Item Type | Name |
Academic Article
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Enhancement of presynaptic calcium current by cysteine string protein.
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Academic Article
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Meaningless minis? Mechanisms of neurotransmitter-receptor clustering.
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Academic Article
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Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development.
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Academic Article
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Senseless acts as a binary switch during sensory organ precursor selection.
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Academic Article
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Mapping and identification of essential gene functions on the X chromosome of Drosophila.
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Academic Article
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Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner.
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Academic Article
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Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila.
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Academic Article
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The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila.
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Academic Article
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Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer.
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Academic Article
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Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo.
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Academic Article
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Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation.
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Academic Article
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Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development.
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Academic Article
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Mapping Drosophila mutations with molecularly defined P element insertions.
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Academic Article
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straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit.
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Academic Article
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Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells.
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Academic Article
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Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster.
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Academic Article
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Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster.
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Academic Article
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Hugo J. Bellen.
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Academic Article
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Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives.
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Academic Article
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100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future.
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Academic Article
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Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions.
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Academic Article
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The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases.
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Academic Article
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Emerging technologies for gene manipulation in Drosophila melanogaster.
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Academic Article
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Internalization is required for proper Wingless signaling in Drosophila melanogaster.
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Academic Article
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Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components.
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Academic Article
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Genetic manipulation of genes and cells in the nervous system of the fruit fly.
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Academic Article
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The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins.
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Academic Article
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Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors.
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Academic Article
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Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins).
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Academic Article
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Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity.
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Academic Article
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P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster.
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Academic Article
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Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission.
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Academic Article
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The dynamin-binding domains of Dap160/intersectin affect bulk membrane retrieval in synapses.
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Academic Article
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The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila.
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Academic Article
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Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator.
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Academic Article
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Activity-independent prespecification of synaptic partners in the visual map of Drosophila.
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Academic Article
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Thirty-one flavors of Drosophila rab proteins.
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Academic Article
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NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.
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Academic Article
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FM 1-43 labeling of synaptic vesicle pools at the Drosophila neuromuscular junction.
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Academic Article
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Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles.
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Academic Article
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Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm.
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Academic Article
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The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors.
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Academic Article
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A novel neuronal pathway for visually guided escape in Drosophila melanogaster.
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Academic Article
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A Notch updated.
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Academic Article
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The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.
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Academic Article
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Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila.
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Academic Article
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The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors.
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Academic Article
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Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling.
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Academic Article
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Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.
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Academic Article
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Rab3 GTPase lands Bruchpilot.
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Academic Article
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Endocytosis and intracellular trafficking of Notch and its ligands.
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Academic Article
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A molecularly defined duplication set for the X chromosome of Drosophila melanogaster.
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Academic Article
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The Drosophila gene disruption project: progress using transposons with distinctive site specificities.
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Academic Article
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Drosophila Ten-m and filamin affect motor neuron growth cone guidance.
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Academic Article
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A genome-wide Drosophila screen for heat nociception identifies a2d3 as an evolutionarily conserved pain gene.
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Academic Article
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Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and FC31 integrase.
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Academic Article
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A cis-regulatory map of the Drosophila genome.
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Academic Article
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An assay to detect in vivo Y chromosome loss in Drosophila wing disc cells.
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Academic Article
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A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.
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Academic Article
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Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6.
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Academic Article
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MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes.
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Academic Article
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The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit.
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Academic Article
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Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes.
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Academic Article
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dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions.
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Academic Article
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Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells.
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Academic Article
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Synaptotagmin I, a Ca2+ sensor for neurotransmitter release.
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Academic Article
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Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating.
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Academic Article
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Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals.
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Academic Article
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The ins and outs of Wingless signaling.
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Academic Article
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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress.
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Academic Article
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The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes.
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Academic Article
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Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis.
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Academic Article
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The architecture of the active zone in the presynaptic nerve terminal.
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Academic Article
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Gfi/Pag-3/senseless zinc finger proteins: a unifying theme?
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Academic Article
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Fighting anthrax with flies.
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Academic Article
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Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin.
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Academic Article
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Transgenesis upgrades for Drosophila melanogaster.
