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TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
DivisionMolecular & Human Genetics
AddressOne Baylor Plaza, S911
Houston TX 77030
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    Collapse Research 
    Collapse research activities and funding
    DP2OD004433     (WANG, JUE D.)Sep 30, 2008 - Aug 31, 2013
    The Molecular Interface of Replication Elongation and the Cellular Environment
    Role: Principal Investigator

    R01GM084003     (WANG, JUE D.)May 1, 2009 - Apr 30, 2018
    Control of GTP Homeostasis by (p)ppGpp
    Role: Principal Investigator

    R35GM127088     (WANG, JUE D.)May 1, 2018 - Apr 30, 2023
    The critical roles of (p)ppGpp in homeostasis and antibiotic tolerance in Gram positive bacteria
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liu K, Myers AR, Pisithkul T, Claas KR, Satyshur KA, Amador-Noguez D, Keck JL, Wang JD. Molecular mechanism and evolution of guanylate kinase regulation by (p)ppGpp. Mol Cell. 2015 Feb 19; 57(4):735-749. PMID: 25661490.
      View in: PubMed
    2. Liu K, Bittner AN, Wang JD. Diversity in (p)ppGpp metabolism and effectors. Curr Opin Microbiol. 2015 Apr; 24:72-9. PMID: 25636134; PMCID: PMC4380541.
    3. Zhang Y, Mooney RA, Grass JA, Sivaramakrishnan P, Herman C, Landick R, Wang JD. DksA guards elongating RNA polymerase against ribosome-stalling-induced arrest. Mol Cell. 2014 Mar 06; 53(5):766-78. PMID: 24606919; PMCID: PMC4023959.
    4. Kriel A, Brinsmade SR, Tse JL, Tehranchi AK, Bittner AN, Sonenshein AL, Wang JD. GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes. J Bacteriol. 2014 Jan; 196(1):189-201. PMID: 24163341; PMCID: PMC3911124.
    5. Denapoli J, Tehranchi AK, Wang JD. Dose-dependent reduction of replication elongation rate by (p)ppGpp in Escherichia coli and Bacillus subtilis. Mol Microbiol. 2013 Apr; 88(1):93-104. PMID: 23461544; PMCID: PMC3640871.
    6. Kriel A, Bittner AN, Kim SH, Liu K, Tehranchi AK, Zou WY, Rendon S, Chen R, Tu BP, Wang JD. Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance. Mol Cell. 2012 Oct 26; 48(2):231-41. PMID: 22981860; PMCID: PMC3483369.
    7. Tehranchi AK, Blankschien MD, Zhang Y, Halliday JA, Srivatsan A, Peng J, Herman C, Wang JD. The transcription factor DksA prevents conflicts between DNA replication and transcription machinery. Cell. 2010 May 14; 141(4):595-605. PMID: 20478253; PMCID: PMC2919171.
    8. Srivatsan A, Tehranchi A, MacAlpine DM, Wang JD. Co-orientation of replication and transcription preserves genome integrity. PLoS Genet. 2010 Jan 15; 6(1):e1000810. PMID: 20090829; PMCID: PMC2797598.
    9. Wang JD, Levin PA. Metabolism, cell growth and the bacterial cell cycle. Nat Rev Microbiol. 2009 11; 7(11):822-7. PMID: 19806155; PMCID: PMC2887316.
    10. Srivatsan A, Han Y, Peng J, Tehranchi AK, Gibbs R, Wang JD, Chen R. High-precision, whole-genome sequencing of laboratory strains facilitates genetic studies. PLoS Genet. 2008 Aug 01; 4(8):e1000139. PMID: 18670626; PMCID: PMC2474695.
    11. Srivatsan A, Wang JD. Control of bacterial transcription, translation and replication by (p)ppGpp. Curr Opin Microbiol. 2008 Apr; 11(2):100-5. PMID: 18359660.
      View in: PubMed
    12. Wang JD, Sanders GM, Grossman AD. Nutritional control of elongation of DNA replication by (p)ppGpp. Cell. 2007 Mar 09; 128(5):865-75. PMID: 17350574; PMCID: PMC1850998.
    13. Goranov AI, Kuester-Schoeck E, Wang JD, Grossman AD. Characterization of the global transcriptional responses to different types of DNA damage and disruption of replication in Bacillus subtilis. J Bacteriol. 2006 Aug; 188(15):5595-605. PMID: 16855250; PMCID: PMC1540033.
    14. Wang JD, Rokop ME, Barker MM, Hanson NR, Grossman AD. Multicopy plasmids affect replisome positioning in Bacillus subtilis. J Bacteriol. 2004 Nov; 186(21):7084-90. PMID: 15489419; PMCID: PMC523195.
    15. Wang JD, Herman C, Tipton KA, Gross CA, Weissman JS. Directed evolution of substrate-optimized GroEL/S chaperonins. Cell. 2002 Dec 27; 111(7):1027-39. PMID: 12507429.
      View in: PubMed
    16. Wang JD, Weissman JS. Thinking outside the box: new insights into the mechanism of GroEL-mediated protein folding. Nat Struct Biol. 1999 Jul; 6(7):597-600. PMID: 10404205.
      View in: PubMed
    17. Wang JD, Michelitsch MD, Weissman JS. GroEL-GroES-mediated protein folding requires an intact central cavity. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12163-8. PMID: 9770457; PMCID: PMC22802.
    18. Johnson BL, Sachrajda AS, Kirczenow G, Feng Y, Taylor RP, Henning L, Wang J, Zawadzki P, Coleridge PT. Quantum Hall effect and inter-edge-state tunneling within a barrier. Phys Rev B Condens Matter. 1995 Mar 15; 51(12):7650-7654. PMID: 9977348.
      View in: PubMed
    19. Kirczenow G, Sachrajda AS, Feng Y, Taylor RP, Henning L, Wang J, Zawadzki P, Coleridge PT. Artificial impurities in quantum wires: From classical to quantum behavior. Phys Rev Lett. 1994 Mar 28; 72(13):2069-2072. PMID: 10055780.
      View in: PubMed
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