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KIRKWOOD, JOHN

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Item Type	Name
Concept	Melanoma
Concept	Melanoma, Experimental
Academic Article	Pan-erbB inhibition potentiates BRAF inhibitors for melanoma treatment.
Academic Article	New TNM melanoma staging system: linking biology and natural history to clinical outcomes.
Academic Article	Age as a predictor of sentinel node metastasis among patients with localized melanoma: an inverse correlation of melanoma mortality and incidence of sentinel node metastasis among young and old patients.
Academic Article	Phase II randomized trial of cisplatin and WR-2721 versus cisplatin alone for metastatic melanoma: an Eastern Cooperative Oncology Group Study (E1686).
Academic Article	Effect of granulocyte/macrophage colony-stimulating factor on circulating CD8+ and CD4+ T-cell responses to a multipeptide melanoma vaccine: outcome of a multicenter randomized trial.
Academic Article	Immunogenicity for CD8+ and CD4+ T cells of 2 formulations of an incomplete freund's adjuvant for multipeptide melanoma vaccines.
Academic Article	Future perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011".
Academic Article	An evidence-based staging system for cutaneous melanoma.
Academic Article	Age as a prognostic factor in patients with localized melanoma and regional metastases.
Academic Article	Interferon alfa-2a for melanoma metastases.
Academic Article	Final version of 2009 AJCC melanoma staging and classification.
Academic Article	Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial.
Academic Article	Innovations and challenges in melanoma: summary statement from the first Cambridge conference.
Academic Article	Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases.
Academic Article	Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th 2010".
Academic Article	PDGFRa up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation.
Academic Article	Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013.
Academic Article	Copy Number Changes Are Associated with Response to Treatment with Carboplatin, Paclitaxel, and Sorafenib in Melanoma.
Academic Article	Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis.
Academic Article	Management of metastatic melanoma.
Academic Article	Safety and efficacy of arsenic trioxide for patients with advanced metastatic melanoma.
Academic Article	Does pegylated interferon alpha-2b confer additional benefit in the adjuvant treatment of high-risk melanoma?
Academic Article	Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma.
Academic Article	Targeted therapies: BREAKing a path for progress--dabrafenib confirms class effect.
Academic Article	PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8? T cells induced by melanoma vaccines.
Academic Article	Melanoma brain metastases: an unmet challenge in the era of active therapy.
Academic Article	Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab.
Academic Article	Dasatinib promotes the expansion of a therapeutically superior T-cell repertoire in response to dendritic cell vaccination against melanoma.
Academic Article	Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype.
Academic Article	MicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603.
Academic Article	The state of melanoma: challenges and opportunities.
Academic Article	A retrospective analysis of High-Dose Interleukin-2 (HD IL-2) following Ipilimumab in metastatic melanoma.
Academic Article	High-dose interleukin-2 (HD IL-2) for advanced melanoma: a single center experience from the University of Pittsburgh Cancer Institute.
Academic Article	Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update.
Academic Article	Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update.
Academic Article	Melanoma staging: Evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual.
Academic Article	Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi.
Academic Article	Targeted Therapy and Immunotherapy Response Assessment with F-18 Fluorothymidine Positron-Emission Tomography/Magnetic Resonance Imaging in Melanoma Brain Metastasis: A Pilot Study.
Academic Article	NCI 8628: A randomized phase 2 study of ziv-aflibercept and high-dose interleukin 2 or high-dose interleukin 2 alone for inoperable stage III or IV melanoma.
Academic Article	PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy.
Academic Article	Phase Ib/II Study of Pembrolizumab and Pegylated-Interferon Alfa-2b in Advanced Melanoma.
Academic Article	Multiple antigen-engineered DC vaccines with or without IFNa to promote antitumor immunity in melanoma.
Concept	gp100 Melanoma Antigen
Academic Article	Neoadjuvant systemic therapy in melanoma: recommendations of the International Neoadjuvant Melanoma Consortium.
Academic Article	KEYNOTE-716: Phase III study of adjuvant pembrolizumab versus placebo in resected high-risk stage II melanoma.
Academic Article	Results from a randomized phase III study comparing combined treatment with histamine dihydrochloride plus interleukin-2 versus interleukin-2 alone in patients with metastatic melanoma.
Academic Article	An update on adjuvant interferon for melanoma.
Academic Article	Differential effect of IFNalpha-2b on the cytochrome P450 enzyme system: a potential basis of IFN toxicity and its modulation by other drugs.
Academic Article	NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells.
Academic Article	Quality-of-life-adjusted survival analysis of high-dose adjuvant interferon alpha-2b for high-risk melanoma patients using intergroup clinical trial data.
