"Costello Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Rare congenital disorder with multiple anomalies including: characteristic dysmorphic craniofacial features, musculoskeletal abnormalities, neurocognitive delay, and high prevalence of cancer. Germline mutations in H-Ras protein can cause Costello syndrome. Costello syndrome shows early phenotypic overlap with other disorders that involve MAP KINASE SIGNALING SYSTEM (e.g., NOONAN SYNDROME and cardiofaciocutaneous syndrome).
| Descriptor ID |
D056685
|
| MeSH Number(s) |
C05.660.207.219 C16.131.077.256 C16.320.185
|
| Concept/Terms |
Costello Syndrome- Costello Syndrome
- Syndrome, Costello
- Faciocutaneoskeletal Syndrome
- Faciocutaneoskeletal Syndromes
- Syndrome, Faciocutaneoskeletal
- Syndromes, Faciocutaneoskeletal
- FCS Syndrome
- FCS Syndromes
- Syndrome, FCS
- Syndromes, FCS
|
Below are MeSH descriptors whose meaning is more general than "Costello Syndrome".
Below are MeSH descriptors whose meaning is more specific than "Costello Syndrome".
This graph shows the total number of publications written about "Costello Syndrome" by people in this website by year, and whether "Costello Syndrome" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 0 | 2 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Costello Syndrome" by people in Profiles.
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Update on Pediatric Cancer Surveillance Recommendations for Patients with Neurofibromatosis Type 1, Noonan Syndrome, CBL Syndrome, Costello Syndrome, and Related RASopathies. Clin Cancer Res. 2024 Nov 01; 30(21):4834-4843.
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The 8th International RASopathies Symposium: Expanding research and care practice through global collaboration and advocacy. Am J Med Genet A. 2024 04; 194(4):e63477.
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The seventh international RASopathies symposium: Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery. Am J Med Genet A. 2022 06; 188(6):1915-1927.
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RASopathies: A significant cause of polyhydramnios? Prenat Diagn. 2021 02; 41(3):362-367.
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Costello syndrome: Clinical phenotype, genotype, and management guidelines. Am J Med Genet A. 2019 09; 179(9):1725-1744.
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Age-related differences in prevalence of autism spectrum disorder symptoms in children and adolescents with Costello syndrome. Am J Med Genet A. 2017 May; 173(5):1294-1300.
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The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello syndrome cell model. BMC Med Genet. 2015 Jul 03; 16:46.
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Verbal memory functioning in adolescents and young adults with Costello syndrome: evidence for relative preservation in recognition memory. Am J Med Genet A. 2013 Sep; 161A(9):2258-65.
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Neurocognitive, adaptive, and behavioral functioning of individuals with Costello syndrome: a review. Am J Med Genet C Semin Med Genet. 2011 May 15; 157C(2):115-22.
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Phenotypic analysis of individuals with Costello syndrome due to HRAS p.G13C. Am J Med Genet A. 2011 Apr; 155A(4):706-16.