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FILIPPO G GIANCOTTI

TitleProfessor
InstitutionMD Anderson
DepartmentCancer Biology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Okada T, Sinha S, Esposito I, Schiavon G, López-Lago MA, Su W, Pratilas CA, Abele C, Hernandez JM, Ohara M, Okada M, Viale A, Heguy A, Socci ND, Sapino A, Seshan VE, Long S, Inghirami G, Rosen N, Giancotti FG. Author Correction: The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. Nat Cell Biol. 2019 04; 21(4):534. PMID: 30842593.
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    2. Cooper J, Giancotti FG. Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance. Cancer Cell. 2019 Mar 18; 35(3):347-367. PMID: 30889378.
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    3. Er EE, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, Griscom B, Rosenblum M, Boire A, Brogi E, Giancotti FG, Schachner M, Malladi S, Massagué J. Author Correction: Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol. 2019 Mar; 21(3):408. PMID: 30542103.
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    4. Er EE, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, Griscom B, Rosenblum M, Boire A, Brogi E, Giancotti FG, Schachner M, Malladi S, Massagué J. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol. 2018 08; 20(8):966-978. PMID: 30038252.
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    5. Cooper J, Xu Q, Zhou L, Pavlovic M, Ojeda V, Moulick K, de Stanchina E, Poirier JT, Zauderer M, Rudin CM, Karajannis MA, Hanemann CO, Giancotti FG. Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis. Mol Cancer Ther. 2017 08; 16(8):1693-1704. PMID: 28468780.
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    6. Cooper J, Giancotti FG. Cancer: a new role for non-canonical Hippo signaling. Cell Res. 2017 Apr; 27(4):459-460. PMID: 28244491.
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    7. Chen YB, Xu J, Skanderup AJ, Dong Y, Brannon AR, Wang L, Won HH, Wang PI, Nanjangud GJ, Jungbluth AA, Li W, Ojeda V, Hakimi AA, Voss MH, Schultz N, Motzer RJ, Russo P, Cheng EH, Giancotti FG, Lee W, Berger MF, Tickoo SK, Reuter VE, Hsieh JJ. Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets. Nat Commun. 2016 10 07; 7:13131. PMID: 27713405.
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    8. Gao H, Chakraborty G, Zhang Z, Akalay I, Gadiya M, Gao Y, Sinha S, Hu J, Jiang C, Akram M, Brogi E, Leitinger B, Giancotti FG. Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling. Cell. 2016 Jun 30; 166(1):47-62. PMID: 27368100.
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    9. Garcia-Rendueles ME, Ricarte-Filho JC, Untch BR, Landa I, Knauf JA, Voza F, Smith VE, Ganly I, Taylor BS, Persaud Y, Oler G, Fang Y, Jhanwar SC, Viale A, Heguy A, Huberman KH, Giancotti F, Ghossein R, Fagin JA. NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition. Cancer Discov. 2015 Nov; 5(11):1178-93. PMID: 26359368.
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    10. Giancotti FG, Haynes CM, Machesky LM, Olson MF, Overholtzer M. Alan Hall 1952-2015. Nat Cell Biol. 2015 Jul; 17(7):839-40. PMID: 26005836.
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    11. Okada T, Sinha S, Esposito I, Schiavon G, López-Lago MA, Su W, Pratilas CA, Abele C, Hernandez JM, Ohara M, Okada M, Viale A, Heguy A, Socci ND, Sapino A, Seshan VE, Long S, Inghirami G, Rosen N, Giancotti FG. The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. Nat Cell Biol. 2015 Jan; 17(1):81-94. PMID: 25531777.
      View in: PubMed
    12. Gao H, Chakraborty G, Lee-Lim AP, Mavrakis KJ, Wendel HG, Giancotti FG. Forward genetic screens in mice uncover mediators and suppressors of metastatic reactivation. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16532-7. PMID: 25378704.
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    13. Li W, Cooper J, Zhou L, Yang C, Erdjument-Bromage H, Zagzag D, Snuderl M, Ladanyi M, Hanemann CO, Zhou P, Karajannis MA, Giancotti FG. Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. Cancer Cell. 2014 Jul 14; 26(1):48-60. PMID: 25026211.
