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JOSHUA WYTHE

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Integrative Physiology
AddressPinn Hall 3073
Charlottesville, 22908
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Long H, Steimle JD, Grisanti Canozo FJ, Kim JH, Li X, Morikawa Y, Park M, Turaga D, Adachi I, Wythe JD, Samee MAH, Martin JF. Endothelial cells adopt a pro-reparative immune responsive signature during cardiac injury. Life Sci Alliance. 2024 Feb; 7(2). PMID: 38012001; PMCID: PMC10681909.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Ricciardelli AR, Robledo A, Fish JE, Kan PT, Harris TH, Wythe JD. The Role and Therapeutic Implications of Inflammation in the Pathogenesis of Brain Arteriovenous Malformations. Biomedicines. 2023 Oct 24; 11(11). PMID: 38001877; PMCID: PMC10669898.
      Citations:    
    3. Kim GS, Harmon E, Gutierrez M, Stephenson J, Chauhan A, Banerjee A, Wise Z, Doan A, Wu T, Lee J, Jung JE, McCullough L, Wythe J, Marrelli S. Single-cell analysis identifies Ifi27l2a as a novel gene regulator of microglial inflammation in the context of aging and stroke. Res Sq. 2023 Feb 15. PMID: 36824976; PMCID: PMC9949241.
      Citations:    
    4. Hsu CW, Cerda J, Kirk JM, Turner WD, Rasmussen TL, Flores Suarez CP, Dickinson ME, Wythe JD. EZ Clear for simple, rapid, and robust mouse whole organ clearing. Elife. 2022 10 11; 11. PMID: 36218247; PMCID: PMC9555867.
      Citations: 3     Fields:    Translation:Animals
    5. Soon K, Li M, Wu R, Zhou A, Khosraviani N, Turner WD, Wythe JD, Fish JE, Nunes SS. A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks. Biomaterials. 2022 09; 288:121729. PMID: 35999080; PMCID: PMC9972357.
      Citations:    
    6. Mayerich D, Wythe JD. Computational insights on coronary artery function. Nat Cardiovasc Res. 2022 Aug; 1(8):691-693. PMID: 37564924; PMCID: PMC10414787.
      Citations:    
    7. Li-Villarreal N, Wong RLY, Garcia MD, Udan RS, Rasmussen TL, Rhyner AM, Wythe JD, Dickinson ME, Poch? RA. FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac. Development. 2022 04 01; 149(7). PMID: 35297995; PMCID: PMC8995087.
      Citations:    Fields:    Translation:AnimalsCells
    8. Verma SK, Deshmukh V, Thatcher K, Belanger KK, Rhyner AM, Meng S, Holcomb RJ, Bressan M, Martin JF, Cooke JP, Wythe JD, Widen SG, Lincoln J, Kuyumcu-Martinez MN. RBFOX2 is required for establishing RNA regulatory networks essential for heart development. Nucleic Acids Res. 2022 02 28; 50(4):2270-2286. PMID: 35137168; PMCID: PMC8881802.
      Citations:    Fields:    Translation:AnimalsCells
    9. Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann V, Wojtkiewicz G, Honold L, Chen Q, Schmidt S, Iwamoto Y, Sun Y, Cremer S, Hoyer FF, Iborra-Egea O, Ji F, Zhou B, Adams RH, Wythe JD, Hidalgo J, Watanabe H, Jung Y, van der Laan AM, Piek JJ, Kfoury Y, Vinegoni C, Dutta P, Sadreyev RI, Caravan P, Bayes-Genis A, Libby P, Scadden DT, Lin CP, Naxerova K, Swirski FK, Nahrendorf M, Mu?oz-Guijosa C, D?sog?re PA. Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease. Nat Cardiovasc Res. 2022 Jan; 1(1):28-44. PMID: 35747128; PMCID: PMC9216333.
