune tolerance. JCI Insight. 2018 02 08; 3(3). PMID: 29415888.
      View in: PubMed
    19. Parra AS, Roth BM, Nguyen TM, Wang L, Pflugfelder SC, Al-Mohtaseb Z. Assessment of the Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) scleral lens on visual acuity for corneal irregularity and ocular surface disease. Ocul Surf. 2018 04; 16(2):254-258. PMID: 29425812.
      View in: PubMed
    20. Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams A, Pflugfelder SC, de Paiva CS. Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice. Exp Eye Res. 2018 04; 169:91-98. PMID: 29407221.
      View in: PubMed
    21. McDonnell PJ, Pflugfelder SC, Stern ME, Hardten DR, Conway T, Villanueva L, Hollander DA. Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye. BMC Ophthalmol. 2017 Dec 28; 17(1):265. PMID: 29284427.
      View in: PubMed
    22. Pflugfelder SC, de Paiva CS. The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmology. 2017 11; 124(11S):S4-S13. PMID: 29055361.
      View in: PubMed
    23. Li J, Xiao Y, Coursey TG, Chen X, Deng R, Lu F, Pflugfelder SC, Li DQ. Identification for Differential Localization of Putative Corneal Epithelial Stem Cells in Mouse and Human. Sci Rep. 2017 07 12; 7(1):5169. PMID: 28701781.
      View in: PubMed
    24. Barbosa FL, Xiao Y, Bian F, Coursey TG, Ko BY, Clevers H, de Paiva CS, Pflugfelder SC. Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease. Int J Mol Sci. 2017 May 05; 18(5). PMID: 28475124.
      View in: PubMed
    25. Jin H, Parker WT, Law NW, Clarke CL, Gisseman JD, Pflugfelder SC, Wang L, Al-Mohtaseb ZN. Evolving risk factors and antibiotic sensitivity patterns for microbial keratitis at a large county hospital. Br J Ophthalmol. 2017 11; 101(11):1483-1487. PMID: 28336675.
      View in: PubMed
    26. Zhao YE, Gong XH, Zhu XN, Li HM, Tu MJ, Coursey TG, Pflugfelder SC, Gu F, Chen D. Long-term outcomes of ciliary sulcus versus capsular bag fixation of intraocular lenses in children: An ultrasound biomicroscopy study. PLoS One. 2017; 12(3):e0172979. PMID: 28301497.
      View in: PubMed
    27. Gumus K, Schuetzle KL, Pflugfelder SC. Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation. Am J Ophthalmol. 2017 May; 177:159-168. PMID: 28302532.
      View in: PubMed
    28. Bian F, Xiao Y, Zaheer M, Volpe EA, Pflugfelder SC, Li DQ, de Paiva CS. Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. Int J Mol Sci. 2017 Mar 05; 18(3). PMID: 28273882.
      View in: PubMed
    29. Chi W, Hua X, Chen X, Bian F, Yuan X, Zhang L, Wang X, Chen D, Deng R, Li Z, Liu Y, de Paiva CS, Pflugfelder SC, Li DQ. Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017 Jun; 80:65-76. PMID: 28238526.
      View in: PubMed
    30. Gumus K, Pflugfelder SC. Anterior Segment Optical Coherence Tomography (AS-OCT) in the Management of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):13-22. PMID: 28282311.
      View in: PubMed
    31. Stern ME, Pflugfelder SC. What We Have Learned From Animal Models of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):109-118. PMID: 28282318.
      View in: PubMed
    32. Pflugfelder SC, Gumus K, Feuerman J, Alex A. Tear Volume-based Diagnostic Classification for Tear Dysfunction. Int Ophthalmol Clin. 2017; 57(2):1-12. PMID: 28282310.
      View in: PubMed
    33. Gumus K, Pflugfelder SC. Intranasal Tear Neurostimulation: An Emerging Concept in the Treatment of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):101-108. PMID: 28282317.
      View in: PubMed
    34. Pflugfelder SC, Stern M, Zhang S, Shojaei A. LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease. J Ocul Pharmacol Ther. 2017 Jan/Feb; 33(1):5-12. PMID: 27906544.
      View in: PubMed
    35. Li J, Zhang L, Chen X, Chen D, Hua X, Bian F, Deng R, Lu F, Li Z, Pflugfelder SC, Li DQ. Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation. Sci Rep. 2016 10 31; 6:36150. PMID: 27796360.
      View in: PubMed
    36. Volpe EA, Henriksson JT, Wang C, Barbosa FL, Zaheer M, Zhang X, Pflugfelder SC, de Paiva CS. Interferon-gamma deficiency protects against aging-related goblet cell loss. Oncotarget. 2016 10 04; 7(40):64605-64614. PMID: 27623073.
      View in: PubMed
    37. Marcano DC, Shin CS, Lee B, Isenhart LC, Liu X, Li F, Jester JV, Pflugfelder SC, Simpson J, Acharya G. Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis. Mol Pharm. 2016 10 03; 13(10):3468-3477. PMID: 27571217.
      View in: PubMed
    38. Bian F, Shin CS, Wang C, Pflugfelder SC, Acharya G, De Paiva CS. Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. Invest Ophthalmol Vis Sci. 2016 06 01; 57(7):3222-30. PMID: 27327581.
      View in: PubMed
    39. Simmons KT, Xiao Y, Pflugfelder SC, de Paiva CS. Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model. Invest Ophthalmol Vis Sci. 2016 05 01; 57(6):2443-51. PMID: 27136463.
      View in: PubMed
    40. de Paiva CS, Jones DB, Stern ME, Bian F, Moore QL, Corbiere S, Streckfus CF, Hutchinson DS, Ajami NJ, Petrosino JF, Pflugfelder SC. Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome. Sci Rep. 2016 Apr 18; 6:23561. PMID: 27087247.
      View in: PubMed
    41. Coursey TG, Tukler Henriksson J, Barbosa FL, de Paiva CS, Pflugfelder SC. Interferon-?-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome. Am J Pathol. 2016 06; 186(6):1547-58. PMID: 27085137.