Academic Article	Medical management of melanoma.
Academic Article	Immunomodulatory effects of high-dose and low-dose interferon alpha2b in patients with high-risk resected melanoma: the E2690 laboratory corollary of intergroup adjuvant trial E1690.
Academic Article	Sentinel lymph node biopsy and adjuvant therapy for melanoma: evidence revisited.
Academic Article	A pooled analysis of eastern cooperative oncology group and intergroup trials of adjuvant high-dose interferon for melanoma.
Academic Article	Re-evaluating the role of dacarbazine in metastatic melanoma: what have we learned in 30 years?
Academic Article	Present status and future prospects for adjuvant therapy of melanoma: time to build upon the foundation of high-dose interferon alfa-2b.
Academic Article	Adjuvant high-dose interferon-alpha therapy for high-risk melanoma.
Academic Article	Mature results of a phase III randomized trial of bacillus Calmette-Guerin (BCG) versus observation and BCG plus dacarbazine versus BCG in the adjuvant therapy of American Joint Committee on Cancer Stage I-III melanoma (E1673): a trial of the Eastern Oncology Group.
Academic Article	Temozolomide in combination with interferon alpha-2b in patients with metastatic melanoma: a phase I dose-escalation study.
Academic Article	MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma.
Academic Article	Fluorescence imaging analysis of upstream regulators and downstream targets of STAT3 in melanoma precursor lesions obtained from patients before and after systemic low-dose interferon-alpha treatment.
Academic Article	Adjuvant therapy of melanoma.
Academic Article	Melanoma vaccines: early progress and future promises.
Academic Article	The alternative open reading frame of LAGE-1 gives rise to multiple promiscuous HLA-DR-restricted epitopes recognized by T-helper 1-type tumor-reactive CD4+ T cells.
Academic Article	Melanoma in the older person.
Academic Article	Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics.
Academic Article	Expression analysis of genes identified by molecular profiling of VGP melanomas and MGP melanoma-positive lymph nodes.
Academic Article	Screening for metastasis from choroidal melanoma: the Collaborative Ocular Melanoma Study Group Report 23.
Academic Article	Temozolomide for the treatment of brain metastases associated with metastatic melanoma: a phase II study.
Academic Article	Phase I/II randomized trial of intrahepatic arterial infusion chemotherapy with cisplatin and chemoembolization with cisplatin and polyvinyl sponge in patients with ocular melanoma metastatic to the liver.
Academic Article	Building upon the standard of care in adjuvant therapy of high-risk melanoma.
Academic Article	Does childhood vaccination and exposure to infection improve long-term survival in patients with malignant melanoma?
Academic Article	Development of metastatic disease after enrollment in the COMS trials for treatment of choroidal melanoma: Collaborative Ocular Melanoma Study Group Report No. 26.
Academic Article	One NY-ESO-1-derived epitope that promiscuously binds to multiple HLA-DR and HLA-DP4 molecules and stimulates autologous CD4+ T cells from patients with NY-ESO-1-expressing melanoma.
Academic Article	Melanoma.
Academic Article	Strategies for the development of more effective adjuvant therapy of melanoma: current and future explorations of antibodies, cytokines, vaccines, and combinations.
Academic Article	Accumulation of low-avidity anti-melanocortin receptor 1 (anti-MC1R) CD8+ T cells in the lesional skin of a patient with melanoma-related depigmentation.
Academic Article	Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress.
Academic Article	Update: current management issues in malignant melanoma.
Academic Article	Prognostic significance of autoimmunity during treatment of melanoma with interferon.
Academic Article	Radiosurgery for the treatment of spinal melanoma metastases.
Academic Article	Response to "helping melanoma patients decide whether to choose adjuvant high-dose interferon-alpha2b".
Academic Article	Multiplex analysis of serum cytokines in melanoma patients treated with interferon-alpha2b.
Academic Article	Endostatin plus interferon-alpha2b therapy for metastatic melanoma: a novel combination of antiangiogenic and immunomodulatory agents.
Academic Article	Durable complete responses with high-dose bolus interleukin-2 in patients with metastatic melanoma who have experienced progression after biochemotherapy.
Academic Article	Polarized type-1 dendritic cells (DC1) producing high levels of IL-12 family members rescue patient TH1-type antimelanoma CD4+ T cell responses in vitro.
Academic Article	Chemotherapy for metastatic melanoma: time for a change?
Academic Article	Neoadjuvant treatment of regional stage IIIB melanoma with high-dose interferon alfa-2b induces objective tumor regression in association with modulation of tumor infiltrating host cellular immune responses.
Academic Article	Spontaneous CD4+ T cell responses against TRAG-3 in patients with melanoma and breast cancers.
