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MARIE-CLAUDE HOFMANN

TitleProfessor
InstitutionMD Anderson
DepartmentEndocrine Neoplasia & HD
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Parekh PA, Garcia TX, Waheeb R, Jain V, Gandhi P, Meistrich ML, Shetty G, Hofmann MC. Undifferentiated spermatogonia regulate Cyp26b1 expression through NOTCH signaling and drive germ cell differentiation. FASEB J. 2019 Jul; 33(7):8423-8435. PMID: 30991836.
      View in: PubMed
    2. Parekh P, Garcia TX, Hofmann MC. Regulation of GDNF expression in Sertoli cells. Reproduction. 2019 Jan 01. PMID: 30620720.
      View in: PubMed
    3. Puli OR, Danysh BP, McBeath E, Sinha DK, Hoang NM, Powell RT, Danysh HE, Cabanillas ME, Cote GJ, Hofmann MC. The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells. Neoplasia. 2018 11; 20(11):1121-1134. PMID: 30265861.
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    4. Paez-Mayorga J, Chen AL, Kotla S, Tao Y, Abe RJ, He ED, Danysh BP, Hofmann MC, Le NT. Ponatinib Activates an Inflammatory Response in Endothelial Cells via ERK5 SUMOylation. Front Cardiovasc Med. 2018; 5:125. PMID: 30238007.
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    5. Cabanillas ME, Ferrarotto R, Garden AS, Ahmed S, Busaidy NL, Dadu R, Williams MD, Skinner H, Gunn GB, Grosu H, Iyer P, Hofmann MC, Zafereo M. Neoadjuvant BRAF- and Immune-Directed Therapy for Anaplastic Thyroid Carcinoma. Thyroid. 2018 07; 28(7):945-951. PMID: 29742974.
      View in: PubMed
    6. Beadnell TC, Nassar KW, Rose MM, Clark EG, Danysh BP, Hofmann MC, Pozdeyev N, Schweppe RE. Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer. Oncogenesis. 2018 Feb 28; 7(2):23. PMID: 29487290.
      View in: PubMed
    7. Garcia TX, Parekh P, Gandhi P, Sinha K, Hofmann MC. The NOTCH Ligand JAG1 Regulates GDNF Expression in Sertoli Cells. Stem Cells Dev. 2017 04 15; 26(8):585-598. PMID: 28051360.
      View in: PubMed
    8. Liang S, Yin L, Shengyang Yu K, Hofmann MC, Yu X. High-Content Analysis Provides Mechanistic Insights into the Testicular Toxicity of Bisphenol A and Selected Analogues in Mouse Spermatogonial Cells. Toxicol Sci. 2017 01; 155(1):43-60. PMID: 27633978.
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    9. Danysh BP, Rieger EY, Sinha DK, Evers CV, Cote GJ, Cabanillas ME, Hofmann MC. Long-term vemurafenib treatment drives inhibitor resistance through a spontaneous KRAS G12D mutation in a BRAF V600E papillary thyroid carcinoma model. Oncotarget. 2016 May 24; 7(21):30907-23. PMID: 27127178.
      View in: PubMed
    10. Phan LM, Fuentes-Mattei E, Wu W, Velazquez-Torres G, Sircar K, Wood CG, Hai T, Jimenez C, Cote GJ, Ozsari L, Hofmann MC, Zheng S, Verhaak R, Pagliaro L, Cortez MA, Lee MH, Yeung SC, Habra MA. Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma. Cancer Res. 2015 Oct 01; 75(19):4131-42. PMID: 26282167.
      View in: PubMed
    11. Cote GJ, Grubbs EG, Hofmann MC. Thyroid C-Cell Biology and Oncogenic Transformation. Recent Results Cancer Res. 2015; 204:1-39. PMID: 26494382.
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    12. Garcia TX, Farmaha JK, Kow S, Hofmann MC. RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. Development. 2014 Dec; 141(23):4468-78. PMID: 25406395.
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    13. Garcia TX, Costa GM, França LR, Hofmann MC. Sub-acute intravenous administration of silver nanoparticles in male mice alters Leydig cell function and testosterone levels. Reprod Toxicol. 2014 Jun; 45:59-70. PMID: 24447867.
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    14. Hofmann MC. Stem cells and nanomaterials. Adv Exp Med Biol. 2014; 811:255-75. PMID: 24683036.
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    15. Garcia TX, Hofmann MC. NOTCH signaling in Sertoli cells regulates gonocyte fate. Cell Cycle. 2013 Aug 15; 12(16):2538-45. PMID: 23907117.
