MINGSHANXUEMINGSHAN XUE7735XUE, MINGSHANAssociate Professorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasMemberRolemember ofvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressMember Rolevivo:memberRoleOfmember role ofvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst nameGroupfoaf:lastNamelast nameOrganizationPersonAnesthesiology & PeriOperative MedicineMD AndersonHUI-LINPANHUI-LIN PAN9317PAN, HUI-LINProfessor74Professor10Assistant Professor14Associate Professor46Distinguished Emeritus Professor47Distinguished Service Professor27328325Meng X, Wang W, Lu H, He LJ, Chen W, Chao ES, Fiorotto ML, Tang B, Herrera JA, Seymour ML, Neul JL, Pereira FA, Tang J, Xue M, Zoghbi HYeLifeManipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders. Elife. 2016 06 21; 5.Elife2016-06-21T00:00:002016Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders.Pediatrics-Neur NRI CAINAuthorship 32472114Authorship 654443428045139Yin J, Chen W, Yang H, Xue M, Schaaf CPScientific reportsChrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes. Sci Rep. 2017 01 03; 7:39941.Sci Rep2017-01-03T00:00:002017Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes.19914185Xue M, Lin YQ, Pan H, Reim K, Deng H, Bellen HJ, Rosenmund CNeuronTilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron. 2009 Nov 12; 64(3):367-80.Neuron2009-11-12T00:00:002009Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.21068835Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HYNatureDysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010 Nov 11; 468(7321):263-9.Nature2010-11-11T00:00:002010Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes.Authorship 8689781228392070Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HYNeuronRespiratory Network Stability and Modulatory Response to Substance P Require Nalcn. Neuron. 2017 Apr 19; 94(2):294-303.e4.Neuron2017-04-06T00:00:002017Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn.Authorship 875498928703127Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang JNature communicationsQuantitative real-time imaging of glutathione. Nat Commun. 2017 07 13; 8:16087.Nat Commun2017-07-13T00:00:002017Quantitative real-time imaging of glutathione.Authorship 8793761429395075Yin J, Chen W, Chao ES, Soriano S, Wang L, Wang W, Cummock SE, Tao H, Pang K, Liu Z, Pereira FA, Samaco RC, Zoghbi HY, Xue M, Schaaf CPAmerican journal of human geneticsOtud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome. Am J Hum Genet. 2018 02 01; 102(2):296-308.Am J Hum Genet2018-02-01T00:00:002018Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome.HSIAO-TUANCHAOHSIAO-TUAN CHAO13688CHAO, HSIAO-TUANAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessortrue1Distinguished Service ProfessorDistinguished Service ProfessorD009474Anatomy61322830.451946NeuronsD017204Disorders46790.932941Angelman Syndrometrue1Postdoc Fellows and AssociatesPostdoc Fellows and AssociatesD013572Anatomy32580.966292Synaptic VesiclesD050863Chemicals & Drugs590.993369Synaptotagmin ID033942Chemicals & Drugs69940.942486Adaptor Proteins, Vesicular TransportAuthorship 932522430091701Messier JE, Chen H, Cai ZL, Xue MeLifeTargeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon. Elife. 2018 08 09; 7.Elife2018-08-09T00:00:002018Targeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon.2024-05-31NIHXUE, MINGSHAN2018-08-16Activity-Dependent Mechanisms Regulating Synaptic Excitation and Inhibition in Neural CircuitsR01MH1170892022-01-31NIHXUE, MINGSHAN2017-02-01Synaptic Dysfunction of Neural Circuits in Neurodevelopmental DisordersR01NS100893Principal InvestigatorPrincipal InvestigatorDepartment of NeurologyDepartment of NeuroscienceDepartment of PediatricsDepartment of Molecular & Human GeneticsMolecular & Human GeneticsNeurologyNeurosciencePediatrics-NeurologyBaylor College of MedicineJIANRONGTANGJIANRONG TANG32.31117320000000-90.07681340000000617TANG, JIANRONGAssociate ProfessorHUDAZOGHBIHUDA ZOGHBI29.71010310000000-95.397396100000002830ZOGHBI, HUDADistinguished Service ProfessorJAMESLUPSKIJAMES LUPSKI29.71073630000000-95.396604500000003140LUPSKI, JAMESProfessorHUGOBELLENHUGO BELLEN29.71010310000000-95.397396100000003292BELLEN, HUGODistinguished Service ProfessorJOHNSWANNJOHN SWANN32.31117320000000-90.076813400000003379SWANN, JOHNDistinguished Emeritus ProfessorJEFFREYNOEBELSJEFFREY NOEBELS0.000000000000000.000000000000003151NOEBELS, JEFFREYProfessorDr. Shaulsky's GroupMemberAuthorship 9555851131524598Meng X, McGraw CM, Wang W, Jing J, Yeh SY, Wang L, Lopez J, Brown AM, Lin T, Chen W, Xue M, Sillitoe RV, Jiang X, Zoghbi HYeLifeNeurexophilin4 is a selectively expressed a-neurexin ligand that modulates specific cerebellar synapses and motor functions. Elife. 2019 09 16; 8.Elife2019-09-16T00:00:002019Neurexophilin4 is a selectively expressed a-neurexin ligand that modulates specific cerebellar synapses and motor functions.71Postdoc Fellows and AssociatesPostDocAuthorship 9780581332073399Chen W, Cai ZL, Chao ES, Chen H, Longley CM, Hao S, Chao HT, Kim JH, Messier JE, Zoghbi HY, Tang J, Swann JW, Xue MeLifeStxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy. Elife. 