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FIOROTTO, MARTA

One or more keywords matched the following properties of FIOROTTO, MARTA

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overview	The major objective of the research in my lab is to identify the mechanisms that underlie the effects of nutrient intake on the growth and function of skeletal muscle. In the perinatal period, skeletal muscle is the fastest growing protein pool in the body and is highly dependent on nutrient supply and the ability to use dietary nutrients efficiently. Thus, one of my research interests is to understand how nutrients regulate the primary anabolic processes responsible for muscle growth, i.e., protein synthesis and satellite cell replication during this period. Recently, this has extended to research on the consequences of Duchenne Muscular Dystrophy for skeletal muscle and whole body protein metabolism with the goal of identifying the contribution of protein and energy intakes on the progression of the disease, especially in its early stages. A second research interest is rooted in the observation that a brief period of growth retardation during a critical period of development results in a lifelong deficit in muscle mass and exercise capacity. We are conducting research to understand why this happens and to identify interventions that can reverse the muscle deficit and improve exercise performance. We perform studies using the mouse and the newborn piglet as animal models, together with a wide array of techniques including in vivo tracer kinetics, in vivo metabolic measurements, an assortment of molecular biology techniques, microscopy, cell culture, and muscle physiology measurements to address these research questions.

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overview

The major objective of the research in my lab is to identify the mechanisms that underlie the effects of nutrient intake on the growth and function of skeletal muscle. In the perinatal period, skeletal muscle is the fastest growing protein pool in the body and is highly dependent on nutrient supply and the ability to use dietary nutrients efficiently. Thus, one of my research interests is to understand how nutrients regulate the primary anabolic processes responsible for muscle growth, i.e., protein synthesis and satellite cell replication during this period. Recently, this has extended to research on the consequences of Duchenne Muscular Dystrophy for skeletal muscle and whole body protein metabolism with the goal of identifying the contribution of protein and energy intakes on the progression of the disease, especially in its early stages. A second research interest is rooted in the observation that a brief period of growth retardation during a critical period of development results in a lifelong deficit in muscle mass and exercise capacity. We are conducting research to understand why this happens and to identify interventions that can reverse the muscle deficit and improve exercise performance. We perform studies using the mouse and the newborn piglet as animal models, together with a wide array of techniques including in vivo tracer kinetics, in vivo metabolic measurements, an assortment of molecular biology techniques, microscopy, cell culture, and muscle physiology measurements to address these research questions.

One or more keywords matched the following items that are connected to FIOROTTO, MARTA

