Loading...
Header Logo
Keywords
Last Name
Institution

KAREN C DWYER

TitleAssociate Professor
InstitutionMD Anderson
DepartmentStem Cell Transplantation
vCardDownload vCard

    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Berglund E, Andersen Ljungdahl M, Bogdanovic D, Berglund D, Wadström J, Kowalski J, Brandacher G, Kaminska D, Kaufman CL, Talbot SG, Azari K, Landin L, Höhnke C, Dwyer KM, Cavadas PC, Thione A, Clarke B, Kay S, Wilks D, Iyer S, Iglesias M, Özkan Ö, Özkan Ö, Krapf J, Weissenbacher A, Petruzzo P, Schneeberger S. Clinical Significance of Alloantibodies in Hand Transplantation: A Multicenter Study. Transplantation. 2019 10; 103(10):2173-2182. PMID: 30817406.
      View in: PubMed
    2. Phillips AA, Fields PA, Hermine O, Ramos JC, Beltran BE, Pereira J, Wandroo F, Feldman T, Taylor GP, Sawas A, Humphrey J, Kurman M, Moriya J, Dwyer K, Leoni M, Conlon K, Cook L, Gonsky J, Horwitz SM. Mogamulizumab versus investigator's choice of chemotherapy regimen in relapsed/refractory adult T-cell leukemia/lymphoma. Haematologica. 2019 05; 104(5):993-1003. PMID: 30573506.
      View in: PubMed
    3. Aleksova J, Ng KW, Jung C, Zeimer H, Dwyer KM, Milat F, MacIsaac RJ. Bone health in chronic kidney disease-mineral and bone disorder: a clinical case seminar and update. Intern Med J. 2018 Dec; 48(12):1435-1446. PMID: 30302919.
      View in: PubMed
    4. Chia JSJ, McRae JL, Enjapoori AK, Lefèvre CM, Kukuljan S, Dwyer KM. Dietary Cows' Milk Protein A1 Beta-Casein Increases the Incidence of T1D in NOD Mice. Nutrients. 2018 Sep 12; 10(9). PMID: 30213104.
      View in: PubMed
    5. Kim YH, Bagot M, Pinter-Brown L, Rook AH, Porcu P, Horwitz SM, Whittaker S, Tokura Y, Vermeer M, Zinzani PL, Sokol L, Morris S, Kim EJ, Ortiz-Romero PL, Eradat H, Scarisbrick J, Tsianakas A, Elmets C, Dalle S, Fisher DC, Halwani A, Poligone B, Greer J, Fierro MT, Khot A, Moskowitz AJ, Musiek A, Shustov A, Pro B, Geskin LJ, Dwyer K, Moriya J, Leoni M, Humphrey JS, Hudgens S, Grebennik DO, Tobinai K, Duvic M. Mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma (MAVORIC): an international, open-label, randomised, controlled phase 3 trial. Lancet Oncol. 2018 09; 19(9):1192-1204. PMID: 30100375.
      View in: PubMed
    6. Kishore BK, Robson SC, Dwyer KM. CD39-adenosinergic axis in renal pathophysiology and therapeutics. Purinergic Signal. 2018 06; 14(2):109-120. PMID: 29332180.
      View in: PubMed
    7. Lecamwasam A, Ekinci EI, J MacIsaac R, Saffery R, Dwyer KM. The threat among us: significance and scale of diabetic chronic kidney disease in Australia. Intern Med J. 2017 12; 47(12):1339-1341. PMID: 29224213.
      View in: PubMed
    8. Holien JK, Seibt B, Roberts V, Salvaris E, Parker MW, Cowan PJ, Dwyer KM. AMP and adenosine are both ligands for adenosine 2B receptor signaling. Bioorg Med Chem Lett. 2018 01 15; 28(2):202-206. PMID: 29191553.
      View in: PubMed
    9. Samudra AN, Dwyer KM, Selan C, Freddi S, Murray-Segal L, Nikpour M, Hickey MJ, Peter K, Robson SC, Sashindranath M, Cowan PJ, Nandurkar HH. CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages. J Autoimmun. 2018 03; 88:131-138. PMID: 29103803.
      View in: PubMed
    10. Dwyer KM, Carroll R, Hill P, Bateman S, Baker C, Langham RG, Morrison W. Refractory Vascular Rejection in a Hand Allograft in the Presence of Antibodies Against Angiotensin II (Type 1) Receptor. Transplantation. 2017 11; 101(11):e344-e345. PMID: 28767535.