Academic Article	Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group.
Academic Article	Molecularly targeted therapy for melanoma: current reality and future options.
Academic Article	Sentinel lymph node biopsy for atypical melanocytic lesions with spitzoid features.
Academic Article	Impact of IFNalpha2b upon pSTAT3 and the MEK/ERK MAPK pathway in melanoma.
Academic Article	Three phase II cytokine working group trials of gp100 (210M) peptide plus high-dose interleukin-2 in patients with HLA-A2-positive advanced melanoma.
Academic Article	Cross-reactive CD4+ T cells against one immunodominant tumor-derived epitope in melanoma patients.
Academic Article	Adjuvant therapy with high-dose interferon alpha 2b in patients with high-risk stage IIB/III melanoma.
Academic Article	Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials.
Academic Article	Practical guidelines for the management of interferon-alpha-2b side effects in patients receiving adjuvant treatment for melanoma: expert opinion.
Academic Article	STAT3 as a biomarker of progression in atypical nevi of patients with melanoma: dose-response effects of systemic IFNalpha therapy.
Academic Article	Gamma knife radiosurgery in the management of malignant melanoma brain metastases.
Academic Article	Modulation of signal transducers and activators of transcription 1 and 3 signaling in melanoma by high-dose IFNalpha2b.
Academic Article	Oblimersen in the treatment of metastatic melanoma.
Academic Article	Present role and future potential of type I interferons in adjuvant therapy of high-risk operable melanoma.
Academic Article	Next generation of immunotherapy for melanoma.
Academic Article	Immunization with analog peptide in combination with CpG and montanide expands tumor antigen-specific CD8+ T cells in melanoma patients.
Academic Article	Phase III trial comparing concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin-2, and interferon alfa-2b with cisplatin, vinblastine, and dacarbazine alone in patients with metastatic malignant melanoma (E3695): a trial coordinated by the Eastern Cooperative Oncology Group.
Academic Article	Phase I/II trial of tremelimumab in patients with metastatic melanoma.
Academic Article	A phase 2, randomized study of SB-485232, rhIL-18, in patients with previously untreated metastatic melanoma.
Academic Article	Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group.
Academic Article	Gamma knife radiosurgery for malignant melanoma brain metastases.
Academic Article	Tremelimumab, a fully human monoclonal IgG2 antibody against CTLA4 for the potential treatment of cancer.
Academic Article	Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression.
Academic Article	Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group.
Academic Article	Focus on FOCIS: interleukin 2 treatment associated autoimmunity.
Academic Article	Biomarkers of therapeutic response in melanoma and renal cell carcinoma: potential inroads to improved immunotherapy.
Academic Article	Meeting report: consensus from the first and second Global Workshops in Melanoma November 19-20, 2008.
Academic Article	Prognostic significance of serum S100B protein in high-risk surgically resected melanoma patients participating in Intergroup Trial ECOG 1694.
Academic Article	Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma.
Academic Article	A phase 2 trial of sequential temozolomide chemotherapy followed by high-dose interleukin 2 immunotherapy for metastatic melanoma.
Academic Article	Adjuvant therapy of melanoma with interferon: lessons of the past decade.
Academic Article	Effects of high-dose IFNalpha2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17.
Academic Article	Immunogenicity and antitumor effects of vaccination with peptide vaccine+/-granulocyte-monocyte colony-stimulating factor and/or IFN-alpha2b in advanced metastatic melanoma: Eastern Cooperative Oncology Group Phase II Trial E1696.
Academic Article	Highlights from the perspectives in melanoma XII conference.
Academic Article	PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients.
Academic Article	Microrna profiling analysis of differences between the melanoma of young adults and older adults.
Academic Article	Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma.
Academic Article	A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or - dacarbazine in patients with stage IV metastatic melanoma.
Academic Article	A multi-center phase II evaluation of the small molecule survivin suppressor YM155 in patients with unresectable stage III or IV melanoma.
Academic Article	Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire.
Academic Article	Correlation of molecular human leukocyte antigen typing and outcome in high-risk melanoma patients receiving adjuvant interferon.
Academic Article	Presence of tumor-infiltrating lymphocytes and a dominant nodule within primary melanoma are prognostic factors for relapse-free survival of patients with thick (t4) primary melanoma: pathologic analysis of the e1690 and e1694 intergroup trials.
Academic Article	Outcome predictors of Gamma Knife surgery for melanoma brain metastases. Clinical article.
Academic Article	Melanoma in pediatric, adolescent, and young adult patients.
Academic Article	Clinical and immunologic basis of interferon therapy in melanoma.
Academic Article	Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma.
