TitleAssistant Professor
InstitutionMD Anderson
DepartmentSystems Biology
Address6565 MD Anderson Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sharma P, Aaroe A, Liang J, Puduvalli VK. Tumor microenvironment in glioblastoma: Current and emerging concepts. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad009. PMID: 36968288; PMCID: PMC10034917.
      Citations: 6     
    2. Liang J, Fang D, Gumin J, Najem H, Sooreshjani M, Song R, Sabbagh A, Kong LY, Duffy J, Balyasnikova IV, Pollack SM, Puduvalli VK, Heimberger AB. A Case Study of Chimeric Antigen Receptor T Cell Function: Donor Therapeutic Differences in Activity and Modulation with Verteporfin. Cancers (Basel). 2023 Feb 08; 15(4). PMID: 36831427; PMCID: PMC9953964.
      Citations: 1     
    3. Shen X, Zhao Y, Liu G, Zhou HL, Fan J, Zhang L, Li YL, Wang Y, Liang J, Xu ZX. Upregulation of programmed death ligand 1 by liver kinase B1 and its implication in programmed death 1 blockade therapy in non-small cell lung cancer. Life Sci. 2020 Sep 01; 256:117923. PMID: 32522567.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    4. Liang J, Wang L, Wang C, Shen J, Su B, Marisetty AL, Fang D, Kassab C, Jeong KJ, Zhao W, Lu Y, Jain AK, Zhou Z, Liang H, Sun SC, Lu C, Xu ZX, Yu Q, Shao S, Chen X, Gao M, Claret FX, Ding Z, Chen J, Chen P, Barton MC, Peng G, Mills GB, Heimberger AB. Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis, Exerting Antitumor Efficacy. Cancer Immunol Res. 2020 07; 8(7):952-965. PMID: 32265228; PMCID: PMC8204534.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    5. Sun QH, Wang YS, Liu G, Zhou HL, Jian YP, Liu MD, Zhang D, Ding Q, Zhao RX, Chen JF, Li YN, Liang J, Li YL, Quan CS, Xu ZX. Enhanced O-linked Glcnacylation in Crohn's disease promotes intestinal inflammation. EBioMedicine. 2020 Mar; 53:102693. PMID: 32114385; PMCID: PMC7047186.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    6. Caruso HG, Tanaka R, Liang J, Ling X, Sabbagh A, Henry VK, Collier TL, Heimberger AB. Shortened ex vivo manufacturing time of EGFRvIII-specific chimeric antigen receptor (CAR) T cells reduces immune exhaustion and enhances antiglioma therapeutic function. J Neurooncol. 2019 Dec; 145(3):429-439. PMID: 31686330.
      Citations: 14     Fields:    Translation:HumansAnimals
    7. Fang Y, McGrail DJ, Sun C, Labrie M, Chen X, Zhang D, Ju Z, Vellano CP, Lu Y, Li Y, Jeong KJ, Ding Z, Liang J, Wang SW, Dai H, Lee S, Sahni N, Mercado-Uribe I, Kim TB, Chen K, Lin SY, Peng G, Westin SN, Liu J, O'Connor MJ, Yap TA, Mills GB. Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy. Cancer Cell. 2019 06 10; 35(6):851-867.e7. PMID: 31185210; PMCID: PMC6642675.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    8. Su B, Xu T, Bruce JP, Yip KW, Zhang N, Huang Z, Zhang G, Liu FF, Liang J, Yang H, Claret FX. hsa-miR-24 suppresses metastasis in nasopharyngeal carcinoma by regulating the c-Myc/epithelial-mesenchymal transition axis. Oncol Rep. 2018 Nov; 40(5):2536-2546. PMID: 30226609; PMCID: PMC6151896.
      Citations: 5     Fields:    Translation:HumansCells
    9. Wang J, Zhao W, Guo H, Fang Y, Stockman SE, Bai S, Ng PK, Li Y, Yu Q, Lu Y, Jeong KJ, Chen X, Gao M, Liang J, Li W, Tian X, Jonasch E, Mills GB, Ding Z. AKT isoform-specific expression and activation across cancer lineages. BMC Cancer. 2018 Jul 16; 18(1):742. PMID: 30012111; PMCID: PMC6048698.
      Citations: 15     Fields:    Translation:HumansCells
    10. Wang YS, Yu P, Wang Y, Zhang J, Hang W, Yin ZX, Liu G, Chen J, Werle KD, Quan CS, Gao H, Zeng Q, Cui R, Liang J, Ding Q, Li YL, Xu ZX. AMP-activated protein kinase protects against necroptosis via regulation of Keap1-PGAM5 complex. Int J Cardiol. 2018 05 15; 259:153-162. PMID: 29579593; PMCID: PMC5873603.