      View in: PubMed
    11. Dwyer KM, Clark CJ, MacDonald K, Paraskeva MA, Rogers N, Ryan J, Webster AC, Wong G. Gender Equity in Transplantation: A Report from the Women in Transplantation Workshop of The Transplantation Society of Australia and New Zealand. Transplantation. 2017 10; 101(10):2266-2270. PMID: 28767533.
      View in: PubMed
    12. Langsford D, Steinberg A, Dwyer KM. Diabetes Mellitus Following Renal Transplantation: Clinical and Pharmacological Considerations for the Elderly Patient. Drugs Aging. 2017 08; 34(8):589-601. PMID: 28718072.
      View in: PubMed
    13. McRae JL, Chia JS, Pommey SA, Dwyer KM. Evaluation of CD4+ CD25+/- CD39+ T-cell populations in peripheral blood of patients following kidney transplantation and during acute allograft rejection. Nephrology (Carlton). 2017 Jul; 22(7):505-512. PMID: 27517975.
      View in: PubMed
    14. Roberts V, Campbell DJ, Lu B, Chia J, Cowan PJ, Dwyer KM. The Differential Effect of Apyrase Treatment and hCD39 Overexpression on Chronic Renal Fibrosis After Ischemia-Reperfusion Injury. Transplantation. 2017 07; 101(7):e194-e204. PMID: 28198766.
      View in: PubMed
    15. Bongoni AK, Lu B, Salvaris EJ, Roberts V, Fang D, McRae JL, Fisicaro N, Dwyer KM, Cowan PJ. Overexpression of Human CD55 and CD59 or Treatment with Human CD55 Protects against Renal Ischemia-Reperfusion Injury in Mice. J Immunol. 2017 06 15; 198(12):4837-4845. PMID: 28500075.
      View in: PubMed
    16. Sashindranath M, Dwyer KM, Dezfouli S, Selan C, Crikis S, Lu B, Yuan Y, Hickey MJ, Peter K, Robson SC, Cowan PJ, Nandurkar HH. Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia-reperfusion injury. Purinergic Signal. 2017 06; 13(2):259-265. PMID: 28343356.
      View in: PubMed
    17. Tan SJ, Crosthwaite A, Langsford D, Obeysekere V, Ierino FL, Roberts MA, Hughes PD, Hewitson TD, Dwyer KM, Toussaint ND. Mineral adaptations following kidney transplantation. Transpl Int. 2017 May; 30(5):463-473. PMID: 28120476.
      View in: PubMed
    18. Langsford D, Obeyesekere V, Vogrin S, Teng J, MacIsaac RJ, Ward G, Alford F, Dwyer KM. A Prospective Study of Renal Transplant Recipients: A Fall in Insulin Secretion Underpins Dysglycemia After Renal Transplantation. Transplant Direct. 2016 Nov; 2(11):e107. PMID: 27826600.
      View in: PubMed
    19. Covarrubias R, Chepurko E, Reynolds A, Huttinger ZM, Huttinger R, Stanfill K, Wheeler DG, Novitskaya T, Robson SC, Dwyer KM, Cowan PJ, Gumina RJ. Role of the CD39/CD73 Purinergic Pathway in Modulating Arterial Thrombosis in Mice. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1809-20. PMID: 27417582.
      View in: PubMed
    20. Zinzani PL, Karlin L, Radford J, Caballero D, Fields P, Chamuleau ME, d'Amore F, Haioun C, Thieblemont C, González-Barca E, García CG, Johnson PW, van Imhoff GW, Ng T, Dwyer K, Morschhauser F. European phase II study of mogamulizumab, an anti-CCR4 monoclonal antibody, in relapsed/refractory peripheral T-cell lymphoma. Haematologica. 2016 10; 101(10):e407-e410. PMID: 27418646.
      View in: PubMed
    21. Fang DY, Lu B, Hayward S, de Kretser DM, Cowan PJ, Dwyer KM. The Role of Activin A and B and the Benefit of Follistatin Treatment in Renal Ischemia-Reperfusion Injury in Mice. Transplant Direct. 2016 Jul; 2(7):e87. PMID: 27830181.
      View in: PubMed
    22. Hill PA, McRae JL, Dwyer KM. PLA2R and membranous nephropathy: A 3?year prospective Australian study. Nephrology (Carlton). 2016 May; 21(5):397-403. PMID: 26369693.