Academic Article	CTLA-4-blocking immunotherapy with ipilimumab for advanced melanoma.
Academic Article	Interferon signaling patterns in peripheral blood lymphocytes may predict clinical outcome after high-dose interferon therapy in melanoma patients.
Academic Article	Epitope hierarchy of spontaneous CD4+ T cell responses to LAGE-1.
Academic Article	Systematic review of medical treatment in melanoma: current status and future prospects.
Academic Article	Prognostic significance of autoimmunity during treatment of melanoma with interferon.
Academic Article	Pharmacodynamic (phase 0) study using etaracizumab in advanced melanoma.
Academic Article	Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-alpha 2b treatment.
Academic Article	Meeting report from the Third Global Workshop on Melanoma.
Academic Article	Evaluation of six CTLA-4 polymorphisms in high-risk melanoma patients receiving adjuvant interferon therapy in the He13A/98 multicenter trial.
Academic Article	Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients.
Academic Article	Phase I/II and pharmacodynamic study of dovitinib (TKI258), an inhibitor of fibroblast growth factor receptors and VEGF receptors, in patients with advanced melanoma.
Academic Article	Methylation levels of the "long interspersed nucleotide element-1" repetitive sequences predict survival of melanoma patients.
Academic Article	Aflibercept (VEGF Trap) in inoperable stage III or stage iv melanoma of cutaneous or uveal origin.
Academic Article	Function but not phenotype of melanoma peptide-specific CD8(+) T cells correlate with survival in a multiepitope peptide vaccine trial (ECOG 1696).
Academic Article	Helper activity of natural killer cells during the dendritic cell-mediated induction of melanoma-specific cytotoxic T cells.
Academic Article	A phase 2 study of tasisulam sodium (LY573636 sodium) as second-line treatment for patients with unresectable or metastatic melanoma.
Academic Article	Improved survival with vemurafenib in melanoma with BRAF V600E mutation.
Academic Article	Neoadjuvant therapy for high-risk bulky regional melanoma.
Academic Article	Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma.
Academic Article	Melanoma: from research to treatment.
Academic Article	Randomized phase II trial of sorafenib with temsirolimus or tipifarnib in untreated metastatic melanoma (S0438).
Academic Article	The role of BRAF V600 mutation in melanoma.
Academic Article	New challenges in endpoints for drug development in advanced melanoma.
Academic Article	CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1.
Academic Article	Pitfalls in retrospective analyses of biomarkers: a case study with metastatic melanoma patients.
Academic Article	Multiplex serum biomarker assessments: technical and biostatistical issues.
Academic Article	Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma.
Academic Article	New therapies in the treatment of melanoma.
Academic Article	Progression of cutaneous melanoma: implications for treatment.
Academic Article	Whole genome methylation profiles as independent markers of survival in stage IIIC melanoma patients.
Academic Article	How much of a good thing? What duration for interferon alfa-2b adjuvant therapy?
Academic Article	IFN-a in the treatment of melanoma.
Academic Article	Adjuvant therapy: melanoma.
Academic Article	Adjuvant therapy for melanoma.
Academic Article	A randomized phase II trial of multiepitope vaccination with melanoma peptides for cytotoxic T cells and helper T cells for patients with metastatic melanoma (E1602).
Academic Article	Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma.
Academic Article	Linear accelerator based stereotactic radiosurgery for melanoma brain metastases.
Academic Article	A multi-factorial genetic model for prognostic assessment of high risk melanoma patients receiving adjuvant interferon.
Academic Article	Mitochondrial respiration--an important therapeutic target in melanoma.
Academic Article	Differing patterns of circulating regulatory T cells and myeloid-derived suppressor cells in metastatic melanoma patients receiving anti-CTLA4 antibody and interferon-a or TLR-9 agonist and GM-CSF with peptide vaccination.
Academic Article	Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma.
Academic Article	The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma.
Academic Article	Advances in adjuvant therapy: potential for prognostic and predictive biomarkers.
Academic Article	Pathologic and gene expression features of metastatic melanomas to the brain.
Academic Article	Pediatric melanoma: analysis of an international registry.
Academic Article	Adjuvant immunotherapy of melanoma and development of new approaches using the neoadjuvant approach.
Academic Article	A new mathematical model for the interpretation of translational research evaluating six CTLA-4 polymorphisms in high-risk melanoma patients receiving adjuvant interferon.
Academic Article	Atypical Spitzoid neoplasms: a review of potential markers of biological behavior including sentinel node biopsy.
Academic Article	A four-marker signature of TNF-RII, TGF-a, TIMP-1 and CRP is prognostic of worse survival in high-risk surgically resected melanoma.