Item Type	Name
Academic Article	Reliability of fat-free mass estimates derived from total-body electrical conductivity measurements as influenced by changes in extracellular fluid volume.
Academic Article	Liver composition and histology in growing infant miniature pigs given different total parenteral nutrition fuel mixes.
Academic Article	Specific effects of weight loss, protein deficiency and energy deprivation on the water and electrolyte composition of young rats.
Academic Article	Effect of different total parenteral nutrition fuel mixes on the body composition of infant miniature pigs.
Academic Article	Total body electrical conductivity measurements: an evaluation of current instrumentation for infants.
Academic Article	A semiautomatic device for feeding liquid milk-replacer diets to infant pigs.
Academic Article	Enhanced response of muscle protein synthesis and plasma insulin to food intake in suckled rats.
Academic Article	Amino acid compositions of body and milk protein change during the suckling period in rats.
Academic Article	Chronic low protein intake reduces tissue protein synthesis in a pig model of protein malnutrition.
Academic Article	Nutrient-independent and nutrient-dependent factors stimulate protein synthesis in colostrum-fed newborn pigs.
Academic Article	Pathogenesis of oedema in protein-energy malnutrition: the significance of plasma colloid osmotic pressure.
Academic Article	Amino acid composition of the milk of some mammalian species changes with stage of lactation.
Academic Article	Protein synthesis in skeletal muscle and jejunum is more responsive to feeding in 7-than in 26-day-old pigs.
Academic Article	Food intake alters muscle protein gain with little effect on Na(+)-K(+)-ATPase and myosin isoforms in suckled rats.
Academic Article	Role of milk-borne vs endogenous insulin-like growth factor I in neonatal growth.
Academic Article	Intrauterine growth restriction does not alter response of protein synthesis to feeding in newborn pigs.
Academic Article	Roles of insulin and amino acids in the regulation of protein synthesis in the neonate.
Academic Article	Postnatal growth of gut and muscle: competitors or collaborators.
Academic Article	Regulation of myofibrillar protein turnover during maturation in normal and undernourished rat pups.
Academic Article	Protein nutrition of the neonate.
Academic Article	Transgenic hypersecretion of des(1-3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pups.
Academic Article	Differential effects of insulin on peripheral and visceral tissue protein synthesis in neonatal pigs.
Academic Article	Myogenic expression of an injectable protease-resistant growth hormone-releasing hormone augments long-term growth in pigs.
Academic Article	Protein kinetics in callipyge lambs.
Academic Article	Lactase phlorizin hydrolase synthesis is decreased in protein-malnourished pigs.
Academic Article	Acute IGF-I infusion stimulates protein synthesis in skeletal muscle and other tissues of neonatal pigs.
Academic Article	Persistent IGF-I overexpression in skeletal muscle transiently enhances DNA accretion and growth.
Academic Article	Maternal GHRH plasmid administration changes pituitary cell lineage and improves progeny growth of pigs.
Academic Article	Response of skeletal muscle protein synthesis to insulin in suckling pigs decreases with development.
Academic Article	Dexamethasone inhibits small intestinal growth via increased protein catabolism in neonatal pigs.
Academic Article	Aminoacyl-tRNA and tissue free amino acid pools are equilibrated after a flooding dose of phenylalanine.
Academic Article	Stimulation of protein synthesis by both insulin and amino acids is unique to skeletal muscle in neonatal pigs.
Academic Article	Somatotropin increases protein balance by lowering body protein degradation in fed, growing pigs.
Academic Article	Insulin-like growth factor-I extends in vitro replicative life span of skeletal muscle satellite cells by enhancing G1/S cell cycle progression via the activation of phosphatidylinositol 3'-kinase/Akt signaling pathway.
Academic Article	Neonatal genetically lean and obese pigs respond differently to dietary cholesterol.
Academic Article	Long-term insulin-like growth factor-I expression in skeletal muscles attenuates the enhanced in vitro proliferation ability of the resident satellite cells in transgenic mice.
Academic Article	Modulation of muscle protein synthesis by insulin is maintained during neonatal endotoxemia.
Academic Article	High-efficiency growth hormone-releasing hormone plasmid vector administration into skeletal muscle mediated by electroporation in pigs.
Academic Article	Stage of development and fasting affect protein synthetic activity in the gastrointestinal tissues of suckling rats.
Academic Article	Feeding rapidly stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing translation initiation.
Academic Article	Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism.
Academic Article	A comparison of the growth responses following intramuscular GHRH plasmid administration versus daily growth hormone injections in young pigs.
Academic Article	Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation.
Academic Article	A new plasmid-mediated approach to supplement somatotropin production in pigs.
Academic Article	Protein turnover in skeletal muscle of suckling rats.
Academic Article	Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways.
Academic Article	The local expression and abundance of insulin-like growth factor (IGF) binding proteins in skeletal muscle are regulated by age and gender but not local IGF-I in vivo.
Academic Article	Changes in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular aging.
Academic Article	Intake and use of milk nutrients by rat pups suckled in small, medium, or large litters.
Academic Article	Regulation of muscle growth in neonates.
Academic Article	Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse.
Academic Article	Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle.
Academic Article	Differential regulation of protein synthesis and mTOR signaling in skeletal muscle and visceral tissues of neonatal pigs after a meal.
Academic Article	Triennial Growth Symposium: leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs.
Academic Article	Chronic maternal protein deprivation in mice is associated with overexpression of the cohesin-mediator complex in liver of their offspring.
Academic Article	In vivo measurement of muscle protein synthesis rate using the flooding dose technique.
Academic Article	Development aggravates the severity of skeletal muscle catabolism induced by endotoxemia in neonatal pigs.
Academic Article	Electrolyte composition changes of chronically K-depleted rats after K loading.
Academic Article	Both maternal over- and undernutrition during gestation increase the adiposity of young adult progeny in rats.
Academic Article	Amino acid composition of human milk is not unique.
Academic Article	Corticosterone has independent effects on tissue maturation and growth in the suckling rat.
Academic Article	Colostrum enhances the nutritional stimulation of vital organ protein synthesis in neonatal pigs.
