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O'MALLEY, BERT

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Item Type	Name
Academic Article	Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency.
Academic Article	Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis.
Academic Article	Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action.
Academic Article	SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells.
Academic Article	Hierarchical affinities and a bipartite interaction model for estrogen receptor isoforms and full-length steroid receptor coactivator (SRC/p160) family members.
Academic Article	Thyroid hormone receptor-specific interactions with steroid receptor coactivator-1 in the pituitary.
Academic Article	Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1.
Academic Article	Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification.
Academic Article	Unfolding the action of progesterone receptors.
Academic Article	Recombinant vaccinia virus expressing IL-2 generates effective anti-tumor responses in an orthotopic murine model of head and neck carcinoma.
Academic Article	GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility.
Academic Article	Progesterone involvement in breast development and tumorigenesis--as revealed by progesterone receptor "knockout" and "knockin" mouse models.
Academic Article	Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction.
Academic Article	Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo.
Academic Article	Combinatorial control of gene expression by nuclear receptors and coregulators.
Academic Article	Anxiolytic activity of progesterone in progesterone receptor knockout mice.
Academic Article	A life-long search for the molecular pathways of steroid hormone action.
Academic Article	Enhanced sexual behaviors and androgen receptor immunoreactivity in the male progesterone receptor knockout mouse.
Academic Article	The Nuclear Receptor Signaling Atlas: development of a functional atlas of nuclear receptors.
Academic Article	Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis.
Academic Article	Regulation of expression of thyroid hormone receptor isoforms and coactivators in liver and heart by thyroid hormone.
Academic Article	Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.
Academic Article	Reproductive functions of progesterone receptors.
Academic Article	Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice.
Academic Article	Genotype differences in behavior and tyrosine hydroxylase expression between wild-type and progesterone receptor knockout mice.
Academic Article	Modulation by steroid receptor coactivator-1 of target-tissue responsiveness in resistance to thyroid hormone.
Academic Article	Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland.
Academic Article	SRC-1 and TIF2 control energy balance between white and brown adipose tissues.
Academic Article	Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis.
Academic Article	Coregulator function: a key to understanding tissue specificity of selective receptor modulators.
Academic Article	A repressive role for prohibitin in estrogen signaling.
Academic Article	Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis.
Academic Article	A contemporary understanding of progesterone receptor function.
Academic Article	Dual roles for coactivator activator and its counterbalancing isoform coactivator modulator in human kidney cell tumorigenesis.
Academic Article	Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo.
Academic Article	Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice.
Academic Article	Nuclear receptor coregulators are new players in nervous system development and function.
Academic Article	Pituitary adenylate cyclase-activating peptide: a pivotal modulator of steroid-induced reproductive behavior in female rodents.
Academic Article	Expanding functional diversity of the coactivators.
Academic Article	Foxa2-dependent hepatic gene regulatory networks depend on physiological state.
Academic Article	Skeletal consequences of deletion of steroid receptor coactivator-2/transcription intermediary factor-2.
Academic Article	Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family.
Academic Article	Rush hour at the promoter: how the ubiquitin-proteasome pathway polices the traffic flow of nuclear receptor-dependent transcription.
Academic Article	Minireview: the SRC family of coactivators: an entr?e to understanding a subset of polygenic diseases?
Academic Article	An estrogen receptor alpha activity indicator model in mice.
Academic Article	Splicing potentiation by growth factor signals via estrogen receptor phosphorylation.
Academic Article	A subset of nuclear receptor coregulators act as coupling proteins during synthesis and maturation of RNA transcripts.
Academic Article	Modulation of steroid hormone receptor activity.
Academic Article	Recombinant vaccinia virus expressing interleukin-2 invokes anti-tumor cellular immunity in an orthotopic murine model of head and neck squamous cell carcinoma.
Academic Article	Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways.
Academic Article	Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).
Academic Article	Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells.
Academic Article	The coactivator SRC-1 is an essential coordinator of hepatic glucose production.
Academic Article	Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD.
Academic Article	The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome.
Academic Article	Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta.
Academic Article	Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo.
Academic Article	Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice.
Academic Article	Results of a search for the mechanisms of steroid receptor regulation of gene expression.
Academic Article	SLIRP, a small SRA binding protein, is a nuclear receptor corepressor.
Academic Article	PAC1 receptors mediate pituitary adenylate cyclase-activating polypeptide- and progesterone-facilitated receptivity in female rats.
Academic Article	Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly.
Academic Article	ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion.
Academic Article	Teaching resources. An interactive course in nuclear receptor signaling: concepts and models.
Academic Article	Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.
Academic Article	Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human.
Academic Article	Inhibition of NK cell activity through TGF-beta 1 by down-regulation of NKG2D in a murine model of head and neck cancer.
Academic Article	Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function.
Academic Article	Distinct temporal and spatial activities of RU486 on progesterone receptor function in reproductive organs of ovariectomized mice.
Academic Article	The expanding cosmos of nuclear receptor coactivators.