Academic Article	ECOG phase II trial of graded-dose peginterferon a-2b in patients with metastatic melanoma overexpressing basic fibroblast growth factor (E2602).
Academic Article	Surrogate endpoints for overall survival in metastatic melanoma: a meta-analysis of randomised controlled trials.
Academic Article	State of melanoma: an historic overview of a field in transition.
Academic Article	Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study.
Academic Article	Serologic evidence of autoimmunity in E2696 and E1694 patients with high-risk melanoma treated with adjuvant interferon alfa.
Academic Article	Correlation of somatic mutations and clinical outcome in melanoma patients treated with Carboplatin, Paclitaxel, and sorafenib.
Academic Article	Blood mRNA expression profiling predicts survival in patients treated with tremelimumab.
Academic Article	Does metastasectomy improve survival in skeletal melanoma?
Academic Article	Southwest Oncology Group S0008: a phase III trial of high-dose interferon Alfa-2b versus cisplatin, vinblastine, and dacarbazine, plus interleukin-2 and interferon in patients with high-risk melanoma--an intergroup study of cancer and leukemia Group B, Children's Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group.
Academic Article	Addressing the knowledge gap in clinical recommendations for management and complete excision of clinically atypical nevi/dysplastic nevi: Pigmented Lesion Subcommittee consensus statement.
Academic Article	Unfolding the mutational landscape of human melanoma.
Academic Article	Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial.
Academic Article	Immune checkpoint blockade and interferon-a in melanoma.
Academic Article	IL10 and PD-1 Cooperate to Limit the Activity of Tumor-Specific CD8+ T Cells.
Academic Article	Intermediate-grade meningeal melanocytoma associated with nevus of Ota: a case report and review of the literature.
Academic Article	Adjuvant Therapy of Melanoma.
Academic Article	CCR 20th Anniversary Commentary: MAPK/ERK Pathway Inhibition in Melanoma-Kinase Inhibition Redux.
Academic Article	Baseline circulating IL-17 predicts toxicity while TGF-?1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma.
Academic Article	PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C and/or HIV.
Academic Article	Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial.
Academic Article	Randomized, Placebo-Controlled, Phase III Trial of Yeast-Derived Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Versus Peptide Vaccination Versus GM-CSF Plus Peptide Vaccination Versus Placebo in Patients With No Evidence of Disease After Complete Surgical Resection of Locally Advanced and/or Stage IV Melanoma: A Trial of the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Cancer Research Group (E4697).
Academic Article	Tumor associated PD-L1 expression pattern in microscopically tumor positive sentinel lymph nodes in patients with melanoma.
Academic Article	BRAF Inhibitors and IFNa: Plus, Minus, or Indeterminate?
Academic Article	Association of TERT promoter mutations with telomerase expression in melanoma.
Academic Article	Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression.
Academic Article	Telomerase Expression by Aberrant Methylation of the TERT Promoter in Melanoma Arising in Giant Congenital Nevi.
Academic Article	Phase III Randomized Study of 4 Weeks of High-Dose Interferon-a-2b in Stage T2bNO, T3a-bNO, T4a-bNO, and T1-4N1a-2a (microscopic) Melanoma: A Trial of the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Cancer Research Group (E1697).
Academic Article	Contemporary experience with high-dose interleukin-2 therapy and impact on survival in patients with metastatic melanoma and metastatic renal cell carcinoma.
Academic Article	Downstream consequences of melanoma screening in a community practice setting: First results.
Academic Article	A phase 2 trial of dasatinib in patients with locally advanced or stage IV mucosal, acral, or vulvovaginal melanoma: A trial of the ECOG-ACRIN Cancer Research Group (E2607).
Academic Article	Genetic and Epigenetic Alterations of TERT Are Associated with Inferior Outcome in Adolescent and Young Adult Patients with Melanoma.
Academic Article	Safety and efficacy of the antiganglioside GD3 antibody ecromeximab (KW2871) combined with high-dose interferon-a2b in patients with metastatic melanoma.
Academic Article	Interferon-? Drives Treg Fragility to Promote Anti-tumor Immunity.
Academic Article	Comparison of prognostic indices in patients who undergo melanoma brain metastasis radiosurgery.
Academic Article	The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo.
Academic Article	Collaborative Care in Melanoma: The Essential Role of the Nurse?.
Academic Article	Whole-blood RNA transcript-based models can predict clinical response in two large independent clinical studies of patients with advanced melanoma treated with the checkpoint inhibitor, tremelimumab.
Academic Article	High frequency of brain metastases after adjuvant therapy for high-risk melanoma.