      View in: PubMed
    23. Langsford D, Dwyer K. Dysglycemia after renal transplantation: Definition, pathogenesis, outcomes and implications for management. World J Diabetes. 2015 Aug 25; 6(10):1132-51. PMID: 26322159.
      View in: PubMed
    24. Colla S, Ong DS, Ogoti Y, Marchesini M, Mistry NA, Clise-Dwyer K, Ang SA, Storti P, Viale A, Giuliani N, Ruisaard K, Ganan Gomez I, Bristow CA, Estecio M, Weksberg DC, Ho YW, Hu B, Genovese G, Pettazzoni P, Multani AS, Jiang S, Hua S, Ryan MC, Carugo A, Nezi L, Wei Y, Yang H, D'Anca M, Zhang L, Gaddis S, Gong T, Horner JW, Heffernan TP, Jones P, Cooper LJ, Liang H, Kantarjian H, Wang YA, Chin L, Bueso-Ramos C, Garcia-Manero G, DePinho RA. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell. 2015 May 11; 27(5):644-57. PMID: 25965571.
      View in: PubMed
    25. Zhang Y, Robson SC, Morris KL, Heiney KM, Dwyer KM, Kishore BK, Ecelbarger CM. Impaired natriuretic response to high-NaCl diet plus aldosterone infusion in mice overexpressing human CD39, an ectonucleotidase (NTPDase1). Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1398-408. PMID: 25877509.
      View in: PubMed
    26. Robson K, Hill P, Langsford D, Dwyer K, Goodman D, Langham R. Galactose therapy reduces proteinuria in patients with recurrent focal segmental glomerulosclerosis after kidney transplantation. Nephrology (Carlton). 2015 Mar; 20 Suppl 1:13-6. PMID: 25807852.
      View in: PubMed
    27. Mallampati S, Leng X, Ma H, Zeng J, Li J, Wang H, Lin K, Lu Y, Yang Y, Sun B, Gong Y, Lee JS, Konopleva M, Andreeff M, Arlinghaus RB, Cai Z, Fang B, Shen H, Han X, Hirsch-Ginsberg CF, Gao X, Paranjape AN, Mani SA, Clise-Dwyer K, Sun X. Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia. Blood. 2015 May 07; 125(19):2968-73. PMID: 25712988.
      View in: PubMed
    28. Duvic M, Pinter-Brown LC, Foss FM, Sokol L, Jorgensen JL, Challagundla P, Dwyer KM, Zhang X, Kurman MR, Ballerini R, Liu L, Kim YH. Phase 1/2 study of mogamulizumab, a defucosylated anti-CCR4 antibody, in previously treated patients with cutaneous T-cell lymphoma. Blood. 2015 Mar 19; 125(12):1883-9. PMID: 25605368.
      View in: PubMed
    29. Li J, Kurasawa Y, Wang Y, Clise-Dwyer K, Klumpp SA, Liang H, Tailor RC, Raymond AC, Estrov Z, Brandt SJ, Davis RE, Zweidler-McKay P, Amin HM, Nagarajan L. Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response. J Immunol. 2014 Nov 01; 193(9):4654-62. PMID: 25238756.
      View in: PubMed
    30. Chakraborty R, Hampton OA, Shen X, Simko SJ, Shih A, Abhyankar H, Lim KP, Covington KR, Trevino L, Dewal N, Muzny DM, Doddapaneni H, Hu J, Wang L, Lupo PJ, Hicks MJ, Bonilla DL, Dwyer KC, Berres ML, Poulikakos PI, Merad M, McClain KL, Wheeler DA, Allen CE, Parsons DW. Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. Blood. 2014 Nov 06; 124(19):3007-15. PMID: 25202140.
      View in: PubMed
    31. Teng J, Dwyer KM, Hill P, See E, Ekinci EI, Jerums G, MacIsaac RJ. Spectrum of renal disease in diabetes. Nephrology (Carlton). 2014 Sep; 19(9):528-36. PMID: 24899354.
      View in: PubMed
    32. Roberts VS, Cowan PJ, Alexander SI, Robson SC, Dwyer KM. The role of adenosine receptors A2A and A2B signaling in renal fibrosis. Kidney Int. 2014 Oct; 86(4):685-92. PMID: 25054776.
      View in: PubMed
    33. Qin H, Lerman B, Sakamaki I, Wei G, Cha SC, Rao SS, Qian J, Hailemichael Y, Nurieva R, Dwyer KC, Roth J, Yi Q, Overwijk WW, Kwak LW. Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice. Nat Med. 2014 Jun; 20(6):676-81. PMID: 24859530.