Academic Article	Exogenous growth hormone stimulates somatotropic axis function and growth in neonatal pigs.
Academic Article	Overexpression of IGF-I in skeletal muscle of transgenic mice does not prevent unloading-induced atrophy.
Academic Article	Hepatic protein synthesis in suckling rats: effects of stage of development and fasting.
Academic Article	Feeding colostrum increases circulating insulin-like growth factor I in newborn pigs independent of endogenous growth hormone secretion.
Academic Article	Local insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice.
Academic Article	Nonnutritive factors in colostrum enhance myofibrillar protein synthesis in the newborn Pig.
Academic Article	Rapid induction of IGF-IR signaling in normal and tumor tissue following intravenous injection of IGF-I in mice.
Academic Article	Response of muscle protein synthesis to fasting in suckling and weaned rats.
Academic Article	Transplacental transfer of a growth hormone-releasing hormone peptide from mother to fetus in the rat.
Academic Article	Postnatal ontogeny of skeletal muscle protein synthesis in pigs.
Academic Article	Growth in perspective.
Academic Article	Effects of maternal plasmid GHRH treatment on offspring growth.
Academic Article	Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation.
Academic Article	Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging.
Academic Article	The effects of different total parenteral nutrition fuel mixes on skeletal muscle composition of infant miniature pigs.
Academic Article	Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs.
Academic Article	In utero glucocorticoid exposure reduces fetal skeletal muscle mass in rats independent of effects on maternal nutrition.
Concept	Mammary Glands, Animal
Concept	Physical Conditioning, Animal
Concept	Disease Models, Animal
Concept	Animals, Newborn
Concept	Animals
Concept	Animal Nutritional Physiological Phenomena
Concept	Models, Animal
Concept	Animal Husbandry
Concept	Animal Feed
Concept	Housing, Animal
Concept	Animals, Suckling
Concept	Behavior, Animal
Academic Article	Early postnatal nutrition determines adult physical activity and energy expenditure in female mice.
Academic Article	Viscera and muscle protein synthesis in neonatal pigs is increased more by intermittent bolus than by continuous feeding.
Academic Article	Dystropathology increases energy expenditure and protein turnover in the mdx mouse model of duchenne muscular dystrophy.
Academic Article	Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake.
Academic Article	Extrarenal citrulline disposal in mice with impaired renal function.
Academic Article	Ribosome abundance regulates the recovery of skeletal muscle protein mass upon recuperation from postnatal undernutrition in mice.
Academic Article	Bolus vs. continuous feeding to optimize anabolism in neonates.
Academic Article	Amino acids and insulin are regulators of muscle protein synthesis in neonatal pigs.
Academic Article	Leucine is a major regulator of muscle protein synthesis in neonates.
Academic Article	Leucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs.
Academic Article	Impact of prolonged leucine supplementation on protein synthesis and lean growth in neonatal pigs.
Academic Article	Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs.
Academic Article	Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders.
Academic Article	Maternal exercise during pregnancy promotes physical activity in adult offspring.
Academic Article	Precocious glucocorticoid exposure reduces skeletal muscle satellite cells in the fetal rat.
Academic Article	Chronic Maternal Low-Protein Diet in Mice Affects Anxiety, Night-Time Energy Expenditure and Sleep Patterns, but Not Circadian Rhythm in Male Offspring.
Academic Article	IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice.
Academic Article	The pathogenesis of oedema in kwashiorkor--the role of plasma proteins.
Academic Article	Proceedings of the 12th Symposium on Energy Metabolism of Farm Animals
Academic Article	Proceedings of 63rd Cornell Nutrition Conference
Academic Article	The Contribution of Nutrition to Human and Animal Health. Widdowson EM, Mathers JC, editors
Academic Article	Biology of Metabolism of Growing Animals. Burrin DG, Mersmann HJ, editors
Academic Article	Methods for Investigation of Amino Acid and Protein Metabolism. El-Khoury AE, editor
Academic Article	Short- and long-term effects of leucine and branched-chain amino acid supplementation of a protein- and energy-reduced diet on muscle protein metabolism in neonatal pigs.
Academic Article	Choline Supplementation Prevents a Hallmark Disturbance of Kwashiorkor in Weanling Mice Fed a Maize Vegetable Diet: Hepatic Steatosis of Undernutrition.
Academic Article	Critical Windows for the Programming Effects of Early-Life Nutrition on Skeletal Muscle Mass.
Academic Article	Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis.
Academic Article	Intermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model.
Academic Article	Regulation of Muscle Growth in Early Postnatal Life in a Swine Model.
Academic Article	Postnatal undernutrition alters adult female mouse cardiac structure and function leading to limited exercise capacity.
Academic Article	Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets.
Academic Article	Leucine Supplementation Does Not Restore Diminished Skeletal Muscle Satellite Cell Abundance and Myonuclear Accretion When Protein Intake Is Limiting in Neonatal Pigs.
Academic Article	DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice.
Academic Article	Differential regulation of mTORC1 activation by leucine and ?-hydroxy-?-methylbutyrate in skeletal muscle of neonatal pigs.
Academic Article	Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs.
Academic Article	Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs.
Academic Article	Should the AIN-93 Rodent Diet Formulas be Revised?
Academic Article	Intermittent Bolus Compared With Continuous Feeding Enhances Insulin and Amino Acid Signaling to Translation Initiation in Skeletal Muscle of Neonatal Pigs.
Academic Article	Variation in AIN-93G/M Diets Across Different Commercial Manufacturers: Not All AIN-93 Diets are Created Equal.
Academic Article	Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model.
Academic Article	High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease.
Academic Article	Regulation of skeletal muscle protein synthesis in the preterm pig by intermittent leucine pulses during continuous parenteral feeding.
Academic Article	Preterm birth alters the feeding-induced activation of Akt signaling in the muscle of neonatal piglets.
Academic Article	Prematurity blunts protein synthesis in skeletal muscle independently of body weight in neonatal pigs.
Academic Article	Dimeric p53 Mutant Elicits Unique Tumor-Suppressive Activities through an Altered Metabolic Program.
Academic Article	Pulsatile Leucine Administration during Continuous Enteral Feeding Enhances Skeletal Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis in a Preterm Piglet Model.
Academic Article	Adverse Metabolic Phenotypes in Parenterally Fed Neonatal Pigs Do Not Persist into Adolescence.

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