Academic Article	Immune Correlates of GM-CSF and Melanoma Peptide Vaccination in a Randomized Trial for the Adjuvant Therapy of Resected High-Risk Melanoma (E4697).
Academic Article	Prospective Validation of Molecular Prognostic Markers in Cutaneous Melanoma: A Correlative Analysis of E1690.
Academic Article	Relapse-Free Survival as a Surrogate for Overall Survival in the Evaluation of Stage II-III Melanoma Adjuvant Therapy.
Academic Article	Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity.
Academic Article	A Large Skin Cancer Screening Quality Initiative: Description and First-Year Outcomes.
Academic Article	Adjuvant interferon-a for the treatment of high-risk melanoma: An individual patient data meta-analysis.
Academic Article	Skin cancer screening: recommendations for data-driven screening guidelines and a review of the US Preventive Services Task Force controversy.
Academic Article	A unique gene expression signature is significantly differentially expressed in tumor-positive or tumor-negative sentinel lymph nodes in patients with melanoma.
Academic Article	Three antigen-loading methods in dendritic cell vaccines for metastatic melanoma.
Academic Article	Management strategies of academic pigmented lesion clinic directors in the United States.
Academic Article	Adjuvant Therapy in Resected Melanoma.
Academic Article	Immunoaffinity-based isolation of melanoma cell-derived exosomes from plasma of patients with melanoma.
Academic Article	Pooled Analysis Safety Profile of Nivolumab and Ipilimumab Combination Therapy in Patients With Advanced Melanoma.
Academic Article	Nivolumab Plus Ipilimumab in Patients With Advanced Melanoma: Updated Survival, Response, and Safety Data in a Phase I Dose-Escalation Study.
Academic Article	Erratum to Adjuvant immunotherapy of melanoma and development of new approaches using the neoadjuvant approach.
Academic Article	Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy.
Academic Article	Adjuvant Dabrafenib plus Trametinib in Stage III BRAF-Mutated Melanoma.
Academic Article	An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0.
Academic Article	MAGE-A3 immunotherapeutic as adjuvant therapy for patients with resected, MAGE-A3-positive, stage III melanoma (DERMA): a double-blind, randomised, placebo-controlled, phase 3 trial.
Academic Article	Anti-PD-1 antibody treatment for melanoma.
Academic Article	Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma.
Academic Article	An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.
Academic Article	Patient-reported outcomes in patients with resected, high-risk melanoma with BRAFV600E or BRAFV600K mutations treated with adjuvant dabrafenib plus trametinib (COMBI-AD): a randomised, placebo-controlled, phase 3 trial.
Academic Article	Longer Follow-Up Confirms Relapse-Free Survival Benefit With Adjuvant Dabrafenib Plus Trametinib in Patients With Resected BRAF V600-Mutant Stage III Melanoma.
Academic Article	Neoadjuvant ipilimumab (3?mg/kg or 10?mg/kg) and high dose IFN-a2b in locally/regionally advanced melanoma: safety, efficacy and impact on T-cell repertoire.
Academic Article	E3611-A Randomized Phase II Study of Ipilimumab at 3 or 10 mg/kg Alone or in Combination with High-Dose Interferon-a2b in Advanced Melanoma.
Academic Article	Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, Gaq and Ga11 and kill uveal melanoma cells.
Academic Article	CD56dim CD16- Natural Killer Cell Profiling in Melanoma Patients Receiving a Cancer Vaccine and Interferon-a.
Academic Article	Reply to E. Hindi? and K.R. Hess.
Academic Article	Observational study of talimogene laherparepvec use for melanoma in clinical practice in the United States (COSMUS-1).
Academic Article	Treatment-Free Survival: A Novel Outcome Measure of the Effects of Immune Checkpoint Inhibition-A Pooled Analysis of Patients With Advanced Melanoma.
Academic Article	An updated analysis of 4 randomized ECOG trials of high-dose interferon in the adjuvant treatment of melanoma.
Academic Article	Thick melanoma is associated with low melanoma knowledge and low perceived health competence, but not delays in care.
Academic Article	Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV600-mutant, stage III melanoma (COMBI-AD): exploratory biomarker analyses from a randomised, phase 3 trial.
Academic Article	Melanoma cell-derived exosomes in plasma of melanoma patients suppress functions of immune effector cells.
Academic Article	Reactivation of tuberculosis in cancer patients following administration of immune checkpoint inhibitors: current evidence and clinical practice recommendations.
Academic Article	A Th1/IFN? Gene Signature Is Prognostic in the Adjuvant Setting of Resectable High-Risk Melanoma but Not in Non-Small Cell Lung Cancer.
