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Protein Interaction Domains and Motifs
Concept
Why?
A conserved pre-block interaction motif regulates potassium channel activation and N-type inactivation.
Academic Article
Why?
Amino acid 72 of mouse and human GDF9 mature domain is responsible for altered homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activities.
Academic Article
Why?
Conserved N-terminal negative charges support optimally efficient N-type inactivation of Kv1 channels.
Academic Article
Why?
LAM, FONG
Person
Why?
Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain.
Academic Article
Why?
Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP.
Academic Article
Why?
Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta.
Academic Article
Why?
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.
Academic Article
Why?
TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs.
Academic Article
Why?
An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels.
Academic Article
Why?
BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells.
Academic Article
Why?
Epileptic Encephalopathy In A Patient With A Novel Variant In The Kv7.2 S2 Transmembrane Segment: Clinical, Genetic, and Functional Features.
Academic Article
Why?
Loss of c-Kit and bone marrow failure upon conditional removal of the GATA-2 C-terminal zinc finger domain in adult mice.
Academic Article
Why?
Two splicing factors carrying serine-arginine motifs, TSR1 and TSR1IP, regulate splicing, mRNA stability, and rRNA processing in Trypanosoma brucei.
Academic Article
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