2020 02 19; 9.Elife2020-02-19T00:00:002020Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy.true1Associate ProfessorAssociate Professor2024-08-31NIHSPUDICH, JOHN LEE;ST-PIERRE, FRANCOIS ;XUE, MINGSHAN2020-08-15Molecular Engineering of Natural Light-Gated Chloride Channels for Optogenetic InhibitionU01NS118288Principal Investigatorhttp://flypush.imgen.bcm.tmc.eduBellen Lab WebsiteAuthorship 10240301034180393Stevens SR, Longley CM, Ogawa Y, Teliska LH, Arumanayagam AS, Nair S, Oses-Prieto JA, Burlingame AL, Cykowski MD, Xue M, Rasband MNeLifeAnkyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels. Elife. 2021 06 28; 10.Elife2021-06-28T00:00:002021Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels.true1Distinguished Service ProfessorDistinguished Service Professortrue1Assistant ProfessorAssistant ProfessorAuthorship 10625351536594817Lee D, Chen W, Kaku HN, Zhuo X, Chao ES, Soriano A, Kuncheria A, Flores S, Kim JH, Rivera A, Rigo F, Jafar-Nejad P, Beaudet AL, Caudill MS, Xue MeLifeAntisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome. Elife. 2023 01 03; 12.Elife2023-01-03T00:00:002023Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome.Authorship 10653321236905087Corriveau ML, Amaya SI, Koebel MC, Lerma VC, Michener SL, Turner A, Schultz RJ, Seto ES, Diaz-Medina GE, Craigen WJ, Swann JW, Xue M, Chao HTAmerican journal of medical genetics. Part APAK1 c.1409?T?>?a (p. Leu470Gln) de novo variant affects the protein kinase domain, leading to epilepsy, macrocephaly, spastic quadriplegia, and hydrocephalus: Case report and review of the literature. Am J Med Genet A. 2023 06; 191(6):1619-1625.Am J Med Genet A2023-03-10T00:00:002023PAK1 c.1409?T?>?a (p. Leu470Gln) de novo variant affects the protein kinase domain, leading to epilepsy, macrocephaly, spastic quadriplegia, and hydrocephalus: Case report and review of the literature.Authorship 10736141837261917Tu L, Bean JC, He Y, Liu H, Yu M, Liu H, Zhang N, Yin N, Han J, Scarcelli NA, Conde KM, Wang M, Li Y, Feng B, Gao P, Cai ZL, Fukuda M, Xue M, Tong Q, Yang Y, Liao L, Xu J, Wang C, He Y, Xu YThe Journal of clinical investigationAnoctamin 4 channel currents activate glucose-inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia. J Clin Invest. 2023 07 17; 133(14).J Clin Invest2023-07-17T00:00:002023Anoctamin 4 channel currents activate glucose-inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia.true1Associate ProfessorAssociate Professortrue1Distinguished Emeritus ProfessorDistinguished Emeritus Professor2026-08-31NIHSPUDICH, JOHN LEE2023-09-01Developing an Optogenetics Technology Based on Natural Potassium-selective ChannelrhodopsinsRF1NS133657Co-Principal Investigatortrue1ProfessorProfessorPediatrics-Genetics1250 MOURSUND STREETHouston, 77030TX111groups1.0380.013326149research areas0.8108120.024737343coauthor of30.17493.9061760similar to1121selected publicationsAuthorship 1475054Authorship 1475741Authorship 1481441Authorship 1481471Authorship 1482711Authorship 1482811Authorship 1486311Authorship 1487381Authorship 148780118505837Xue M, Stradomska A, Chen H, Brose N, Zhang W, Rosenmund C, Reim KProceedings of the National Academy of Sciences of the United States of AmericaComplexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7875-80.Proc Natl Acad Sci U S A2008-05-27T00:00:002008Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system.20824061Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, S?dhof TC, Rosenmund C, Rizo JPloS oneStructural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. PLoS One. 2010 Sep 02; 5(9).PLoS One2010-09-02T00:00:002010Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.17828276Xue M, Reim K, Chen X, Chao HT, Deng H, Rizo J, Brose N, Rosenmund CNature structural & molecular biologyDistinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol. 2007 Oct; 14(10):949-58.Nat Struct Mol Biol2007-09-09T00:00:002007Distinct domains of complexin I differentially regulate neurotransmitter release.18953334Xue M, Ma C, Craig TK, Rosenmund C, Rizo JNature structural & molecular biologyThe Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function. Nat Struct Mol Biol. 2008 Nov; 15(11):1160-8.Nat Struct Mol Biol2008-10-26T00:00:002008The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.25043046Xue M, Atallah BV, Scanziani MNatureEqualizing excitation-inhibition ratios across visual cortical neurons. Nature. 2014 Jul 31; 511(7511):596-600.Nature2014-06-22T00:00:002014Equalizing excitation-inhibition ratios across visual cortical neurons.19285460Xue M, Rosenmund CNeuronThe headache of a hyperactive calcium channel. Neuron. 2009 Mar 12; 61(5):653-4.Neuron2009-03-12T00:00:002009The headache of a hyperactive calcium channel.20400951Xue M, Craig TK, Xu J, Chao HT, Rizo J, Rosenmund CNature structural & molecular biologyBinding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Nat Struct Mol Biol. 2010 May; 17(5):568-75.Nat Struct Mol Biol2010-04-18T00:00:002010Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.Zhao-LinCaiZhao-Lin Cai7999Cai, Zhao-LinPostdoc Fellows and Associates