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HUGO VILLANUEVA

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Otolaryngology-Head and Neck Surgery
Address6501 Fannin St
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    F31CA159774     (VILLANUEVA, HUGO)Aug 1, 2011 - Jul 31, 2014
    NIH
    Smoothened function as a G-Protein Coupled Receptor in mammary epithelial cells
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Romero JM, Magrill J, Kalashnikov N, Luo YZ, Chen OJ, Busque S, Ma R, Atallah A, Lazaratos AM, Mendelson D, Wilson L, Deshmukh S, Taifour T, Sorin M, Arthur I, Kuasne H, Levett JY, Wang Y, Seufferlein T, Kleger A, Gout J, Beutel AK, Brugarolas J, Poshusta ZS, Hogenson TL, Fernandez-Zapico ME, Hamada A, Yagishita S, Nichols A, Barrett JW, Papaccio F, Castillo J, Inoue M, Massfelder T, Lang H, Lindner V, Nilsson J, Dantes Z, Wells GA, Kim SH, Ittmann MM, Villanueva H, Lerner SP, Sikora AG, Theillet C, Huang DQ, Khuong-Quang DA, Yeung JC, Siegel PM, Watson IR, Zogopoulos G, Rose AAN, Dankner M. Comparative analysis of patient-derived organoids and patient-derived xenografts as avatar models for predicting response to anti-cancer therapy. medRxiv. 2025 Aug 12. PMID: 40832408; PMCID: PMC12363698.
      Citations:    
    2. Holt MV, Dou Y, Young MN, Saltzman AB, Anurag M, Lei JT, Jain A, Leng M, Kim BJ, Dobrolecki LE, Faucher SF, Savage S, Wang C, Shi Z, Villanueva H, Kremers K, Drinnon KD, Castro PD, Ittmann MM, Khatani MM, Kim SH, Ellis MJ, Zhang B, Malovannaya A, Lerner SP. Proteogenomic characterization unveils biomarkers associated with chemoresistance in muscle-invasive bladder cancer. Cell Rep Med. 2025 Aug 19; 6(8):102255. PMID: 40749681; PMCID: PMC12432383.
      Citations:    Fields:    Translation:HumansCells
    3. Safe S, Oany AR, Upadhyay S, Tsui WN, Hailemariam A, Latka S, Landua J, Scherer S, Welm AL, Villanueva H, Lewis M. Orphan Nuclear Receptor 4A1 (NR4A1) and NR4A2are Endogenous Regulators of CD71 and TheirLigands Induce Ferroptosis in Breast Cancer. Res Sq. 2025 Apr 21. PMID: 40313760; PMCID: PMC12045456.
      Citations:    
    4. Nipper AJ, Warren EAK, Liao KS, Liu HC, Michikawa C, Porter CE, Wells GA, Villanueva M, Brasil da Costa FH, Veeramachaneni R, Villanueva H, Suzuki M, Sikora AG. Chick Embryo Chorioallantoic Membrane as a Platform for Assessing the In?Vivo Efficacy of Chimeric Antigen Receptor T-cell Therapy in Solid Tumors. Immunohorizons. 2024 08 01; 8(8):598-605. PMID: 39225630; PMCID: PMC11374747.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Villanueva H, Wells GA, Miller MT, Villanueva M, Pathak R, Castro P, Ittmann MM, Sikora AG, Lerner SP. Characterizing treatment resistance in muscle invasive bladder cancer using the chicken egg chorioallantoic membrane patient-derived xenograft model. Heliyon. 2022 Dec; 8(12):e12570. PMID: 36643309; PMCID: PMC9834740.
      Citations:    
    6. Chattopadhyay C, Bhattacharya R, Roszik J, Khan FS, Wells GA, Villanueva H, Qin Y, Bhattacharya R, Patel SP, Grimm EA. Targeting IRS-1/2 in Uveal Melanoma Inhibits In Vitro Cell Growth, Survival and Migration, and In Vivo Tumor Growth. Cancers (Basel). 2022 Dec 19; 14(24). PMID: 36551732; PMCID: PMC9777326.
      Citations: 1     
    7. Souto EP, Dobrolecki LE, Villanueva H, Sikora AG, Lewis MT. In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts. J Mammary Gland Biol Neoplasia. 2022 06; 27(2):211-230. PMID: 35697909; PMCID: PMC9433358.
      Citations:    Fields:    
    8. Souto EP, Dobrolecki LE, Villanueva H, Sikora AG, Lewis MT. Correction to: In Vivo Modeling of Human Breast Cancer Using Cell Line and Patient-Derived Xenografts. J Mammary Gland Biol Neoplasia. 2022 Jun; 27(2):231. PMID: 35881233; PMCID: PMC9433351.