Academic Article	Phase III Study of Adjuvant Ipilimumab (3 or 10 mg/kg) Versus High-Dose Interferon Alfa-2b for Resected High-Risk Melanoma: North American Intergroup E1609.
Academic Article	Developing agents for the therapeutic prevention of melanoma: can the assessment of cutaneous precursor lesions help?
Academic Article	Systemic Therapy for Melanoma: ASCO Guideline.
Academic Article	Impact of checkpoint blockade on cancer vaccine-activated CD8+ T cell responses.
Academic Article	Clinical Development of BRAF plus MEK Inhibitor Combinations.
Academic Article	IL15 Stimulation with TIGIT Blockade Reverses CD155-mediated NK-Cell Dysfunction in Melanoma.
Academic Article	Prognostic Gene Expression Profiling in Cutaneous Melanoma: Identifying the Knowledge Gaps and Assessing the Clinical Benefit.
Academic Article	Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma.
Academic Article	Cancer vaccine induces potent T cell responses - but is it enough?
Academic Article	Molecular and immunological associations of elevated serum lactate dehydrogenase in metastatic melanoma patients: A fresh look at an old biomarker.
Academic Article	Indoor tanning exposure in association with multiple primary melanoma.
Academic Article	Ipilimumab plus nivolumab for patients with metastatic uveal melanoma: a multicenter, retrospective study.
Academic Article	The State of Melanoma: Emergent Challenges and Opportunities.
Academic Article	CTLA-4 blockade and interferon-a induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma.
Academic Article	Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients.
Academic Article	Beyond PD-1: The Next Frontier for Immunotherapy in Melanoma.
Academic Article	Neoadjuvant Pembrolizumab and High-Dose IFNa-2b in Resectable Regionally Advanced Melanoma.
Academic Article	State of Melanoma: An Historic Overview of a Field in Transition.
Academic Article	A phase 1 study of NY-ESO-1 vaccine + anti-CTLA4 antibody Ipilimumab (IPI) in patients with unresectable or metastatic melanoma.
Academic Article	Melanoma-specific expression of the tumor suppressor proteins p16 and PTEN is a favorable prognostic factor in established melanoma brain metastases.
Academic Article	GZ17-6.02 Interacts With [MEK1/2 and B-RAF Inhibitors] to Kill Melanoma Cells.
Academic Article	Immune adverse events (irAEs) with adjuvant ipilimumab in melanoma, use of immunosuppressants and association with outcome: ECOG-ACRIN E1609 study analysis.
Academic Article	Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma.
Academic Article	Prognosis and Management of BRAF V600E-Mutated Pregnancy-Associated Melanoma.
Academic Article	Overcoming PD-1 Blockade Resistance with CpG-A Toll-Like Receptor 9 Agonist Vidutolimod in Patients with Metastatic Melanoma.
Academic Article	Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma.
Academic Article	Dysregulated NF-?B-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma.
Academic Article	Adjuvant Pembrolizumab versus IFNa2b or Ipilimumab in Resected High-Risk Melanoma.
Academic Article	Dendritic cell vaccines targeting tumor blood vessel antigens in combination with dasatinib induce therapeutic immune responses in patients with checkpoint-refractory advanced melanoma.
Academic Article	Immune-Related Adverse Events in PD-1 Treated Melanoma and Impact Upon Anti-Tumor Efficacy: A Real World Analysis.
Academic Article	Proteomic profile of melanoma cell-derived small extracellular vesicles in patients' plasma: a potential correlate of melanoma progression.
Academic Article	Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding.
Academic Article	Tumor MHC Class I Expression Associates with Intralesional IL2 Response in Melanoma.
Academic Article	Improved prognosis and evidence of enhanced immunogenicity in tumor and circulation of high-risk melanoma patients with unknown primary.
Academic Article	Poorer survival outcomes in patients with multiple versus single primary melanoma.
Academic Article	Unbiased High-Throughput Drug Combination Pilot Screening Identifies Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines.
Academic Article	Neratinib kills B-RAF V600E melanoma via ROS-dependent autophagosome formation and death receptor signaling.
Academic Article	Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial.
Academic Article	Five-Year Outcomes of a Melanoma Screening Initiative in a Large Health Care System.
Academic Article	A retrospective analysis of the impact of the COVID-19 pandemic on staging at presentation of patients with invasive melanoma.
Academic Article	Molecular Pathways and Mechanisms of LAG3 in Cancer Therapy.
Academic Article	Clinically Significant Risk Thresholds in the Management of Primary Cutaneous Melanoma: A Survey of Melanoma Experts.
Academic Article	Enhanced immune activation within the tumor microenvironment and circulation of female high-risk melanoma patients and improved survival with adjuvant CTLA4 blockade compared to males.
