Last Name


TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Tropical Medicine
AddressOne Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Asojo OA, Kelleher A, Liu Z, Pollet J, Hudspeth EM, Rezende WC, Groen MJ, Seid CA, Abdeladhim M, Townsend S, de Castro W, Mendes-Sousa A, Bartholomeu DC, Fujiwara RT, Bottazzi ME, Hotez PJ, Zhan B, Oliveira F, Kamhawi S, Valenzuela JG. Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis. PLoS Negl Trop Dis. 2017 Mar; 11(3):e0005374. PMID: 28278244.
      View in: PubMed
    2. Versteeg L, Le Guezennec X, Zhan B, Liu Z, Angagaw M, Woodhouse JD, Biswas S, Beaumier CM. Transferring Luminex® cytokine assays to a wall-less plate technology: Validation and comparison study with plasma and cell culture supernatants. J Immunol Methods. 2017 Jan; 440:74-82. PMID: 27840065.
      View in: PubMed
    3. McAtee CP, Seid CA, Hammond M, Hudspeth E, Keegan BP, Liu Z, Wei J, Zhan B, Arjona-Sabido R, Cruz-Chan V, Dumonteil E, Hotez PJ, Bottazzi ME. Expression, purification, immunogenicity and protective efficacy of a recombinant nucleoside hydrolase from Leishmania donovani, a vaccine candidate for preventing cutaneous leishmaniasis. Protein Expr Purif. 2017 Feb; 130:129-136. PMID: 27773761.
      View in: PubMed
    4. Seid CA, Jones KM, Pollet J, Keegan B, Hudspeth E, Hammond M, Wei J, McAtee CP, Versteeg L, Gutierrez A, Liu Z, Zhan B, Respress JL, Strych U, Bottazzi ME, Hotez PJ. Cysteine Mutagenesis Improves the Production without Abrogating Antigenicity of a Recombinant Protein Vaccine Candidate for Human Chagas Disease. Hum Vaccin Immunother. 2016 Oct 13; 0. PMID: 27737611.
      View in: PubMed
    5. Wei J, Damania A, Gao X, Liu Z, Mejia R, Mitreva M, Strych U, Bottazzi ME, Hotez PJ, Zhan B. The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates. Parasit Vectors. 2016 Sep 27; 9(1):518. PMID: 27677574.
      View in: PubMed
    6. Yang J, Zhu W, Huang J, Wang X, Sun X, Zhan B, Zhu X. Partially protective immunity induced by the 14-3-3 protein from Trichinella spiralis. Vet Parasitol. 2016 Jun 22. PMID: 27387374.
      View in: PubMed
    7. Gu Y, Huang J, Wang X, Wang L, Yang J, Zhan B, Zhu X. Identification and characterization of CD4(+) T cell epitopes present in Trichinella spiralis paramyosin. Vet Parasitol. 2016 Jun 16. PMID: 27353726.
      View in: PubMed
    8. Arumugam S, Wei J, Liu Z, Abraham D, Bell A, Bottazzi ME, Hotez PJ, Zhan B, Lustigman S, Klei TR. Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection. PLoS Negl Trop Dis. 2016 Apr; 10(4):e0004586. PMID: 27045170; PMCID: PMC4821550.
    9. Barry MA, Wang Q, Jones KM, Heffernan MJ, Buhaya MH, Beaumier CM, Keegan BP, Zhan B, Dumonteil E, Bottazzi ME, Hotez PJ. A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease. Hum Vaccin Immunother. 2016 Apr 2; 12(4):976-87. PMID: 26890466.
      View in: PubMed
    10. Hudspeth EM, Wang Q, Seid CA, Hammond M, Wei J, Liu Z, Zhan B, Pollet J, Heffernan MJ, McAtee CP, Engler DA, Matsunami RK, Strych U, Asojo OA, Hotez PJ, Bottazzi ME. Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic properties. Hum Vaccin Immunother. 2016 Feb 2; 1-14. PMID: 26839079.
      View in: PubMed
    11. Gunter SM, Jones KM, Zhan B, Essigmann HT, Murray KO, Garcia MN, Gorchakov R, Bottazzi ME, Hotez PJ, Brown EL. Identification and Characterization of the Trypanosoma cruzi B-cell Superantigen Tc24. Am J Trop Med Hyg. 2016 Jan 6; 94(1):114-21. PMID: 26598565.
