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MCDONNELL, DONALD
One or more keywords matched the following items that are connected to MCDONNELL, DONALD
Item TypeName
Academic Article Elucidation of the molecular mechanism of action of selective estrogen receptor modulators.
Academic Article Identification of a negative regulatory surface within estrogen receptor alpha provides evidence in support of a role for corepressors in regulating cellular responses to agonists and antagonists.
Academic Article Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators.
Academic Article Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.
Academic Article Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease.
Academic Article A negative coregulator for the human ER.
Academic Article Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators.
Academic Article Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes.
Concept Tamoxifen
Academic Article From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs).
Academic Article Delineation of a FOXA1/ERa/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer.
Academic Article Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer.
Academic Article Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer.
Grant Development of peptide antagonists of estrogen signaling
Grant Mechanism of Action of Estrogens and Antiestrogens
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  • Tamoxifen