      View in: PubMed
    34. Jiang H, Clise-Dwyer K, Ruisaard KE, Fan X, Tian W, Gumin J, Lamfers ML, Kleijn A, Lang FF, Yung WK, Vence LM, Gomez-Manzano C, Fueyo J. Delta-24-RGD oncolytic adenovirus elicits anti-glioma immunity in an immunocompetent mouse model. PLoS One. 2014; 9(5):e97407. PMID: 24827739.
      View in: PubMed
    35. Ducharlet K, Murphy C, Tan SJ, Dwyer KM, Goodman D, Aboltins C, Daffy JR, Langham RG. Recurrent Mycobacterium haemophilum in a renal transplant recipient. Nephrology (Carlton). 2014 Apr; 19 Suppl 1:14-7. PMID: 24460607.
      View in: PubMed
    36. Roberts V, Stagg J, Dwyer KM. The Role of Ectonucleotidases CD39 and CD73 and Adenosine Signaling in Solid Organ Transplantation. Front Immunol. 2014; 5:64. PMID: 24600452.
      View in: PubMed
    37. Tay SS, Lu B, Sierro F, Benseler V, McGuffog CM, Bishop GA, Cowan PJ, McCaughan GW, Dwyer KM, Bowen DG, Bertolino P. Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation. Liver Transpl. 2013 Nov; 19(11):1224-35. PMID: 23913831.
      View in: PubMed
    38. Beavis PA, Divisekera U, Paget C, Chow MT, John LB, Devaud C, Dwyer K, Stagg J, Smyth MJ, Darcy PK. Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14711-6. PMID: 23964122.
      View in: PubMed
    39. Dwyer KM, Webb AR, Furniss HS, Anjou KE, Gibbs-Dwyer JM, McCombe DB, Grinsell DG, Dickinson GF, Williams RA, Russell PA, Scott DA, Baker C, Vogrin SJ, Langham RG, Opdam HI, Morrison WA. First hand transplant procedure in Australia: outcome at 2 years. Med J Aust. 2013 Aug 19; 199(4):285-7. PMID: 23984788.
      View in: PubMed
    40. Westall GP, Levvey BJ, Salvaris E, Gooi J, Marasco S, Rosenfeldt F, Egan C, McEgan Ccp R, Mennen M, Russell P, Robson SC, Nottle MB, Dwyer KM, Snell GI, Cowan PJ. Sustained function of genetically modified porcine lungs in an ex vivo model of pulmonary xenotransplantation. J Heart Lung Transplant. 2013 Nov; 32(11):1123-30. PMID: 23932853.
      View in: PubMed
    41. McFarlin BK, Williams RR, Venable AS, Dwyer KC, Haviland DL. Image-based cytometry reveals three distinct subsets of activated granulocytes based on phagocytosis and oxidative burst. Cytometry A. 2013 Aug; 83(8):745-51. PMID: 23839911.
      View in: PubMed
    42. Fraser SA, Choy SW, Pastor-Soler NM, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJ, Hallows KR, Kemp BE, Power DA. AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F679-90. PMID: 23785098.
      View in: PubMed
    43. Tan SJ, Ducharlet K, Dwyer KM, Myers D, Langham RG, Hill PA. A case of triple pathology: seronegative anti-glomerular basement membrane antibody-mediated glomerulonephritis and membranous nephropathy in a patient with underlying diabetic kidney disease. Clin Kidney J. 2013 Jun; 6(3):322-6. PMID: 26064494.
      View in: PubMed
    44. McRae JL, Russell PA, Chia JS, Dwyer KM. Overexpression of CD39 protects in a mouse model of preeclampsia. Nephrology (Carlton). 2013 May; 18(5):351-5. PMID: 23600369.
      View in: PubMed
    45. Roberts V, Rajakumar SV, Crikis S, Dwyer KM, Hill PA, Goodman DJ. Long-term renal allograft survival after posttransplantation diagnosis of primary hyperoxaluria. Transplantation. 2013 Mar 27; 95(6):e35-6. PMID: 23507654.
      View in: PubMed
    46. Pommey S, Lu B, McRae J, Stagg J, Hill P, Salvaris E, Robson SC, d'Apice AJ, Cowan PJ, Dwyer KM. Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+ T cells. Hepatology. 2013 Apr; 57(4):1597-606. PMID: 22829222.
