"Aflatoxin B1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
| Descriptor ID |
D016604
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| MeSH Number(s) |
D03.383.663.283.119.075 D03.633.100.150.119.075 D23.946.587.142.075
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Aflatoxin B1".
Below are MeSH descriptors whose meaning is more specific than "Aflatoxin B1".
This graph shows the total number of publications written about "Aflatoxin B1" by people in this website by year, and whether "Aflatoxin B1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 1 | 2 |
| 2002 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Aflatoxin B1" by people in Profiles.
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Association of Aflatoxin and Gallbladder Cancer. Gastroenterology. 2017 08; 153(2):488-494.e1.
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DNA polymerase ? limits chromosomal damage and promotes cell survival following aflatoxin exposure. Proc Natl Acad Sci U S A. 2016 11 29; 113(48):13774-13779.
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Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology. 2012 May; 142(6):1264-1273.e1.
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A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin. Cancer Res. 2008 Aug 15; 68(16):6727-33.
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Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Res. 2006 Feb 15; 66(4):2488-94.
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Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein. J Virol. 2002 Nov; 76(22):11770-4.
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Immunoaffinity column clean-up for the high-performance liquid chromatographic determination of aflatoxins B1, B2, G1, G2, M1 and Q1 in urine. J Chromatogr B Biomed Appl. 1995 Oct 20; 672(2):253-9.
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Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Mol Carcinog. 1995 Jun; 13(2):104-11.