| Item Type | Name |
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Concept
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Antimetabolites, Antineoplastic
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Academic Article
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A sensitive fluorescence assay for quantitation of fludarabine and metabolites in biological fluids.
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Academic Article
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Fludarabine- and gemcitabine-induced apoptosis: incorporation of analogs into DNA is a critical event.
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Academic Article
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Deoxynucleotide pool depletion and sustained inhibition of ribonucleotide reductase and DNA synthesis after treatment of human lymphoblastoid cells with 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine.
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Academic Article
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Pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine in a patient with ascites.
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Academic Article
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Phase II clinical investigation of gemcitabine in advanced soft tissue sarcomas and window evaluation of dose rate on gemcitabine triphosphate accumulation.
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Academic Article
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Genetic variants in cytosolic 5'-nucleotidase II are associated with its expression and cytarabine sensitivity in HapMap cell lines and in patients with acute myeloid leukemia.
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Academic Article
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Phase II trial of fludarabine phosphate in lymphoma: an effective new agent in low-grade lymphoma.
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Academic Article
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Action of 2',2'-difluorodeoxycytidine on DNA synthesis.
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Academic Article
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Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation.
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Academic Article
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Cytotoxicity and antitumor activity of 2',2'-difluorodeoxycytidine (Gemcitabine).
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Academic Article
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9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate pharmacokinetics in plasma and tumor cells of patients with relapsed leukemia and lymphoma.
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Academic Article
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5'-Fluorosulfonylbenzoyl derivatives of therapeutic nucleoside analogs.
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Academic Article
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Gemcitabine: metabolism, mechanisms of action, and self-potentiation.
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Academic Article
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Difluorodeoxyguanosine: cytotoxicity, metabolism, and actions on DNA synthesis in human leukemia cells.
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Academic Article
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Excision of 2',2'-difluorodeoxycytidine (gemcitabine) monophosphate residues from DNA.
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Academic Article
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Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma.
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Academic Article
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H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation.
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Academic Article
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Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes.
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Academic Article
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Transport properties of pancreatic cancer describe gemcitabine delivery and response.
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Academic Article
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Metabolism and action of fludarabine phosphate.
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Academic Article
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Saturation of 2',2'-difluorodeoxycytidine 5'-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine.
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Academic Article
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A phase I clinical, plasma, and cellular pharmacology study of gemcitabine.
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Academic Article
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Pharmacologically directed design of the dose rate and schedule of 2',2'-difluorodeoxycytidine (Gemcitabine) administration in leukemia.
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Academic Article
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Fludarabine: a new agent with major activity against chronic lymphocytic leukemia.
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Academic Article
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Aspartate carbamoyltransferase activity, drug concentrations, and pyrimidine nucleotides in tissue from patients treated with N-(phosphonacetyl)-L-aspartate.
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Academic Article
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Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism.
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Academic Article
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Metabolism and actions of 2-chloro-9-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl)-adenine in human lymphoblastoid cells.
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Academic Article
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Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic, and molecular interactions.
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Academic Article
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Preclinical characteristics of gemcitabine.
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Academic Article
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Gemcitabine: preclinical pharmacology and mechanisms of action.
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Academic Article
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Differential induction of apoptosis by fludarabine monophosphate in leukemic B and normal T cells in chronic lymphocytic leukemia.
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Academic Article
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Minimum dose of fludarabine for the maximal modulation of 1-beta-D-arabinofuranosylcytosine triphosphate in human leukemia blasts during therapy.
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Academic Article
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Influence of fludarabine on pharmacokinetics and pharmacodynamics of cytarabine: implications for a continuous infusion schedule.
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Academic Article
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Clinical results of a pharmacodynamically-based strategy for higher dosing of gemcitabine in patients with solid tumors.
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Academic Article
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Enhancement of tumor radioresponse in vivo by gemcitabine.
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Academic Article
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Phase II trial and pharmacokinetic evaluation of cytosine arabinoside for leptomeningeal metastases from breast cancer.
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Academic Article
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Gemcitabine modulation of alkylator therapy: a phase I trial of escalating gemcitabine added to fixed doses of ifosfamide and doxorubicin.
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Academic Article
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Mechanisms of apoptosis induction by nucleoside analogs.
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Academic Article
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Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants.
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Academic Article
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Modulation of deoxycytidylate deaminase in intact human leukemia cells. Action of 2',2'-difluorodeoxycytidine.
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Academic Article
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A quantitative assay for fragmented DNA in apoptotic cells.
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Academic Article
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Gemcitabine in leukemia: a phase I clinical, plasma, and cellular pharmacology study.
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Academic Article
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New initiatives with fludarabine monophosphate in hematologic malignancies.
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Academic Article
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S-Phase arrest by nucleoside analogues and abrogation of survival without cell cycle progression by 7-hydroxystaurosporine.
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Academic Article
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Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage.
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Academic Article
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Prolonged infusion of gemcitabine: clinical and pharmacodynamic studies during a phase I trial in relapsed acute myelogenous leukemia.
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Academic Article
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Clofarabine in adult acute leukemias: clinical success and pharmacokinetics.
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Academic Article
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Why do drugs work in CLL?
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Academic Article
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Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks.
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Academic Article
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Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer.
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