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Academic Article
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V-ATPase V0 sector subunit a1 in neurons is a target of calmodulin.
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Academic Article
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Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.
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Academic Article
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Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction.
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Academic Article
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A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis.
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Academic Article
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Drosophila P elements preferentially transpose to replication origins.
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Academic Article
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Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.
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Academic Article
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Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans.
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Concept
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Disease Models, Animal
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Concept
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Wings, Animal
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Concept
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Animals
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Concept
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Models, Animal
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Concept
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Sexual Behavior, Animal
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Concept
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Behavior, Animal
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Concept
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Animals, Genetically Modified
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Academic Article
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Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition.
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Academic Article
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Protein phosphatase 1? limits ring canal constriction during Drosophila germline cyst formation.
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Academic Article
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VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.
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Academic Article
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NMNATs, evolutionarily conserved neuronal maintenance factors.
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Academic Article
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Rhodopsin homeostasis and retinal degeneration: lessons from the fly.
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Academic Article
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miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor.
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Academic Article
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Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster.
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Academic Article
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A mitocentric view of Parkinson's disease.
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Academic Article
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Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases.
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Academic Article
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The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration.
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Academic Article
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The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control.
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Academic Article
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Drosophila Tempura, a novel protein prenyltransferase a subunit, regulates notch signaling via Rab1 and Rab11.
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Academic Article
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Introduction to Notch signaling.
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Academic Article
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Preface. Notch signaling.
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Academic Article
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Large-scale identification of chemically induced mutations in Drosophila melanogaster.
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Academic Article
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A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases.
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Academic Article
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Survival of the fittest tools.
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Academic Article
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Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production.
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Academic Article
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A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.
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Academic Article
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Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration.
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Academic Article
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Fruit flies in biomedical research.
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Academic Article
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Huntingtin functions as a scaffold for selective macroautophagy.
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Academic Article
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A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.
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Academic Article
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A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila.
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Academic Article
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A genetic toolkit for tagging intronic MiMIC containing genes.
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Academic Article
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Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.
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Academic Article
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The retromer complex in development and disease.
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Academic Article
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BIOSAFETY. Safeguarding gene drive experiments in the laboratory.
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Academic Article
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FlyVar: a database for genetic variation in Drosophila melanogaster.
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Academic Article
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Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure.
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Academic Article
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Morgan's legacy: fruit flies and the functional annotation of conserved genes.
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Academic Article
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Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila.
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Academic Article
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Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins.
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Academic Article
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WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.
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Academic Article
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Drosophila tools and assays for the study of human diseases.
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Academic Article
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Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.
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Academic Article
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NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.
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Academic Article
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Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease.
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Academic Article
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The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.
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Academic Article
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Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.
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Academic Article
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Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila.
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Academic Article
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Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes.
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Academic Article
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Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals.
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Academic Article
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Loss of Nardilysin, a Mitochondrial Co-chaperone for a-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration.
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Academic Article
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Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease.
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Academic Article
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Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.
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Academic Article
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A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells.
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Academic Article
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Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages.
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Academic Article
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Building dialogues between clinical and biomedical research through cross-species collaborations.
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Academic Article
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Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse.
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Academic Article
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Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially.
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Academic Article
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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D.
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Academic Article
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The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.
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Academic Article
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Genetic strategies to tackle neurological diseases in fruit flies.
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Academic Article
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Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research.
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Academic Article
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Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model.
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Academic Article
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A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.
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Academic Article
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A gene-specific T2A-GAL4 library for Drosophila.
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Academic Article
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Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms.
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Academic Article
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Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder.
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Academic Article
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Gene Tagging Strategies To Assess Protein Expression, Localization, and Function in Drosophila.
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Academic Article
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Using Drosophila to study mechanisms of hereditary hearing loss.
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Academic Article
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Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to a-Synuclein Gain.
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Academic Article
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Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3.
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Academic Article
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An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila.
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Academic Article
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Bi-allelic Loss-of-Function Variants in DNMBP Cause Infantile Cataracts.
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Academic Article
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Sphingolipids in the Pathogenesis of Parkinson's Disease and Parkinsonism.
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Academic Article
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VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway.