      View in: PubMed
    16. Gabrielson NP, Desai AV, Mahadik B, Hofmann MC, Kenis PJ, Harley BA. Cell-laden hydrogels in integrated microfluidic devices for long-term cell culture and tubulogenesis assays. Small. 2013 Sep 23; 9(18):3076-81. PMID: 23468408.
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    17. Ayala-Ramirez M, Palmer JL, Hofmann MC, de la Cruz M, Moon BS, Waguespack SG, Habra MA, Jimenez C. Bone metastases and skeletal-related events in patients with malignant pheochromocytoma and sympathetic paraganglioma. J Clin Endocrinol Metab. 2013 Apr; 98(4):1492-7. PMID: 23436918.
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    18. Garcia TX, DeFalco T, Capel B, Hofmann MC. Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. Dev Biol. 2013 May 01; 377(1):188-201. PMID: 23391689.
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    19. Costa GM, Avelar GF, Rezende-Neto JV, Campos-Junior PH, Lacerda SM, Andrade BS, Thomé RG, Hofmann MC, Franca LR. Spermatogonial stem cell markers and niche in equids. PLoS One. 2012; 7(8):e44091. PMID: 22937157.
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    20. Campos-Junior PH, Costa GM, Lacerda SM, Rezende-Neto JV, de Paula AM, Hofmann MC, de França LR. The spermatogonial stem cell niche in the collared peccary (Tayassu tajacu). Biol Reprod. 2012 May; 86(5):155, 1-10. PMID: 22262689.
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    21. Lucas BE, Fields C, Joshi N, Hofmann MC. Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signalling in mouse stem-progenitor spermatogonia. Toxicology. 2012 Sep 04; 299(1):10-9. PMID: 22564763.
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    22. Garcia T, Hofmann MC. Isolation of undifferentiated and early differentiating type A spermatogonia from Pou5f1-GFP reporter mice. Methods Mol Biol. 2012; 825:31-44. PMID: 22144234.
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    23. Waheeb R, Hofmann MC. Human spermatogonial stem cells: a possible origin for spermatocytic seminoma. Int J Androl. 2011 Aug; 34(4 Pt 2):e296-305; discussion e305. PMID: 21790653.
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    24. Simon L, Ekman GC, Garcia T, Carnes K, Zhang Z, Murphy T, Murphy KM, Hess RA, Cooke PS, Hofmann MC. ETV5 regulates sertoli cell chemokines involved in mouse stem/progenitor spermatogonia maintenance. Stem Cells. 2010 Oct; 28(10):1882-92. PMID: 20799334.
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    25. Braydich-Stolle LK, Lucas B, Schrand A, Murdock RC, Lee T, Schlager JJ, Hussain SM, Hofmann MC. Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells. Toxicol Sci. 2010 Aug; 116(2):577-89. PMID: 20488942.
      View in: PubMed
    26. Kokkinaki M, Lee TL, He Z, Jiang J, Golestaneh N, Hofmann MC, Chan WY, Dym M. Age affects gene expression in mouse spermatogonial stem/progenitor cells. Reproduction. 2010 Jun; 139(6):1011-20. PMID: 20371641.
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    27. Simon L, Ekman GC, Kostereva N, Zhang Z, Hess RA, Hofmann MC, Cooke PS. Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and nonreproductive tissues of all germ layers. Stem Cells. 2009 Jul; 27(7):1666-75. PMID: 19544441.
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    28. Morrow CM, Tyagi G, Simon L, Carnes K, Murphy KM, Cooke PS, Hofmann MC, Hess RA. Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function. Biol Reprod. 2009 Nov; 81(5):871-9. PMID: 19571261.
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    29. Liu CF, Barsoum I, Gupta R, Hofmann MC, Yao HH. Stem cell potential of the mammalian gonad. Front Biosci (Elite Ed). 2009 Jun 01; 1:510-8. PMID: 19482665.
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    30. Tyagi G, Carnes K, Morrow C, Kostereva NV, Ekman GC, Meling DD, Hostetler C, Griswold M, Murphy KM, Hess RA, Hofmann MC, Cooke PS. Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesis. Biol Reprod. 2009 Aug; 81(2):258-66. PMID: 19369650.
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    31. Lucas B, Fields C, Hofmann MC. Signaling pathways in spermatogonial stem cells and their disruption by toxicants. Birth Defects Res C Embryo Today. 2009 Mar; 87(1):35-42. PMID: 19306349.
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    32. Chu C, Schmidt JJ, Carnes K, Zhang Z, Kong HJ, Hofmann MC. Three-dimensional synthetic niche components to control germ cell proliferation. Tissue Eng Part A. 2009 Feb; 15(2):255-62. PMID: 18816170.