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    14. Cooper J, Giancotti FG. Molecular insights into NF2/Merlin tumor suppressor function. FEBS Lett. 2014 Aug 19; 588(16):2743-52. PMID: 24726726.
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    15. Giancotti FG. Deregulation of cell signaling in cancer. FEBS Lett. 2014 Aug 19; 588(16):2558-70. PMID: 24561200.
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    16. Karajannis MA, Legault G, Hagiwara M, Giancotti FG, Filatov A, Derman A, Hochman T, Goldberg JD, Vega E, Wisoff JH, Golfinos JG, Merkelson A, Roland JT, Allen JC. Phase II study of everolimus in children and adults with neurofibromatosis type 2 and progressive vestibular schwannomas. Neuro Oncol. 2014 Jan; 16(2):292-7. PMID: 24311643.
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    17. Giancotti FG. Mechanisms governing metastatic dormancy and reactivation. Cell. 2013 Nov 07; 155(4):750-64. PMID: 24209616.
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    18. Yoshioka T, Otero J, Chen Y, Kim YM, Koutcher JA, Satagopan J, Reuter V, Carver B, de Stanchina E, Enomoto K, Greenberg NM, Scardino PT, Scher HI, Sawyers CL, Giancotti FG. ß4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest. 2013 Feb; 123(2):682-99. PMID: 23348745.
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    19. Gao H, Chakraborty G, Lee-Lim AP, Mo Q, Decker M, Vonica A, Shen R, Brogi E, Brivanlou AH, Giancotti FG. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell. 2012 Aug 17; 150(4):764-79. PMID: 22901808.
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    20. Ladanyi M, Zauderer MG, Krug LM, Ito T, McMillan R, Bott M, Giancotti F. New strategies in pleural mesothelioma: BAP1 and NF2 as novel targets for therapeutic development and risk assessment. Clin Cancer Res. 2012 Sep 01; 18(17):4485-90. PMID: 22825583.
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    21. Li W, Cooper J, Karajannis MA, Giancotti FG. Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus. EMBO Rep. 2012 Mar; 13(3):204-15. PMID: 22482125.
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    22. Kalamarides M, Acosta MT, Babovic-Vuksanovic D, Carpen O, Cichowski K, Evans DG, Giancotti F, Hanemann CO, Ingram D, Lloyd AC, Mayes DA, Messiaen L, Morrison H, North K, Packer R, Pan D, Stemmer-Rachamimov A, Upadhyaya M, Viskochil D, Wallace MR, Hunter-Schaedle K, Ratner N. Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting. Acta Neuropathol. 2012 Mar; 123(3):369-80. PMID: 22083253.
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    23. Cooper J, Li W, You L, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG. Merlin/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression. Sci Signal. 2011 Aug 23; 4(188):pt6. PMID: 21878678.
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    24. Li W, Giancotti FG. Merlin's tumor suppression linked to inhibition of the E3 ubiquitin ligase CRL4 (DCAF1). Cell Cycle. 2010 Nov 15; 9(22):4433-6. PMID: 21084862.
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    25. Rossi F, Yozgat Y, de Stanchina E, Veach D, Clarkson B, Manova K, Giancotti FG, Antonescu CR, Besmer P. Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib. Mol Cancer Res. 2010 Sep; 8(9):1271-83. PMID: 20736294.
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    26. Li W, You L, Cooper J, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG. Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell. 2010 Feb 19; 140(4):477-90. PMID: 20178741.
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    27. Ammoun S, Cunliffe CH, Allen JC, Chiriboga L, Giancotti FG, Zagzag D, Hanemann CO, Karajannis MA. ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma. Neuro Oncol. 2010 Aug; 12(8):834-43. PMID: 20511180.
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    28. López-Lago MA, Okada T, Murillo MM, Socci N, Giancotti FG. Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling. Mol Cell Biol. 2009 Aug; 29(15):4235-49. PMID: 19451229.
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    29. Pylayeva Y, Gillen KM, Gerald W, Beggs HE, Reichardt LF, Giancotti FG. Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling. J Clin Invest. 2009 Feb; 119(2):252-66. PMID: 19147981.
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    30. Giancotti FG. Targeting integrin beta4 for cancer and anti-angiogenic therapy. Trends Pharmacol Sci. 2007 Oct; 28(10):506-11. PMID: 17822782.