      Citations: 11     Fields:    Translation:AnimalsCells
    11. Shen J, Ju Z, Zhao W, Wang L, Peng Y, Ge Z, Nagel ZD, Zou J, Wang C, Kapoor P, Ma X, Ma D, Liang J, Song S, Liu J, Samson LD, Ajani JA, Li GM, Liang H, Shen X, Mills GB, Peng G. ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Nat Med. 2018 05; 24(5):556-562. PMID: 29736026; PMCID: PMC6076433.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    12. Wang YS, Chen J, Cui F, Wang H, Wang S, Hang W, Zeng Q, Quan CS, Zhai YX, Wang JW, Shen XF, Jian YP, Zhao RX, Werle KD, Cui R, Liang J, Li YL, Xu ZX. LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors. Oncotarget. 2016 Nov 08; 7(45):73389-73401. PMID: 27705915; PMCID: PMC5341986.
      Citations: 13     Fields:    Translation:HumansCells
    13. Zeng Q, Zhao RX, Chen J, Li Y, Li XD, Liu XL, Zhang WM, Quan CS, Wang YS, Zhai YX, Wang JW, Youssef M, Cui R, Liang J, Genovese N, Chow LT, Li YL, Xu ZX. O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):9333-8. PMID: 27482104; PMCID: PMC4995993.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    14. Wang C, Jeong K, Jiang H, Guo W, Gu C, Lu Y, Liang J. YAP/TAZ regulates the insulin signaling via IRS1/2 in endometrial cancer. Am J Cancer Res. 2016; 6(5):996-1010. PMID: 27293994; PMCID: PMC4889715.
      Citations: 24     
    15. Liang J, Xu ZX, Ding Z, Lu Y, Yu Q, Werle KD, Zhou G, Park YY, Peng G, Gambello MJ, Mills GB. Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance. Nat Commun. 2015 Aug 14; 6:7926. PMID: 26272043.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    16. Guo H, German P, Bai S, Barnes S, Guo W, Qi X, Lou H, Liang J, Jonasch E, Mills GB, Ding Z. The PI3K/AKT Pathway and Renal Cell Carcinoma. J Genet Genomics. 2015 Jul 20; 42(7):343-53. PMID: 26233890; PMCID: PMC4624215.
      Citations: 125     Fields:    Translation:HumansAnimalsCells
    17. Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell. 2014 Jun 19; 54(6):960-974. PMID: 24857548; PMCID: PMC4067806.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    18. Wang Y, Wang JW, Xiao X, Shan Y, Xue B, Jiang G, He Q, Chen J, Xu HG, Zhao RX, Werle KD, Cui R, Liang J, Li YL, Xu ZX. Piperlongumine induces autophagy by targeting p38 signaling. Cell Death Dis. 2013 Oct 03; 4:e824. PMID: 24091667; PMCID: PMC3824668.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    19. Lu C, Chen J, Xu HG, Zhou X, He Q, Li YL, Jiang G, Shan Y, Xue B, Zhao RX, Wang Y, Werle KD, Cui R, Liang J, Xu ZX. MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy. Gastroenterology. 2014 Jan; 146(1):188-99. PMID: 24036151; PMCID: PMC3870037.
      Citations: 51     Fields:    Translation:HumansCells
    20. Guo H, Gao M, Lu Y, Liang J, Lorenzi PL, Bai S, Hawke DH, Li J, Dogruluk T, Scott KL, Jonasch E, Mills GB, Ding Z. Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules. Oncogene. 2014 Jun 26; 33(26):3463-72. PMID: 23912456; PMCID: PMC3915040.
      Citations: 22     Fields:    Translation:HumansCells
    21. Park YY, Kim SB, Han HD, Sohn BH, Kim JH, Liang J, Lu Y, Rodriguez-Aguayo C, Lopez-Berestein G, Mills GB, Sood AK, Lee JS. Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520. Hepatology. 2013 Jul; 58(1):182-91. PMID: 23389994; PMCID: PMC3923572.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    22. Liang J, Mills GB. AMPK: a contextual oncogene or tumor suppressor? Cancer Res. 2013 May 15; 73(10):2929-35. PMID: 23644529; PMCID: PMC3725287.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    23. Gao M, Liang J, Lu Y, Guo H, German P, Bai S, Jonasch E, Yang X, Mills GB, Ding Z. Site-specific activation of AKT protects cells from death induced by glucose deprivation. Oncogene. 2014 Feb 06; 33(6):745-55. PMID: 23396361; PMCID: PMC3874430.
      Citations: 33     Fields:    Translation:HumansCells
    24. Xiao X, He Q, Lu C, Werle KD, Zhao RX, Chen J, Davis BC, Cui R, Liang J, Xu ZX. Metformin impairs the growth of liver kinase B1-intact cervical cancer cells. Gynecol Oncol. 2012 Oct; 127(1):249-55. PMID: 22735790; PMCID: PMC3432698.
      Citations: 37     Fields:    Translation:HumansCells
    25. Cheong JH, Park ES, Liang J, Dennison JB, Tsavachidou D, Nguyen-Charles C, Wa Cheng K, Hall H, Zhang D, Lu Y, Ravoori M, Kundra V, Ajani J, Lee JS, Ki Hong W, Mills GB. Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models. Mol Cancer Ther. 2011 Dec; 10(12):2350-62. PMID: 21992792; PMCID: PMC3237863.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    26. Wang S, Wang H, Davis BC, Liang J, Cui R, Chen SJ, Xu ZX. PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1. Biochem Biophys Res Commun. 2011 Aug 26; 412(2):379-84. PMID: 21821012; PMCID: PMC3163691.