      View in: PubMed
    42. Bian F, Wang C, Tukler-Henriksson J, Pflugfelder SC, Camodeca C, Nuti E, Rossello A, Li DQ, de Paiva CS. MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. J Cell Physiol. 2016 11; 231(11):2506-16. PMID: 26923552.
      View in: PubMed
    43. Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gomes JA, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J. Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease. Ocul Surf. 2016 04; 14(2):168-88. PMID: 26882981.
      View in: PubMed
    44. Perez VL, Pflugfelder SC, Zhang S, Shojaei A, Haque R. Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 04; 14(2):207-15. PMID: 26807723.
      View in: PubMed
    45. Li J, Hua X, Zhang L, Lu F, Coursey TG, Pflugfelder SC, Li DQ. Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway. Sci Rep. 2016 Jan 14; 6:19408. PMID: 26762881.
      View in: PubMed
    46. Bian F, Pelegrino FS, Henriksson JT, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS. Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye. Ocul Surf. 2016 04; 14(2):242-54. PMID: 26772899.
      View in: PubMed
    47. Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gomes JA, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis--A Comprehensive Review and Guide to Therapy. I. Systemic Disease. Ocul Surf. 2016 Jan; 14(1):2-19. PMID: 26549248.
      View in: PubMed
    48. Pflugfelder SC, De Paiva CS, Moore QL, Volpe EA, Li DQ, Gumus K, Zaheer ML, Corrales RM. Aqueous Tear Deficiency Increases Conjunctival Interferon-? (IFN-?) Expression and Goblet Cell Loss. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7545-50. PMID: 26618646.
      View in: PubMed
    49. Zhang L, Su Z, Zhang Z, Lin J, Li DQ, Pflugfelder SC. Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease. JAMA Ophthalmol. 2015 Oct; 133(10):1117-23. PMID: 26204109.
      View in: PubMed
    50. Bauskar A, Mack WJ, Mauris J, Argüeso P, Heur M, Nagel BA, Kolar GR, Gleave ME, Nakamura T, Kinoshita S, Moradian-Oldak J, Panjwani N, Pflugfelder SC, Wilson MR, Fini ME, Jeong S. Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye. PLoS One. 2015; 10(9):e0138958. PMID: 26402857.
      View in: PubMed
    51. Krauss AH, Corrales RM, Pelegrino FS, Tukler-Henriksson J, Pflugfelder SC, de Paiva CS. Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5888-95. PMID: 26348638.
      View in: PubMed
    52. Rahman EZ, Lam PK, Chu CK, Moore Q, Pflugfelder SC. Corneal Sensitivity in Tear Dysfunction and its Correlation With Clinical Parameters and Blink Rate. Am J Ophthalmol. 2015 Nov; 160(5):858-866.e5. PMID: 26255576.
      View in: PubMed
    53. Hua X, Deng R, Li J, Chi W, Su Z, Lin J, Pflugfelder SC, Li DQ. Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells. Invest Ophthalmol Vis Sci. 2015 Aug; 56(9):5503-11. PMID: 26284556.
      View in: PubMed
    54. Coursey TG, Henriksson JT, Marcano DC, Shin CS, Isenhart LC, Ahmed F, De Paiva CS, Pflugfelder SC, Acharya G. Dexamethasone nanowafer as an effective therapy for dry eye disease. J Control Release. 2015 Sep 10; 213:168-174. PMID: 26184051.
      View in: PubMed
    55. Tukler Henriksson J, Coursey TG, Corry DB, De Paiva CS, Pflugfelder SC. IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4186-97. PMID: 26132778.
      View in: PubMed
    56. Bian F, Pelegrino FS, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS. Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4908-18. PMID: 26225631.
      View in: PubMed
    57. Hua X, Yuan X, Li Z, Coursey TG, Pflugfelder SC, Li DQ. A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins. PLoS One. 2015; 10(6):e0128039. PMID: 26039076.
      View in: PubMed
    58. Deng R, Hua X, Li J, Chi W, Zhang Z, Lu F, Zhang L, Pflugfelder SC, Li DQ. Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells. PLoS One. 2015; 10(5):e0126561. PMID: 26024535.
      View in: PubMed
    59. Moore QL, De Paiva CS, Pflugfelder SC. Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease. Am J Ophthalmol. 2015 Jul; 160(1):135-42.e1. PMID: 25868759.
      View in: PubMed
    60. You IC, Bian F, Volpe EA, de Paiva CS, Pflugfelder SC. Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2224-33. PMID: 25758816.
      View in: PubMed
    61. You IC, Coursey TG, Bian F, Barbosa FL, de Paiva CS, Pflugfelder SC. Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease. Arch Immunol Ther Exp (Warsz). 2015 Aug; 63(4):299-304. PMID: 25772203.
      View in: PubMed
    62. Bian F, Barbosa FL, Corrales RM, Pelegrino FS, Volpe EA, Pflugfelder SC, de Paiva CS. Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome. Arthritis Res Ther. 2015 Mar 10; 17:53. PMID: 25889094.
      View in: PubMed
    63. Qu Y, Chi W, Hua X, Deng R, Li J, Liu Z, Pflugfelder SC, Li DQ. Unique expression pattern and functional role of periostin in human limbal stem cells. PLoS One. 2015; 10(2):e0117139. PMID: 25658308.
      View in: PubMed
    64. Yuan X, Marcano DC, Shin CS, Hua X, Isenhart LC, Pflugfelder SC, Acharya G. Ocular drug delivery nanowafer with enhanced therapeutic efficacy. ACS Nano. 2015 Feb 24; 9(2):1749-58. PMID: 25585134.
