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BELLEN, HUGO
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overview Investigator, Howard Hughes Medical Institute, Baylor College of Medicine Professor, Departments of Molecular and Human Genetics and Neuroscience Director, Program in Developmental Biology I am interested in (1) providing a better fundamental understanding of the biology that governs the proper function and maintenance of neurons in aging adults (2) developing tools that can be applied to most genes to control transcript and protein levels in adult neurons to assess which proteins are required for neuronal survival and proper function (3) creating genome wide libraries to manipulate most genes in vivo. My lab uses the fruit fly Drosophila melanogaster as a model system because most biological processes are evolutionarily conserved and studies in fruit flies provide many important clues about the aging process in animals and human diseases.
One or more keywords matched the following items that are connected to BELLEN, HUGO
Item TypeName
Academic Article Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner.
Academic Article straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit.
Academic Article Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives.
Academic Article Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions.
Academic Article Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components.
Academic Article Genetic manipulation of genes and cells in the nervous system of the fruit fly.
Academic Article Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity.
Academic Article Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator.
Academic Article Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm.
Academic Article A novel neuronal pathway for visually guided escape in Drosophila melanogaster.
Academic Article Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling.
Academic Article Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.
Academic Article Rab3 GTPase lands Bruchpilot.
Academic Article Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.
Academic Article Drosophila Ten-m and filamin affect motor neuron growth cone guidance.
Academic Article Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6.
Academic Article Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating.
Academic Article Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress.
Academic Article Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis.
Academic Article The architecture of the active zone in the presynaptic nerve terminal.
Academic Article Hauling t-SNAREs on the microtubule highway.
Academic Article Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin.
Academic Article V-ATPase V0 sector subunit a1 in neurons is a target of calmodulin.
Academic Article Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.
Concept Neurons
Concept Motor Neurons
Academic Article VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.
Academic Article NMNATs, evolutionarily conserved neuronal maintenance factors.
Academic Article A mitocentric view of Parkinson's disease.
Academic Article A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.
Academic Article Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration.
Academic Article A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.
Academic Article The retromer complex in development and disease.
Academic Article Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila.
Academic Article Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins.
Academic Article NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.
Academic Article Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease.
Academic Article Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes.
Academic Article Loss of Nardilysin, a Mitochondrial Co-chaperone for a-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration.
Academic Article Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.
Academic Article The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D.
Academic Article Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to a-Synuclein Gain.
Academic Article Interactions between the Ig-Superfamily Proteins DIP-a and Dpr6/10 Regulate Assembly of Neural Circuits.
Academic Article Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.
Concept Dopaminergic Neurons
Academic Article cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.
Academic Article Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders.
Academic Article La CaSSA da Drosophila: A Versatile Expansion of the Tool Box.
Academic Article Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly.
Academic Article Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms.
Academic Article Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction.
Academic Article Drosophila Voltage-Gated Sodium Channels Are Only Expressed in Active Neurons and Are Localized to Distal Axonal Initial Segment-like Domains.
Academic Article Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila.
Academic Article BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.
Academic Article TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.
Grant IMPACTS OF GLIAL LIPID DROPLETS ON OXIDATIVE STRESS AND NEURODEGENERATION IN ALZHEIMER'S DISEASE
Academic Article Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes.
Academic Article Loss of Neuron Navigator 2 Impairs Brain and Cerebellar Development.
Academic Article Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons.
Academic Article Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia.
Academic Article Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS.
Academic Article Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14).
Academic Article Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila.
Academic Article Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila.
Academic Article Autolysosomal exocytosis of lipids protect neurons from ferroptosis.
Academic Article The Voltage-Gated Sodium Channel in Drosophila, Para, Localizes to Dendrites As Well As Axons in Mechanosensitive Chordotonal Neurons.
Academic Article OXR1 maintains the retromer to delay brain aging under dietary restriction.
Academic Article Glial lipid droplets resolve ROS during sleep.
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  • Neurons