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LEMAIRE, SCOTT
One or more keywords matched the following properties of LEMAIRE, SCOTT
PropertyValue
keywords Aortic aneurysm Aortic dissection Thoracic aortic surgery Academic surgery Career development Mentorship
overview The focus of our research program, which derives directly from our clinical interest in the surgical treatment of patients with thoracic aortic aneurysms and dissections, encompasses outcomes after thoracic aortic repair, strategies for preventing perioperative complications, genetic factors related to aortic disease, and the pathobiology of aortic wall degeneration. Our clinical research team has had a long-standing interest in the analysis of outcomes following aortic surgery, and has conducted randomized clinical trials comparing the effectiveness of various techniques for preventing associated ischemic complications. Further, our research team has conducted several studies to evaluate the safety profile of surgical adhesives, which are an important adjunct for limiting bleeding complications during aortic repairs. In 2002, our research group initiated the Thoracic Aortic Disease Tissue Bank, which currently houses samples and corresponding phenotypic data from over 2,500 patients with thoracic aortic disease and has served as a core for the NHLBI supported Specialized Center of Clinical Oriented Research in Thoracic Aortic Aneurysms and Dissection, as well as a resource for numerous collaborative studies evaluating the genetic factors and molecular mechanisms involved in the development of thoracic aortic disease. Our basic science laboratory is currently focusing on the role of various aspects of extracellular matrix metabolism in the development of aortic aneurysms and dissections. In particular, our group is studying the roles of destructive factors, such as inflammatory cells and proteases, as well as reparative mechanisms, such as stem cell recruitment and transformation, during the development of aortic aneurysms and dissections.
One or more keywords matched the following items that are connected to LEMAIRE, SCOTT
Item TypeName
Academic Article Marfan syndrome: the variability and outcome of operative management.
Academic Article Paraplegia after thoracoabdominal aortic aneurysm repair: is dissection a risk factor?
Academic Article Aortic root surgery in Marfan syndrome: current practice and evolving techniques.
Academic Article Current status of thoracoabdominal aortic aneurysm repair in Marfan syndrome.
Academic Article Thoracoabdominal fenestration for aortic dissection with ischemic colonic perforation.
Academic Article Evaluating aortic dissection: when is coronary angiography indicated?
Academic Article Rupture of a dissecting thoracic aortic aneurysm into the pulmonary artery: successful surgical repair.
Academic Article Thoracoabdominal aortic aneurysm repair: review and update of current strategies.
Academic Article A new predictive model for adverse outcomes after elective thoracoabdominal aortic aneurysm repair.
Academic Article Surgical techniques. Thoracoabdominal aorta.
Academic Article Acute aortic dissection associated with use of cocaine.
Academic Article Assessment of aortic pathology and peripheral arterial disease using multidetector computed tomographic angiography.
Academic Article Bridge to transplantation with the TandemHeart: bending the indications in a chronic aortic dissection patient with postcardiotomy shock.
Academic Article Early outcomes after aortic arch replacement by using the Y-graft technique.
Academic Article Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1.
Academic Article Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection.
Academic Article AKT2 confers protection against aortic aneurysms and dissections.
Academic Article Increased collagen deposition and elevated expression of connective tissue growth factor in human thoracic aortic dissection.
Academic Article Aortic root replacement with stentless porcine xenografts: early and late outcomes in 132 patients.
Academic Article Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations.
Academic Article Thoracic aortic dissection: are matrix metalloproteinases involved?
Academic Article FBN1 mutations in patients with descending thoracic aortic dissections.
Academic Article Open repair of thoracoabdominal aortic aneurysm in the modern surgical era: contemporary outcomes in 509 patients.
Academic Article Large deletions and uniparental disomy detected by SNP arrays in adults with thoracic aortic aneurysms and dissections.
Academic Article Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections.
Academic Article Notch signaling in descending thoracic aortic aneurysm and dissection.
Academic Article Thoracic aortic dissection: genes, molecules, and the knife.
Academic Article GenTAC registry report: gender differences among individuals with genetically triggered thoracic aortic aneurysm and dissection.