      View in: PubMed
    65. Foulks GN, Forstot SL, Donshik PC, Forstot JZ, Goldstein MH, Lemp MA, Nelson JD, Nichols KK, Pflugfelder SC, Tanzer JM, Asbell P, Hammitt K, Jacobs DS. Clinical guidelines for management of dry eye associated with Sjögren disease. Ocul Surf. 2015 Apr; 13(2):118-32. PMID: 25881996.
      View in: PubMed
    66. Coursey TG, Bohat R, Barbosa FL, Pflugfelder SC, de Paiva CS. Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-? in experimental dry eye. J Immunol. 2014 Nov 15; 193(10):5264-72. PMID: 25288568.
      View in: PubMed
    67. Hua X, Su Z, Deng R, Lin J, Li DQ, Pflugfelder SC. Effects of L-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stress. Curr Eye Res. 2015 Jul; 40(7):657-67. PMID: 25271595.
      View in: PubMed
    68. Deng R, Su Z, Hua X, Zhang Z, Li DQ, Pflugfelder SC. Osmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cells. Mol Vis. 2014; 20:1243-52. PMID: 25352733.
      View in: PubMed
    69. Sheppard JD, Donnenfeld ED, Holland EJ, Slonim CB, Solomon R, Solomon KD, McDonald MB, Perry HD, Lane SS, Pflugfelder SC, Samudre SS. Effect of loteprednol etabonate 0.5% on initiation of dry eye treatment with topical cyclosporine 0.05%. Eye Contact Lens. 2014 Sep; 40(5):289-96. PMID: 25083776.
      View in: PubMed
    70. Pflugfelder SC, Stern ME. Mucosal environmental sensors in the pathogenesis of dry eye. Expert Rev Clin Immunol. 2014 Sep; 10(9):1137-40. PMID: 25075545.
      View in: PubMed
    71. Vo RC, Stafeeva K, Aldave AJ, Stulting RD, Moore Q, Pflugfelder SC, Chungfat NC, Holsclaw DS, Margolis TP, Deng SX. Complications related to a cosmetic eye-whitening procedure. Am J Ophthalmol. 2014 Nov; 158(5):967-73. PMID: 25072832.
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    72. Pflugfelder SC, Karpecki PM, Perez VL. Treatment of blepharitis: recent clinical trials. Ocul Surf. 2014 Oct; 12(4):273-84. PMID: 25284773.
      View in: PubMed
    73. Hua X, Yuan X, Tang X, Li Z, Pflugfelder SC, Li DQ. Human corneal epithelial cells produce antimicrobial peptides LL-37 and ß-defensins in response to heat-killed Candida albicans. Ophthalmic Res. 2014; 51(4):179-86. PMID: 24662332.
      View in: PubMed
    74. Foulks GN, Pflugfelder SC. New testing options for diagnosing and grading dry eye disease. Am J Ophthalmol. 2014 Jun; 157(6):1122-9. PMID: 24631478.
      View in: PubMed
    75. Pflugfelder SC. What causes dryness in Sjögren's syndrome patients and how can it be targeted? Expert Rev Clin Immunol. 2014 Apr; 10(4):425-7. PMID: 24564508.
      View in: PubMed
    76. Deng R, Su Z, Lu F, Zhang L, Lin J, Zhang X, de Paiva CS, Pflugfelder SC, Li DQ. A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells. Exp Eye Res. 2014 Mar; 120:118-26. PMID: 24486456.
      View in: PubMed
    77. McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, de Paiva CS. Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 2014 Mar; 184(3):631-43. PMID: 24389165.
      View in: PubMed
    78. Chen JJ, Applebaum DS, Sun GS, Pflugfelder SC. Atopic keratoconjunctivitis: A review. J Am Acad Dermatol. 2014 Mar; 70(3):569-75. PMID: 24342754.
      View in: PubMed
    79. Zhang X, De Paiva CS, Su Z, Volpe EA, Li DQ, Pflugfelder SC. Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye. Exp Eye Res. 2014 Jan; 118:117-24. PMID: 24315969.
      View in: PubMed
    80. Villani E, Baudouin C, Efron N, Hamrah P, Kojima T, Patel SV, Pflugfelder SC, Zhivov A, Dogru M. In vivo confocal microscopy of the ocular surface: from bench to bedside. Curr Eye Res. 2014 Mar; 39(3):213-31. PMID: 24215436.
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    81. Coursey TG, Gandhi NB, Volpe EA, Pflugfelder SC, de Paiva CS. Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease. PLoS One. 2013; 8(11):e78508. PMID: 24223818.
      View in: PubMed
    82. Suhalim JL, Parfitt GJ, Xie Y, De Paiva CS, De Pavia CS, Pflugfelder SC, Shah TN, Potma EO, Brown DJ, Jester JV. Effect of desiccating stress on mouse meibomian gland function. Ocul Surf. 2014 Jan; 12(1):59-68. PMID: 24439047.
      View in: PubMed
    83. Sheppard JD, Singh R, McClellan AJ, Weikert MP, Scoper SV, Joly TJ, Whitley WO, Kakkar E, Pflugfelder SC. Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial. Cornea. 2013 Oct; 32(10):1297-304. PMID: 23884332.
      View in: PubMed
    84. Tung CI, Perin AF, Gumus K, Pflugfelder SC. Tear meniscus dimensions in tear dysfunction and their correlation with clinical parameters. Am J Ophthalmol. 2014 Feb; 157(2):301-310.e1. PMID: 24315297.
      View in: PubMed
    85. Pflugfelder SC, Corrales RM, de Paiva CS. T helper cytokines in dry eye disease. Exp Eye Res. 2013 Dec; 117:118-25. PMID: 24012834.
      View in: PubMed
    86. Gandhi NB, Su Z, Zhang X, Volpe EA, Pelegrino FS, Rahman SA, Li DQ, Pflugfelder SC, de Paiva CS. Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol. 2013 Dec; 94(6):1293-301. PMID: 23983225.
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    87. Alex A, Edwards A, Hays JD, Kerkstra M, Shih A, de Paiva CS, Pflugfelder SC. Factors predicting the ocular surface response to desiccating environmental stress. Invest Ophthalmol Vis Sci. 2013 May 07; 54(5):3325-32. PMID: 23572103.