      View in: PubMed
    47. Chia JS, McRae JL, Thomas HE, Fynch S, Elkerbout L, Hill P, Murray-Segal L, Robson SC, Chen JF, d'Apice AJ, Cowan PJ, Dwyer KM. The protective effects of CD39 overexpression in multiple low-dose streptozotocin-induced diabetes in mice. Diabetes. 2013 Jun; 62(6):2026-35. PMID: 23364452.
      View in: PubMed
    48. Roberts V, Lu B, Rajakumar S, Cowan PJ, Dwyer KM. The CD39-adenosinergic axis in the pathogenesis of renal ischemia-reperfusion injury. Purinergic Signal. 2013 Jun; 9(2):135-43. PMID: 23188420.
      View in: PubMed
    49. Zhang M, Sukhumalchandra P, Enyenihi AA, St John LS, Hunsucker SA, Mittendorf EA, Sergeeva A, Ruisaard K, Al-Atrache Z, Ropp PA, Jakher H, Rodriguez-Cruz T, Lizee G, Clise-Dwyer K, Lu S, Molldrem JJ, Glish GL, Armistead PM, Alatrash G. A novel HLA-A*0201 restricted peptide derived from cathepsin G is an effective immunotherapeutic target in acute myeloid leukemia. Clin Cancer Res. 2013 Jan 01; 19(1):247-57. PMID: 23147993.
      View in: PubMed
    50. Alatrash G, Mittendorf EA, Sergeeva A, Sukhumalchandra P, Qiao N, Zhang M, St John LS, Ruisaard K, Haugen CE, Al-Atrache Z, Jakher H, Philips AV, Ding X, Chen JQ, Wu Y, Patenia RS, Bernatchez C, Vence LM, Radvanyi LG, Hwu P, Clise-Dwyer K, Ma Q, Lu S, Molldrem JJ. Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapy. J Immunol. 2012 Dec 01; 189(11):5476-84. PMID: 23105141.
      View in: PubMed
    51. Stagg J, Thompson LF, Dwyer KM. Ectonucleotidases in cancer and inflammation. J Biomed Biotechnol. 2012; 2012:951423. PMID: 23125527.
      View in: PubMed
    52. Chia JS, McRae JL, Cowan PJ, Dwyer KM. The CD39-adenosinergic axis in the pathogenesis of immune and nonimmune diabetes. J Biomed Biotechnol. 2012; 2012:320495. PMID: 23118504.
      View in: PubMed
    53. Wang YM, McRae JL, Robson SC, Cowan PJ, Zhang GY, Hu M, Polhill T, Wang Y, Zheng G, Wang Y, Lee VW, Unwin RJ, Harris DC, Dwyer KM, Alexander SI. Regulatory T cells participate in CD39-mediated protection from renal injury. Eur J Immunol. 2012 Sep; 42(9):2441-51. PMID: 22684996.
      View in: PubMed
    54. Foglietta M, Neelapu SS, Kwak LW, Jiang Y, Nattamai D, Lee ST, Fowler DH, Sportes C, Gress RE, Steinberg SM, Vence LM, Radvanyi L, Dwyer KC, Qazilbash MH, Bryant RN, Bishop MR. Neoantigen and tumor antigen-specific immunity transferred from immunized donors is detectable early after allogeneic transplantation in myeloma patients. Bone Marrow Transplant. 2013 Feb; 48(2):269-77. PMID: 22773122.
      View in: PubMed
    55. Teng J, Hoo XN, Tan SJ, Dwyer K. Serum sickness following rabbit anti-thymocyte globulin for acute vascular renal allograft rejection. Clin Kidney J. 2012 Aug; 5(4):334-5. PMID: 25874092.
      View in: PubMed
    56. Spain L, Iser P, Steinberg A, Dwyer KM. Hypertensive crisis precipitated by insulin-induced hypoglycemia with end-stage renal failure. Clin Kidney J. 2012 Aug; 5(4):362-3. PMID: 25874100.
      View in: PubMed
    57. Zhang Y, Morris KL, Sparrow SK, Dwyer KM, Enjyoji K, Robson SC, Kishore BK. Defective renal water handling in transgenic mice over-expressing human CD39/NTPDase1. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F420-30. PMID: 22622462.
      View in: PubMed
    58. Huttinger ZM, Milks MW, Nickoli MS, Aurand WL, Long LC, Wheeler DG, Dwyer KM, d'Apice AJ, Robson SC, Cowan PJ, Gumina RJ. Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice. Am J Pathol. 2012 Jul; 181(1):322-33. PMID: 22613024.
