Signal Recognition Particle
"Signal Recognition Particle" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytosolic ribonucleoprotein complex that acts to induce elongation arrest of nascent presecretory and membrane proteins until the ribosome becomes associated with the rough endoplasmic reticulum. It consists of a 7S RNA and at least six polypeptide subunits (relative molecular masses 9, 14, 19, 54, 68, and 72K).
| Descriptor ID |
D018271
|
| MeSH Number(s) |
D12.776.157.725.500.750.800 D12.776.664.962.500.750.800
|
| Concept/Terms |
Signal Recognition Particle- Signal Recognition Particle
- Particle, Signal Recognition
- Recognition Particle, Signal
- SRP (Signal Recognition Particle)
|
Below are MeSH descriptors whose meaning is more general than "Signal Recognition Particle".
Below are MeSH descriptors whose meaning is more specific than "Signal Recognition Particle".
This graph shows the total number of publications written about "Signal Recognition Particle" by people in this website by year, and whether "Signal Recognition Particle" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 2 | 0 | 2 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 1 | 2 |
| 2001 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Signal Recognition Particle" by people in Profiles.
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Mutations in signal recognition particle SRP54 cause syndromic neutropenia with Shwachman-Diamond-like features. J Clin Invest. 2017 Nov 01; 127(11):4090-4103.
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Hereditary Predispositions to Myelodysplastic Syndrome. Int J Mol Sci. 2016 May 30; 17(6).
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Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease. Arthritis Rheum. 2009 Jul; 60(7):2183-92.
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Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme. J Biol Chem. 2001 Jun 15; 276(24):21791-6.
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Effect of 3' terminal adenylic acid residue on the uridylation of human small RNAs in vitro and in frog oocytes. RNA. 2000 Sep; 6(9):1277-88.
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Evolutionary conservation of post-transcriptional 3' end adenylation of small RNAs: S. cerevisiae signal recognition particle RNA and U2 small nuclear RNA are post-transcriptionally adenylated. Mol Cell Biochem. 2000 May; 208(1-2):99-109.
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Post-transcriptional adenylation of signal recognition particle RNA is carried out by an enzyme different from mRNA Poly(A) polymerase. J Biol Chem. 1999 Oct 22; 274(43):30826-31.
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Accurate 3' end processing and adenylation of human signal recognition particle RNA and alu RNA in vitro. J Biol Chem. 1998 Dec 25; 273(52):35023-31.
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A role for SRp54 during intron bridging of small introns with pyrimidine tracts upstream of the branch point. Mol Cell Biol. 1998 Sep; 18(9):5425-34.
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Adenylation of small RNAs in human cells. Development of a cell-free system for accurate adenylation on the 3'-end of human signal recognition particle RNA. J Biol Chem. 1998 Mar 20; 273(12):6853-9.