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    88. Lin J, Zhang L, Zhao G, Su Z, Deng R, Pflugfelder SC, Li DQ. A novel interleukin 33/ST2 signaling regulates inflammatory response in human corneal epithelium. PLoS One. 2013; 8(4):e60963. PMID: 23585867.
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    89. Henriksson JT, De Paiva CS, Farley W, Pflugfelder SC, Burns AR, Bergmanson JP. Morphologic alterations of the palpebral conjunctival epithelium in a dry eye model. Cornea. 2013 Apr; 32(4):483-90. PMID: 23146932.
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    90. Dimit R, Gire A, Pflugfelder SC, Bergmanson JP. Patient ocular conditions and clinical outcomes using a PROSE scleral device. Cont Lens Anterior Eye. 2013 Aug; 36(4):159-63. PMID: 23499361.
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    91. Redfern RL, Patel N, Hanlon S, Farley W, Gondo M, Pflugfelder SC, McDermott AM. Toll-like receptor expression and activation in mice with experimental dry eye. Invest Ophthalmol Vis Sci. 2013 Feb 28; 54(2):1554-63. PMID: 23372055.
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    92. Stern ME, Schaumburg CS, Pflugfelder SC. Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013 Feb; 32(1):19-41. PMID: 23360156.
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    93. Ling JD, Gire A, Pflugfelder SC. PROSE therapy used to minimize corneal trauma in patients with corneal epithelial defects. Am J Ophthalmol. 2013 Apr; 155(4):615-619, 619.e1-2. PMID: 23218704.
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    94. Lin J, Yoon KC, Zhang L, Su Z, Lu R, Ma P, De Paiva CS, Pflugfelder SC, Li DQ. A native-like corneal construct using donor corneal stroma for tissue engineering. PLoS One. 2012; 7(11):e49571. PMID: 23166715.
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    95. de Paiva CS, Schwartz CE, Gjörstrup P, Pflugfelder SC. Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye. Cornea. 2012 Nov; 31(11):1299-303. PMID: 22257864.
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    96. Pelegrino FS, Volpe EA, Gandhi NB, Li DQ, Pflugfelder SC, de Paiva CS. Deletion of interferon-? delays onset and severity of dacryoadenitis in CD25KO mice. Arthritis Res Ther. 2012 Nov 01; 14(6):R234. PMID: 23116218.
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    97. Gumus K, Pflugfelder SC. Increasing prevalence and severity of conjunctivochalasis with aging detected by anterior segment optical coherence tomography. Am J Ophthalmol. 2013 Feb; 155(2):238-242.e2. PMID: 23036571.
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    98. Lu R, Bian F, Lin J, Su Z, Qu Y, Pflugfelder SC, Li DQ. Identification of human fibroblast cell lines as a feeder layer for human corneal epithelial regeneration. PLoS One. 2012; 7(6):e38825. PMID: 22723892.
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    99. Zhang X, Volpe EA, Gandhi NB, Schaumburg CS, Siemasko KF, Pangelinan SB, Kelly SD, Hayday AC, Li DQ, Stern ME, Niederkorn JY, Pflugfelder SC, De Paiva CS. NK cells promote Th-17 mediated corneal barrier disruption in dry eye. PLoS One. 2012; 7(5):e36822. PMID: 22590618.
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    100. Stern ME, Schaumburg CS, Siemasko KF, Gao J, Wheeler LA, Grupe DA, De Paiva CS, Calder VL, Calonge M, Niederkorn JY, Pflugfelder SC. Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2062-75. PMID: 22395876.
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    101. Gumus K, Lee S, Yen MT, Pflugfelder SC. Botulinum toxin injection for the management of refractory filamentary keratitis. Arch Ophthalmol. 2012 Apr; 130(4):446-50. PMID: 22491914.
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    102. Lu R, Qu Y, Ge J, Zhang L, Su Z, Pflugfelder SC, Li DQ. Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells. Stem Cells. 2012 Apr; 30(4):753-61. PMID: 22232078.
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    103. De Paiva CS, Volpe EA, Gandhi NB, Zhang X, Zheng X, Pitcher JD, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Flavell RA, Pflugfelder SC. Disruption of TGF-ß signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca. PLoS One. 2011; 6(12):e29017. PMID: 22194977.
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    104. Pflugfelder SC, Baudouin C. Challenges in the clinical measurement of ocular surface disease in glaucoma patients. Clin Ophthalmol. 2011; 5:1575-83. PMID: 22125404.
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    105. Chang E, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC, De Paiva CS. Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease under Experimental Murine Dry Eye. J Clin Exp Ophthalmol. 2011 Nov 01; 2(11). PMID: 23560247.
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    106. Pflugfelder SC. Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture. Am J Ophthalmol. 2011 Dec; 152(6):900-909.e1. PMID: 22019306.
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    107. Schaumburg CS, Siemasko KF, De Paiva CS, Wheeler LA, Niederkorn JY, Pflugfelder SC, Stern ME. Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J Immunol. 2011 Oct 01; 187(7):3653-62. PMID: 21880984.
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    108. Zhang X, Chen W, De Paiva CS, Volpe EA, Gandhi NB, Farley WJ, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC. Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-?. Am J Pathol. 2011 Oct; 179(4):1807-14. PMID: 21843497.
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    109. Zhang X, Chen W, De Paiva CS, Corrales RM, Volpe EA, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC. Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6279-85. PMID: 21474767.
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    110. Li DQ, Zhang L, Pflugfelder SC, De Paiva CS, Zhang X, Zhao G, Zheng X, Su Z, Qu Y. Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. J Allergy Clin Immunol. 2011 Dec; 128(6):1318-1325.e2. PMID: 21820713.
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    111. Zhang L, Lu R, Zhao G, Pflugfelder SC, Li DQ. TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium. Int J Biochem Cell Biol. 2011 Sep; 43(9):1383-91. PMID: 21684348.