      View in: PubMed
    12. Zhan B, Ajmera R, Geiger SM, Gon├žalves MT, Liu Z, Wei J, Wilkins PP, Fujiwara R, Gazzinelli-Guimaraes PH, Bottazzi ME, Hotez P. Identification of immunodominant antigens for the laboratory diagnosis of toxocariasis. Trop Med Int Health. 2015 Dec; 20(12):1787-96. PMID: 26426162.
      View in: PubMed
    13. Bi K, Yang J, Wang L, Gu Y, Zhan B, Zhu X. Partially Protective Immunity Induced by a 20 kDa Protein Secreted by Trichinella spiralis Stichocytes. PLoS One. 2015; 10(8):e0136189. PMID: 26288365; PMCID: PMC4545582.
    14. Kelleher A, Liu Z, Seid CA, Zhan B, Asojo OA. Expression, purification, crystallization and crystallographic study of Lutzomyia longipalpis LJL143. Acta Crystallogr F Struct Biol Commun. 2015 Jul; 71(Pt 7):925-8. PMID: 26144240.
      View in: PubMed
    15. Hotez PJ, Bottazzi ME, Zhan B, Makepeace BL, Klei TR, Abraham D, Taylor DW, Lustigman S. The Onchocerciasis Vaccine for Africa--TOVA--Initiative. PLoS Negl Trop Dis. 2015 Jan; 9(1):e0003422. PMID: 25634641; PMCID: PMC4310604.
    16. Knight JM, Zingales B, Bottazzi ME, Hotez P, Zhan B. Limited antigenic variation in the Trypanosoma cruzi candidate vaccine antigen TSA-1. Parasite Immunol. 2014 Dec; 36(12):708-12. PMID: 25040249.
      View in: PubMed
    17. Gu Y, Zhan B, Yang Y, Yang X, Zhao X, Wang L, Yang J, Bi K, Wang Y, Zhu X. Protective effect of a prime-boost strategy with the Ts87 vaccine against Trichinella spiralis infection in mice. Biomed Res Int. 2014; 2014:326860. PMID: 25250316; PMCID: PMC4164511.
    18. Fang L, Sun L, Yang J, Gu Y, Zhan B, Huang J, Zhu X. Heat shock protein 70 from Trichinella spiralis induces protective immunity in BALB/c mice by activating dendritic cells. Vaccine. 2014 Jul 31; 32(35):4412-9. PMID: 24962751.
      View in: PubMed
    19. Hotez PJ, Bottazzi ME, Tseng CT, Zhan B, Lustigman S, Du L, Jiang S. Calling for rapid development of a safe and effective MERS vaccine. Microbes Infect. 2014 Jul; 16(7):529-31. PMID: 24931059.
      View in: PubMed
    20. Zhan B, Beaumier CM, Briggs N, Jones KM, Keegan BP, Bottazzi ME, Hotez PJ. Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections. Expert Rev Vaccines. 2014 Mar; 13(3):321-31. PMID: 24392641; PMCID: PMC3934375.
    21. Chen WH, Du L, Chag SM, Ma C, Tricoche N, Tao X, Seid CA, Hudspeth EM, Lustigman S, Tseng CT, Bottazzi ME, Hotez PJ, Zhan B, Jiang S. Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate. Hum Vaccin Immunother. 2014; 10(3):648-58. PMID: 24355931; PMCID: PMC4130269.
    22. Curti E, Kwityn C, Zhan B, Gillespie P, Brelsford J, Deumic V, Plieskatt J, Rezende WC, Tsao E, Kalampanayil B, Hotez PJ, Bottazzi ME. Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoni TSP-2 recombinant protein: a vaccine candidate for human intestinal schistosomiasis. Hum Vaccin Immunother. 2013 Nov; 9(11):2342-50. PMID: 23899507; PMCID: PMC3981843.
    23. Kelleher A, Zhan B, Asojo OA. Structure of monomeric Na-GST-3, a glutathione S-transferase from the major human hookworm parasite Necator americanus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Aug; 69(Pt 8):839-43. PMID: 23908024; PMCID: PMC3729155.
    24. Hu Y, Zhan B, Keegan B, Yiu YY, Miller MM, Jones K, Aroian RV. Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms. PLoS Negl Trop Dis. 2012; 6(11):e1900. PMID: 23145203; PMCID: PMC3493396.
