"Valproic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.
| Descriptor ID |
D014635
|
| MeSH Number(s) |
D02.241.081.944.509.900 D10.251.400.895.593.900
|
| Concept/Terms |
Valproic Acid- Valproic Acid
- Propylisopropylacetic Acid
- 2-Propylpentanoic Acid
- 2 Propylpentanoic Acid
- Divalproex
Divalproex Sodium- Divalproex Sodium
- Semisodium Valproate
- Valproic Acid, Sodium Salt (2:1)
|
Below are MeSH descriptors whose meaning is more general than "Valproic Acid".
Below are MeSH descriptors whose meaning is more specific than "Valproic Acid".
This graph shows the total number of publications written about "Valproic Acid" by people in this website by year, and whether "Valproic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 2 | 0 | 2 |
| 1993 | 2 | 1 | 3 |
| 1994 | 2 | 0 | 2 |
| 1995 | 1 | 2 | 3 |
| 1996 | 2 | 0 | 2 |
| 1997 | 4 | 0 | 4 |
| 1998 | 1 | 1 | 2 |
| 1999 | 4 | 1 | 5 |
| 2000 | 6 | 2 | 8 |
| 2001 | 1 | 1 | 2 |
| 2002 | 3 | 1 | 4 |
| 2003 | 8 | 0 | 8 |
| 2004 | 1 | 1 | 2 |
| 2005 | 7 | 3 | 10 |
| 2006 | 6 | 4 | 10 |
| 2007 | 5 | 2 | 7 |
| 2008 | 5 | 5 | 10 |
| 2009 | 2 | 3 | 5 |
| 2010 | 6 | 3 | 9 |
| 2011 | 2 | 4 | 6 |
| 2012 | 3 | 2 | 5 |
| 2013 | 4 | 4 | 8 |
| 2014 | 3 | 1 | 4 |
| 2015 | 2 | 1 | 3 |
| 2016 | 0 | 1 | 1 |
| 2017 | 5 | 1 | 6 |
| 2018 | 2 | 2 | 4 |
| 2019 | 2 | 1 | 3 |
| 2020 | 0 | 2 | 2 |
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click here.
Below are the most recent publications written about "Valproic Acid" by people in Profiles.
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Rej S, Herrmann N, Gruneir A, McArthur E, Jeyakumar N, Muanda FT, Harel Z, Dixon S, Garg AX. Association of Lithium Use and a Higher Serum Concentration of Lithium With the Risk of Declining Renal Function in Older Adults: A Population-Based Cohort Study. J Clin Psychiatry. 2020 08 18; 81(5).
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Su JM, Murray JC, McNall-Knapp RY, Bowers DC, Shah S, Adesina AM, Paulino AC, Jo E, Mo Q, Baxter PA, Blaney SM. A phase 2 study of valproic acid and radiation, followed by maintenance valproic acid and bevacizumab in children with newly diagnosed diffuse intrinsic pontine glioma or high-grade glioma. Pediatr Blood Cancer. 2020 06; 67(6):e28283.
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Gandhi M, Rac MWF, McKinney J. Radial Ray Malformation. Am J Obstet Gynecol. 2019 12; 221(6):B16-B18.
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Mohammadi S, Asadi-Shekaari M, Basiri M, Parvan M, Shabani M, Nozari M. Improvement of autistic-like behaviors in adult rats prenatally exposed to valproic acid through early suppression of NMDA receptor function. Psychopharmacology (Berl). 2020 Jan; 237(1):199-208.
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Jorge RE, Li R, Liu X, McGavin JK, Shorter DI, Acion L, Arndt S. Treating Alcohol Use Disorder in U.S. Veterans: The Role of Traumatic Brain Injury. J Neuropsychiatry Clin Neurosci. 2019; 31(4):319-327.
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Soria-Castro R, Schcolnik-Cabrera A, Rodríguez-López G, Campillo-Navarro M, Puebla-Osorio N, Estrada-Parra S, Estrada-García I, Chacón-Salinas R, Chávez-Blanco AD. Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells. J Immunol Res. 2019; 2019:9678098.
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Sgritta M, Dooling SW, Buffington SA, Momin EN, Francis MB, Britton RA, Costa-Mattioli M. Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder. Neuron. 2019 01 16; 101(2):246-259.e6.
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Rej S, Herrmann N, Gruneir A, Jandoc R, McArthur E, Dixon S, Garg AX. Blood Lithium Monitoring Practices in a Population-Based Sample of Older Adults. J Clin Psychiatry. 2018 11 20; 79(6).
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Lin YL, Bialer M, Cabrera RM, Finnell RH, Wlodarczyk BJ. Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice. Birth Defects Res. 2019 08 15; 111(14):1013-1023.
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Tatsumi Y, Matsumoto N, Iibe N, Watanabe N, Torii T, Sango K, Homma K, Miyamoto Y, Sakagami H, Yamauchi J. CMT type 2N disease-associated AARS mutant inhibits neurite growth that can be reversed by valproic acid. Neurosci Res. 2019 Feb; 139:69-78.