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KATHARINA SCHLACHER

TitleAssistant Professor
InstitutionMD Anderson
DepartmentCancer Biology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ma S, Pradeep S, Villar-Prados A, Wen Y, Bayraktar E, Mangala LS, Kim MS, Wu SY, Hu W, Rodriguez-Aguayo C, Leuschner C, Liang X, Ram PT, Schlacher K, Coleman RL, Sood AK. GnRH-R-Targeted Lytic Peptide Sensitizes BRCA Wild-type Ovarian Cancer to PARP Inhibition. Mol Cancer Ther. 2019 05; 18(5):969-979. PMID: 30926640.
      View in: PubMed
    2. Schlacher K. Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics. J Cell Biol. 2019 Mar 04; 218(3):732-734. PMID: 30782782.
      View in: PubMed
    3. Lazarchuk P, Roy S, Schlacher K, Sidorova J. Detection and Quantitation of Acetylated Histones on Replicating DNA Using In Situ Proximity Ligation Assay and Click-It Chemistry. Methods Mol Biol. 2019; 1983:29-45. PMID: 31087291.
      View in: PubMed
    4. Schlacher K. A new road to cancer-drug resistance. Nature. 2018 11; 563(7732):478-480. PMID: 30459368.
      View in: PubMed
    5. Roy S, Luzwick JW, Schlacher K. Correction: SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks. J Cell Biol. 2018 04 02; 217(4):1553. PMID: 29572381.
      View in: PubMed
    6. Roy S, Luzwick JW, Schlacher K. SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks. J Cell Biol. 2018 04 02; 217(4):1521-1536. PMID: 29475976.
      View in: PubMed
    7. Roy S, Tomaszowski KH, Luzwick JW, Park S, Li J, Murphy M, Schlacher K. p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POL? pathways. Elife. 2018 01 15; 7. PMID: 29334356.
      View in: PubMed
    8. Gadhikar MA, Zhang J, Shen L, Rao X, Wang J, Zhao M, Kalu NN, Johnson FM, Byers LA, Heymach J, Hittelman WN, Udayakumar D, Pandita RK, Pandita TK, Pickering CR, Redwood AB, Piwnica-Worms H, Schlacher K, Frederick MJ, Myers JN. CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition. Cancer Res. 2018 02 01; 78(3):781-797. PMID: 29229598.
      View in: PubMed
    9. Schlacher K. PARPi focus the spotlight on replication fork protection in cancer. Nat Cell Biol. 2017 Oct 31; 19(11):1309-1310. PMID: 29087384.
      View in: PubMed
    10. Tian Y, Shen X, Wang R, Klages-Mundt NL, Lynn EJ, Martin SK, Ye Y, Gao M, Chen J, Schlacher K, Li L. Constitutive role of the Fanconi anemia D2 gene in the replication stress response. J Biol Chem. 2017 12 08; 292(49):20184-20195. PMID: 29021208.
      View in: PubMed
    11. Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, Wang B. Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev. 2017 07 15; 31(14):1469-1482. PMID: 28860160.
      View in: PubMed
    12. Liu W, Zhou M, Li Z, Li H, Polaczek P, Dai H, Wu Q, Liu C, Karanja KK, Popuri V, Shan SO, Schlacher K, Zheng L, Campbell JL, Shen B. A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy. EBioMedicine. 2016 Apr; 6:73-86. PMID: 27211550.
      View in: PubMed
    13. Guo C, Kumagai A, Schlacher K, Shevchenko A, Shevchenko A, Dunphy WG. Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. Mol Cell. 2015 Feb 05; 57(3):492-505. PMID: 25557548.
      View in: PubMed
    14. Schlacher K, Wu H, Jasin M. A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell. 2012 Jul 10; 22(1):106-16. PMID: 22789542.
      View in: PubMed
    15. Siaud N, Barbera MA, Egashira A, Lam I, Christ N, Schlacher K, Xia B, Jasin M. Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. PLoS Genet. 2011 Dec; 7(12):e1002409. PMID: 22194698.
      View in: PubMed
    16. Schlacher K, Christ N, Siaud N, Egashira A, Wu H, Jasin M. Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell. 2011 May 13; 145(4):529-42. PMID: 21565612.
      View in: PubMed
    17. Schlacher K, Goodman MF. Lessons from 50 years of SOS DNA-damage-induced mutagenesis. Nat Rev Mol Cell Biol. 2007 07; 8(7):587-94. PMID: 17551516.
      View in: PubMed
    18. Schlacher K, Cox MM, Woodgate R, Goodman MF. RecA acts in trans to allow replication of damaged DNA by DNA polymerase V. Nature. 2006 Aug 24; 442(7105):883-7. PMID: 16929290.
      View in: PubMed
    19. Schlacher K, Pham P, Cox MM, Goodman MF. Roles of DNA polymerase V and RecA protein in SOS damage-induced mutation. Chem Rev. 2006 Feb; 106(2):406-19. PMID: 16464012.
      View in: PubMed
    20. Schlacher K, Jiang Q, Woodgate R, Goodman MF. Purification and characterization of Escherichia coli DNA polymerase V. Methods Enzymol. 2006; 408:378-90. PMID: 16793381.
      View in: PubMed
    21. Schlacher K, Leslie K, Wyman C, Woodgate R, Cox MM, Goodman MF. DNA polymerase V and RecA protein, a minimal mutasome. Mol Cell. 2005 Feb 18; 17(4):561-72. PMID: 15721259.
      View in: PubMed
    22. A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy. EBioMedicine.
    23. Erratum. Cell. 145:993.
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