      Citations:    Fields:    
    9. Vyas A, Gomez-Casal R, Cruz-Rangel S, Villanueva H, Sikora AG, Rajagopalan P, Basu D, Pacheco J, Hammond GRV, Kiselyov K, Duvvuri U. Lysosomal inhibition sensitizes TMEM16A-expressing cancer cells to chemotherapy. Proc Natl Acad Sci U S A. 2022 03 22; 119(12):e2100670119. PMID: 35286200; PMCID: PMC8944912.
      Citations: 1     Fields:    Translation:HumansCells
    10. Villanueva H, Sikora AG. The Chicken Embryo Chorioallantoic Membrane (CAM): A Versatile Tool for the Study of Patient-Derived Xenografts. Methods Mol Biol. 2022; 2471:209-220. PMID: 35175599.
      Citations: 1     Fields:    Translation:HumansAnimals
    11. Vantaku V, Putluri V, Bader DA, Maity S, Ma J, Arnold JM, Rajapakshe K, Donepudi SR, von Rundstedt FC, Devarakonda V, Dubrulle J, Karanam B, McGuire SE, Stossi F, Jain AK, Coarfa C, Cao Q, Sikora AG, Villanueva H, Kavuri SM, Lotan Y, Sreekumar A, Putluri N. Correction: Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. Oncogene. 2020 Oct; 39(40):6387-6392. PMID: 32820250.
      Citations: 2     Fields:    
    12. Vantaku V, Putluri V, Bader DA, Maity S, Ma J, Arnold JM, Rajapakshe K, Donepudi SR, von Rundstedt FC, Devarakonda V, Dubrulle J, Karanam B, McGuire SE, Stossi F, Jain AK, Coarfa C, Cao Q, Sikora AG, Villanueva H, Kavuri SM, Lotan Y, Sreekumar A, Putluri N. Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. Oncogene. 2020 10; 39(40):6265-6285. PMID: 31383940; PMCID: PMC8058741.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    13. Vantaku V, Dong J, Ambati CR, Perera D, Donepudi SR, Amara CS, Putluri V, Ravi SS, Robertson MJ, Piyarathna DWB, Villanueva M, von Rundstedt FC, Karanam B, Ballester LY, Terris MK, Bollag RJ, Lerner SP, Apolo AB, Villanueva H, Lee M, Sikora AG, Lotan Y, Sreekumar A, Coarfa C, Putluri N. Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer. Clin Cancer Res. 2019 06 15; 25(12):3689-3701. PMID: 30846479; PMCID: PMC6571061.
      Citations: 39     Fields:    Translation:HumansCells
    14. Villanueva H, Grimm SL, Dhamne S, Rajapakshe K, Visbal AP, Davis CM, Ehli EA, Hartig SM, Coarfa C, Edwards DP. Correction to: The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast. J Mammary Gland Biol Neoplasia. 2019 Mar; 24(1):109-110. PMID: 30465315; PMCID: PMC6828223.
      Citations:    Fields:    
    15. Villanueva H, Grimm S, Dhamne S, Rajapakshe K, Visbal A, Davis CM, Ehli EA, Hartig SM, Coarfa C, Edwards DP. The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast. J Mammary Gland Biol Neoplasia. 2018 12; 23(4):237-248. PMID: 30338425; PMCID: PMC6244884.
      Citations: 6     Fields:    Translation:HumansAnimals
    16. Villanueva H, Visbal AP, Obeid NF, Ta AQ, Faruki AA, Wu MF, Hilsenbeck SG, Shaw CA, Yu P, Plummer NW, Birnbaumer L, Lewis MT. An essential role for Ga(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland. Sci Signal. 2015 Sep 15; 8(394):ra92. PMID: 26373672.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    17. Visbal AP, LaMarca HL, Villanueva H, Toneff MJ, Li Y, Rosen JM, Lewis MT. Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened. Dev Biol. 2011 Apr 01; 352(1):116-27. PMID: 21276786; PMCID: PMC3057274.
      Citations: 26     Fields:    Translation:AnimalsCells
    18. Acevedo R, Parnell PG, Villanueva H, Chapman LM, Gimenez T, Gray SL, Baldwin WS. The contribution of hepatic steroid metabolism to serum estradiol and estriol concentrations in nonylphenol treated MMTVneu mice and its potential effects on breast cancer incidence and latency. J Appl Toxicol. 2005 Sep-Oct; 25(5):339-53. PMID: 16013040.
      Citations:    
    19. Lau PP, Villanueva H, Kobayashi K, Nakamuta M, Chang BH, Chan L. A DnaJ protein, apobec-1-binding protein-2, modulates apolipoprotein B mRNA editing. J Biol Chem. 2001 Dec 07; 276(49):46445-52. PMID: 11584023.
      Citations: 15     Fields:    Translation:Cells
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