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    31. Okada T, You L, Giancotti FG. Shedding light on Merlin's wizardry. Trends Cell Biol. 2007 May; 17(5):222-9. PMID: 17442573.
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    32. Pylayeva Y, Guo W, Giancotti FG. Analysis of integrin signaling in genetically engineered mouse models of mammary tumor progression. Methods Enzymol. 2007; 426:439-61. PMID: 17697895.
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    33. Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller WJ, Inghirami G, Giancotti FG. Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell. 2006 Aug 11; 126(3):489-502. PMID: 16901783.
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    34. Pylayeva Y, Giancotti FG. Development requires activation but not phosphorylation of beta1 integrins. Genes Dev. 2006 May 01; 20(9):1057-60. PMID: 16651652.
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    35. Okada T, Lopez-Lago M, Giancotti FG. Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane. J Cell Biol. 2005 Oct 24; 171(2):361-71. PMID: 16247032.
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    36. Nikolopoulos SN, Blaikie P, Yoshioka T, Guo W, Puri C, Tacchetti C, Giancotti FG. Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol Cell Biol. 2005 Jul; 25(14):6090-102. PMID: 15988021.
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    37. Vidal A, Zacharoulis S, Guo W, Shaffer D, Giancotti F, Bramley AH, de la Hoz C, Jensen KK, Kato D, MacDonald DD, Knowles J, Yeh N, Frohman LA, Rafii S, Lyden D, Koff A. p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6890-5. PMID: 15867156.
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    38. Nikolopoulos SN, Giancotti FG. Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning. Cell Cycle. 2005 Mar; 4(3):e131-5. PMID: 15725728.
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    39. Nikolopoulos SN, Blaikie P, Yoshioka T, Guo W, Giancotti FG. Integrin beta4 signaling promotes tumor angiogenesis. Cancer Cell. 2004 Nov; 6(5):471-83. PMID: 15542431.
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    40. Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol. 2004 Oct; 5(10):816-26. PMID: 15459662.
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    41. Gagnoux-Palacios L, Dans M, van't Hof W, Mariotti A, Pepe A, Meneguzzi G, Resh MD, Giancotti FG. Compartmentalization of integrin alpha6beta4 signaling in lipid rafts. J Cell Biol. 2003 Sep 29; 162(7):1189-96. PMID: 14517202.
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    42. Giancotti FG. A structural view of integrin activation and signaling. Dev Cell. 2003 Feb; 4(2):149-51. PMID: 12586058.
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    43. Giancotti FG, Tarone G. Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu Rev Cell Dev Biol. 2003; 19:173-206. PMID: 14570568.
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    44. Klein S, de Fougerolles AR, Blaikie P, Khan L, Pepe A, Green CD, Koteliansky V, Giancotti FG. Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation. Mol Cell Biol. 2002 Aug; 22(16):5912-22. PMID: 12138201.
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    45. Effects of integrin signaling on mammary tumor cells adhesion to microvascular endothelium in vivo. 175-176.
    46. Expression of fibronectin receptor activity on immature hemopoietic cells. Cell Biology International Reports. 10:173.
    47. Erratum. EMBO Journal. 19:5585.
    48. Effects of VEGF on adhesion of mammary carcinoma cells to brain microvascular endothelium.
    49. RSV transformed fibroblasts and monocytes share peculiar adhesion sites. Cell Biology International Reports. 10:161.
    50. Erratum. Molecular and Cellular Biology. 25:7926.
    51. Integrin expression in the developing mouse retina. Investigative Ophthalmology and Visual Science. 37.
    52. NF2 loss promotes oncogenic RAS-induced thyroid cancers via YAP-dependent transactivation of RAS proteins and sensitizes them to MEK inhibition. Cancer Discovery. 5:1178-1193.
    53. Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets. Nature Communications. 7.
    54. Merlin. EMBO Reports.
    55. Do cell cycle inhibitors promote angiogenesis by altering the bone marrow microenvironment?. Cancer Biology and Therapy. 4.
    56. Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling. Cell. 166:47-62.
    57. EGF-R signaling through Fyn kinase disrupts the function of integrin α6β4 at hemidesmosomes. Journal of Cell Biology. 155:447-457.
    58. The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. Nature Cell Biology. 17:81-94.
    59. The adapter protein. Kidney International. 56:1189.
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