TitleAssociate Professor
InstitutionMD Anderson
DepartmentHead & Neck Surgery
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    R01DE026735     (CAULIN, CARLOS)Jan 1, 2018 - Dec 31, 2023
    Mechanisms of Adenoid Cystic Carcinoma Development and Tumor Maintenance
    Role: Principal Investigator

    R21DE023656     (CAULIN, CARLOS)Jul 10, 2014 - Dec 31, 2016
    Role of MYB and MYB-NFIB fusions in Salivary Adenoid Cystic Carcinoma
    Role: Principal Investigator

    R01DE015344     (CAULIN, CARLOS)Jan 13, 2005 - Dec 31, 2010
    Inductible mouse models for oral cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bauman JE, Saba NF, Roe D, Bauman JR, Kaczmar J, Bhatia A, Muzaffar J, Julian R, Wang S, Bearelly S, Baker A, Steuer C, Giri A, Burtness B, Centuori S, Caulin C, Klein R, Saboda K, Obara S, Chung CH. Randomized Phase II Trial of Ficlatuzumab With or Without Cetuximab in Pan-Refractory, Recurrent/Metastatic Head and Neck Cancer. J Clin Oncol. 2023 08 01; 41(22):3851-3862. PMID: 36977289.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    2. Yan H, Ma Y, Zhou X, He Y, Liu Y, Caulin C, Wang L, Xu H, Luo H. Spontaneous Murine Model of Anaplastic Thyroid Cancer. J Vis Exp. 2023 02 03; (192). PMID: 36804915.
      Citations:    Fields:    Translation:HumansAnimals
    3. Luo H, Xia X, Huang LB, An H, Cao M, Kim GD, Chen HN, Zhang WH, Shu Y, Kong X, Ren Z, Li PH, Liu Y, Tang H, Sun R, Li C, Bai B, Jia W, Liu Y, Zhang W, Yang L, Peng Y, Dai L, Hu H, Jiang Y, Hu Y, Zhu J, Jiang H, Li Z, Caulin C, Park J, Xu H. Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment. Nat Commun. 2022 Nov 04; 13(1):6619. PMID: 36333338; PMCID: PMC9636408.
      Citations: 29     Fields:    Translation:HumansCells
    4. Luo H, Xia X, Kim GD, Liu Y, Xue Z, Zhang L, Shu Y, Yang T, Chen Y, Zhang S, Chen H, Zhang W, Li R, Tang H, Dong B, Fu X, Cheng W, Zhang W, Yang L, Peng Y, Dai L, Hu H, Jiang Y, Gong C, Hu Y, Zhu J, Li Z, Caulin C, Wei T, Park J, Xu H. Characterizing dedifferentiation of thyroid cancer by integrated analysis. Sci Adv. 2021 Jul; 7(31). PMID: 34321197; PMCID: PMC8318367.
      Citations: 12     Fields:    
    5. Centuori SM, Caulin C, Bauman JE. Precision and Immunoprevention Strategies for Tobacco-Related Head and Neck Cancer Chemoprevention. Curr Treat Options Oncol. 2021 05 15; 22(6):52. PMID: 33991232; PMCID: PMC8122210.
      Citations:    Fields:    Translation:HumansAnimals
    6. Wang J, Hu Y, Escamilla-Rivera V, Gonzalez CL, Tang L, Wang B, El-Naggar AK, Myers JN, Caulin C. Epithelial Mutant p53 Promotes Resistance to Anti-PD-1-Mediated Oral Cancer Immunoprevention in Carcinogen-Induced Mouse Models. Cancers (Basel). 2021 Mar 23; 13(6). PMID: 33806894; PMCID: PMC8005156.
      Citations: 1     
    7. Chari NS, Ivan C, Le X, Li J, Mijiti A, Patel AA, Osman AA, Peterson CB, Williams MD, Pickering CR, Caulin C, Myers JN, Calin GA, Lai SY. Disruption of TP63-miR-27a* Feedback Loop by Mutant TP53 in Head and Neck Cancer. J Natl Cancer Inst. 2020 03 01; 112(3):266-277. PMID: 31124563; PMCID: PMC7073912.