      Citations: 10     Fields:    Translation:HumansCells
    27. Short JD, Dere R, Houston KD, Cai SL, Kim J, Bergeron JM, Shen J, Liang J, Bedford MT, Mills GB, Walker CL. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog. 2010 May; 49(5):429-39. PMID: 20146253; PMCID: PMC3818129.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    28. Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. PLoS One. 2010 Mar 26; 5(3):e9910. PMID: 20361045; PMCID: PMC2845649.
      Citations: 23     Fields:    Translation:HumansCells
    29. Larrea MD, Liang J, Da Silva T, Hong F, Shao SH, Han K, Dumont D, Slingerland JM. Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4. Mol Cell Biol. 2008 Oct; 28(20):6462-72. PMID: 18710949; PMCID: PMC2577417.
      Citations: 52     Fields:    Translation:HumansCells
    30. Xu ZX, Liang J, Haridas V, Gaikwad A, Connolly FP, Mills GB, Gutterman JU. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell Death Differ. 2007 Nov; 14(11):1948-57. PMID: 17690712.
      Citations: 36     Fields:    Translation:HumansCells
    31. Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol. 2007 Feb; 9(2):218-24. PMID: 17237771.
      Citations: 408     Fields:    Translation:HumansCells
    32. Ding Z, Liang J, Lu Y, Yu Q, Songyang Z, Lin SY, Mills GB. A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15014-9. PMID: 17018644; PMCID: PMC1636760.
      Citations: 46     Fields:    Translation:HumansCells
    33. Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F, Lin SY. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell. 2006 Aug; 10(2):145-57. PMID: 16872911; PMCID: PMC1557410.
      Citations: 79     Fields:    Translation:HumansCells
    34. Sheng W, Wang G, Wang Y, Liang J, Wen J, Zheng PS, Wu Y, Lee V, Slingerland J, Dumont D, Yang BB. The roles of versican V1 and V2 isoforms in cell proliferation and apoptosis. Mol Biol Cell. 2005 Mar; 16(3):1330-40. PMID: 15635104; PMCID: PMC551496.
      Citations: 79     Fields:    Translation:AnimalsCells
    35. Liang J, Slingerland JM. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle. 2003 Jul-Aug; 2(4):339-45. PMID: 12851486.
      Citations: 348     Fields:    Translation:AnimalsCells
    36. Rao JN, Liang JY, Chakraborti P, Feng P. Effect of thyroid hormone on the development and gene expression of hormone receptors in rat testes in vivo. J Endocrinol Invest. 2003 May; 26(5):435-43. PMID: 12906371.
      Citations: 13     Fields:    Translation:Animals
    37. Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K, Lee JH, Ciarallo S, Catzavelos C, Beniston R, Franssen E, Slingerland JM. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med. 2002 Oct; 8(10):1153-60. PMID: 12244302.
      Citations: 339     Fields:    Translation:HumansCells
    38. Feng P, Liang JY, Li TL, Guan ZX, Zou J, Franklin R, Costello LC. Zinc induces mitochondria apoptogenesis in prostate cells. Mol Urol. 2000; 4(1):31-6. PMID: 10851304.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    39. Liang JY, Liu YY, Zou J, Franklin RB, Costello LC, Feng P. Inhibitory effect of zinc on human prostatic carcinoma cell growth. Prostate. 1999 Aug 01; 40(3):200-7. PMID: 10398282; PMCID: PMC4465333.
      Citations: 70     Fields:    Translation:HumansCells
    40. Liang JY, Fontana JA, Rao JN, Ordonez JV, Dawson MI, Shroot B, Wilber JF, Feng P. Synthetic retinoid CD437 induces S-phase arrest and apoptosis in human prostate cancer cells LNCaP and PC-3. Prostate. 1999 Feb 15; 38(3):228-36. PMID: 10068347.
      Citations: 13     Fields:    Translation:HumansCells
    41. The PI3K/AKT Pathway and Renal Cell Carcinoma. Journal of Genetics and Genomics.
    42. YAP/TAZ regulates the insulin signaling via IRS1/2 in endometrial cancer. American Journal of Cancer Research. 6:996-1010.
    43. Dihydroartemisinin induces endothelial cell anoikis through the activation of the JNK signaling pathway. Oncology Letters. 12:1896-1900.
    44. MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy. Gastroenterology. 146:188-199.
    45. LKB1 inhibits HPV-associated cancer progression by targeting cellular metabolism. Oncogene.
    46. LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors. Oncotarget. 7:73389-73401.
    47. O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis. Proceedings of the National Academy of Sciences of the United States of America. 113:9333-9338.
    48. Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance. Nature Communications. 6.
    49. LKB1 reduces ROS-mediated cell damage via activation of p38. Oncogene. 34:3848-3859.
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