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DAVIES, MICHAEL A

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Item Type	Name
Academic Article	The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models.
Academic Article	Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy.
Concept	Melanoma
Concept	Melanoma, Experimental
Academic Article	Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436).
Academic Article	Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2.
Academic Article	Phase I study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma.
Academic Article	Special issue on melanoma.
Academic Article	Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients.
Academic Article	BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.
Academic Article	Tissue resources for clinical use and marker studies in melanoma.
Academic Article	Emerging insights into resistance to BRAF inhibitors in melanoma.
Academic Article	Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates.
Academic Article	Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells.
Academic Article	Prognostic factors for survival in melanoma patients with brain metastases.
Academic Article	Pharmacokinetics and safety of Marqibo (vincristine sulfate liposomes injection) in cancer patients with impaired liver function.
Academic Article	Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma.
Academic Article	In vitro studies of dasatinib, its targets and predictors of sensitivity.
Academic Article	Exome sequencing identifies GRIN2A as frequently mutated in melanoma.
Academic Article	Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner.
Academic Article	BRAF, NRAS and KIT sequencing analysis of spindle cell melanoma.
Academic Article	Overcoming resistance to MAPK pathway inhibitors.
Academic Article	Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma.
Academic Article	Somatic mutations in MAP3K5 attenuate its proapoptotic function in melanoma through increased binding to thioredoxin.
Academic Article	A novel AKT3 mutation in melanoma tumours and cell lines.
Academic Article	Phosphorylated 4E-BP1 is associated with poor survival in melanoma.
Academic Article	Phosphatidylinositol-3-kinase as a therapeutic target in melanoma.
Academic Article	Targeting KIT in melanoma: a paradigm of molecular medicine and targeted therapeutics.
Academic Article	Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.
Academic Article	Targeted therapy for melanoma: a primer.
Academic Article	Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.
Academic Article	Association of activated c-Met with NRAS-mutated human melanomas.
Academic Article	Correlation of NRAS mutations with clinical response to high-dose IL-2 in patients with advanced melanoma.
Academic Article	Risk of intracranial hemorrhage with anticoagulation therapy in melanoma patients with brain metastases.
Academic Article	A landscape of driver mutations in melanoma.
Academic Article	Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma.
Academic Article	Clinical responses to selumetinib (AZD6244; ARRY-142886)-based combination therapy stratified by gene mutations in patients with metastatic melanoma.
Academic Article	Characterizing the clinical benefit of ipilimumab in patients who progressed on high-dose IL-2.
Academic Article	Clinical characteristics and outcomes with specific BRAF and NRAS mutations in patients with metastatic melanoma.
Academic Article	Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma.
Academic Article	Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.
Academic Article	The role of the PI3K-AKT pathway in melanoma.
Academic Article	Lysophosphatidic acid induces lymphangiogenesis and IL-8 production in vitro in human lymphatic endothelial cells.
Academic Article	A phase I multi-institutional study of systemic sorafenib in conjunction with regional melphalan for in-transit melanoma of the extremity.
Academic Article	Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial.
Academic Article	Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma.
Academic Article	NRAS mutation status is an independent prognostic factor in metastatic melanoma.
Academic Article	New strategies in melanoma: molecular testing in advanced disease.
Academic Article	Phase I trial of biochemotherapy with cisplatin, temozolomide, and dose escalation of nab-paclitaxel combined with interleukin-2 and interferon-a in patients with metastatic melanoma.
Academic Article	Finding the right balance of BRAF inhibition in melanoma.
Academic Article	Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target.
Academic Article	Targeted therapy resistance mechanisms and therapeutic implications in melanoma.
Academic Article	A highly recurrent RPS27 5'UTR mutation in melanoma.
Academic Article	The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF.
Academic Article	Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma.
Academic Article	Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations.
Academic Article	Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1a and oxidative phosphorylation in melanoma.
Academic Article	Use of clinical next-generation sequencing to identify melanomas harboring SMARCB1 mutations.
Academic Article	BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma.
Academic Article	Role and complexity of next-generation sequencing in melanoma.
Academic Article	Utility of BRAF V600E Immunohistochemistry Expression Pattern as a Surrogate of BRAF Mutation Status in 154 Patients with Advanced Melanoma.
Academic Article	Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma.
Academic Article	BRAF in early stage melanoma: rationale for testing and treatment?
Academic Article	ErbB3-ErbB2 Complexes as a Therapeutic Target in a Subset of Wild-type BRAF/NRAS Cutaneous Melanomas.