      Citations: 1     Fields:    Translation:HumansCells
    8. Amit M, Takahashi H, Dragomir MP, Lindemann A, Gleber-Netto FO, Pickering CR, Anfossi S, Osman AA, Cai Y, Wang R, Knutsen E, Shimizu M, Ivan C, Rao X, Wang J, Silverman DA, Tam S, Zhao M, Caulin C, Zinger A, Tasciotti E, Dougherty PM, El-Naggar A, Calin GA, Myers JN. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature. 2020 02; 578(7795):449-454. PMID: 32051587; PMCID: PMC9723538.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    9. Hu Y, Song Z, Chen J, Caulin C. Overexpression of MYB in the Skin Induces Alopecia and Epidermal Hyperplasia. J Invest Dermatol. 2020 06; 140(6):1204-1213.e5. PMID: 31758945; PMCID: PMC7239756.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Wang J, Xie T, Wang B, William WN, Heymach JV, El-Naggar AK, Myers JN, Caulin C. PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions. Cancer Prev Res (Phila). 2017 Dec; 10(12):684-693. PMID: 29018057; PMCID: PMC5716880.
      Citations: 23     Fields:    Translation:AnimalsCells
    11. Li Z, Gonzalez CL, Wang B, Zhang Y, Mejia O, Katsonis P, Lichtarge O, Myers JN, El-Naggar AK, Caulin C. Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H). J Pathol. 2016 10; 240(2):224-34. PMID: 27447534; PMCID: PMC8570672.
      Citations: 17     Fields:    Translation:HumansAnimals
    12. Foy JP, Caulin C, Lang W, Hong WK, Lippman SM, Saintigny P, Tortereau A, Le Texier V, Lavergne E, Thomas E, Chabaud S, Perol D, Lachuer J, Goudot P, Bertolus C. The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. Oncotarget. 2016 Jun 14; 7(24):35932-35945. PMID: 27027432; PMCID: PMC5094973.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    13. Mitani Y, Liu B, Rao PH, Borra VJ, Zafereo M, Weber RS, Kies M, Lozano G, Futreal PA, Caulin C, El-Naggar AK. Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations. Clin Cancer Res. 2016 Feb 01; 22(3):725-33. PMID: 26631609; PMCID: PMC4807116.
      Citations: 61     Fields:    Translation:HumansCells
    14. Tanaka N, Patel AA, Wang J, Frederick MJ, Kalu NN, Zhao M, Fitzgerald AL, Xie TX, Silver NL, Caulin C, Zhou G, Skinner HD, Johnson FM, Myers JN, Osman AA. Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins. Clin Cancer Res. 2015 Nov 01; 21(21):4831-44. PMID: 26124202; PMCID: PMC4631620.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    15. Neskey DM, Osman AA, Ow TJ, Katsonis P, McDonald T, Hicks SC, Hsu TK, Pickering CR, Ward A, Patel A, Yordy JS, Skinner HD, Giri U, Sano D, Story MD, Beadle BM, El-Naggar AK, Kies MS, William WN, Caulin C, Frederick M, Kimmel M, Myers JN, Lichtarge O. Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. Cancer Res. 2015 Apr 01; 75(7):1527-36. PMID: 25634208; PMCID: PMC4383697.
      Citations: 80     Fields:    Translation:HumansCells
    16. Li X, Moses RE, Jin J, Cao W, Caulin C. Stresses, aging, and age-related disorders. Oxid Med Cell Longev. 2014; 2014:320564. PMID: 25610525; PMCID: PMC4293784.