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Academic Article
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Interactions between the Ig-Superfamily Proteins DIP-a and Dpr6/10 Regulate Assembly of Neural Circuits.
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Academic Article
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Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.
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Academic Article
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Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.
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Academic Article
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Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease.
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Academic Article
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Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
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Academic Article
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Loss of proteins associated with amyotrophic lateral sclerosis affects lysosomal acidification via different routes.
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Academic Article
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The fruit fly at the interface of diagnosis and pathogenic mechanisms of rare and common human diseases.
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Academic Article
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De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia.
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Academic Article
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cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.
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Academic Article
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information.
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Academic Article
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Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders.
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Academic Article
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Bi-allelic Variants in IQSEC1 Cause Intellectual Disability, Developmental Delay, and Short Stature.
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Academic Article
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An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms.
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Academic Article
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Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly.
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Academic Article
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Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction.
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Academic Article
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Use of the CRISPR-Cas9 System in Drosophila Cultured Cells to Introduce Fluorescent Tags into Endogenous Genes.
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Academic Article
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Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms.
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Academic Article
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Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain.
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Academic Article
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Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue.
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Academic Article
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De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy.
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Academic Article
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Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction.
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Academic Article
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The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation.
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Academic Article
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Drosophila Voltage-Gated Sodium Channels Are Only Expressed in Active Neurons and Are Localized to Distal Axonal Initial Segment-like Domains.
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Academic Article
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Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases.
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Academic Article
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Low doses of the neonicotinoid insecticide imidacloprid induce ROS triggering neurological and metabolic impairments in Drosophila.
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Academic Article
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BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.
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Academic Article
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TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS.
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Academic Article
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Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision.
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Academic Article
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Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11.
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Academic Article
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TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.
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Academic Article
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Recent insights into the role of glia and oxidative stress in Alzheimer's disease gained from Drosophila.
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Academic Article
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Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes.
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Academic Article
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Loss of Neuron Navigator 2 Impairs Brain and Cerebellar Development.
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Academic Article
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Model organism databases are in jeopardy.
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Academic Article
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Lord of the fruit flies: an interview with Hugo Bellen.
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Academic Article
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Low doses of the organic insecticide spinosad trigger lysosomal defects, elevated ROS, lipid dysregulation, and neurodegeneration in flies.
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Academic Article
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Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin.
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Academic Article
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Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms.
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Academic Article
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De novo variants in EMC1 lead to neurodevelopmental delay and cerebellar degeneration and affect glial function in Drosophila.
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Academic Article
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Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures.
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Academic Article
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Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling.
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Academic Article
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'Fly-ing' from rare to common neurodegenerative disease mechanisms.
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Academic Article
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Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons.
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Academic Article
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An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination.
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Academic Article
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Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia.
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Academic Article
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ANKLE2-related microcephaly: A variable microcephaly syndrome resembling Zika infection.
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Academic Article
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Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS.
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Academic Article
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Drosophila as a diet discovery tool for treating amino acid disorders.
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Academic Article
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De novo variants in FRMD5 are associated with developmental delay, intellectual disability, ataxia, and abnormalities of eye movement.
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Academic Article
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The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival.
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Academic Article
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Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14).
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Academic Article
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Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila.
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Academic Article
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Promoting validation and cross-phylogenetic integration in model organism research.
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Academic Article
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The recurrent de novo c.2011C>T missense variant in MTSS2 causes syndromic intellectual disability.
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Academic Article
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SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia.
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Academic Article
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Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila.
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Academic Article
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Bi-allelic variants in INTS11 are associated with a complex neurological disorder.
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Academic Article
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Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation.
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Academic Article
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De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features.
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Academic Article
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Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution.
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Academic Article
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The Voltage-Gated Sodium Channel in Drosophila, Para, Localizes to Dendrites As Well As Axons in Mechanosensitive Chordotonal Neurons.
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Academic Article
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A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins.
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Academic Article
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Integrating non-mammalian model organisms in the diagnosis of rare genetic diseases in humans.
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Academic Article
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A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels.
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Academic Article
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Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability.
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Academic Article
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Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics.
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Academic Article
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De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features.
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