"Leukocyte Rolling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature. The tethering and rolling involves interaction with SELECTINS and other adhesion molecules in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation for transmigration through the interendothelial cell junction. (From Abbas, Cellular and Molecular Immunology, 3rd ed)
| Descriptor ID |
D036904
|
| MeSH Number(s) |
G04.198.424.233.500
|
| Concept/Terms |
Leukocyte Rolling- Leukocyte Rolling
- Rolling, Leukocyte
- Leucocyte Rolling
- Rolling, Leucocyte
|
Below are MeSH descriptors whose meaning is more general than "Leukocyte Rolling".
Below are MeSH descriptors whose meaning is more specific than "Leukocyte Rolling".
This graph shows the total number of publications written about "Leukocyte Rolling" by people in this website by year, and whether "Leukocyte Rolling" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 2 | 3 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leukocyte Rolling" by people in Profiles.
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Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents. J Immunol. 2014 Oct 01; 193(7):3803-15.
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A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation. 2013 Jan 29; 127(4):486-99.
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Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):321-9.
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Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2. Circ Res. 2012 Feb 17; 110(4):560-8.
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Effects of irradiation on brain vasculature using an in situ tumor model. Int J Radiat Oncol Biol Phys. 2012 Mar 01; 82(3):1075-82.
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Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation. Cardiovasc Res. 2009 Aug 01; 83(3):511-8.
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Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2009 May; 296(5):H1281-8.
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Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest. 2007 Jun; 117(6):1718-26.
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Platelets adhered to endothelial cell-bound ultra-large von Willebrand factor strings support leukocyte tethering and rolling under high shear stress. J Thromb Haemost. 2005 Mar; 3(3):562-70.
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Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammation. J Immunol. 2003 Dec 01; 171(11):6105-11.