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    112. Corrales RM, de Paiva CS, Li DQ, Farley WJ, Henriksson JT, Bergmanson JP, Pflugfelder SC. Entrapment of conjunctival goblet cells by desiccation-induced cornification. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3492-9. PMID: 21421863.
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    113. Pitcher JD, De Paiva CS, Pelegrino FS, McClellan AJ, Raince JK, Pangelinan SB, Rahimy E, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 16; 52(6):3221-7. PMID: 21273534.
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    114. Lu R, Bian F, Zhang X, Qi H, Chuang EY, Pflugfelder SC, Li DQ. The ß-catenin/Tcf4/survivin signaling maintains a less differentiated phenotype and high proliferative capacity of human corneal epithelial progenitor cells. Int J Biochem Cell Biol. 2011 May; 43(5):751-9. PMID: 21292023.
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    115. Gumus K, Gire A, Pflugfelder SC. The impact of the Boston ocular surface prosthesis on wavefront higher-order aberrations. Am J Ophthalmol. 2011 Apr; 151(4):682-690.e2. PMID: 21269603.
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    116. Gumus K, Crockett CH, Rao K, Yeu E, Weikert MP, Shirayama M, Hada S, Pflugfelder SC. Noninvasive assessment of tear stability with the tear stability analysis system in tear dysfunction patients. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1):456-61. PMID: 20631241.
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    117. Bian F, Qi H, Ma P, Zhang L, Yoon KC, Pflugfelder SC, Li DQ. An immunoprotective privilege of corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factor. Stem Cells. 2010 Dec; 28(12):2172-81. PMID: 20936708.
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    118. Gumus K, Crockett CH, Pflugfelder SC. Anterior segment optical coherence tomography: a diagnostic instrument for conjunctivochalasis. Am J Ophthalmol. 2010 Dec; 150(6):798-806. PMID: 20869039.
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    119. Gumus K, Gire A, Pflugfelder SC. The successful use of Boston ocular surface prosthesis in the treatment of persistent corneal epithelial defect after herpes zoster ophthalmicus. Cornea. 2010 Dec; 29(12):1465-8. PMID: 20847682.
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    120. Qi H, Zheng X, Yuan X, Pflugfelder SC, Li DQ. Potential localization of putative stem/progenitor cells in human bulbar conjunctival epithelium. J Cell Physiol. 2010 Oct; 225(1):180-5. PMID: 20458737.
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    121. Zheng X, De Paiva CS, Rao K, Li DQ, Farley WJ, Stern M, Pflugfelder SC. Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay. Cornea. 2010 Sep; 29(9):1048-54. PMID: 20539212.
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    122. Haque RM, Torkildsen GL, Brubaker K, Zink RC, Kowalski RP, Mah FS, Pflugfelder SC. Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with blepharitis. Cornea. 2010 Aug; 29(8):871-7. PMID: 20508503.
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    123. Nettune GR, Pflugfelder SC. Post-LASIK tear dysfunction and dysesthesia. Ocul Surf. 2010 Jul; 8(3):135-45. PMID: 20712970.
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    124. Rahimy E, Pitcher JD, Pangelinan SB, Chen W, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC, De Paiva CS. Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. Am J Pathol. 2010 Aug; 177(2):744-53. PMID: 20566743.
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    125. Li DQ, Zhou N, Zhang L, Ma P, Pflugfelder SC. Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5623-9. PMID: 20538995.
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    126. Chen Z, Li Z, Basti S, Farley WJ, Pflugfelder SC. Altered morphology and function of the lacrimal functional unit in protein kinase C{alpha} knockout mice. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5592-600. PMID: 20505191.
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    127. Bian F, Liu W, Yoon KC, Lu R, Zhou N, Ma P, Pflugfelder SC, Li DQ. Molecular signatures and biological pathway profiles of human corneal epithelial progenitor cells. Int J Biochem Cell Biol. 2010 Jul; 42(7):1142-53. PMID: 20363357.
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    128. Zheng X, de Paiva CS, Li DQ, Farley WJ, Pflugfelder SC. Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3083-91. PMID: 20130281.
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    129. Zheng X, Ma P, de Paiva CS, Cunningham MA, Hwang CS, Pflugfelder SC, Li DQ. TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3076-82. PMID: 20107175.
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    130. Miller KL, Walt JG, Mink DR, Satram-Hoang S, Wilson SE, Perry HD, Asbell PA, Pflugfelder SC. Minimal clinically important difference for the ocular surface disease index. Arch Ophthalmol. 2010 Jan; 128(1):94-101. PMID: 20065224.
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    131. Zheng X, Bian F, Ma P, De Paiva CS, Stern M, Pflugfelder SC, Li DQ. Induction of Th17 differentiation by corneal epithelial-derived cytokines. J Cell Physiol. 2010 Jan; 222(1):95-102. PMID: 19746420.
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    132. De Paiva CS, Hwang CS, Pitcher JD, Pangelinan SB, Rahimy E, Chen W, Yoon KC, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford). 2010 Feb; 49(2):246-58. PMID: 20007286.
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    133. Rao K, Leveque C, Pflugfelder SC. Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy. Br J Ophthalmol. 2010 May; 94(5):584-91. PMID: 19965821.
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    134. De Paiva CS, Pangelinan SB, Chang E, Yoon KC, Farley WJ, Li DQ, Pflugfelder SC. Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol. 2009 Dec; 127(12):1625-31. PMID: 20008718.
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    135. De Paiva CS, Yoon KC, Pangelinan SB, Pham S, Puthenparambil LM, Chuang EY, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9. J Inflamm (Lond). 2009 Oct 31; 6:31. PMID: 19878594.
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    136. Yoon KC, Park CS, You IC, Choi HJ, Lee KH, Im SK, Park HY, Pflugfelder SC. Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):643-50. PMID: 19850844.
