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ASHIZAWA, TETSUO
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ASHIZAWA, TETSUO
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Concept
DNA Repair Enzymes
Academic Article
Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3.
Academic Article
The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.
Academic Article
Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.
Academic Article
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.
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DNA Repair Enzymes