Academic Article Experience with retrograde cerebral perfusion during proximal aortic surgery in 290 patients.
Academic Article Impact of previous thoracic aneurysm repair on thoracoabdominal aortic aneurysm management.
Academic Article Emergency surgery for thoracoabdominal aortic aneurysms with acute presentation.
Academic Article The elephant trunk technique for staged repair of complex aneurysms of the entire thoracic aorta.
Academic Article A single nucleotide polymorphism in the matrix metalloproteinase 9 gene (-8202A/G) is associated with thoracic aortic aneurysms and thoracic aortic dissection.
Academic Article Spectrum of aortic operations in 300 patients with confirmed or suspected Marfan syndrome.
Academic Article Open surgical repair of 2286 thoracoabdominal aortic aneurysms.
Academic Article Invited commentary.
Academic Article Managing dissections of the thoracic aorta.
Academic Article Descending thoracic aortic dissection: evaluation and management in the era of endovascular technology.
Academic Article Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.
Academic Article Surgical treatment of patients enrolled in the national registry of genetically triggered thoracic aortic conditions.
Academic Article Axillary artery cannulation in surgery for acute or subacute ascending aortic dissections.
Academic Article Rare copy number variants disrupt genes regulating vascular smooth muscle cell adhesion and contractility in sporadic thoracic aortic aneurysms and dissections.
Academic Article Epidemiology of thoracic aortic dissection.
Academic Article Commentary: Advances in noninvasive perispinal oximetry.
Academic Article Long-term implications of emergency versus elective proximal aortic surgery in patients with Marfan syndrome in the Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions Consortium Registry.
Academic Article Stem cells in thoracic aortic aneurysms and dissections: potential contributors to aortic repair.
Academic Article ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissections.
Concept Dissection
Academic Article Molecular mechanisms of thoracic aortic dissection.
Academic Article Extent II repair of thoracoabdominal aortic aneurysm secondary to chronic dissection.
Academic Article Thoracic aortic aneurysm frequency and dissection are associated with fibrillin-1 fragment concentrations in circulation.
Academic Article D-dimer levels remain elevated in acute aortic dissection after 24?h.
Academic Article Matrix metalloproteinase levels in chronic thoracic aortic dissection.
Academic Article Endovascular repair as a bridge to surgical repair of an aortobronchial fistula complicating chronic residual aortic dissection.
Academic Article Outcomes of open distal aortic aneurysm repair in patients with chronic DeBakey type I dissection.
Academic Article Valve-sparing aortic root replacement in patients with Marfan syndrome enrolled in the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions.
Academic Article Contemporary outcomes of open thoracoabdominal aortic aneurysm repair in octogenarians.
Academic Article Hemiarch and Total Arch Surgery in Patients With Previous Repair of Acute Type I Aortic Dissection.
Academic Article Inflammatory Cell Infiltrates in Acute and Chronic Thoracic Aortic Dissection.
Academic Article Results of Open Surgical Repair in Patients With Marfan Syndrome and Distal Aortic Dissection.
Academic Article Outcomes of 3309 thoracoabdominal aortic aneurysm repairs.
Academic Article AKT2 Promotes Bone Marrow Cell-Mediated Aortic Protection in Mice.
Academic Article Aortic Dissection in Patients With Genetically Mediated Aneurysms: Incidence and Predictors in the GenTAC Registry.
Academic Article Aortic Complications Associated With Pregnancy in Marfan Syndrome: The NHLBI National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC).
Academic Article Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections.
Academic Article Open Repair of Thoracoabdominal Aortic Aneurysm in Patients 50 Years Old and?Younger.
Academic Article Chronobiology of Acute Aortic Dissection in the Marfan Syndrome (from the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions and the International Registry of Acute Aortic Dissection).
Academic Article NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation.
Academic Article Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections.
Academic Article Open descending thoracic or thoracoabdominal aortic approaches for complications of endovascular aortic procedures: 19-year experience.
Academic Article Heritable Thoracic Aortic?Disease Genes in Sporadic Aortic Dissection.