      Citations:    
    10. Carlson JC, Cantu Gutierrez M, Lozzi B, Huang-Hobbs E, Turner WD, Tepe B, Zhang Y, Herman AM, Rao G, Creighton CJ, Wythe JD, Deneen B. Identification of diverse tumor endothelial cell populations in malignant glioma. Neuro Oncol. 2021 06 01; 23(6):932-944. PMID: 33367832; PMCID: PMC8168823.
      Citations: 11     Fields:    Translation:HumansCells
    11. Shao Y, Bajikar SS, Tirumala HP, Gutierrez MC, Wythe JD, Zoghbi HY. Identification and characterization of conserved noncoding cis-regulatory elements that impact Mecp2 expression and neurological functions. Genes Dev. 2021 04 01; 35(7-8):489-494. PMID: 33737384; PMCID: PMC8015713.
      Citations:    Fields:    Translation:HumansAnimalsCells
    12. Geng X, Yanagida K, Akwii RG, Choi D, Chen L, Ho Y, Cha B, Mahamud MR, Berman de Ruiz K, Ichise H, Chen H, Wythe JD, Mikelis CM, Hla T, Srinivasan RS. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling. JCI Insight. 2020 07 23; 5(14). PMID: 32544090; PMCID: PMC7453895.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    13. Fish JE, Flores Suarez CP, Boudreau E, Herman AM, Gutierrez MC, Gustafson D, DiStefano PV, Cui M, Chen Z, De Ruiz KB, Schexnayder TS, Ward CS, Radovanovic I, Wythe JD. Somatic Gain of KRAS Function in the Endothelium Is Sufficient to Cause Vascular Malformations That Require MEK but Not PI3K Signaling. Circ Res. 2020 08 28; 127(6):727-743. PMID: 32552404; PMCID: PMC7447191.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    14. Cain MP, Hutchison V, Flodby P, Crandall ED, Borok Z, Zhou B, Ostrin EJ, Wythe JD, Chen J, Vila Ellis L. Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell. 2020 03 09; 52(5):617-630.e6. PMID: 32059772; PMCID: PMC7170573.
      Citations: 44     Fields:    Translation:AnimalsCells
    15. Hong SH, Herman AM, Stephenson JM, Wu T, Bahadur AN, Burns AR, Marrelli SP, Wythe JD. Development of barium-based low viscosity contrast agents for micro CT vascular casting: Application to 3D visualization of the adult mouse cerebrovasculature. J Neurosci Res. 2020 02; 98(2):312-324. PMID: 31630455; PMCID: PMC8063604.
      Citations: 3     Fields:    Translation:Animals
    16. Cantu Gutierrez A, Cantu Gutierrez M, Rhyner AM, Ruiz OE, Eisenhoffer GT, Wythe JD. FishNET: An automated relational database for zebrafish colony management. PLoS Biol. 2019 06; 17(6):e3000343. PMID: 31220074; PMCID: PMC6605666.
      Citations: 1     Fields:    Translation:Animals
    17. Hill MC, Kadow ZA, Li L, Tran TT, Wythe JD, Martin JF. A cellular atlas of Pitx2-dependent cardiac development. Development. 2019 06 14; 146(12). PMID: 31201182; PMCID: PMC6602352.
      Citations: 11     Fields:    Translation:AnimalsCells
    18. Wang K, Zhao S, Liu B, Zhang Q, Li Y, Liu J, Shen Y, Ding X, Lin J, Wu Y, Yan Z, Chen J, Li X, Song X, Niu Y, Liu J, Chen W, Ming Y, Du R, Chen C, Long B, Zhang Y, Tong X, Zhang S, Posey JE, Zhang B, Wu Z, Wythe JD, Liu P, Lupski JR, Yang X, Wu N. Perturbations of BMP/TGF-? and VEGF/VEGFR signalling pathways in non-syndromic sporadic brain arteriovenous malformations (BAVM). J Med Genet. 2018 10; 55(10):675-684. PMID: 30120215; PMCID: PMC6161649.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    19. Xiao Y, Hill MC, Zhang M, Martin TJ, Morikawa Y, Wang S, Moise AR, Wythe JD, Martin JF. Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development. Dev Cell. 2018 04 23; 45(2):153-169.e6. PMID: 29689192; PMCID: PMC5947860.