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    137. Rao K, Farley WJ, Pflugfelder SC. Association between high tear epidermal growth factor levels and corneal subepithelial fibrosis in dry eye conditions. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):844-9. PMID: 19815739.
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    138. Ma P, Wang Z, Pflugfelder SC, Li DQ. Toll-like receptors mediate induction of peptidoglycan recognition proteins in human corneal epithelial cells. Exp Eye Res. 2010 Jan; 90(1):130-6. PMID: 19799901.
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    139. Chen JJ, Rao K, Pflugfelder SC. Corneal epithelial opacity in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Sep; 148(3):376-82. PMID: 19541283.
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    140. Donnenfeld E, Pflugfelder SC. Topical ophthalmic cyclosporine: pharmacology and clinical uses. Surv Ophthalmol. 2009 May-Jun; 54(3):321-38. PMID: 19422961.
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    141. Pflugfelder SC, Stern ME. Immunoregulation on the ocular surface: 2nd Cullen Symposium. Ocul Surf. 2009 Apr; 7(2):67-77. PMID: 19383275.
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    142. Chotikavanich S, de Paiva CS, Li de Q, Chen JJ, Bian F, Farley WJ, Pflugfelder SC. Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3203-9. PMID: 19255163.
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    143. Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ. Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2702-9. PMID: 19151401.
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    144. Lam H, Bleiden L, de Paiva CS, Farley W, Stern ME, Pflugfelder SC. Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Feb; 147(2):198-205. e1. PMID: 18992869.
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    145. Qi H, Shine HD, Li DQ, de Paiva CS, Farley WJ, Jones DB, Pflugfelder SC. Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs. Exp Eye Res. 2008 Dec; 87(6):580-6. PMID: 18938159.
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    146. Pflugfelder SC, de Paiva CS, Li DQ, Stern ME. Epithelial-immune cell interaction in dry eye. Cornea. 2008 Sep; 27 Suppl 1:S9-11. PMID: 18813079.
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    147. Beardsley RM, De Paiva CS, Power DF, Pflugfelder SC. Desiccating stress decreases apical corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline. Cornea. 2008 Sep; 27(8):935-40. PMID: 18724157.
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    148. Chuang EY, Li DQ, Bian F, Zheng X, Pflugfelder SC. Effects of contact lens multipurpose solutions on human corneal epithelial survival and barrier function. Eye Contact Lens. 2008 Sep; 34(5):281-6. PMID: 18779668.
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    149. Narayanan S, Corrales RM, Farley W, McDermott AM, Pflugfelder SC. Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye. Cornea. 2008 Aug; 27(7):811-7. PMID: 18650668.
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    150. Siemasko KF, Gao J, Calder VL, Hanna R, Calonge M, Pflugfelder SC, Niederkorn JY, Stern ME. In vitro expanded CD4+CD25+Foxp3+ regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5434-40. PMID: 18658093.
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    151. Corrales RM, Luo L, Chang EY, Pflugfelder SC. Effects of osmoprotectants on hyperosmolar stress in cultured human corneal epithelial cells. Cornea. 2008 Jun; 27(5):574-9. PMID: 18520508.
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    152. Pflugfelder SC. Prevalence, burden, and pharmacoeconomics of dry eye disease. Am J Manag Care. 2008 Apr; 14(3 Suppl):S102-6. PMID: 18452369.
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    153. Chen Z, Tong L, Li Z, Yoon KC, Qi H, Farley W, Li DQ, Pflugfelder SC. Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK. Invest Ophthalmol Vis Sci. 2008 Feb; 49(2):539-49. PMID: 18234997.
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    154. Wilhelmus KR, Jones DB, Matoba AY, Hamill MB, Pflugfelder SC, Weikert MP. Bilateral acanthamoeba keratitis. Am J Ophthalmol. 2008 Feb; 145(2):193-197. PMID: 18222188.
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    155. Pflugfelder SC, De Paiva CS, Villarreal AL, Stern ME. Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production. Cornea. 2008 Jan; 27(1):64-9. PMID: 18245969.
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    156. Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. J Autoimmun. 2008 Jun; 30(4):212-21. PMID: 17988834.
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    157. Qi H, Chuang EY, Yoon KC, de Paiva CS, Shine HD, Jones DB, Pflugfelder SC, Li DQ. Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Mol Vis. 2007 Oct 16; 13:1934-41. PMID: 17982417.
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    158. Pflugfelder SC, Stern ME. Future directions in therapeutic interventions for conjunctival inflammatory disorders. Curr Opin Allergy Clin Immunol. 2007 Oct; 7(5):450-3. PMID: 17873588.
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    159. Qi H, Li DQ, Shine HD, Chen Z, Yoon KC, Jones DB, Pflugfelder SC. Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells. Exp Eye Res. 2008 Jan; 86(1):34-40. PMID: 17980361.
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    160. De Paiva CS, Villarreal AL, Corrales RM, Rahman HT, Chang VY, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Pflugfelder SC. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2553-60. PMID: 17525184.
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    161. Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Pflugfelder SC. Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2561-9. PMID: 17525185.
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    162. Corrales RM, Villarreal A, Farley W, Stern ME, Li DQ, Pflugfelder SC. Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress. Cornea. 2007 Jun; 26(5):579-84. PMID: 17525655.
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    163. Luo L, Li DQ, Pflugfelder SC. Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways. Cornea. 2007 May; 26(4):452-60. PMID: 17457195.
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    164. Parghi C, McKnight GT, Pflugfelder SC. Prominent corneal nerves in a patient with multiple myeloma. Cornea. 2007 Feb; 26(2):220-2. PMID: 17251817.
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    165. Villareal AL, Farley W, Pflugfelder SC. Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice. Eye Contact Lens. 2006 Dec; 32(6):272-6. PMID: 17099387.
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    166. Tong L, Chen Z, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006 Oct; 47(10):4295-301. PMID: 17003418.