    25. Zhan B, Santiago H, Keegan B, Gillespie P, Xue J, Bethony J, de Oliveira LM, Jiang D, Diemert D, Xiao SH, Jones K, Feng X, Hotez PJ, Bottazzi ME. Fusion of Na-ASP-2 with human immunoglobulin Fc? abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE. Parasite Immunol. 2012 Aug-Sep; 34(8-9):404-11. PMID: 22651670.
      View in: PubMed
    26. Gao X, Chang XB, Wu RY, Zhan BY. Allotransplantation of cryopreserved human Leydig cells. Transplant Proc. 1994 Dec; 26(6):3490. PMID: 7998241.
      View in: PubMed
    27. Gao X, Chang XB, Wu RY, Zhan BY. Prolonged survival of allogeneic Leydig cells after in vitro culture and intramuscular transplantation. Transplant Proc. 1994 Dec; 26(6):3491. PMID: 7998242.
      View in: PubMed
    28. Zhan BY, Wang LL, Zhang XB, Zhang J, Gao X. Advances of homotransplantation of testes in China. Chin Med J (Engl). 1993 Jul; 106(7):486-8. PMID: 8243117.
      View in: PubMed
    29. Zhan, B. and J. Wang. Analyses on the Protein Composition and Antigenicity of Leishmania gerbilli Promastigotes. Endemic Diseases Bulletin. 5(3):63-6.
    30. Zhang, L.X., B. Zhan, X.P. Feng and J. Wang. Detection of RESA Antibody in Falciparum Malaria Patients by Double RESA-IFA Method. Shanghai J. Immunology. 11:295.
    31. Zhang, L.X., B, Zhan, X.P. Feng and J. Wang. Study on Relationship between Antibodies to Plasmodium falciparum and Clinical Immunity to infection in Falciparum Malaria Patients in Hyperendemic Areas. Shanghai J. Immunology. 11:279-81.
    32. Zhan, B., L.X. Zhang, X.P. Feng and W.H. Huang. Detection of Anti-RESA antibody in Population of Endemic Malaria Area. Chinese J. Parasitic Diseases Control. 5(3):167.
    33. Zhang, L.X., J.H. Chai, B. Zhan, X.P. Feng and J. Wang. Study on the Detection of Plasmodium vivax by a Specific DNA Probe. Chinese J.Parasitol & Parasitic Dis. 11:141.
    34. Zhan, B., L.X. Zhang, J.J. Wang and X.P. Feng. Detection of Plasmodium falciparum by Polymerase Chain Reaction. Chinese J. Parasitol & Parasitic Dis. 12(2):111.
    35. Zhang, L.X., J.H. Chai, B. Zhan, X.P. Feng and J.J. Wang. Further Report on Application of DNA Probe in Diagnosis of Vivax Malaria Infection. Chinese J. Parasitol & Parasitic Dis. 11:86.
    36. Zhang, L.X., B. Zhan, X.P. Feng and J.J. Wang. Observation on Interfering Factors in detection of Falciparum Malaria Patients in Co-endemic Areas by IFA Test. Chinese J. Parasitol & Parasitic Dis. 12(2):151.
    37. Zhan, B., L.X. Zhang, J.J. Wang and X.P. Feng. Application of PCR on the Diagnosis of Falciparum Malaria in a Malaria endemic field. Chinese J. Parasitol & Parasitic Dis. 12(1):37.
    38. Yang, H.L., P.F. Yang, Y. Dong, L.G. Che, W.C. Chen, H. He, D.Q. Liu, R.J. Liu, B. Zhan, C.Y. Zhang, D.Q. Gao. Longitudinal Surveillance of Chloroquine Resistance of Plasmodium falciparum after Cessation of Medication in South Yunnan. Chinese J. Parasitol & Parasitic Dis. 12(1):31-3.
    39. Yang, H.L., D.Q. Liu, Y. Dong, R.J. Liu, B. Zhan, C.Y. Zhang. Sensitivity of Plasmodium falciparum to seven anti-malaria Medicines in vitro. Chinese J. Parasitol & Parasitic Dis. 13(2):111-3.
    40. Zhang, L.X., R.L. Coppel, V.M. Marshall, B. Zhan, X.P. Feng and J.J. Wang. Application of Plasmodium falciparum DNA Extracted from Dried Blood Spot of Falciparum Malaria Patients for Polymerase Chain Reaction. Chinese J. Parasitol & Parasitic Dis. 13(2):120-2.