Academic Article	Intrathecal Administration of Tumor-Infiltrating Lymphocytes Is Well Tolerated in a Patient with Leptomeningeal Disease from Metastatic Melanoma: A Case Report.
Academic Article	Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.
Academic Article	Melanoma central nervous system metastases
Academic Article	Clinicopathological features and clinical outcomes associated with TP53 and BRAF^N ^on- ^V ⁶⁰⁰ mutations in cutaneous melanoma patients
Academic Article	Molecular biology of cutaneous melanoma
Academic Article	Molecular biology of cutaneous melanoma
Academic Article	Intrathecal Administration of Tumor-Infiltrating Lymphocytes Is Well Tolerated in a Patient with Leptomeningeal Disease from Metastatic Melanoma
Academic Article	SBI-0640756 attenuates the growth of clinically unresponsive melanomas by disrupting the eIF4F translation initiation complex
Academic Article	Role and complexity of next-generation sequencing in melanoma
Academic Article	A phase I study of TPI 287 in combination with temozolomide for patients with metastatic melanoma
Academic Article	Parallel and Serial Blockade Strategies in BRAF-Mutant Melanoma
Academic Article	An in vivo reporter to quantitatively and temporally analyze the effects of CDK4/6 inhibitor-based therapies in melanoma
Academic Article	PDK1 and SGK3 contribute to the growth of BRAF-mutant melanomas and are potential therapeutic targets
Academic Article	AKT1 Activation Promotes Development of Melanoma Metastases
Academic Article	Molecular approaches to tumor inhibition in melanoma
Academic Article	Targeted therapy for melanoma
Academic Article	Genotyping of cutaneous melanoma
Academic Article	Inflammatory marker testing identifies CD74 expression in melanoma tumor cells, and its expression associates with favorable survival for stage III melanoma
Academic Article	RMEL3, a novel BRAF^V600E-associated long noncoding RNA, is required for MAPK and PI3K signaling in melanoma
Academic Article	Phase I dose-escalation study of the multikinase inhibitor lenvatinib in patients with advanced solid tumors and in an expanded cohort of patients with melanoma
Academic Article	BRAF^V600E co-opts a conserved MHC class I internalization pathway to diminish antigen presentation and CD8⁺ T-cell recognition of melanoma
Academic Article	The multi-faceted roles of the PI3K-AKT pathway in melanoma
Academic Article	RAC1 P29S regulates PD-L1 expression in melanoma
Academic Article	Integrated molecular and clinical analysis of AKT activation in metastatic melanoma
Academic Article	Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma
Academic Article	Targeting Notch enhances the efficacy of ERK inhibitors in BRAFV600E melanoma
Academic Article	Future perspectives in melanoma research
Academic Article	Future perspectives in melanoma research
Academic Article	MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRASÂ Melanoma
Academic Article	Association between Body Mass Index, C-Reactive Protein Levels, and Melanoma Patient Outcomes.
Academic Article	The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression.
Academic Article	Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.
Academic Article	Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis.
Academic Article	Genotyping of cutaneous melanoma.
Academic Article	Converting biology into clinical benefit: lessons learned from BRAF inhibitors.
Academic Article	Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and Its Expression Associates with Favorable Survival for Stage III Melanoma.
Academic Article	Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade.
Academic Article	Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma.
Academic Article	Molecular approaches to tumor inhibition in melanoma.
Academic Article	Clinical, Molecular, and Immune Analysis of Dabrafenib-Trametinib Combination Treatment for BRAF Inhibitor-Refractory Metastatic Melanoma: A Phase 2 Clinical Trial.
Academic Article	Tumor Thickness and Mitotic Rate Robustly Predict Melanoma-Specific Survival in Patients with Primary Vulvar Melanoma: A Retrospective Review of 100 Cases.
Academic Article	Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.
Academic Article	Melanoma Brain Metastases: Current Areas of Investigation and Future Directions.
Academic Article	A phase I study of TPI 287 in combination with temozolomide for patients with metastatic melanoma.
Academic Article	Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial.
Academic Article	Resistance mechanisms to genetic suppression of mutant NRAS in melanoma.
Academic Article	Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications.
Academic Article	Melanoma in 2017: Moving treatments earlier to move further forwards.
Academic Article	Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma.
Academic Article	Primary medical therapy for BRAFV600E-mutant melanoma brain metastases-is this good enough? - Authors' reply.
Academic Article	Retrospective review of metastatic melanoma patients with leptomeningeal disease treated with intrathecal interleukin-2.