Academic Article	Nuclear receptor coregulators and human disease.
Academic Article	Regulation of SRC-3 intercompartmental dynamics by estrogen receptor and phosphorylation.
Academic Article	Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse.
Academic Article	Coregulators: from whence came these "master genes".
Academic Article	An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response.
Academic Article	The p160 steroid receptor coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone-independent and -dependent gene expression.
Academic Article	Coregulators in adipogenesis: what could we learn from the SRC (p160) coactivator family?
Academic Article	The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.
Academic Article	Cracking the coregulator codes.
Academic Article	Bone growth and turnover in progesterone receptor knockout mice.
Academic Article	Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.
Academic Article	The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression.
Academic Article	The Year in Basic Science: nuclear receptors and coregulators.
Academic Article	Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation.
Academic Article	The "fourth dimension" of gene transcription.
Academic Article	Maturation of microRNA is hormonally regulated by a nuclear receptor.
Academic Article	SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration.
Academic Article	Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology.
Academic Article	SnapShot: NR coregulators.
Academic Article	Hormone action in the mammary gland.
Academic Article	SnapShot: Nuclear receptors II.
Academic Article	Steroid receptor coactivator (SRC) family: masters of systems biology.
Academic Article	Nuclear receptor coactivators: structural and functional biochemistry.
Academic Article	A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.
Academic Article	Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA.
Academic Article	Multiple coregulatory control of tyrosine hydroxylase gene transcription.
Academic Article	SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart.
Academic Article	Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family.
Academic Article	Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor.
Academic Article	DNA transcription and repair: a confluence.
Academic Article	Progesterone receptors: a key for neuroprotection in experimental stroke.
Academic Article	A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis.
Academic Article	Nuclear receptor coregulators: modulators of pathology and therapeutic targets.
Academic Article	Minireview: nuclear receptor and coregulator proteomics--2012 and beyond.
Academic Article	Prohibitin-1 deficiency promotes inflammation and increases sensitivity to liver injury.
Academic Article	SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization.
Academic Article	Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction.
Academic Article	Ligand-inducible transgene regulation for gene therapy.
Academic Article	Molecular mechanisms and cellular biology of the steroid receptor coactivator (SRC) family in steroid receptor function.
Academic Article	Progesterone receptors mediate male aggression toward infants.
Academic Article	Steroid receptor coactivator-1 is not required for androgen-mediated sexual differentiation of spinal motoneurons.
Academic Article	AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice.
Academic Article	Transcriptional regulation by steroid receptor coactivator phosphorylation.
Academic Article	Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice.
Academic Article	Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice.
Academic Article	Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor.
Academic Article	Regulatable atrial natriuretic peptide gene therapy for hypertension.
Academic Article	The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism.
Academic Article	Absence of the steroid receptor coactivator-3 induces B-cell lymphoma.
Academic Article	Molecular biology. Little molecules with big goals.
Academic Article	Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program.
Academic Article	DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs.
Academic Article	Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway.
Academic Article	The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.
Academic Article	Multi-modulation of nuclear receptor coactivators through posttranslational modifications.
Academic Article	Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease.
Academic Article	Biochemical control of CARM1 enzymatic activity by phosphorylation.
Academic Article	Nuclear receptor coregulators in cancer biology.
Academic Article	Emerging roles of the ubiquitin proteasome system in nuclear hormone receptor signaling.
Academic Article	SnapShot: Nuclear receptors I.
Academic Article	Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption.
Academic Article	Estrogen-regulated prohibitin is required for mouse uterine development and adult function.
Academic Article	Cellular proteome, coregulators, endocrine system and the human brain: the Regulatory biology of humanism.
Academic Article	Steroid receptor coactivators 1, 2, and 3: critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy.
Academic Article	Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1.
Academic Article	PDX-1 is a therapeutic target for pancreatic cancer, insulinoma and islet neoplasia using a novel RNA interference platform.
Academic Article	Elwood V. Jensen (1920-2012): father of the nuclear receptors.
Concept	Mammary Glands, Animal
Concept	Disease Models, Animal
Concept	Mammary Neoplasms, Animal
Concept	Animals
Concept	Models, Animal
Concept	Sexual Behavior, Animal
Concept	Behavior, Animal
Academic Article	REG? deficiency promotes premature aging via the casein kinase 1 pathway.
Academic Article	Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences.
Academic Article	The REG? proteasome regulates hepatic lipid metabolism through inhibition of autophagy.
Academic Article	Gonadotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells.
Academic Article	Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization.
Academic Article	The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis.
Academic Article	SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm.
Academic Article	Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.
Academic Article	A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells.
Academic Article	An epigenomic approach to therapy for tamoxifen-resistant breast cancer.
Academic Article	Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function.
Academic Article	Proteomics analysis of the non-muscle myosin heavy chain IIa-enriched actin-myosin complex reveals multiple functions within the podocyte.
Academic Article	Steroid receptor coactivator-2 is a dual regulator of cardiac transcription factor function.