    41. Zhang, L.X., R.L.Coppel, V.M.Marshall, B.Zhan, X.P.Feng and J.J.Wang. DNA Sequence Analysis of Apical Membrane Antigen-1 from a Plasmodium falciparum Isolate Collected from Meng-Peng Township, Yun-Nan. Chinese J. Parasitol & Parasitic Dis. 13(3):203-8.
    42. Sun FH, Wu ZX, Qian YX, Cao HG, Xue HC, Xiao SH, Ren HN, Zhan B, Hawdon JM, Hotez PJ. Epidemiology of human intestinal nematode infection in Wujiang and Pizhou counties, Jiangsu Province, China. Southeast Asian J. Trop. Publ. Health. 17(2):81-83.
    43. Li Tiehua, Zhan Bin, John M Hawdon, Gong Xin, Xiao Shuhua, Shan Qiang, Feng Zheng, Peter J Hotez. Sequencing of Cytochrome C Oxidatase I Gene of Ancylostoma duodenale and Necator americanus. Chinese J Parasitol & Parasitic Dis. 17(2):81-83.
    44. Peter J Hotez, Ghosh K, Hawdon JM, Narasimhan S, Johes B, Xiao SH, Liu S, Zhan B, Xue HC, Ren HN, Wang H and Koski RA. Experimental approaches to the development of a recombinant hookworm vaccine. Immunological Reviews. 171:163-171.
    45. Wang Y, Shen GJ, Wu WT, Xiao SH, Hotez PJ, Li QY, Xue HC, Yi XM, Liu XM, Zhan B, Hawdon JM, Chou L, Ji Hong, Hu CM, Feng Z. Epidemiology of human ancylostomiasis among rural villagers in Nanlin County (Zhongzhou village), Anhui Province, China: age-associated prevalence, intensity and hookworm species identification. Southeast Asian J Trop Med Public Health. 30(4):692-7.
    46. Liu CH, Zhang XR, Qiu DC, Xiao SH, Hotez PJ, Zheng DF, Xue HC, Zhen HL, Li MG, Ren HN, Zhan B, Hawdon JM, Feng Z. Epidemiology of human hookworm infections among adult rural villagers in Heijiang and Santai counties, Sichuan province, China. Acta Tropica. 73:243-249.
    47. Zhan Bin, John Hawdon, Shan Qiang, Ren Hainan, Qiang Huiqing, Hu Wei, Xiao Shu-hua, Li Tiehua, Gong Xin, Feng Zheng, Peter Hotez. Ancylostoma-secreted Protein 1 (ASP-1) Homologues in Human Hookworms. Mol Biochem Parasitol. 98:143-149.
    48. Zhan Bin, John Hawdon, Shan Qiang, Ren Hainan, Qiang Huiqing, Xiao Shu-hua, Li Tiehua, Feng Zheng, Peter Hotez. Construction and analysis of cDNA Library of the third stage larvae of Necator americanus. Chinese J Parasitol & Parasitic Dis. 18(1):26-29.
    49. Shan Qiang, Zhan Bin, Xiao shu-hua, Feng Zheng, Peter Hotez, and John M. Hawdon. Variation between ASP-1molecules from Ancylostoma caninum in China and the United States. J. Parasitol. 86(1):181-5.
    50. Liu Sen, Kashinath Ghosh, Zhan Bin, Shan Qiang , Thompson MG, Hawdon JM, Koski RA, Shuhua X, Hotez PJ. Hookworm burden reductions in BALB/c mice vaccinated with recombinant Ancylostoma secreted proteins (ASPs) from Ancylostoma duodenale, Ancylostoma caninum and Necator americanus. Vaccine. 18(11-12):1096-1102.
    51. Lili Z, Bingxiang Z, Hong T, Shuhua X, Hotez P, Bin Zhan, Yangzhong L, Ying L, Haichou X, Hawdon J, Hui Y, Huizhen W, Zhen F. Epidemiology of human geohelminth infections (ascariasis, trichuriasis and necatoriasis) in Lushui and Puer Counties, Yunnan Province, China. Southeast Asian J Trop Med Public Health. 31(3):448-53.
    52. Bin Zhan, Shuhua Xiao, Tiehua Li and Meihua Bo. Current prevalence and vaccine development of hookworm. Chinese J Parasitol & Parsitic Dis 2000. 18(3):182-5.
