KATHARINA SCHLACHER

TitleAssistant Professor
InstitutionMD Anderson
DepartmentCancer Biology
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Msaouel P, Malouf GG, Su X, Yao H, Tripathi DN, Soeung M, Gao J, Rao P, Coarfa C, Creighton CJ, Bertocchio JP, Kunnimalaiyaan S, Multani AS, Blando J, He R, Shapiro DD, Perelli L, Srinivasan S, Carbone F, PiliƩ PG, Karki M, Seervai RNH, Vokshi BH, Lopez-Terrada D, Cheng EH, Tang X, Lu W, Wistuba II, Thompson TC, Davidson I, Giuliani V, Schlacher K, Carugo A, Heffernan TP, Sharma P, Karam JA, Wood CG, Walker CL, Genovese G, Tannir NM. Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer Cell. 2020 05 11; 37(5):720-734.e13. PMID: 32359397.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    2. Roy S, Schlacher K. SIRF: A Single-cell Assay for in situ Protein Interaction with Nascent DNA Replication Forks. Bio Protoc. 2019 Sep 20; 9(18):e3377. PMID: 33654873.
      Citations:    
    3. Ma S, Pradeep S, Villar-Prados A, Wen Y, Bayraktar E, Mangala LS, Kim MS, Wu SY, Hu W, Rodriguez-Aguayo C, Leuschner C, Liang X, Ram PT, Schlacher K, Coleman RL, Sood AK. GnRH-R-Targeted Lytic Peptide Sensitizes BRCA Wild-type Ovarian Cancer to PARP Inhibition. Mol Cancer Ther. 2019 05; 18(5):969-979. PMID: 30926640.
      Citations: 1     Translation:HumansAnimals
    4. Schlacher K. Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics. J Cell Biol. 2019 03 04; 218(3):732-734. PMID: 30782782.
      Citations:    Fields:    Translation:HumansCells
    5. Lazarchuk P, Roy S, Schlacher K, Sidorova J. Detection and Quantitation of Acetylated Histones on Replicating DNA Using In Situ Proximity Ligation Assay and Click-It Chemistry. Methods Mol Biol. 2019; 1983:29-45. PMID: 31087291.
      Citations: 2     Fields:    Translation:HumansCells
    6. Schlacher K. A new road to cancer-drug resistance. Nature. 2018 11; 563(7732):478-480. PMID: 30459368.
      Citations:    Fields:    Translation:Humans
    7. Roy S, Luzwick JW, Schlacher K. Correction: SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks. J Cell Biol. 2018 04 02; 217(4):1553. PMID: 29572381.
      Citations: 1     Fields:    
    8. Roy S, Luzwick JW, Schlacher K. SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks. J Cell Biol. 2018 04 02; 217(4):1521-1536. PMID: 29475976.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    9. Roy S, Tomaszowski KH, Luzwick JW, Park S, Li J, Murphy M, Schlacher K. p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POL? pathways. Elife. 2018 01 15; 7. PMID: 29334356.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    10. Gadhikar MA, Zhang J, Shen L, Rao X, Wang J, Zhao M, Kalu NN, Johnson FM, Byers LA, Heymach J, Hittelman WN, Udayakumar D, Pandita RK, Pandita TK, Pickering CR, Redwood AB, Piwnica-Worms H, Schlacher K, Frederick MJ, Myers JN. CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition. Cancer Res. 2018 02 01; 78(3):781-797. PMID: 29229598.
      Citations: 12     Fields:    Translation:HumansCells
    11. Schlacher K. PARPi focus the spotlight on replication fork protection in cancer. Nat Cell Biol. 2017 Oct 31; 19(11):1309-1310. PMID: 29087384.
      Citations: 10     Fields:    Translation:HumansCells
    12. Tian Y, Shen X, Wang R, Klages-Mundt NL, Lynn EJ, Martin SK, Ye Y, Gao M, Chen J, Schlacher K, Li L. Constitutive role of the Fanconi anemia D2 gene in the replication stress response. J Biol Chem. 2017 12 08; 292(49):20184-20195. PMID: 29021208.
      Citations: 9     Fields:    Translation:HumansCells
    13. Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, Wang B. Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev. 2017 07 15; 31(14):1469-1482. PMID: 28860160.
      Citations: 19     Fields:    Translation:AnimalsCells
    14. Liu W, Zhou M, Li Z, Li H, Polaczek P, Dai H, Wu Q, Liu C, Karanja KK, Popuri V, Shan SO, Schlacher K, Zheng L, Campbell JL, Shen B. A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy. EBioMedicine. 2016 Apr; 6:73-86. PMID: 27211550.
      Citations: 24     Fields:    Translation:HumansCells
    15. Guo C, Kumagai A, Schlacher K, Shevchenko A, Shevchenko A, Dunphy WG. Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. Mol Cell. 2015 Feb 05; 57(3):492-505. PMID: 25557548.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    16. Schlacher K, Wu H, Jasin M. A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell. 2012 Jul 10; 22(1):106-16. PMID: 22789542.
      Citations: 362     Fields:    Translation:HumansCells
    17. Siaud N, Barbera MA, Egashira A, Lam I, Christ N, Schlacher K, Xia B, Jasin M. Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. PLoS Genet. 2011 Dec; 7(12):e1002409. PMID: 22194698.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    18. Schlacher K, Christ N, Siaud N, Egashira A, Wu H, Jasin M. Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell. 2011 May 13; 145(4):529-42. PMID: 21565612.
      Citations: 457     Fields:    Translation:HumansAnimalsCells
    19. Schlacher K, Goodman MF. Lessons from 50 years of SOS DNA-damage-induced mutagenesis. Nat Rev Mol Cell Biol. 2007 07; 8(7):587-94. PMID: 17551516.
      Citations: 42     Fields:    Translation:Cells
    20. Schlacher K, Cox MM, Woodgate R, Goodman MF. RecA acts in trans to allow replication of damaged DNA by DNA polymerase V. Nature. 2006 Aug 24; 442(7105):883-7. PMID: 16929290.
      Citations: 50     Fields:    Translation:Cells
    21. Schlacher K, Pham P, Cox MM, Goodman MF. Roles of DNA polymerase V and RecA protein in SOS damage-induced mutation. Chem Rev. 2006 Feb; 106(2):406-19. PMID: 16464012.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    22. Schlacher K, Jiang Q, Woodgate R, Goodman MF. Purification and characterization of Escherichia coli DNA polymerase V. Methods Enzymol. 2006; 408:378-90. PMID: 16793381.
      Citations: 3     Fields:    Translation:Cells
    23. Schlacher K, Leslie K, Wyman C, Woodgate R, Cox MM, Goodman MF. DNA polymerase V and RecA protein, a minimal mutasome. Mol Cell. 2005 Feb 18; 17(4):561-72. PMID: 15721259.
      Citations: 37     Fields:    Translation:Cells
    24. A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy. EBioMedicine.
    25. Erratum. Cell. 145:993.
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