      View in: PubMed
    59. Mittendorf EA, Alatrash G, Qiao N, Wu Y, Sukhumalchandra P, St John LS, Philips AV, Xiao H, Zhang M, Ruisaard K, Clise-Dwyer K, Lu S, Molldrem JJ. Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response. Cancer Res. 2012 Jul 01; 72(13):3153-62. PMID: 22564522.
      View in: PubMed
    60. Alatrash G, Ono Y, Sergeeva A, Sukhumalchandra P, Zhang M, St John LS, Yang TH, Ruisaard K, Armistead PM, Mittendorf EA, He H, Qiao N, Rodriguez-Cruz T, Liang S, Clise-Dwyer K, Wieder ED, Lizee G, Lu S, Molldrem JJ. The role of antigen cross-presentation from leukemia blasts on immunity to the leukemia-associated antigen PR1. J Immunother. 2012 May; 35(4):309-20. PMID: 22495388.
      View in: PubMed
    61. Wheeler DG, Joseph ME, Mahamud SD, Aurand WL, Mohler PJ, Pompili VJ, Dwyer KM, Nottle MB, Harrison SJ, d'Apice AJ, Robson SC, Cowan PJ, Gumina RJ. Transgenic swine: expression of human CD39 protects against myocardial injury. J Mol Cell Cardiol. 2012 May; 52(5):958-61. PMID: 22269791.
      View in: PubMed
    62. Tehan JV, Tan SJ, Gregg W, Dwyer K. An interaction between tacrolimus and pristinamycin resulting in an elevated tacrolimus level. NDT Plus. 2011 Dec; 4(6):456-7. PMID: 25984230.
      View in: PubMed
    63. Cai M, Huttinger ZM, He H, Zhang W, Li F, Goodman LA, Wheeler DG, Druhan LJ, Zweier JL, Dwyer KM, He G, d'Apice AJ, Robson SC, Cowan PJ, Gumina RJ. Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury. J Mol Cell Cardiol. 2011 Dec; 51(6):927-35. PMID: 21939667.
      View in: PubMed
    64. Künzli BM, Bernlochner MI, Rath S, Käser S, Csizmadia E, Enjyoji K, Cowan P, d'Apice A, Dwyer K, Rosenberg R, Perren A, Friess H, Maurer CA, Robson SC. Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer. Purinergic Signal. 2011 Jun; 7(2):231-41. PMID: 21484085.
      View in: PubMed
    65. Sergeeva A, Alatrash G, He H, Ruisaard K, Lu S, Wygant J, McIntyre BW, Ma Q, Li D, St John L, Clise-Dwyer K, Molldrem JJ. An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells. Blood. 2011 Apr 21; 117(16):4262-72. PMID: 21296998.
      View in: PubMed
    66. Rajakumar SV, Lu B, Crikis S, Robson SC, d'Apice AJ, Cowan PJ, Dwyer KM. Deficiency or inhibition of CD73 protects in mild kidney ischemia-reperfusion injury. Transplantation. 2010 Dec 27; 90(12):1260-4. PMID: 21063242.
      View in: PubMed
    67. Künzli BM, Berberat PO, Dwyer K, Deaglio S, Csizmadia E, Cowan P, d'Apice A, Moore G, Enjyoji K, Friess H, Robson SC. Variable impact of CD39 in experimental murine colitis. Dig Dis Sci. 2011 May; 56(5):1393-403. PMID: 20936356.
      View in: PubMed
    68. Ma Q, Wang C, Jones D, Quintanilla KE, Li D, Wang Y, Wieder ED, Clise-Dwyer K, Alatrash G, Mj Y, Munsell MF, Lu S, Qazilbash MH, Molldrem JJ. Adoptive transfer of PR1 cytotoxic T lymphocytes associated with reduced leukemia burden in a mouse acute myeloid leukemia xenograft model. Cytotherapy. 2010 Dec; 12(8):1056-62. PMID: 20735170.
      View in: PubMed
    69. Kanodia S, Wieder E, Lu S, Talpaz M, Alatrash G, Clise-Dwyer K, Molldrem JJ. PR1-specific T cells are associated with unmaintained cytogenetic remission of chronic myelogenous leukemia after interferon withdrawal. PLoS One. 2010 Jul 26; 5(7):e11770. PMID: 20668669.