    53. Xue Haichou, Wang Yan, Xiao Shuhua, Liu Sen, Wang Yong, Shen Guangjin, Wu Weituo, Zhan Bin, L Drake, Feng Zheng and Peter J Hotez. Epidemiology of human ancylostomiasis among rural villagers in Nanlin County (Zhongzhou village), Anhui Province, China: II. Seroepidemiological studies of the age relationships of serum antibody levels and infection status. Southeast Asian J Trop Med Public Health 2000. 31(4):736-741.
    54. Nishiena S. Gandhi, Chen Jizhang, Kaveh Khoshnood, Xing Fuying, Li Shanwen, Liu Yaoruo, Zhan Bin, Xue Haichou, Tong Chougjin, Wang Yan, Wang Wensen, He Dungxing, Chen Chong, Xiao Shuhua, John M. Hawdon, Peter J. Hawdon. Epidemiology of Necator americanus hookworm infections in Xiulongkan Village, Hainan Province, China: High Prevalence and Intensity Among Middle-aged and Elderly. J. Parasitol. 87(4):739-43.
    55. Bin Zhan, Tiehua Li Shuhua Xiao, Zheng Feng and John M Hawdon. Species-specific Identification of Human Hookworms by PCR of the Mitochondrial Cytochrome Oxidase I Gene. J. Parasitol. 87(5):1227.
    56. Menfo A. Imoisili, Ekopimo Ibia, Ariel R. Porcalla, Xiao Shuhua, Bin Zhan, Sridhar Basavaraju, George M. Davis, Peter J. Hotez. Helminth infections in China and southeast Asia: Their diseases burden in childhood and novel approaches to their control and diagnosis. Asian Journal of Pediatric Practice. 5(2):51-62.
    57. Xiao Shuhua, Peter J. Hotez, Sen Binggui, Liu Sen, Qiang Huiqing, Xue Haichou, Zhan Bin, Feng Zheng. Electron and light microscopy of neutrophil responses in mice vaccinated and challenged with third-stage infective hookworm (Ancylostoma caninum) larvae. Parasitology International. 50:241-8.
    58. J.M. Hawdon, T. Li, B. Zhan, and M.S. Blouin. Genetic structure of populations of the human hookworm, Necator americanus, in China. Molecular Ecology. 10(6):1433-7.
    59. Peter J. Hotez, Zhan Bin, Jeffrey Bethony, Qun Jin, John M. Hawdon, HeatherA. Young, Samuel Simmens, Richard Hitzelberg, and Bernard C. Zook . Natural history of primary canine hookworm infections after three different oral doses of third-stage infective larvae of Ancylostoma caninum. . Comparative Parasitolog. 69(1):72-80.
    60. Peter J. Hotez, James Ashcom, Zhan Bin, Jeff Bethony, Angela Williamson, John M. Hawdon, Feng Jianjun, Azra Dobardzic, Ivania Rizo, Janelle Bolder, Qun Jin, Wang Yan, Reshad Dobardzic, Sophia Chung-Debose, Melissa Crowell, Bennett Datu, Angela Delaney, Dilyan Dragonovski, Yang Jiang, Liu Yueyuan, Kshinath Ghosh, Alex Loukas, Walter Brandt, Philip K. Russell, and Bernard C. Zook. Effect of vaccinations with recombinant fusion protein on Ancylostoma caninum habitat selection in the canine intestine. J.Parasitol. 88(4):684-690.
    61. Xue Jian, Xiao Shu-Hua, Qiang Hui-qing, Liu Sen, Peter Hotez, Shen Bing-Gui, Xue Hai-Chou, Li Tie-Hua and Zhan Bin. Necator americanus: maintenance through one hundred generations in golden hamsters (Mesocricetus auratus). II. Morphological development of the adult and its comparison with humans. Exp. Parasitol. 105(3-4):192-200.
    62. Li TH, Guo XR, Xue J, Hu L, Qiang HQ, Xue HC, Zhan B, Hawdon JM, Xiao SH. Comparison of mitochondrial cytochrome oxidase 1 DNA sequences from Necator americanus hookworms maintained for 100 generations in golden hamsters (Mesocricetus auratus) and hookworms from natural human infections. Acta Trop. 92(1):71-5.
    63. Jian X, Jun-Min Y, Hai-Chou X, Hui-Qing Q, Hai-Nan R, Hotez P, Zhan B, Shu-Hua X. Protective immunity elicited by ultraviolet-irradiated third-stage infective hookworm (Necator americanus and Ancylostoma caninum) larvae in mice and hamsters. Southeast Asian J Trop Med Public Health. 37(5):885-95.
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