      Citations: 63     Fields:    Translation:AnimalsCells
    20. Herman AM, Rhyner AM, Devine WP, Marrelli SP, Bruneau BG, Wythe JD. A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse. Biol Open. 2018 Mar 12; 7(3). PMID: 29437553; PMCID: PMC5898260.
      Citations: 6     Fields:    
    21. Nikolaev SI, Vetiska S, Bonilla X, Boudreau E, Jauhiainen S, Rezai Jahromi B, Khyzha N, DiStefano PV, Suutarinen S, Kiehl TR, Mendes Pereira V, Herman AM, Krings T, Andrade-Barazarte H, Tung T, Valiante T, Zadeh G, Tymianski M, Rauramaa T, Wythe JD, Antonarakis SE, Fish JE, Radovanovic I, Yl?-Herttuala S, Fr?sen J. Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain. N Engl J Med. 2018 01 18; 378(3):250-261. PMID: 29298116; PMCID: PMC8161530.
      Citations: 95     Fields:    Translation:HumansCells
    22. Fish JE, Cantu Gutierrez M, Dang LT, Khyzha N, Chen Z, Veitch S, Cheng HS, Khor M, Antounians L, Boudreau E, Herman AM, Rhyner AM, Ruiz OE, Eisenhoffer GT, Medina-Rivera A, Wilson MD, Wythe JD, Njock MS. Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development. 2017 07 01; 144(13):2428-2444. PMID: 28536097; PMCID: PMC5536864.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    23. Liu Q, Zhang H, Tian X, He L, Huang X, Tan Z, Yan Y, Evans SM, Wythe JD, Zhou B. Smooth muscle origin of postnatal 2nd CVP is pre-determined in early embryo. Biochem Biophys Res Commun. 2016 Mar 18; 471(4):430-6. PMID: 26902114; PMCID: PMC5555742.
      Citations: 4     Fields:    Translation:Animals
    24. He L, Liu Q, Hu T, Huang X, Zhang H, Tian X, Yan Y, Wang L, Huang Y, Miquerol L, Wythe JD, Zhou B. Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart. Cardiovasc Res. 2016 Mar 01; 109(3):419-30. PMID: 26768261; PMCID: PMC4752045.
      Citations: 17     Fields:    Translation:AnimalsCells
    25. Wang J, Xiao Y, Hsu CW, Martinez-Traverso IM, Zhang M, Bai Y, Ishii M, Maxson RE, Olson EN, Dickinson ME, Wythe JD, Martin JF. Yap and Taz play a crucial role in neural crest-derived craniofacial development. Development. 2016 Feb 01; 143(3):504-15. PMID: 26718006; PMCID: PMC4760309.
      Citations: 45     Fields:    Translation:AnimalsCells
    26. Lizama CO, Hawkins JS, Schmitt CE, Bos FL, Zape JP, Borges Pinto H, Rhyner AM, Yu H, Donohoe ME, Wythe JD, Zovein AC, Cautivo KM. Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat Commun. 2015 Jul 23; 6:7739. PMID: 26204127; PMCID: PMC4519987.
      Citations: 61     Fields:    Translation:AnimalsCells
    27. Fish JE, Wythe JD. The molecular regulation of arteriovenous specification and maintenance. Dev Dyn. 2015 Mar; 244(3):391-409. PMID: 25641373.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    28. Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, Fang J, Yu Y, Duan S, Hu C, Hui L, Zhang H, Quertermous T, Xu Q, Red-Horse K, Wythe JD, Zhou B. Genetic targeting of sprouting angiogenesis using Apln-CreER. Nat Commun. 2015 Jan 19; 6:6020. PMID: 25597280; PMCID: PMC4309445.