      View in: PubMed
    70. Samudio IJ, Duvvuri S, Clise-Dwyer K, Watt JC, Mak D, Kantarjian H, Yang D, Ruvolo V, Borthakur G. Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells. Leuk Lymphoma. 2010 May; 51(5):911-919. PMID: 20423286.
      View in: PubMed
    71. Ling X, Marini F, Konopleva M, Schober W, Shi Y, Burks J, Clise-Dwyer K, Wang RY, Zhang W, Yuan X, Lu H, Caldwell L, Andreeff M. Mesenchymal Stem Cells Overexpressing IFN-ß Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model. Cancer Microenviron. 2010 Mar 19; 3(1):83-95. PMID: 21209776.
      View in: PubMed
    72. Stagg J, Divisekera U, McLaughlin N, Sharkey J, Pommey S, Denoyer D, Dwyer KM, Smyth MJ. Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1547-52. PMID: 20080644.
      View in: PubMed
    73. Tsukamoto H, Clise-Dwyer K, Huston GE, Duso DK, Buck AL, Johnson LL, Haynes L, Swain SL. Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18333-8. PMID: 19815516.
      View in: PubMed
    74. Lu B, Rajakumar SV, Robson SC, Lee EK, Crikis S, d'Apice AJ, Cowan PJ, Dwyer KM. The impact of purinergic signaling on renal ischemia-reperfusion injury. Transplantation. 2008 Dec 27; 86(12):1707-12. PMID: 19104409.
      View in: PubMed
    75. Hill P, Russell P, Sammartino C, Wiggins K, Dwyer K. Acute kidney injury and proteinuria in a patient with diabetes and a submandibular mass. Am J Kidney Dis. 2009 Aug; 54(2):375-80. PMID: 18976846.
      View in: PubMed
    76. Fiegl M, Samudio I, Clise-Dwyer K, Burks JK, Mnjoyan Z, Andreeff M. CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure. Blood. 2009 Feb 12; 113(7):1504-12. PMID: 18957686.
      View in: PubMed
    77. Samudio I, Fiegl M, McQueen T, Clise-Dwyer K, Andreeff M. The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation. Cancer Res. 2008 Jul 01; 68(13):5198-205. PMID: 18593920.
      View in: PubMed
    78. Jones SC, Clise-Dwyer K, Huston G, Dibble J, Eaton S, Haynes L, Swain SL. Impact of post-thymic cellular longevity on the development of age-associated CD4+ T cell defects. J Immunol. 2008 Apr 01; 180(7):4465-75. PMID: 18354168.
      View in: PubMed
    79. Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007 Jun 11; 204(6):1257-65. PMID: 17502665.
      View in: PubMed
    80. Dwyer KM, Deaglio S, Gao W, Friedman D, Strom TB, Robson SC. CD39 and control of cellular immune responses. Purinergic Signal. 2007 Mar; 3(1-2):171-80. PMID: 18404431.
      View in: PubMed
    81. Clise-Dwyer K, Huston GE, Buck AL, Duso DK, Swain SL. Environmental and intrinsic factors lead to antigen unresponsiveness in CD4(+) recent thymic emigrants from aged mice. J Immunol. 2007 Feb 01; 178(3):1321-31. PMID: 17237378.
      View in: PubMed
    82. Dwyer KM, Mysore TB, Crikis S, Robson SC, Nandurkar H, Cowan PJ, D'Apice AJ. The transgenic expression of human CD39 on murine islets inhibits clotting of human blood. Transplantation. 2006 Aug 15; 82(3):428-32. PMID: 16906044.
      View in: PubMed
    83. Wu Y, Sun X, Kaczmarek E, Dwyer KM, Bianchi E, Usheva A, Robson SC. RanBPM associates with CD39 and modulates ecto-nucleotidase activity. Biochem J. 2006 May 15; 396(1):23-30. PMID: 16478441.
      View in: PubMed
    84. Atkinson B, Dwyer K, Enjyoji K, Robson SC. Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):217-22. PMID: 16476557.
      View in: PubMed
    85. Swain S, Clise-Dwyer K, Haynes L. Homeostasis and the age-associated defect of CD4 T cells. Semin Immunol. 2005 Oct; 17(5):370-7. PMID: 15964201.
      View in: PubMed
    86. Kalogerakis G, Baker AM, Christov S, Rowley KG, Dwyer K, Winterbourn C, Best JD, Jenkins AJ. Oxidative stress and high-density lipoprotein function in Type I diabetes and end-stage renal disease. Clin Sci (Lond). 2005 Jun; 108(6):497-506. PMID: 15634192.
