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WENSEL, THEODORE

One or more keywords matched the following properties of WENSEL, THEODORE

Property	Value
overview	Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2012, it ranked 11th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research. The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include: Visual transduction in the vertebrate retina G protein pathways and proteins that regulate them in the retina and the brain RGS proteins: GAPs for heterotrimeric G proteins Biomembranes Ocular Proteomics Gene repair in neurons Time-resolved fluorescence and luminescence Electron and x-ray crystallography Cryo-electron tomography Gene engineering in mice and frogs TRP Channels
overview	Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2013, it ranked 10th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research. The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include: Visual transduction in the vertebrate retina G protein pathways and proteins that regulate them in the retina and the brain RGS proteins: GAPs for heterotrimeric G proteins Biomembranes Ocular Proteomics Gene repair in neurons Time-resolved fluorescence and luminescence Electron and x-ray crystallography Cryo-electron tomography Gene engineering in mice and frogs TRP Channels

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overview

Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2012, it ranked 11th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research. The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include: Visual transduction in the vertebrate retina G protein pathways and proteins that regulate them in the retina and the brain RGS proteins: GAPs for heterotrimeric G proteins Biomembranes Ocular Proteomics Gene repair in neurons Time-resolved fluorescence and luminescence Electron and x-ray crystallography Cryo-electron tomography Gene engineering in mice and frogs TRP Channels

overview

Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2013, it ranked 10th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research. The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include: Visual transduction in the vertebrate retina G protein pathways and proteins that regulate them in the retina and the brain RGS proteins: GAPs for heterotrimeric G proteins Biomembranes Ocular Proteomics Gene repair in neurons Time-resolved fluorescence and luminescence Electron and x-ray crystallography Cryo-electron tomography Gene engineering in mice and frogs TRP Channels

One or more keywords matched the following items that are connected to WENSEL, THEODORE

Item Type	Name
Academic Article	Formation of helical protein assemblies of IgG and transducin on varied lipid tubules.
Academic Article	Activation of RGS9-1GTPase acceleration by its membrane anchor, R9AP.
Academic Article	Activation-dependent hindrance of photoreceptor G protein diffusion by lipid microdomains.
Academic Article	How a G protein binds a membrane.
Academic Article	Defective development of photoreceptor membranes in a mouse model of recessive retinal degeneration.
Academic Article	Hot on the trail of TRP channel structure.
Academic Article	Multiphoton adaptation of a commercial low-cost confocal microscope for live tissue imaging.
Academic Article	Topical mydriatics affect light-evoked retinal responses in anesthetized mice.
Academic Article	Functional and structural studies of TRP channels heterologously expressed in budding yeast.
Academic Article	Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa.
Academic Article	Nanosecond fluorescence microscopy. Emission kinetics of fura-2 in single cells.
Academic Article	Structure of TRPV1 channel revealed by electron cryomicroscopy.
Academic Article	R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells.
Concept	Microscopy, Fluorescence
Concept	Microscopy, Electron
Concept	Cryoelectron Microscopy
Concept	Microscopy
Concept	Microscopy, Electron, Transmission
Concept	Microscopy, Fluorescence, Multiphoton
Concept	Microscopy, Confocal
Academic Article	Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice.
Academic Article	Three-dimensional architecture of murine rod cilium revealed by cryo-EM.
Academic Article	Structural and molecular bases of rod photoreceptor morphogenesis and disease.
Academic Article	Differential epitope masking reveals synapse-specific complexes of TRPM1.
Grant	Cilium-associated structures in rod cells
Grant	Houston Area Molecular Biophysics Program
Academic Article	Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells.
Academic Article	Single-Atom Fluorescence Switch: A General Approach toward Visible-Light-Activated Dyes for Biological Imaging.
Academic Article	Defining the layers of a sensory cilium with STORM and cryoelectron nanoscopy.
Academic Article	Super-resolution microscopy reveals photoreceptor-specific subciliary location and function of ciliopathy-associated protein CEP290.
Academic Article	Expansion Microscopy of Mouse Photoreceptor Cilia.
Academic Article	Correction to: Expansion Microscopy of Mouse Photoreceptor Cilia.
Academic Article	Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography.

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Microscopy