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    33. Kokkinaki M, Lee TL, He Z, Jiang J, Golestaneh N, Hofmann MC, Chan WY, Dym M. The molecular signature of spermatogonial stem/progenitor cells in the 6-day-old mouse testis. Biol Reprod. 2009 Apr; 80(4):707-17. PMID: 19109221.
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    34. Buchenauer A, Hofmann MC, Funke M, Büchs J, Mokwa W, Schnakenberg U. Micro-bioreactors for fed-batch fermentations with integrated online monitoring and microfluidic devices. Biosens Bioelectron. 2009 Jan 01; 24(5):1411-6. PMID: 18929478.
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    35. Kostereva N, Hofmann MC. Regulation of the spermatogonial stem cell niche. Reprod Domest Anim. 2008 Jul; 43 Suppl 2:386-92. PMID: 18638151.
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    36. Hofmann MC. Gdnf signaling pathways within the mammalian spermatogonial stem cell niche. Mol Cell Endocrinol. 2008 Jun 25; 288(1-2):95-103. PMID: 18485583.
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    37. Schlesser HN, Simon L, Hofmann MC, Murphy KM, Murphy T, Hess RA, Cooke PS. Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice. Biol Reprod. 2008 Mar; 78(3):483-9. PMID: 18032421.
      View in: PubMed
    38. He Z, Jiang J, Kokkinaki M, Golestaneh N, Hofmann MC, Dym M. Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation. Stem Cells. 2008 Jan; 26(1):266-78. PMID: 17962702.
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    39. Morrow CM, Hostetler CE, Griswold MD, Hofmann MC, Murphy KM, Cooke PS, Hess RA. ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilege. Ann N Y Acad Sci. 2007 Dec; 1120:144-51. PMID: 17911411.
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    40. He Z, Jiang J, Hofmann MC, Dym M. Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase. Biol Reprod. 2007 Oct; 77(4):723-33. PMID: 17625109.
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    41. Braydich-Stolle L, Kostereva N, Dym M, Hofmann MC. Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation. Dev Biol. 2007 Apr 01; 304(1):34-45. PMID: 17222400.
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    42. Hess RA, Cooke PS, Hofmann MC, Murphy KM. Mechanistic insights into the regulation of the spermatogonial stem cell niche. Cell Cycle. 2006 Jun; 5(11):1164-70. PMID: 16721062.
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    43. Braydich-Stolle L, Nolan C, Dym M, Hofmann MC. Role of glial cell line-derived neurotrophic factor in germ-line stem cell fate. Ann N Y Acad Sci. 2005 Dec; 1061:94-9. PMID: 16467260.
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    44. Chen C, Ouyang W, Grigura V, Zhou Q, Carnes K, Lim H, Zhao GQ, Arber S, Kurpios N, Murphy TL, Cheng AM, Hassell JA, Chandrashekar V, Hofmann MC, Hess RA, Murphy KM. ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature. 2005 Aug 18; 436(7053):1030-4. PMID: 16107850.
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    45. Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci. 2005 Dec; 88(2):412-9. PMID: 16014736.
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    46. Hofmann MC, Braydich-Stolle L, Dym M. Isolation of male germ-line stem cells; influence of GDNF. Dev Biol. 2005 Mar 01; 279(1):114-24. PMID: 15708562.
      View in: PubMed
    47. Hofmann MC, Braydich-Stolle L, Dettin L, Johnson E, Dym M. Immortalization of mouse germ line stem cells. Stem Cells. 2005 Feb; 23(2):200-10. PMID: 15671143.
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    48. Dettin L, Ravindranath N, Hofmann MC, Dym M. Morphological characterization of the spermatogonial subtypes in the neonatal mouse testis. Biol Reprod. 2003 Nov; 69(5):1565-71. PMID: 12855601.
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    49. Hofmann MC, Van Der Wee KS, Dargart JL, Dirami G, Dettin L, Dym M. Establishment and characterization of neonatal mouse sertoli cell lines. J Androl. 2003 Jan-Feb; 24(1):120-30. PMID: 12514093.
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    50. van der Wee KS, Johnson EW, Dirami G, Dym TM, Hofmann MC. Immunomagnetic isolation and long-term culture of mouse type A spermatogonia. J Androl. 2001 Jul-Aug; 22(4):696-704. PMID: 11451367.
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    51. Billotte WG, Dumas K, Hofmann MC. Transcriptional pathways induced by fluid shear stress in mouse preosteoblast cells. Biomed Sci Instrum. 2001; 37:1-6. PMID: 11347369.
