Proteostasis Deficiencies
"Proteostasis Deficiencies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Disorders caused by imbalances in the PROTEIN HOMEOSTASIS network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins.
| Descriptor ID |
D057165
|
| MeSH Number(s) |
C18.452.845
|
| Concept/Terms |
Proteostasis Deficiencies- Proteostasis Deficiencies
- Deficiencies, Proteostasis
- Deficiency, Proteostasis
- Proteostasis Deficiency
- Proteostasis Dysfunctions
- Dysfunction, Proteostasis
- Dysfunctions, Proteostasis
- Proteostasis Dysfunction
Protein Misfolding Disorders- Protein Misfolding Disorders
- Disorder, Protein Misfolding
- Disorders, Protein Misfolding
- Misfolding Disorder, Protein
- Misfolding Disorders, Protein
- Protein Misfolding Disorder
- Protein Folding Disorders
- Disorder, Protein Folding
- Disorders, Protein Folding
- Folding Disorder, Protein
- Folding Disorders, Protein
- Protein Folding Disorder
- Protein Folding Diseases
- Disease, Protein Folding
- Diseases, Protein Folding
- Folding Disease, Protein
- Folding Diseases, Protein
- Protein Folding Disease
- Protein Misfolding Diseases
- Disease, Protein Misfolding
- Diseases, Protein Misfolding
- Misfolding Disease, Protein
- Misfolding Diseases, Protein
- Protein Misfolding Disease
|
Below are MeSH descriptors whose meaning is more general than "Proteostasis Deficiencies".
Below are MeSH descriptors whose meaning is more specific than "Proteostasis Deficiencies".
This graph shows the total number of publications written about "Proteostasis Deficiencies" by people in this website by year, and whether "Proteostasis Deficiencies" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proteostasis Deficiencies" by people in Profiles.
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Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults. JAMA Neurol. 2020 10 01; 77(10):1299-1307.
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Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease. J Mol Biol. 2020 01 17; 432(2):305-323.
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Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events. Structure. 2019 03 05; 27(3):449-463.e7.
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Differential a-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity. Acta Neuropathol. 2018 06; 135(6):855-875.
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The role of protein intrinsic disorder in major psychiatric disorders. Am J Med Genet B Neuropsychiatr Genet. 2016 09; 171(6):848-60.
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Systematic identification of pathological lamin A interactors. Mol Biol Cell. 2014 May; 25(9):1493-510.
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Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):21030-5.
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Mice harboring Gnrhr E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reduction and ovulation failure. Mol Endocrinol. 2012 Nov; 26(11):1847-56.
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Islet autoantigens: structure, function, localization, and regulation. Cold Spring Harb Perspect Med. 2012 Aug 01; 2(8).
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Structural dynamics associated with intermediate formation in an archetypal conformational disease. Structure. 2012 Mar 07; 20(3):504-12.