Academic Article Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Academic Article Endovascular thoracic aortic repair in confirmed or suspected genetically triggered thoracic aortic dissection.
Academic Article Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice.
Grant Targeting the Inflammasome to Prevent Thoracic Aortic Aneurysms and Dissections
Grant Targeting the Inflammasome to Prevent Thoracic Aortic Aneurysms and Dissections
Grant Mitochondrial Damage-Induced Necroptotic Cell Death in SporadicAscending Thoracic Aortic Aneurysms and Dissections
Grant Targeting ER stress to Treat Aortic Aneurysms and Dissections
Grant Extracellular Matrix Metabolism in Thoracic Aortic Aneurysm and Dissection
Grant Matrix Metalloproteinases in Thoracic Aortic Dissection
Academic Article SMAD4 rare variants in individuals and families with thoracic aortic aneurysms and dissections.
Academic Article Acute type I aortic dissection with or without antegrade stent delivery: Mid-term outcomes.
Academic Article Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease.
Academic Article Tracheostomy After Thoracoabdominal Aortic Aneurysm Repair: Risk Factors and Outcomes.
Academic Article Type B Aortic Dissection in Young Individuals With Confirmed and Presumed Heritable Thoracic Aortic?Disease.
Academic Article Activation of Bone Marrow-Derived Cells and Resident Aortic Cells During Aortic Injury.
Academic Article Unfolding the Story of Proteoglycan Accumulation in Thoracic Aortic Aneurysm and Dissection.
Academic Article Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture.
Academic Article Aortic Aneurysms and Dissections Series.
Academic Article Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections.
Academic Article Targeting the NLRP3 Inflammasome With Inhibitor MCC950 Prevents Aortic Aneurysms and Dissections in Mice.
Academic Article A 23-year experience with the reversed elephant trunk technique for staged repair of extensive thoracic aortic aneurysm.
Academic Article Open Repair of Acute Type A Intramural Hematoma in 3 Patients.
Academic Article Early Detection of Aortic Degeneration in a Mouse Model of Sporadic Aortic Aneurysm and Dissection Using Nanoparticle Contrast-Enhanced Computed Tomography.
Academic Article Commentary: Fluoroquinolones and Aortic Complications: Are We Ready for a Class III Recommendation With Level Z Evidence?
Academic Article Fluoroquinolones in Patients With Aortic Aneurysms or Dissections: Pouring Gasoline on a Fire.
Academic Article Ninety-Day Readmission After Open Surgical Repair of Stanford Type A Aortic Dissection.
Academic Article Ciprofloxacin accelerates aortic enlargement and promotes dissection and rupture in Marfan mice.
Academic Article Programmed cell death in aortic aneurysm and dissection: A potential therapeutic target.
Academic Article AIM2 Inflammasome Activation Contributes to Aortic Dissection in a Sporadic Aortic Disease Mouse Model.
Academic Article Reducing Transfusions After Acute Aortic Dissection: Still a Long Way to?Go.
Academic Article Cardiovascular Outcomes in Aortopathy: GenTAC Registry of Genetically Triggered Aortic Aneurysms and Related Conditions.
Academic Article Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in Mice.
Academic Article Comparative Risks of Initial Aortic Events Associated With Genetic Thoracic Aortic?Disease.
Academic Article Contemporary Midterm Outcomes After Primary Repair of Chronic Type A Aortic Dissection.
Academic Article Independent associations with early mortality after open repair of Crawford extent IV thoracoabdominal aortic aneurysms.
Academic Article Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.
Academic Article Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections.
Academic Article Discussion to: Risk profile and operative outcomes in patients with and without Marfan syndrome undergoing thoracoabdominal aortic aneurysm repair.
Academic Article Vertebral Tortuosity Is Associated With Increased Rate of Cardiovascular Events in Vascular Ehlers-Danlos Syndrome.
Academic Article Comparison of open thoracoabdominal repair for chronic aortic dissections and aneurysms.
Grant Endothelial Dysfunction in the Development of Aortic Degeneration, Dissection, and Rupture
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  • Dissection