TitleAssistant Professor
InstitutionMD Anderson
DepartmentCancer Biology
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tomaszowski KH, Roy S, Guerrero C, Shukla P, Keshvani C, Chen Y, Ott M, Wu X, Zhang J, DiNardo CD, Schindler D, Schlacher K. Author Correction: Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress. Nat Commun. 2024 Mar 12; 15(1):2214. PMID: 38472265; PMCID: PMC10933324.
      Citations:    Fields:    
    2. Ye Z, Xu S, Shi Y, Cheng X, Zhang Y, Roy S, Namjoshi S, Longo MA, Link TM, Schlacher K, Peng G, Yu D, Wang B, Tainer JA, Ahmed Z. GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nat Commun. 2024 Mar 08; 15(1):2132. PMID: 38459011; PMCID: PMC10923831.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Ngoi NYL, Pili? PG, McGrail DJ, Zimmermann M, Schlacher K, Yap TA. Targeting ATR in patients with cancer. Nat Rev Clin Oncol. 2024 Apr; 21(4):278-293. PMID: 38378898.
      Citations:    Fields:    Translation:HumansCells
    4. Longo MA, Roy S, Chen Y, Tomaszowski KH, Arvai AS, Pepper JT, Boisvert RA, Kunnimalaiyaan S, Keshvani C, Schild D, Bacolla A, Williams GJ, Tainer JA, Schlacher K. RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles. Nat Commun. 2023 07 24; 14(1):4445. PMID: 37488098; PMCID: PMC10366140.
      Citations: 4     Fields:    Translation:HumansCells
    5. Lozen M, Chen Y, Boisvert RA, Schlacher K. Mitochondrial Replication Assay (MIRA) for Efficient in situ Quantification of Nascent mtDNA and Protein Interactions with Nascent mtDNA (mitoSIRF). Bio Protoc. 2023 May 20; 13(10):e4680. PMID: 37251092; PMCID: PMC10213078.
    6. Tomaszowski KH, Roy S, Guerrero C, Shukla P, Keshvani C, Chen Y, Ott M, Wu X, Zhang J, DiNardo CD, Schindler D, Schlacher K. Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress. Nat Commun. 2023 03 11; 14(1):1333. PMID: 36906610; PMCID: PMC10008622.
      Citations: 1     Fields:    Translation:HumansAnimals
    7. Luzwick JW, Dombi E, Boisvert RA, Roy S, Park S, Kunnimalaiyaan S, Goffart S, Schlacher K, Schindler D. MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway. Sci Adv. 2021 Dec 17; 7(51):eabf9441. PMID: 34910513; PMCID: PMC8673762.
      Citations: 2     Fields:    
    8. Zhang A, Thege FI, Cowan RW, Rupani DN, Wang R, Manning SL, Gates C, Wu W, Levin-Klein R, Rajapakshe KI, Yu M, Multani AS, Kang Y, Taniguchi CM, Schlacher K, Bellin MD, Katz MHG, Kim MP, Fleming JB, Gallinger S, Maddipati R, Harris RS, Notta F, Ross SR, Maitra A, Rhim AD, W?rmann SM. APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis. Nat Cancer. 2021 12; 2(12):1338-1356. PMID: 35121902.
      Citations:    Translation:HumansAnimals
    9. Hambarde S, Tsai CL, Pandita RK, Bacolla A, Maitra A, Charaka V, Hunt CR, Kumar R, Limbo O, Le Meur R, Chazin WJ, Tsutakawa SE, Russell P, Schlacher K, Pandita TK, Tainer JA. EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart. Mol Cell. 2021 07 15; 81(14):2989-3006.e9. PMID: 34197737; PMCID: PMC8720176.
      Citations: 8     Fields:    Translation:HumansCells
    10. Msaouel P, Su X, Yao H, Tripathi DN, Soeung M, Gao J, Rao P, Coarfa C, Creighton CJ, Bertocchio JP, Kunnimalaiyaan S, Multani AS, Blando J, He R, Shapiro DD, Perelli L, Srinivasan S, Carbone F, Karki M, Seervai RNH, Lopez-Terrada D, Cheng EH, Tang X, Lu W, Wistuba II, Thompson TC, Giuliani V, Schlacher K, Carugo A, Heffernan TP, Sharma P, Karam JA, Wood CG, Walker CL, Genovese G, Tannir NM, Malouf GG, Pili? PG, Vokshi BH, Davidson I. Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer Cell. 2020 05 11; 37(5):720-734.e13. PMID: 32359397; PMCID: PMC7288373.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    11. Roy S, Schlacher K. SIRF: A Single-cell Assay for in situ Protein Interaction with Nascent DNA Replication Forks. Bio Protoc. 2019 Sep 20; 9(18):e3377. PMID: 33654873; PMCID: PMC7854004.
      Citations: 1     
    12. Ma S, Pradeep S, Villar-Prados A, Wen Y, Bayraktar E, Mangala LS, Kim MS, Wu SY, Hu W, Rodriguez-Aguayo C, Leuschner C, Liang X, Ram PT, Schlacher K, Coleman RL, Sood AK. GnRH-R-Targeted Lytic Peptide Sensitizes BRCA Wild-type Ovarian Cancer to PARP Inhibition. Mol Cancer Ther. 2019 05; 18(5):969-979. PMID: 30926640; PMCID: PMC6497555.
      Citations: 3     Fields:    Translation:HumansAnimals
    13. Schlacher K. Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics. J Cell Biol. 2019 03 04; 218(3):732-734. PMID: 30782782; PMCID: PMC6400571.