      Citations:    Fields:    Translation:HumansAnimals
    17. Osman AA, Monroe MM, Ortega Alves MV, Patel AA, Katsonis P, Fitzgerald AL, Neskey DM, Frederick MJ, Woo SH, Caulin C, Hsu TK, McDonald TO, Kimmel M, Meyn RE, Lichtarge O, Myers JN. Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence. Mol Cancer Ther. 2015 Feb; 14(2):608-19. PMID: 25504633; PMCID: PMC4557970.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    18. Mitani Y, Rao PH, Maity SN, Lee YC, Ferrarotto R, Post JC, Licitra L, Lippman SM, Kies MS, Weber RS, Caulin C, Lin SH, El-Naggar AK. Alterations associated with androgen receptor gene activation in salivary duct carcinoma of both sexes: potential therapeutic ramifications. Clin Cancer Res. 2014 Dec 15; 20(24):6570-81. PMID: 25316813; PMCID: PMC4268116.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    19. Pickering CR, Zhou JH, Lee JJ, Drummond JA, Peng SA, Saade RE, Tsai KY, Curry JL, Tetzlaff MT, Lai SY, Yu J, Muzny DM, Doddapaneni H, Shinbrot E, Covington KR, Zhang J, Seth S, Caulin C, Clayman GL, El-Naggar AK, Gibbs RA, Weber RS, Myers JN, Wheeler DA, Frederick MJ. Mutational landscape of aggressive cutaneous squamous cell carcinoma. Clin Cancer Res. 2014 Dec 15; 20(24):6582-92. PMID: 25303977; PMCID: PMC4367811.
      Citations: 210     Fields:    Translation:Humans
    20. Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell. 2014 Jun 19; 54(6):960-974. PMID: 24857548; PMCID: PMC4067806.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    21. Zhang L, Mitani Y, Caulin C, Rao PH, Kies MS, Saintigny P, Zhang N, Weber RS, Lippman SM, El-Naggar AK. Detailed genome-wide SNP analysis of major salivary carcinomas localizes subtype-specific chromosome sites and oncogenes of potential clinical significance. Am J Pathol. 2013 Jun; 182(6):2048-57. PMID: 23583282; PMCID: PMC3668022.
      Citations: 9     Fields:    Translation:Humans
    22. Caulin C. Modeling squamous cell carcinoma development and malignant progression in mice. BMC Proc. 2013; 7 Suppl 2:K3. PMID: 24764482; PMCID: PMC3624509.
    23. Ali A, Wang Z, Fu J, Ji L, Liu J, Li L, Wang H, Chen J, Caulin C, Myers JN, Zhang P, Xiao J, Zhang B, Li X. Differential regulation of the REG?-proteasome pathway by p53/TGF-? signalling and mutant p53 in cancer cells. Nat Commun. 2013; 4:2667. PMID: 24157709; PMCID: PMC3876931.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    24. Mitani Y, Rao PH, Futreal PA, Roberts DB, Stephens PJ, Zhao YJ, Zhang L, Mitani M, Weber RS, Lippman SM, Caulin C, El-Naggar AK. Novel chromosomal rearrangements and break points at the t(6;9) in salivary adenoid cystic carcinoma: association with MYB-NFIB chimeric fusion, MYB expression, and clinical outcome. Clin Cancer Res. 2011 Nov 15; 17(22):7003-14. PMID: 21976542; PMCID: PMC3225955.
      Citations: 44     Fields:    Translation:HumansCells
    25. Torchia EC, Caulin C, Acin S, Terzian T, Kubick BJ, Box NF, Roop DR. Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma. Oncogene. 2012 May 24; 31(21):2680-90. PMID: 21963848; PMCID: PMC4576849.
      Citations: 13     Fields:    Translation:AnimalsCells
    26. Acin S, Li Z, Mejia O, Roop DR, El-Naggar AK, Caulin C. Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras. J Pathol. 2011 Dec; 225(4):479-89. PMID: 21952947; PMCID: PMC4302750.
      Citations: 26     Fields:    Translation:AnimalsCells
    27. Sano D, Xie TX, Ow TJ, Zhao M, Pickering CR, Zhou G, Sandulache VC, Wheeler DA, Gibbs RA, Caulin C, Myers JN. Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer. Clin Cancer Res. 2011 Nov 01; 17(21):6658-70. PMID: 21903770; PMCID: PMC3207013.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    28. Mitani Y, Li J, Weber RS, Lippman SL, Flores ER, Caulin C, El-Naggar AK. Expression and regulation of the ?N and TAp63 isoforms in salivary gland tumorigenesis clinical and experimental findings. Am J Pathol. 2011 Jul; 179(1):391-9. PMID: 21703418; PMCID: PMC3123859.