Academic Article	Steroid receptor coactivators: servants and masters for control of systems metabolism.
Academic Article	Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis.
Academic Article	Nuclear receptor modulation--role of coregulators in selective estrogen receptor modulator (SERM) actions.
Academic Article	Transcriptional coregulators: emerging roles of SRC family of coactivators in disease pathology.
Academic Article	Dual disruption of DNA repair and telomere maintenance for the treatment of head and neck cancer.
Academic Article	A novel chitosan-hydrogel-based nanoparticle delivery system for local inner ear application.
Academic Article	Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis.
Academic Article	Bufalin is a steroid receptor coactivator inhibitor-response.
Academic Article	CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-a-Gabpa and stress-induced adaptive responses via NF-?B-cMYC.
Academic Article	The Dual Estrogen Receptor a Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.
Academic Article	Estrogen Receptor ? Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis.
Academic Article	Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug.
Academic Article	Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.
Academic Article	Steroid receptor coactivators as therapeutic targets in the female reproductive system.
Academic Article	SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis.
Academic Article	Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading.
Academic Article	The REG?-proteasome forms a regulatory circuit with I?B? and NF?B in experimental colitis.
Academic Article	Application of infrared-based molecular imaging to a mouse model with head and neck cancer.
Academic Article	Upregulation of GSK3? Contributes to Brain Disorders in Elderly REG?-knockout Mice.
Academic Article	Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3.
Academic Article	The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets.
Academic Article	Reprogramming of the Epigenome by MLL1 Links Early-Life Environmental Exposures to Prostate Cancer Risk.
Academic Article	Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology.
Academic Article	Origins of the Field of Molecular Endocrinology: A Personal Perspective.
Academic Article	Molecular Pathways: Targeting Steroid Receptor Coactivators in Cancer.
Academic Article	A Gingiva-Derived Mesenchymal Stem Cell-Laden Porcine Small Intestinal Submucosa Extracellular Matrix Construct Promotes Myomucosal Regeneration of the Tongue.
Academic Article	Brain nuclear receptors and body weight regulation.
Academic Article	A Cell-Autonomous Mammalian 12?hr Clock Coordinates Metabolic and Stress Rhythms.
Academic Article	Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells.
Academic Article	Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas.
Academic Article	Evaluation of high-fidelity simulation as a training tool in transoral robotic surgery.
Academic Article	Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation.
Academic Article	Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.
Academic Article	Maintenance of hemostasis in transoral robotic surgery.
Academic Article	Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization.
Academic Article	The Development of a Nano-based Approach to Alleviate Cisplatin-Induced Ototoxicity.
Academic Article	Challenges and opportunities in developing targeted molecular imaging to determine inner ear defects of sensorineural hearing loss.
Academic Article	Bufalin suppresses endometriosis progression by inducing pyroptosis and apoptosis.
Academic Article	A novel nanoparticle delivery system for targeted therapy of noise-induced hearing loss.
Academic Article	TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis.
Academic Article	Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3.
Academic Article	SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma.
Grant	Genetic and Metabolic Fingerprints of Coativators Program Project
Grant	Center for Reproductive Biological Research
Grant	Nuclear Receptors and Coregulators in Health and Disease
Grant	Reproductive Biology: Regulatory Mechanisms
Academic Article	A novel mathematical method for disclosing oscillations in gene transcription: A comparative study.
Academic Article	Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis.
Academic Article	Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer.
Academic Article	Genomic Function of Estrogen Receptor ? in Endometriosis.
Academic Article	Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination.
Academic Article	PD-L1 and MRN synergy in platinum-based chemoresistance of head and neck squamous cell carcinoma.
Academic Article	12-h clock regulation of genetic information flow by XBP1s.
Academic Article	Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer.
Academic Article	90 YEARS OF PROGESTERONE: Reminiscing on the origins of the field of progesterone and estrogen receptor action.
Academic Article	Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone.
Academic Article	A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction.
Academic Article	XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis.
Academic Article	Emerging roles of steroid receptor coactivators in stromal cell responses.
Academic Article	Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family.
Academic Article	Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs.
Academic Article	Mechanisms of enhancer action: the known and the unknown.
Academic Article	Cell lineage tracing links ERa loss in Erbb2-positive breast cancers to the arising of a highly aggressive breast cancer subtype.
Academic Article	Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells.
Academic Article	Development of improved SRC-3 inhibitors as breast cancer therapeutic agents.
Academic Article	Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination.
Academic Article	Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition.
Academic Article	Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism.
Academic Article	Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment.
Academic Article	Oleuropein suppresses endometriosis progression and improves the fertility of mice with endometriosis.
Academic Article	Aging-associated REG? proteasome decline predisposes to tauopathy.
Academic Article	Subclinical diagnosis of cisplatin-induced ototoxicity with biomarkers.
Academic Article	Steroid receptor coactivator 3 is a key modulator of regulatory T cell-mediated tumor evasion.
Academic Article	Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation.
Academic Article	A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis.

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