      Citations:    Fields:    Translation:HumansCells
    14. Lazarchuk P, Roy S, Schlacher K, Sidorova J. Detection and Quantitation of Acetylated Histones on Replicating DNA Using In Situ Proximity Ligation Assay and Click-It Chemistry. Methods Mol Biol. 2019; 1983:29-45. PMID: 31087291; PMCID: PMC10439737.
      Citations: 2     Fields:    Translation:HumansCells
    15. Schlacher K. A new road to cancer-drug resistance. Nature. 2018 11; 563(7732):478-480. PMID: 30459368.
      Citations: 2     Fields:    Translation:Humans
    16. Roy S, Luzwick JW, Schlacher K. Correction: SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks. J Cell Biol. 2018 04 02; 217(4):1553. PMID: 29572381; PMCID: PMC5881508.
      Citations: 2     Fields:    
    17. Roy S, Luzwick JW, Schlacher K. SIRF: Quantitative in situ analysis of protein interactions at DNA replication forks. J Cell Biol. 2018 04 02; 217(4):1521-1536. PMID: 29475976; PMCID: PMC5881507.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    18. Roy S, Tomaszowski KH, Luzwick JW, Park S, Li J, Murphy M, Schlacher K. p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POL? pathways. Elife. 2018 01 15; 7. PMID: 29334356; PMCID: PMC5832412.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    19. Gadhikar MA, Zhang J, Shen L, Rao X, Wang J, Zhao M, Kalu NN, Johnson FM, Byers LA, Heymach J, Hittelman WN, Udayakumar D, Pandita RK, Pandita TK, Pickering CR, Redwood AB, Piwnica-Worms H, Schlacher K, Frederick MJ, Myers JN. CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition. Cancer Res. 2018 02 01; 78(3):781-797. PMID: 29229598; PMCID: PMC5811346.
      Citations: 21     Fields:    Translation:HumansCells
    20. Schlacher K. PARPi focus the spotlight on replication fork protection in cancer. Nat Cell Biol. 2017 Oct 31; 19(11):1309-1310. PMID: 29087384.
      Citations: 12     Fields:    Translation:HumansCells
    21. Tian Y, Shen X, Wang R, Klages-Mundt NL, Lynn EJ, Martin SK, Ye Y, Gao M, Chen J, Schlacher K, Li L. Constitutive role of the Fanconi anemia D2 gene in the replication stress response. J Biol Chem. 2017 12 08; 292(49):20184-20195. PMID: 29021208; PMCID: PMC5724005.
      Citations: 13     Fields:    Translation:HumansCells
    22. Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, Wang B. Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev. 2017 07 15; 31(14):1469-1482. PMID: 28860160; PMCID: PMC5588928.
      Citations: 29     Fields:    Translation:AnimalsCells
    23. Liu W, Zhou M, Li Z, Li H, Polaczek P, Dai H, Wu Q, Liu C, Karanja KK, Popuri V, Shan SO, Schlacher K, Zheng L, Campbell JL, Shen B. A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy. EBioMedicine. 2016 Apr; 6:73-86. PMID: 27211550; PMCID: PMC4856754.
      Citations: 37     Fields:    Translation:HumansCells
    24. Guo C, Kumagai A, Schlacher K, Shevchenko A, Shevchenko A, Dunphy WG. Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. Mol Cell. 2015 Feb 05; 57(3):492-505. PMID: 25557548; PMCID: PMC4321788.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    25. Schlacher K, Wu H, Jasin M. A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell. 2012 Jul 10; 22(1):106-16. PMID: 22789542; PMCID: PMC3954744.
      Citations: 479     Fields:    Translation:HumansCells
    26. Siaud N, Barbera MA, Egashira A, Lam I, Christ N, Schlacher K, Xia B, Jasin M. Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. PLoS Genet. 2011 Dec; 7(12):e1002409. PMID: 22194698; PMCID: PMC3240595.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    27. Schlacher K, Christ N, Siaud N, Egashira A, Wu H, Jasin M. Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. Cell. 2011 May 13; 145(4):529-42. PMID: 21565612; PMCID: PMC3261725.
      Citations: 608     Fields:    Translation:HumansAnimalsCells
    28. Schlacher K, Goodman MF. Lessons from 50 years of SOS DNA-damage-induced mutagenesis. Nat Rev Mol Cell Biol. 2007 07; 8(7):587-94. PMID: 17551516.
      Citations: 52     Fields:    Translation:Cells
    29. Schlacher K, Cox MM, Woodgate R, Goodman MF. RecA acts in trans to allow replication of damaged DNA by DNA polymerase V. Nature. 2006 Aug 24; 442(7105):883-7. PMID: 16929290.
      Citations: 56     Fields:    Translation:Cells
    30. Schlacher K, Pham P, Cox MM, Goodman MF. Roles of DNA polymerase V and RecA protein in SOS damage-induced mutation. Chem Rev. 2006 Feb; 106(2):406-19. PMID: 16464012.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    31. Schlacher K, Jiang Q, Woodgate R, Goodman MF. Purification and characterization of Escherichia coli DNA polymerase V. Methods Enzymol. 2006; 408:378-90. PMID: 16793381.
      Citations: 3     Fields:    Translation:Cells
    32. Schlacher K, Leslie K, Wyman C, Woodgate R, Cox MM, Goodman MF. DNA polymerase V and RecA protein, a minimal mutasome. Mol Cell. 2005 Feb 18; 17(4):561-72. PMID: 15721259.
      Citations: 42     Fields:    Translation:Cells
    33. A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy. EBioMedicine.
    34. Erratum. Cell. 145:993.
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