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    167. Behrens A, Doyle JJ, Stern L, Chuck RS, McDonnell PJ, Azar DT, Dua HS, Hom M, Karpecki PM, Laibson PR, Lemp MA, Meisler DM, Del Castillo JM, O'Brien TP, Pflugfelder SC, Rolando M, Schein OD, Seitz B, Tseng SC, van Setten G, Wilson SE, Yiu SC. Dysfunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea. 2006 Sep; 25(8):900-7. PMID: 17102664.
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    168. Chen Z, Li DQ, Tong L, Stewart P, Chu C, Pflugfelder SC. Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells. Mol Vis. 2006 Aug 23; 12:983-94. PMID: 16943770.
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    169. Corrales RM, Stern ME, De Paiva CS, Welch J, Li DQ, Pflugfelder SC. Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3293-302. PMID: 16877394.
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    170. Pflugfelder SC. Is autologous serum a tonic for the ailing corneal epithelium? Am J Ophthalmol. 2006 Aug; 142(2):316-7. PMID: 16876515.
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    171. De Paiva CS, Corrales RM, Villarreal AL, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2847-56. PMID: 16799024.
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    172. Chen Z, Mok H, Pflugfelder SC, Li DQ, Barry MA. Improved transduction of human corneal epithelial progenitor cells with cell-targeting adenoviral vectors. Exp Eye Res. 2006 Oct; 83(4):798-806. PMID: 16793039.
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    173. Tong L, Corrales RM, Chen Z, Villarreal AL, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Expression and regulation of cornified envelope proteins in human corneal epithelium. Invest Ophthalmol Vis Sci. 2006 May; 47(5):1938-46. PMID: 16639001.
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    174. De Paiva CS, Corrales RM, Villarreal AL, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res. 2006 Sep; 83(3):526-35. PMID: 16643899.
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    175. Niederkorn JY, Stern ME, Pflugfelder SC, De Paiva CS, Corrales RM, Gao J, Siemasko K. Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitis. J Immunol. 2006 Apr 01; 176(7):3950-7. PMID: 16547229.
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    176. De Paiva CS, Chen Z, Koch DD, Hamill MB, Manuel FK, Hassan SS, Wilhelmus KR, Pflugfelder SC. The incidence and risk factors for developing dry eye after myopic LASIK. Am J Ophthalmol. 2006 Mar; 141(3):438-45. PMID: 16490488.
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    177. Chen Z, Evans WH, Pflugfelder SC, Li DQ. Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells. Stem Cells. 2006 May; 24(5):1265-73. PMID: 16424398.
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    178. Pflugfelder SC. Integrating restasis into the management of dry eye. Int Ophthalmol Clin. 2006; 46(4):101-3. PMID: 17060796.
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    179. Li DQ, Luo L, Chen Z, Kim HS, Song XJ, Pflugfelder SC. JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res. 2006 Apr; 82(4):588-96. PMID: 16202406.
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    180. McDermott AM, Perez V, Huang AJ, Pflugfelder SC, Stern ME, Baudouin C, Beuerman RW, Burns AR, Calder VL, Calonge M, Chodosh J, Coster DJ, Dana R, Hazlett LD, Jones DB, Kim SK, Knop E, Li DQ, Mitchell BM, Niederkorn JY, Pearlman E, Wilhelmus KR, Kurie E. Pathways of corneal and ocular surface inflammation: a perspective from the cullen symposium. Ocul Surf. 2005 Oct; 3(4 Suppl):S131-8. PMID: 17216102.
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    181. Stern ME, Siemasko KF, Gao J, Calonge M, Niederkorn JY, Pflugfelder SC. Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease. Ocul Surf. 2005 Oct; 3(4 Suppl):S161-4. PMID: 17216110.
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    182. Li DQ, Pflugfelder SC. Matrix metalloproteinases in corneal inflammation. Ocul Surf. 2005 Oct; 3(4 Suppl):S198-202. PMID: 17216119.
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    183. Pflugfelder SC, de Paiva CS, Tong L, Luo L, Stern ME, Li DQ. Stress-activated protein kinase signaling pathways in dry eye and ocular surface disease. Ocul Surf. 2005 Oct; 3(4 Suppl):S154-7. PMID: 17216108.
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    184. Barber LD, Pflugfelder SC, Tauber J, Foulks GN. Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years. Ophthalmology. 2005 Oct; 112(10):1790-4. PMID: 16102833.
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    185. Luo L, Li DQ, Corrales RM, Pflugfelder SC. Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens. 2005 Sep; 31(5):186-93. PMID: 16163009.
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    186. De Paiva CS, Pflugfelder SC, Li DQ. Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells. Stem Cells. 2006 Feb; 24(2):368-75. PMID: 16123387.
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    187. Thomas JW, Pflugfelder SC. Therapy of progressive rheumatoid arthritis-associated corneal ulceration with infliximab. Cornea. 2005 Aug; 24(6):742-4. PMID: 16015096.
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    188. Stewart P, Chen Z, Farley W, Olmos L, Pflugfelder SC. Effect of experimental dry eye on tear sodium concentration in the mouse. Eye Contact Lens. 2005 Jul; 31(4):175-8. PMID: 16021005.
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    189. Li DQ, Chen Z, Song XJ, de Paiva CS, Kim HS, Pflugfelder SC. Partial enrichment of a population of human limbal epithelial cells with putative stem cell properties based on collagen type IV adhesiveness. Exp Eye Res. 2005 Apr; 80(4):581-90. PMID: 15781286.
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    190. Kim HS, Luo L, Pflugfelder SC, Li DQ. Doxycycline inhibits TGF-beta1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):840-8. PMID: 15728539.
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    191. Strong B, Farley W, Stern ME, Pflugfelder SC. Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca. Cornea. 2005 Jan; 24(1):80-5. PMID: 15604871.
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    192. Pflugfelder SC, Farley W, Luo L, Chen LZ, de Paiva CS, Olmos LC, Li DQ, Fini ME. Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005 Jan; 166(1):61-71. PMID: 15632000.