      Citations: 8     Fields:    Translation:HumansCells
    29. Mitani Y, Li J, Rao PH, Zhao YJ, Bell D, Lippman SM, Weber RS, Caulin C, El-Naggar AK. Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance. Clin Cancer Res. 2010 Oct 01; 16(19):4722-31. PMID: 20702610; PMCID: PMC5862426.
      Citations: 84     Fields:    Translation:Humans
    30. Torchia EC, Chen Y, Sheng H, Katayama H, Fitzpatrick J, Brinkley WR, Caulin C, Sen S, Roop DR. A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors. Cancer Res. 2009 Sep 15; 69(18):7207-15. PMID: 19738056; PMCID: PMC2745523.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    31. Caulin C, Nguyen T, Lang GA, Goepfert TM, Brinkley BR, Cai WW, Lozano G, Roop DR. An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest. 2007 Jul; 117(7):1893-901. PMID: 17607363; PMCID: PMC1904325.
      Citations: 63     Fields:    Translation:AnimalsCells
    32. Chen J, Cheng X, Merched-Sauvage M, Caulin C, Roop DR, Koch PJ. An unexpected role for keratin 10 end domains in susceptibility to skin cancer. J Cell Sci. 2006 Dec 15; 119(Pt 24):5067-76. PMID: 17118961.
      Citations: 18     Fields:    Translation:AnimalsCells
    33. Caulin C, Nguyen T, Longley MA, Zhou Z, Wang XJ, Roop DR. Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity. Cancer Res. 2004 Aug 01; 64(15):5054-8. PMID: 15289303.
      Citations: 51     Fields:    Translation:AnimalsCells
    34. Caulin C, Ware CF, Magin TM, Oshima RG. Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J Cell Biol. 2000 Apr 03; 149(1):17-22. PMID: 10747083; PMCID: PMC2175089.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    35. Salvesen GS, Oshima RG, Caul?n C. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. J Cell Biol. 1997 Sep 22; 138(6):1379-94. PMID: 9298992; PMCID: PMC2132555.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    36. Oshima RG, Baribault H, Caul?n C. Oncogenic regulation and function of keratins 8 and 18. Cancer Metastasis Rev. 1996 Dec; 15(4):445-71. PMID: 9034603.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    37. Navarro P, Lozano E, Rodrigo I, Gamallo C, Cano A, Fabra A, Quintanilla M, Caul?n C, L?pez-Barcons L, Gonz?les-Garrigues M. Suppression of the metastatic phenotype of a mouse skin carcinoma cell line independent of E-cadherin expression and correlated with reduced Ha-ras oncogene products. Mol Carcinog. 1996 Feb; 15(2):104-14. PMID: 8599577.
      Citations: 1     Fields:    Translation:AnimalsCells
    38. Scholl FG, Frontelo P, Gamallo C, Quintanilla M, Caul?n C. Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-beta 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype. Cell Growth Differ. 1995 Aug; 6(8):1027-35. PMID: 8547217.
      Citations: 27     Fields:    Translation:AnimalsCells
    39. Bauluz C, Gandarillas A, Cano A, Quintanilla M, Caul?n C. Changes in keratin expression during malignant progression of transformed mouse epidermal keratinocytes. Exp Cell Res. 1993 Jan; 204(1):11-21. PMID: 7677983.
      Citations: 22     Fields:    Translation:AnimalsCells
    40. Reply to. Journal of Cell Science. 120:1147-1148.
    41. Wee-1 kinase inhibition sensitizes high-risk HPV+ HNSCC to apoptosis accompanied by downregulation of MCl-1 and XIAP antiapoptotic proteins. Clinical Cancer Research. 21:4831-4844.
    42. The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. Oncotarget. 7:35932-35945.
    43. Evolutionary action score of TP53 identifies high-risk mutations associated with decreased survival and increased distant metastases in head and neck cancer. Cancer Research. 75:1527-1536.
    44. Ras oncogenes in chemical carcinogenesis. Oncologia. 14:101-106.
    45. Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations. Clinical Cancer Research. 22:725-733.
    46. Animal models of oral cancer metastasis. 135-161.
    47. Expression of intermediate filament proteins by normal and transformed mouse epidermal keratinocytes in culture. International Journal of Oncology. 2:373-379.
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