Academic Article	Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome.
Academic Article	Neoadjuvant plus adjuvant dabrafenib and trametinib versus standard of care in patients with high-risk, surgically resectable melanoma: a single-centre, open-label, randomised, phase 2 trial.
Academic Article	A Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling.
Academic Article	Phase I/II Study of Hepatic Arterial Infusion of Nab-paclitaxel in Patients With Metastatic Melanoma to the Liver.
Academic Article	Body-mass index and metastatic melanoma outcomes - Authors' reply.
Academic Article	Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.
Academic Article	Author Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.
Academic Article	Publisher Correction: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma.
Academic Article	Predictors of survival in metastatic melanoma patients with leptomeningeal disease (LMD).
Academic Article	Reply to A. Shinde et al.
Academic Article	Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases.
Academic Article	Biological Validation of RNA Sequencing Data from Formalin-Fixed Paraffin-Embedded Primary Melanomas.
Academic Article	Neoadjuvant systemic therapy in melanoma: recommendations of the International Neoadjuvant Melanoma Consortium.
Academic Article	Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3K? Inhibition in PTEN Loss Melanoma.
Academic Article	Prognostic model for patient survival in primary anorectal mucosal melanoma: stage at presentation determines relevance of histopathologic features.
Academic Article	Intracranial antitumor activity with encorafenib plus binimetinib in patients with melanoma brain metastases: A case series.
Academic Article	Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions.
Academic Article	B cells and tertiary lymphoid structures promote immunotherapy response.
Academic Article	Cumulative Incidence and Predictors of CNS Metastasis for Patients With American Joint Committee on Cancer 8th Edition Stage III Melanoma.
Academic Article	Circulating Tumor Cells and Early Relapse in Node-positive Melanoma.
Academic Article	Is It Safe to Stop Anti-PD-1 Immunotherapy in Patients With Metastatic Melanoma Who Achieve a Complete Response?
Academic Article	Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma.
Academic Article	Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype.
Academic Article	Osteonecrosis of the jaw induced by treatment with anti-PD-1 immunotherapy: a case report.
Academic Article	Molecular and immunological associations of elevated serum lactate dehydrogenase in metastatic melanoma patients: A fresh look at an old biomarker.
Academic Article	Clinical, molecular, metabolic, and immune features associated with oxidative phosphorylation in melanoma brain metastases.
Academic Article	iNOS Associates With Poor Survival in Melanoma: A Role for Nitric Oxide in the PI3K-AKT Pathway Stimulation and PTEN S-Nitrosylation.
Academic Article	Tilsotolimod with Ipilimumab Drives Tumor Responses in Anti-PD-1 Refractory Melanoma.
Academic Article	The efficacy of anti-programmed cell death protein 1 therapy among patients with metastatic acral and metastatic mucosal melanoma.
Academic Article	Nodal Recurrence is a Primary Driver of Early Relapse for Patients with Sentinel Lymph Node-Positive Melanoma in the Modern Therapeutic Era.
Academic Article	Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients with metastatic melanoma.
Academic Article	Re-thinking therapeutic development for CNS metastatic disease.
Academic Article	Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade.
Academic Article	Identification of MicroRNA-mRNA Networks in Melanoma and Their Association with PD-1 Checkpoint Blockade Outcomes.
Academic Article	Short-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in Braf-mutated melanoma.
Academic Article	Cutaneous adverse events in 155 patients with metastatic melanoma consecutively treated with anti-CTLA4 and anti-PD1 combination immunotherapy: Incidence, management, and clinical benefit.
Academic Article	Targeted therapy strategies for melanoma brain metastasis.
Academic Article	Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response.
Academic Article	Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma.
Academic Article	Outcomes After Sphincter-Sparing Local Therapy for Anorectal Melanoma: 1989 to 2020.
Academic Article	Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition.
Academic Article	Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy.
Academic Article	Neoadjuvant relatlimab and nivolumab in resectable melanoma.
Academic Article	Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma.
Academic Article	Neoadjuvant checkpoint inhibitor immunotherapy for resectable mucosal melanoma.
Academic Article	Changes in outcomes and factors associated with survival in melanoma patients with brain metastases.
Academic Article	Multiplatform Analysis of Intratumoral PTEN Heterogeneity in Melanoma.
Academic Article	Author Correction: Neoadjuvant relatlimab and nivolumab in resectable melanoma.
Academic Article	Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results.
Academic Article	Gut Microbiome in Patients With Early-Stage and Late-Stage Melanoma.

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