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    52. van der Wee K, Hofmann MC. An in vitro tubule assay identifies HGF as a morphogen for the formation of seminiferous tubules in the postnatal mouse testis. Exp Cell Res. 1999 Oct 10; 252(1):175-85. PMID: 10502410.
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    53. Encina NR, Billotte WG, Hofmann MC. Immunomagnetic isolation of osteoprogenitors from human bone marrow stroma. Lab Invest. 1999 Apr; 79(4):449-57. PMID: 10211997.
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    54. Billotte WG, Hofmann MC. Establishment of a shear stress protocol to study the mechanosensitivity of human primary osteogenic cells in vitro. Biomed Sci Instrum. 1999; 35:327-32. PMID: 11143372.
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    55. Hofmann MC, Millan JL. Establishment of mammalian testicular cell lines. Methods Cell Biol. 1998; 57:93-110. PMID: 9648101.
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    56. Wolkowicz MJ, Coonrod SA, Reddi PP, Millan JL, Hofmann MC, Herr JC, Coonrod SM. Refinement of the differentiated phenotype of the spermatogenic cell line GC-2spd(ts) Biol Reprod. 1996 Oct; 55(4):923-32. PMID: 8879510.
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    57. Tsonis PA, Del Rio-Tsonis K, Wallace JL, Burns JC, Hofmann MC, Millan JL, Washabaugh CH. Can insights into urodele limb regeneration be achieved with cell cultures and retroviruses? Int J Dev Biol. 1996 Aug; 40(4):813-6. PMID: 8877455.
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    58. Hofmann MC, Abramian D, Millán JL. A haploid and a diploid cell coexist in an in vitro immortalized spermatogenic cell line. Dev Genet. 1995; 16(2):119-27. PMID: 7736662.
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    59. Hofmann MC, Hess RA, Goldberg E, Millán JL. Immortalized germ cells undergo meiosis in vitro. Proc Natl Acad Sci U S A. 1994 Jun 07; 91(12):5533-7. PMID: 8202522.
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    60. Cooker LA, Brooke CD, Kumari M, Hofmann MC, Millán JL, Goldberg E. Genomic structure and promoter activity of the human testis lactate dehydrogenase gene. Biol Reprod. 1993 Jun; 48(6):1309-19. PMID: 8318584.
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    61. Hofmann MC, Millán JL. Developmental expression of alkaline phosphatase genes; reexpression in germ cell tumours and in vitro immortalized germ cells. Eur Urol. 1993; 23(1):38-44; discussion 45. PMID: 8386657.
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    62. Narisawa S, Hofmann MC, Ziomek CA, Millán JL. Embryonic alkaline phosphatase is expressed at M-phase in the spermatogenic lineage of the mouse. Development. 1992 Sep; 116(1):159-65. PMID: 1483384.
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    63. Hofmann MC, Narisawa S, Hess RA, Millán JL. Immortalization of germ cells and somatic testicular cells using the SV40 large T antigen. Exp Cell Res. 1992 Aug; 201(2):417-35. PMID: 1322317.
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    64. Walt H, Emmerich P, Cremer T, Hofmann MC, Bannwart F. Supernumerary chromosome 1 in interphase nuclei of atypical germ cells in paraffin-embedded human seminiferous tubules. Lab Invest. 1989 Nov; 61(5):527-31. PMID: 2811300.
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    65. Hofmann MC, Jeltsch W, Brecher J, Walt H. Alkaline phosphatase isozymes in human testicular germ cell tumors, their precancerous stage, and three related cell lines. Cancer Res. 1989 Sep 01; 49(17):4696-700. PMID: 2547514.
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    66. Emmerich P, Jauch A, Hofmann MC, Cremer T, Walt H. Interphase cytogenetics in paraffin embedded sections from human testicular germ cell tumor xenografts and in corresponding cultured cells. Lab Invest. 1989 Aug; 61(2):235-42. PMID: 2755080.
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    67. The Sertoli cell. Andrology. 4:189-212.
    68. Synthetic stem cell niche for in vitro spermatogonial stem cell culture.
    69. Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma. Cancer Research. 75:4131-4142.
    70. Neurotrophic factors in the development of the postnatal male germ line. 149-184.
    71. Long-Term vemurafenib treatment drives inhibitor resistance through a spontaneous KRAS G12D mutation in a BRAF V600E papillary thyroid carcinoma model. Oncotarget. 7:30907-30923.
    72. Regulation of germ line stem cell homeostasis. Animal Reproduction. 12:35-45.
    73. Long-Term Cultures of Mammalian Spermatogonia. 449-470.
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