      Citations: 60     Fields:    Translation:AnimalsCells
    29. Devine WP, Wythe JD, George M, Koshiba-Takeuchi K, Bruneau BG. Early patterning and specification of cardiac progenitors in gastrulating mesoderm. Elife. 2014 Oct 08; 3. PMID: 25296024; PMCID: PMC4356145.
      Citations: 83     Fields:    Translation:AnimalsCells
    30. He L, Tian X, Zhang H, Wythe JD, Zhou B. Fabp4-CreER lineage tracing reveals two distinctive coronary vascular populations. J Cell Mol Med. 2014 Nov; 18(11):2152-6. PMID: 25265869; PMCID: PMC4224549.
      Citations: 18     Fields:    Translation:HumansAnimals
    31. Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE. ETS factors regulate Vegf-dependent arterial specification. Dev Cell. 2013 Jul 15; 26(1):45-58. PMID: 23830865; PMCID: PMC3754838.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    32. Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol. 2011 Jun 27; 193(7):1181-96. PMID: 21690310; PMCID: PMC3216339.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    33. Wythe JD, Jurynec MJ, Urness LD, Jones CA, Sabeh MK, Werdich AA, Sato M, Yost HJ, Grunwald DJ, Macrae CA, Li DY. Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. Dis Model Mech. 2011 Sep; 4(5):607-21. PMID: 21628396; PMCID: PMC3180224.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    34. Fish JE, Wythe JD, Xiao T, Bruneau BG, Stainier DY, Srivastava D, Woo S. A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development. 2011 Apr; 138(7):1409-19. PMID: 21385766; PMCID: PMC3050667.
      Citations: 75     Fields:    Translation:AnimalsCells
    35. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008 Aug; 15(2):272-84. PMID: 18694566; PMCID: PMC2604134.
      Citations: 690     Fields:    Translation:HumansAnimalsCells
    36. Jones CA, London NR, Chen H, Park KW, Sauvaget D, Stockton RA, Wythe JD, Suh W, Larrieu-Lahargue F, Mukouyama YS, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg MH, Gerhardt H, Zhang K, Li DY. Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med. 2008 Apr; 14(4):448-53. PMID: 18345009; PMCID: PMC2875252.
      Citations: 187     Fields:    Translation:HumansAnimalsCells
    37. Navankasattusas S, Whitehead KJ, Suli A, Sorensen LK, Lim AH, Zhao J, Park KW, Wythe JD, Thomas KR, Chien CB, Li DY. The netrin receptor UNC5B promotes angiogenesis in specific vascular beds. Development. 2008 Feb; 135(4):659-67. PMID: 18223200; PMCID: PMC2612632.
      Citations: 53     Fields:    Translation:AnimalsCells
    38. Park KW, Urness LD, Senchuk MM, Colvin CJ, Wythe JD, Chien CB, Li DY. Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4. Dev Dyn. 2005 Nov; 234(3):726-31. PMID: 15973704; PMCID: PMC2612631.
      Citations: 12     Fields:    Translation:AnimalsCells
    39. Karnik SK, Wythe JD, Sorensen L, Brooke BS, Urness LD, Li DY. Elastin induces myofibrillogenesis via a specific domain, VGVAPG. Matrix Biol. 2003 Sep; 22(5):409-25. PMID: 14614988.
      Citations: 18     Fields:    Translation:AnimalsCells
    40. Karnik SK, Brooke BS, Bayes-Genis A, Sorensen L, Wythe JD, Schwartz RS, Keating MT, Li DY. A critical role for elastin signaling in vascular morphogenesis and disease. Development. 2003 Jan; 130(2):411-23. PMID: 12466207.
      Citations: 174     Fields:    Translation:HumansAnimalsCells
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