      View in: PubMed
    87. Robson SC, Wu Y, Sun X, Knosalla C, Dwyer K, Enjyoji K. Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation. Semin Thromb Hemost. 2005 Apr; 31(2):217-33. PMID: 15852225.
      View in: PubMed
    88. Firkin F, Hill PA, Dwyer K, Gock H. Reversal of dialysis-dependent renal failure in light-chain deposition disease by autologous peripheral blood stem cell transplantation. Am J Kidney Dis. 2004 Sep; 44(3):551-5. PMID: 15332228.
      View in: PubMed
    89. Dwyer KM, Robson SC, Nandurkar HH, Campbell DJ, Gock H, Murray-Segal LJ, Fisicaro N, Mysore TB, Kaczmarek E, Cowan PJ, d'Apice AJ. Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation. J Clin Invest. 2004 May; 113(10):1440-6. PMID: 15146241.
      View in: PubMed
    90. Hill P, Dwyer K, Kay T, Murphy B. Severe chronic renal failure in association with oxycodone addiction: a new form of fibrillary glomerulopathy. Hum Pathol. 2002 Aug; 33(8):783-7. PMID: 12203209.
      View in: PubMed
    91. Dwyer KM, Vrazas JI, Lodge RS, Humphery TJ, Schlicht SM, Murphy BF, Mossop PJ, Goodman DJ. Treatment of acute renal failure caused by renal artery occlusion with renal artery angioplasty. Am J Kidney Dis. 2002 Jul; 40(1):189-94. PMID: 12087578.
      View in: PubMed
    92. Dwyer KM, Francis DM, Hill PA, Murphy BF. Calcific uraemic arteriolopathy: local treatment and hyperbaric oxygen therapy. Nephrol Dial Transplant. 2002 Jun; 17(6):1148-9. PMID: 12032219.
      View in: PubMed
    93. Hill PA, Firkin F, Dwyer KM, Lee P, Murphy BF. Membranoproliferative glomerulonephritis in association with chronic lymphocytic leukaemia: a report of three cases. Pathology. 2002 Apr; 34(2):138-43. PMID: 12009095.
      View in: PubMed
    94. Dwyer KM, Cowan PJ, d'Apice AJ. Xenotransplantation: past achievements and future promise. Heart Lung Circ. 2002; 11(1):32-41. PMID: 16352066.
      View in: PubMed
    95. Clise-Dwyer K, Amanna IJ, Duzeski JL, Nashold FE, Hayes CE. Genetic studies of B-lymphocyte deficiency and mastocytosis in strain A/WySnJ mice. Immunogenetics. 2001 Dec; 53(9):729-35. PMID: 11862404.
      View in: PubMed
    96. Harless SM, Lentz VM, Sah AP, Hsu BL, Clise-Dwyer K, Hilbert DM, Hayes CE, Cancro MP. Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers. Curr Biol. 2001 Dec 11; 11(24):1986-9. PMID: 11747827.
      View in: PubMed
    97. Amanna IJ, Clise-Dwyer K, Nashold FE, Hoag KA, Hayes CE. Cutting edge: A/WySnJ transitional B cells overexpress the chromosome 15 proapoptotic Blk gene and succumb to premature apoptosis. J Immunol. 2001 Dec 01; 167(11):6069-72. PMID: 11714762.
      View in: PubMed
    98. Hoag KA, Clise-Dwyer K, Lim YH, Nashold FE, Gestwicki J, Cancro MP, Hayes CE. A quantitative-trait locus controlling peripheral B-cell deficiency maps to mouse Chromosome 15. Immunogenetics. 2000 Sep; 51(11):924-9. PMID: 11003386.
      View in: PubMed
    99. Neutrophil elastase enhances antigen presentation by upregulating human leukocyte antigen class I expression on tumor cells. Cancer Immunology, Immunotherapy. 1-11.
    100. A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells. Cytotherapy.
    101. PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies. Leukemia.
    102. Activity of 8F4, a T-cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo. Leukemia.
    103. Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma. OncoImmunology. 5.
    104. PR1-specific cytotoxic T lymphocytes are relatively frequent in umbilical cord blood and can be effectively expanded to target myeloid leukemia. Cytotherapy. 18:995-1001.
    105. Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target. Leukemia.
    106. Batf is important for IL-4 expression in T follicular helper cells. Nature Communications. 6.
    DWYER's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description