Academic Article	Prognosis of Patients With Primary Melanoma Stage I and II According to American Joint Committee on Cancer Version 8 Validated in Two Independent Cohorts: Implications for Adjuvant Treatment.
Academic Article	Co-expression of TNF receptors 1 and 2 on melanomas facilitates soluble TNF-induced resistance to MAPK pathway inhibitors.
Academic Article	Interferon-alpha in tumor immunity and immunotherapy.
Academic Article	Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF-Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134.
Academic Article	Clinical Features Associated with Outcomes and Biomarker Analysis of Dabrafenib plus Trametinib Treatment in Patients with BRAF-Mutant Melanoma Brain Metastases.
Academic Article	Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial.
Academic Article	Effectiveness of Adjuvant Pembrolizumab vs High-Dose Interferon or Ipilimumab for Quality-of-Life Outcomes in Patients With Resected Melanoma: A Secondary Analysis of the SWOG S1404 Randomized Clinical Trial.
Academic Article	Neoadjuvant treatment for melanoma: current challenges and future perspectives.
Academic Article	TPP1 promoter mutations cooperate with TERT promoter mutations to lengthen telomeres in melanoma.
Academic Article	Phase I trial of pembrolizumab plus vemurafenib and cobimetinib in patients with metastatic melanoma.
Academic Article	Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma.
Academic Article	Second primary cancers after enrollment in the COMS trials for treatment of choroidal melanoma: COMS Report No. 25.
Academic Article	Multiple primary melanoma in association with other personal and familial cancers.
Academic Article	Sentinel Lymph Node Gene Expression Signature Predicts Recurrence-Free Survival in Cutaneous Melanoma.
Academic Article	Adjuvant pembrolizumab versus placebo in resected high-risk stage II melanoma: Health-related quality of life from the randomized phase 3 KEYNOTE-716 study.
Academic Article	Patient-reported tolerability of adjuvant ipilimumab (3 or 10?mg/kg) versus high-dose interferon alfa-2b for resected high-risk stage III-IV melanoma in phase III trial E1609.
Academic Article	Efficacy and safety of lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in patients with advanced melanoma after progression on immune checkpoint inhibitors and targeted therapies: pooled analysis of consecutive cohorts of the C-144-01 study.
Academic Article	Randomized, Double-Blind, Placebo-Controlled, Global Phase III Trial of Talimogene Laherparepvec Combined With Pembrolizumab for Advanced Melanoma.
Academic Article	Immunotherapy in Melanoma: Recent Advances and Future Directions.
Academic Article	Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma.
Academic Article	Early Detection and Prognostic Assessment of Cutaneous Melanoma: Consensus on Optimal Practice and the Role of Gene Expression Profile Testing.
Academic Article	Granulomatous and Sarcoid-like Immune-Related Adverse Events following CTLA4 and PD1 Blockade Adjuvant Therapy of Melanoma: A Combined Analysis of ECOG-ACRIN E1609 and SWOG S1404 Phase III Trials and a Literature Review.
Academic Article	Tebentafusp in combination with durvalumab and/or tremelimumab in patients with metastatic cutaneous melanoma: a phase 1 study.
Academic Article	Expression of lymphoid structure-associated cytokine/chemokine gene transcripts in tumor and protein in serum are prognostic of melanoma patient outcomes.
Academic Article	Metformin is associated with improved clinical outcomes in patients with melanoma: a retrospective, multi-institutional study.
Academic Article	Systemic Therapy for Melanoma: ASCO Guideline Update.
Academic Article	Identification of tumor-intrinsic drivers of immune exclusion in acral melanoma.
Academic Article	Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial.
Academic Article	Identification of tumor-intrinsic drivers of immune exclusion in acral melanoma.
Academic Article	Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma.
Academic Article	Real-world outcomes with immuno-oncology therapies in advanced melanoma: final results of the OPTIMIzE registry study.
Academic Article	Publisher Correction: Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial.
Academic Article	Prognostic gene expression profile testing to inform use of adjuvant therapy: A survey of melanoma experts.
Academic Article	Author Correction: Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial.
Academic Article	Plain language summary of the CheckMate 76K study results: nivolumab given after stage 2B/2C?melanoma is removed by surgery.
Academic Article	Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial.
Academic Article	Pembrolizumab Versus Placebo as Adjuvant Therapy in Resected Stage IIB or IIC Melanoma: Final Analysis of Distant Metastasis-Free Survival in the Phase III KEYNOTE-716 Study.
Academic Article	Neoadjuvant Dual Checkpoint Inhibitors vs Anti-PD1 Therapy in High-Risk Resectable Melanoma: A Pooled Analysis.

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