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    193. de Paiva CS, Chen Z, Corrales RM, Pflugfelder SC, Li DQ. ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells. Stem Cells. 2005; 23(1):63-73. PMID: 15625123.
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    194. Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4302-11. PMID: 15557436.
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    195. Luo L, Li DQ, Doshi A, Farley W, Corrales RM, Pflugfelder SC. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4293-301. PMID: 15557435.
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    196. Seth RK, Su GW, Pflugfelder SC. Mucous membrane pemphigoid in a patient with chronic lymphocytic leukemia. Cornea. 2004 Oct; 23(7):740-3. PMID: 15448507.
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    197. Pflugfelder SC, Maskin SL, Anderson B, Chodosh J, Holland EJ, De Paiva CS, Bartels SP, Micuda T, Proskin HM, Vogel R. A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. Am J Ophthalmol. 2004 Sep; 138(3):444-57. PMID: 15364229.
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    198. Kim HS, Shang T, Chen Z, Pflugfelder SC, Li DQ. TGF-beta1 stimulates production of gelatinase (MMP-9), collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells. Exp Eye Res. 2004 Aug; 79(2):263-74. PMID: 15325573.
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    199. Kim HS, Jun Song X, de Paiva CS, Chen Z, Pflugfelder SC, Li DQ. Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures. Exp Eye Res. 2004 Jul; 79(1):41-9. PMID: 15183099.
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    200. Stern ME, Pflugfelder SC. Inflammation in dry eye. Ocul Surf. 2004 Apr; 2(2):124-30. PMID: 17216083.
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    201. Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004 Mar; 78(3):409-16. PMID: 15106920.
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    202. de Paiva CS, Pflugfelder SC. Tear clearance implications for ocular surface health. Exp Eye Res. 2004 Mar; 78(3):395-7. PMID: 15106918.
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    203. Pflugfelder SC. Hormonal deficiencies and dry eye. Arch Ophthalmol. 2004 Feb; 122(2):273-4. PMID: 14769606.
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    204. Pflugfelder SC. Antiinflammatory therapy for dry eye. Am J Ophthalmol. 2004 Feb; 137(2):337-42. PMID: 14962426.
      View in: PubMed
    205. Chen Z, de Paiva CS, Luo L, Kretzer FL, Pflugfelder SC, Li DQ. Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells. 2004; 22(3):355-66. PMID: 15153612.
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    206. Hernandez-Illas M, Tozman E, Fulcher SF, Jundt JW, Davis J, Pflugfelder SC. Recombinant human tumor necrosis factor receptor Fc fusion protein (Etanercept): experience as a therapy for sight-threatening scleritis and sterile corneal ulceration. Eye Contact Lens. 2004 Jan; 30(1):2-5. PMID: 14722460.
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    207. De Paiva CS, Pflugfelder SC. Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am J Ophthalmol. 2004 Jan; 137(1):109-15. PMID: 14700652.
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    208. Solomon R, Donnenfeld ED, Azar DT, Holland EJ, Palmon FR, Pflugfelder SC, Rubenstein JB. Infectious keratitis after laser in situ keratomileusis: results of an ASCRS survey. J Cataract Refract Surg. 2003 Oct; 29(10):2001-6. PMID: 14604725.
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    209. Song XJ, Li DQ, Farley W, Luo LH, Heuckeroth RO, Milbrandt J, Pflugfelder SC. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4223-9. PMID: 14507865.
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    210. Wall V, Yen MT, Yang MC, Huang AJ, Pflugfelder SC. Management of the late ocular sequelae of Stevens-Johnson syndrome. Ocul Surf. 2003 Oct; 1(4):192-201. PMID: 17075650.
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    211. Li DQ, Shang TY, Kim HS, Solomon A, Lokeshwar BL, Pflugfelder SC. Regulated expression of collagenases MMP-1, -8, and -13 and stromelysins MMP-3, -10, and -11 by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2003 Jul; 44(7):2928-36. PMID: 12824233.
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    212. de Paiva CS, Lindsey JL, Pflugfelder SC. Assessing the severity of keratitis sicca with videokeratoscopic indices. Ophthalmology. 2003 Jun; 110(6):1102-9. PMID: 12799233.
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    213. Pflugfelder SC. The Ocular Surface Center at the Baylor College of Medicine, Houston. Ocul Surf. 2003 Apr; 1(2):89-90. PMID: 17075639.
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    214. Karp CL, Tuli SS, Yoo SH, Vroman DT, Alfonso EC, Huang AH, Pflugfelder SC, Culbertson WW. Infectious keratitis after LASIK. Ophthalmology. 2003 Mar; 110(3):503-10. PMID: 12623812.
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    215. Yeh S, Song XJ, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):124-9. PMID: 12506064.
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    216. De Paiva CS, Harris LD, Pflugfelder SC. Keratoconus-like topographic changes in keratoconjunctivitis sicca. Cornea. 2003 Jan; 22(1):22-4. PMID: 12502943.
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    217. Pflugfelder SC. Anti-inflammatory therapy of dry eye. Ocul Surf. 2003 Jan; 1(1):31-6. PMID: 17075627.
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    218. Pflugfelder SC, Liu Z, Feuer W, Verm A. Corneal thickness indices discriminate between keratoconus and contact lens-induced corneal thinning. Ophthalmology. 2002 Dec; 109(12):2336-41. PMID: 12466180.
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    219. Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern ME, Pflugfelder SC. A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2002 Mar; 43(3):632-8. PMID: 11867577.
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    220. Pflugfelder SC, Solomon A, Dursun D, Li DQ. Dry eye and delayed tear clearance: "a call to arms.". Adv Exp Med Biol. 2002; 506(Pt B):739-43. PMID: 12613986.
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    221. Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern M, Pflugfelder SC. Experimentally induced dry eye produces ocular surface inflammation and epithelial disease. Adv Exp Med Biol. 2002; 506(Pt A):647-55. PMID: 12613973.
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